Details for: PPM1B

Gene ID: 5495

Symbol: PPM1B

Ensembl ID: ENSG00000138032

Description: protein phosphatase, Mg2+/Mn2+ dependent 1B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.51
    Marker Score: 11297
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.54
    Marker Score: 1673
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.49
    Marker Score: 3106
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.17
    Marker Score: 46251.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.97
    Marker Score: 1102
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.97
    Marker Score: 4716
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.93
    Marker Score: 3375
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.93
    Marker Score: 28884
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.93
    Marker Score: 7999
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.91
    Marker Score: 72430
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.91
    Marker Score: 37927.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.9
    Marker Score: 794
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.84
    Marker Score: 67912
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.83
    Marker Score: 7057.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.82
    Marker Score: 13930
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.82
    Marker Score: 111685
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.74
    Marker Score: 1997
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.73
    Marker Score: 16439
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.7
    Marker Score: 14578
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.68
    Marker Score: 15808
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.62
    Marker Score: 592.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.59
    Marker Score: 771
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.59
    Marker Score: 1963
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.57
    Marker Score: 7249
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.56
    Marker Score: 471.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.54
    Marker Score: 6255
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.54
    Marker Score: 2954
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.48
    Marker Score: 2284
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.45
    Marker Score: 507
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.45
    Marker Score: 14974
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.43
    Marker Score: 3505
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.39
    Marker Score: 380
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.38
    Marker Score: 805
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.37
    Marker Score: 722
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.36
    Marker Score: 2763
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.35
    Marker Score: 1167
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.33
    Marker Score: 924
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.33
    Marker Score: 497
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.33
    Marker Score: 1430
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.31
    Marker Score: 3734
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.3
    Marker Score: 703
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.29
    Marker Score: 43499
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.27
    Marker Score: 3503
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.26
    Marker Score: 406
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.26
    Marker Score: 1268
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.26
    Marker Score: 394
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.25
    Marker Score: 8027
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.24
    Marker Score: 370
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.23
    Marker Score: 611.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.23
    Marker Score: 2886
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.23
    Marker Score: 1168
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.22
    Marker Score: 679
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.22
    Marker Score: 1727.5
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.22
    Marker Score: 351
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.21
    Marker Score: 18997
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.21
    Marker Score: 5216
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.21
    Marker Score: 3446
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.21
    Marker Score: 446.5
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.2
    Marker Score: 380
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.2
    Marker Score: 26729
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.19
    Marker Score: 1168
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.18
    Marker Score: 778
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.17
    Marker Score: 1073
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.15
    Marker Score: 415
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.15
    Marker Score: 689
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.15
    Marker Score: 693
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.15
    Marker Score: 601
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.15
    Marker Score: 993
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.14
    Marker Score: 272
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.14
    Marker Score: 709
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.13
    Marker Score: 248
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.1
    Marker Score: 1237
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.1
    Marker Score: 834
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1
    Marker Score: 17664
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.1
    Marker Score: 399
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.1
    Marker Score: 5899.5
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.1
    Marker Score: 233
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.09
    Marker Score: 1830
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.09
    Marker Score: 1153
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.09
    Marker Score: 286
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.08
    Marker Score: 760
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.06
    Marker Score: 1125
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.06
    Marker Score: 638.5
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.05
    Marker Score: 518
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.04
    Marker Score: 257
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.04
    Marker Score: 4484
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.04
    Marker Score: 241
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.03
    Marker Score: 522
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.03
    Marker Score: 236
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.03
    Marker Score: 1453
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.03
    Marker Score: 790
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 1.02
    Marker Score: 252
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.02
    Marker Score: 260.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.02
    Marker Score: 694
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.01
    Marker Score: 1014
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.01
    Marker Score: 893
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.01
    Marker Score: 356
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1
    Marker Score: 789
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1
    Marker Score: 232
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1
    Marker Score: 430

