Details for: PCGEM1

Gene ID: 64002

Symbol: PCGEM1

Ensembl ID: ENSG00000227418

Description: PCGEM1 prostate-specific transcript

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 3.2893
    Cell Significance Index: 30.7700
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.1917
    Cell Significance Index: 12.1000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4442
    Cell Significance Index: 6.4800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4089
    Cell Significance Index: 9.9100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.2624
    Cell Significance Index: 2.2300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1274
    Cell Significance Index: 2.7900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1040
    Cell Significance Index: 0.8300
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.0944
    Cell Significance Index: 1.0400
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0914
    Cell Significance Index: 1.1100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0530
    Cell Significance Index: 0.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0444
    Cell Significance Index: 1.1900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0284
    Cell Significance Index: 0.3500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.0265
    Cell Significance Index: 0.3400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0188
    Cell Significance Index: 0.2500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0179
    Cell Significance Index: 0.2900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0131
    Cell Significance Index: 0.2200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0103
    Cell Significance Index: 0.1300
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.0046
    Cell Significance Index: 0.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0020
    Cell Significance Index: 0.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0014
    Cell Significance Index: 0.0400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0003
    Cell Significance Index: 0.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0002
    Cell Significance Index: 0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0000
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0003
    Cell Significance Index: -0.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0003
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0006
    Cell Significance Index: -0.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0007
    Cell Significance Index: -0.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0011
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0013
    Cell Significance Index: -0.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0019
    Cell Significance Index: -0.2700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0021
    Cell Significance Index: -0.2500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0031
    Cell Significance Index: -0.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0038
    Cell Significance Index: -0.2600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0056
    Cell Significance Index: -0.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0057
    Cell Significance Index: -0.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0058
    Cell Significance Index: -0.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0059
    Cell Significance Index: -0.3000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0066
    Cell Significance Index: -0.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0070
    Cell Significance Index: -0.2300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0076
    Cell Significance Index: -0.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0077
    Cell Significance Index: -0.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0078
    Cell Significance Index: -0.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0087
    Cell Significance Index: -0.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0087
    Cell Significance Index: -0.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0092
    Cell Significance Index: -0.2700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0097
    Cell Significance Index: -0.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0102
    Cell Significance Index: -0.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0103
    Cell Significance Index: -0.3000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0105
    Cell Significance Index: -0.0800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0112
    Cell Significance Index: -0.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0116
    Cell Significance Index: -0.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0118
    Cell Significance Index: -0.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0120
    Cell Significance Index: -0.2600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0120
    Cell Significance Index: -0.1600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0125
    Cell Significance Index: -0.1900
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0130
    Cell Significance Index: -0.1400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0132
    Cell Significance Index: -0.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0133
    Cell Significance Index: -0.3200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0138
    Cell Significance Index: -0.1900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0138
    Cell Significance Index: -0.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0139
    Cell Significance Index: -0.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0139
    Cell Significance Index: -0.2800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0142
    Cell Significance Index: -0.1600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0143
    Cell Significance Index: -0.1900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0144
    Cell Significance Index: -0.3000
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0145
    Cell Significance Index: -0.1600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0152
    Cell Significance Index: -0.1900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0153
    Cell Significance Index: -0.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0156
    Cell Significance Index: -0.2300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0161
    Cell Significance Index: -0.1800
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0161
    Cell Significance Index: -0.1600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0162
    Cell Significance Index: -0.3000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0162
    Cell Significance Index: -0.2800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0162
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0168
    Cell Significance Index: -0.2900
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0172
    Cell Significance Index: -0.1600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0173
    Cell Significance Index: -0.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0174
    Cell Significance Index: -0.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0176
    Cell Significance Index: -0.2400
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: -0.0181
    Cell Significance Index: -0.1600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0181
    Cell Significance Index: -0.2200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0184
    Cell Significance Index: -0.1800
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0185
    Cell Significance Index: -0.2200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0187
    Cell Significance Index: -0.1900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0187
    Cell Significance Index: -0.2400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0188
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0191
    Cell Significance Index: -0.2400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0193
    Cell Significance Index: -0.3300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0194
    Cell Significance Index: -0.1700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0197
    Cell Significance Index: -0.2700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0203
    Cell Significance Index: -0.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PCGEM1 is a transcript specifically expressed in various cell types, including progenitor cells, which are crucial for tissue development and regeneration. The gene's expression profile suggests a role in maintaining cellular homeostasis, particularly in regulating apoptosis, a process essential for eliminating damaged or dysfunctional cells. The significant expression of PCGEM1 in microglial cells, a type of immune cell, highlights its potential involvement in immune responses and neuroinflammation. **Pathways and Functions:** PCGEM1's involvement in regulating the apoptotic process is mediated through its interaction with key signaling pathways. The gene's expression is associated with the regulation of apoptosis, autophagy, and cell cycle progression. Specifically, PCGEM1 has been shown to: 1. **Regulate apoptosis**: PCGEM1's expression is inversely correlated with pro-apoptotic factors, suggesting its role in promoting cell survival and preventing apoptosis. 2. **Influence autophagy**: PCGEM1's interaction with autophagy-related genes indicates its involvement in regulating autophagy, a process essential for maintaining cellular homeostasis. 3. **Modulate cell cycle progression**: PCGEM1's expression is associated with cell cycle regulation, suggesting its role in controlling cell proliferation and differentiation. **Clinical Significance:** The dysregulation of PCGEM1 has significant implications for various diseases, including: 1. **Cancer**: Altered expression of PCGEM1 has been observed in various cancers, including prostate cancer, suggesting its potential as a prognostic biomarker. 2. **Neurodegenerative diseases**: PCGEM1's involvement in regulating apoptosis and autophagy in microglial cells highlights its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Immune disorders**: PCGEM1's expression in immune cells suggests its potential involvement in immune responses and the pathogenesis of autoimmune diseases. In conclusion, PCGEM1's role in regulating apoptotic processes, autophagy, and cell cycle progression underscores its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the functional significance of PCGEM1 and its potential as a therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.