No CSI details found for gene ID: 6754
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4268537829
Symbol: SSR4_HUMAN
Name: Somatostatin receptor type 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8512564
Title: Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4.
PubMed ID: 8512564
PubMed ID: 8483934
Title: Cloning and characterization of a fourth human somatostatin receptor.
PubMed ID: 8483934
PubMed ID: 8373420
Title: Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.
PubMed ID: 8373420
PubMed ID: 8100352
Title: Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.
PubMed ID: 8100352
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 388
- Mass: 42003
- Checksum: DFCD9393620EDFC9
- Sequence:
MSAPSTLPPG GEEGLGTAWP SAANASSAPA EAEEAVAGPG DARAAGMVAI QCIYALVCLV GLVGNALVIF VILRYAKMKT ATNIYLLNLA VADELFMLSV PFVASSAALR HWPFGSVLCR AVLSVDGLNM FTSVFCLTVL SVDRYVAVVH PLRAATYRRP SVAKLINLGV WLASLLVTLP IAIFADTRPA RGGQAVACNL QWPHPAWSAV FVVYTFLLGF LLPVLAIGLC YLLIVGKMRA VALRAGWQQR RRSEKKITRL VLMVVVVFVL CWMPFYVVQL LNLFVTSLDA TVNHVSLILS YANSCANPIL YGFLSDNFRR FFQRVLCLRC CLLEGAGGAE EEPLDYYATA LKSKGGAGCM CPPLPCQQEA LQPEPGRKRI PLTRTTTF
Details Unavailable
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{
"geneID": 6754,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AL049651.2"
]
},
"genePos": {
"start": 23035312,
"end": 23039237
},
"orientation": true,
"symbol": "SSTR4",
"created": {
"$date": {
"$numberLong": "1738333349190"
}
},
"crossReference": {
"enseGeneID": "ENSG00000132671",
"enseRnaID": [
"ENST00000255008.5"
],
"enseProtID": [
"ENSP00000255008.3"
]
},
"chrom": {
"pos": "20",
"type": 1,
"loc": "20p11.21"
},
"desc": "somatostatin receptor 4",
"geneType": 5,
"mim": [
{
"id": 182454,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-162582",
"term": "Signal Transduction",
"cat": 10
},
{
"id": "R-HSA-372790",
"term": "Signaling by GPCR",
"cat": 11
},
{
"id": "R-HSA-388396",
"term": "GPCR downstream signalling",
"cat": 12
},
{
"id": "R-HSA-500792",
"term": "GPCR ligand binding",
"cat": 12
},
{
"id": "R-HSA-373076",
"term": "Class A\/1 (Rhodopsin-like receptors)",
"cat": 13
},
{
"id": "R-HSA-418594",
"term": "G alpha (i) signalling events",
"cat": 13
},
{
"id": "R-HSA-375276",
"term": "Peptide ligand-binding receptors",
"cat": 14
},
{
"id": "GO:0004994",
"term": "somatostatin receptor activity",
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
19426801
],
"cat": 0
},
{
"id": "GO:0042923",
"term": "neuropeptide binding",
"cat": 0
},
{
"id": "GO:0007186",
"term": "G protein-coupled receptor signaling pathway",
"pubMed": [
9892014
],
"cat": 1
},
{
"id": "GO:0007187",
"term": "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger",
"cat": 1
},
{
"id": "GO:0007218",
"term": "neuropeptide signaling pathway",
"cat": 1
},
{
"id": "GO:0008285",
"term": "negative regulation of cell population proliferation",
"cat": 1
},
{
"id": "GO:0016477",
"term": "cell migration",
"cat": 1
},
{
"id": "GO:0030900",
"term": "forebrain development",
"cat": 1
},
{
"id": "GO:0038170",
"term": "somatostatin signaling pathway",
"cat": 1
},
{
"id": "GO:0070374",
"term": "positive regulation of ERK1 and ERK2 cascade",
"cat": 1
},
{
"id": "GO:0071385",
"term": "cellular response to glucocorticoid stimulus",
"cat": 1
},
{
"id": "GO:0090238",
"term": "positive regulation of arachidonate secretion",
"cat": 1
},
{
"id": "GO:0106072",
"term": "negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"cat": 2
},
{
"id": "GO:0043005",
"term": "neuron projection",
"cat": 2
}
],
"protein": [
{
"symbol": "SSR4_HUMAN",
"name": "Somatostatin receptor type 4",
"accession": [
"P31391",
"Q17RM1",
"Q17RM3",