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Other Information

**Key Characteristics:** PPM1B is a unique phosphatase that exhibits dual specificity for magnesium (Mg2+) and manganese (Mn2+) ions, allowing it to regulate a wide range of cellular functions. Its expression is widespread, with significant presence in various tissues, including skeletal muscle, cardiac neurons, astrocytes, and fat cells. This ubiquitous expression suggests that PPM1B plays a critical role in maintaining cellular homeostasis and responding to environmental cues. **Pathways and Functions:** PPM1B is involved in multiple signaling pathways, including: 1. **Cytokine signaling in the immune system:** PPM1B modulates the activity of cytokines, such as interferon-alpha (IFN-α) and tumor necrosis factor-alpha (TNF-α), which are essential for immune response and inflammation. 2. **Antiviral mechanisms:** PPM1B interacts with interferon-stimulated genes (ISGs) to regulate antiviral responses, providing protection against viral infections. 3. **Negative regulation of NF-κB signaling:** PPM1B inhibits the activation of NF-κB, a transcription factor that regulates inflammation and immune response. 4. **Negative regulation of defense response to virus:** PPM1B modulates the expression of genes involved in the defense response to viral infections. 5. **Positive regulation of Wnt signaling:** PPM1B activates the Wnt/β-catenin signaling pathway, which is involved in cell proliferation and differentiation. **Clinical Significance:** The dysregulation of PPM1B has been implicated in various diseases, including: 1. **Cancer:** Alk fusions and activated point mutants of PPM1B have been found in cancer cells, suggesting its role in tumorigenesis and cancer progression. 2. **Autoimmune diseases:** Alterations in PPM1B expression and activity have been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological disorders:** PPM1B has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, PPM1B is a multifaceted phosphatase that plays a critical role in regulating immune responses, antiviral mechanisms, and cellular homeostasis. Further research is needed to elucidate the precise mechanisms of PPM1B and its potential therapeutic applications in disease prevention and treatment. **Recommendations:** 1. Further studies should investigate the role of PPM1B in specific disease models, including cancer, autoimmune diseases, and neurological disorders. 2. The development of PPM1B-targeting therapies should be explored, with a focus on modulating its activity in disease-relevant contexts. 3. The expression and activity of PPM1B should be evaluated in various tissues and cell types to better understand its role in maintaining cellular homeostasis. By advancing our understanding of PPM1B, we can uncover new avenues for disease prevention and treatment, ultimately improving human health and well-being.

Genular Protein ID: 886676343

Symbol: PPM1B_HUMAN

Name: Protein phosphatase 1B

UniProtKB Accession Codes:

O75688 Q461Q2 Q4J6C1 Q4J6C2 Q658R4 Q96ER6 Q9HAY8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DEPOD 1 DNASU 1 DisGeNET 1 EC 3 EMBL 15 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 Rhea 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9684878

Title: The cloning expression and tissue distribution of human PP2Cbeta.

PubMed ID: 9684878

DOI: 10.1016/s0014-5793(98)00708-x

PubMed ID: 10934208

Title: Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2Calpha and beta2 isoforms.

PubMed ID: 10934208

DOI: 10.1074/jbc.m006210200

PubMed ID: 15913950

Title: The 2p21 deletion syndrome: characterization of the transcription content.

PubMed ID: 15913950

DOI: 10.1016/j.ygeno.2005.04.001

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16872604

Title: Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation.

PubMed ID: 16872604

DOI: 10.1016/j.febslet.2006.07.032

PubMed ID: 18642328

Title: Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins.

PubMed ID: 18642328

DOI: 10.1002/pros.20787

PubMed ID: 18930133

Title: PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.

PubMed ID: 18930133

DOI: 10.1016/j.cellsig.2008.09.012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22781750

Title: Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.

PubMed ID: 22781750

DOI: 10.1016/j.cellsig.2012.07.003

PubMed ID: 22750291

Title: PPM1B negatively regulates antiviral response via dephosphorylating TBK1.

PubMed ID: 22750291

DOI: 10.1016/j.cellsig.2012.06.017

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 18058037

Title: Structural genomics of protein phosphatases.

PubMed ID: 18058037

DOI: 10.1007/s10969-007-9036-1

Sequence Information:

  • Length: 479
  • Mass: 52643
  • Checksum: A3A5797AD263DFBD
  • Sequence:
    • MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL EDWSFFAVYD 
GHAGSRVANY CSTHLLEHIT TNEDFRAAGK SGSALELSVE NVKNGIRTGF LKIDEYMRNF 
SDLRNGMDRS GSTAVGVMIS PKHIYFINCG DSRAVLYRNG QVCFSTQDHK PCNPREKERI 
QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFIIL 
ACDGIWDVMS NEELCEYVKS RLEVSDDLEN VCNWVVDTCL HKGSRDNMSI VLVCFSNAPK 
VSDEAVKKDS ELDKHLESRV EEIMEKSGEE GMPDLAHVMR ILSAENIPNL PPGGGLAGKR 
NVIEAVYSRL NPHRESDGAS DEAEESGSQG KLVEALRQMR INHRGNYRQL LEEMLTSYRL 
AKVEGEESPA EPAATATSSN SDAGNPVTMQ ESHTESESGL AELDSSNEDA GTKMSGEKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.