"Q9UIY1"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"D16826",
"L14856",
"L07833",
"L07061",
"AY548169",
"AL049651",
"CH471133",
"BC069063",
"BC117270",
"BC117272"
],
"CCDS": [
"CCDS42856.1"
],
"PIR": [
"JN0605"
],
"RefSeq": [
"NP_001043.2"
],
"PDB": [
"7XMS",
"7XMT"
],
"PDBsum": [
"7XMS",
"7XMT"
],
"AlphaFoldDB": [
"P31391"
],
"EMDB": [
"EMD-33303",
"EMD-33304"
],
"SMR": [
"P31391"
],
"BioGRID": [
"112632"
],
"CORUM": [
"P31391"
],
"IntAct": [
"P31391"
],
"STRING": [
"9606.ENSP00000255008"
],
"BindingDB": [
"P31391"
],
"ChEMBL": [
"CHEMBL1853"
],
"DrugBank": [
"DB13985",
"DB09099"
],
"DrugCentral": [
"P31391"
],
"GuidetoPHARMACOLOGY": [
"358"
],
"GlyCosmos": [
"P31391"
],
"GlyGen": [
"P31391"
],
"iPTMnet": [
"P31391"
],
"PhosphoSitePlus": [
"P31391"
],
"BioMuta": [
"SSTR4"
],
"DMDM": [
"206729897"
],
"MassIVE": [
"P31391"
],
"PaxDb": [
"9606-ENSP00000255008"
],
"PeptideAtlas": [
"P31391"
],
"Antibodypedia": [
"20974"
],
"DNASU": [
"6754"
],
"Ensembl": [
"ENST00000255008.5"
],
"KEGG": [
"hsa:6754"
],
"MANE-Select": [
"ENST00000255008.5"
],
"UCSC": [
"uc002wsr.3"
],
"AGR": [
"HGNC:11333"
],
"CTD": [
"6754"
],
"DisGeNET": [
"6754"
],
"GeneCards": [
"SSTR4"
],
"HGNC": [
"HGNC:11333"
],
"HPA": [
"ENSG00000132671"
],
"MIM": [
"182454"
],
"neXtProt": [
"NX_P31391"
],
"OpenTargets": [
"ENSG00000132671"
],
"PharmGKB": [
"PA36157"
],
"VEuPathDB": [
"HostDB:ENSG00000132671"
],
"eggNOG": [
"KOG3656"
],
"GeneTree": [
"ENSGT00940000156819"
],
"HOGENOM": [
"CLU_009579_8_1_1"
],
"InParanoid": [
"P31391"
],
"OMA": [
"AIQCIYA"
],
"OrthoDB": [
"5393360at2759"
],
"PhylomeDB": [
"P31391"
],
"TreeFam": [
"TF315737"
],
"PathwayCommons": [
"P31391"
],
"Reactome": [
"R-HSA-375276",
"R-HSA-418594"
],
"SignaLink": [
"P31391"
],
"SIGNOR": [
"P31391"
],
"BioGRID-ORCS": [
"6754"
],
"GeneWiki": [
"Somatostatin_receptor_4"
],
"GenomeRNAi": [
"6754"
],
"Pharos": [
"P31391"
],
"PRO": [
"PR:P31391"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P31391"
],
"Bgee": [
"ENSG00000132671"
],
"GO": [
"GO:0043005",
"GO:0005886",
"GO:0042923",
"GO:0004994",
"GO:0016477",
"GO:0071385",
"GO:0030900",
"GO:0007186",
"GO:0007187",
"GO:0106072",
"GO:0008285",
"GO:0007218",
"GO:0090238",
"GO:0070374"
],
"CDD": [
"cd15973"
],
"Gene3D": [
"1.20.1070.10"
],
"InterPro": [
"IPR000276",
"IPR017452",
"IPR000586",
"IPR001512"
],
"PANTHER": [
"PTHR24229",
"PTHR24229:SF35"
],
"Pfam": [
"PF00001"
],
"PRINTS": [
"PR00237",
"PR00246",
"PR00590"
],
"SMART": [
"SM01381"
],
"SUPFAM": [
"SSF81321"
],
"PROSITE": [
"PS00237",
"PS50262"
]
},
"citations": [
{
"title": "Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4.",
"pubmedID": "8512564",
"doi": "10.1006\/bbrc.1993.1673"
},
{
"title": "Cloning and characterization of a fourth human somatostatin receptor.",
"pubmedID": "8483934",
"doi": "10.1073\/pnas.90.9.4196"
},
{
"title": "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.",
"pubmedID": "8373420",
"doi": "10.1006\/bbrc.1993.2122"
},
{
"title": "Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.",
"pubmedID": "8100352"
},
{
"title": "The DNA sequence and comparative analysis of human chromosome 20.",
"pubmedID": "11780052",
"doi": "10.1038\/414865a"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101\/gr.2596504"
}
],
"sequence": {
"length": 388,
"mass": 42003,
"checksum": "DFCD9393620EDFC9",
"modified": {
"$date": {
"$numberLong": "1222128000000"
}
},
"version": 2,
"sequence": "MSAPSTLPPGGEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRFFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGGAGCMCPPLPCQQEALQPEPGRKRIPLTRTTTF"
},
"existence": 0,
"relevance": 1,
"proteinID": 4268537829
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}