Details for: SSTR4

Gene ID: 6754

Symbol: SSTR4

Ensembl ID: ENSG00000132671

Description: somatostatin receptor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0656
    Cell Significance Index: 0.9400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0450
    Cell Significance Index: 0.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.0068
    Cell Significance Index: 0.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0032
    Cell Significance Index: 2.2400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0014
    Cell Significance Index: -0.5000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0063
    Cell Significance Index: -1.8000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0079
    Cell Significance Index: -0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0082
    Cell Significance Index: -1.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0088
    Cell Significance Index: -0.3100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0091
    Cell Significance Index: -0.1200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0137
    Cell Significance Index: -0.1600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0147
    Cell Significance Index: -0.1000
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0155
    Cell Significance Index: -0.1400
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0170
    Cell Significance Index: -0.1500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0180
    Cell Significance Index: -0.1600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0188
    Cell Significance Index: -0.2100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0196
    Cell Significance Index: -0.1700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0282
    Cell Significance Index: -0.3400
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0328
    Cell Significance Index: -0.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0355
    Cell Significance Index: -2.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0381
    Cell Significance Index: -2.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0451
    Cell Significance Index: -2.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0451
    Cell Significance Index: -1.4400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0459
    Cell Significance Index: -0.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0467
    Cell Significance Index: -1.5300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0527
    Cell Significance Index: -1.0500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0591
    Cell Significance Index: -0.3900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0601
    Cell Significance Index: -0.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0613
    Cell Significance Index: -1.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0632
    Cell Significance Index: -1.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0667
    Cell Significance Index: -1.4400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0671
    Cell Significance Index: -1.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0767
    Cell Significance Index: -1.5400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0772
    Cell Significance Index: -1.5100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0783
    Cell Significance Index: -0.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0801
    Cell Significance Index: -1.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0806
    Cell Significance Index: -2.1200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0808
    Cell Significance Index: -1.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0855
    Cell Significance Index: -2.4400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0880
    Cell Significance Index: -1.7400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0906
    Cell Significance Index: -1.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0916
    Cell Significance Index: -2.3400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0938
    Cell Significance Index: -2.3900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1032
    Cell Significance Index: -2.4800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1048
    Cell Significance Index: -1.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1083
    Cell Significance Index: -1.1800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1094
    Cell Significance Index: -1.5000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1140
    Cell Significance Index: -1.5200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1211
    Cell Significance Index: -1.4300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1216
    Cell Significance Index: -1.7700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1224
    Cell Significance Index: -1.3000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1236
    Cell Significance Index: -1.1600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1330
    Cell Significance Index: -1.5300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1335
    Cell Significance Index: -1.5700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1354
    Cell Significance Index: -1.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1362
    Cell Significance Index: -2.2800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1364
    Cell Significance Index: -1.7800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1372
    Cell Significance Index: -1.8000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1379
    Cell Significance Index: -1.8000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1426
    Cell Significance Index: -1.7100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1426
    Cell Significance Index: -2.3100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1434
    Cell Significance Index: -1.5100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1470
    Cell Significance Index: -1.5900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1478
    Cell Significance Index: -1.5100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1489
    Cell Significance Index: -1.7600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1509
    Cell Significance Index: -1.5200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1623
    Cell Significance Index: -2.1000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1643
    Cell Significance Index: -1.8800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1657
    Cell Significance Index: -2.1800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1681
    Cell Significance Index: -1.4700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1725
    Cell Significance Index: -2.4200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1731
    Cell Significance Index: -2.0500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1789
    Cell Significance Index: -2.2600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1791
    Cell Significance Index: -1.9200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1801
    Cell Significance Index: -2.2500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1803
    Cell Significance Index: -2.2300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1806
    Cell Significance Index: -2.2200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1815
    Cell Significance Index: -2.1600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1835
    Cell Significance Index: -2.2000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1848
    Cell Significance Index: -2.3400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1851
    Cell Significance Index: -2.2500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1866
    Cell Significance Index: -2.4200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1885
    Cell Significance Index: -2.2400
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.1892
    Cell Significance Index: -2.2100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1895
    Cell Significance Index: -2.2300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1925
    Cell Significance Index: -2.0700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1960
    Cell Significance Index: -2.5100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1960
    Cell Significance Index: -1.5300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2012
    Cell Significance Index: -1.7100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2014
    Cell Significance Index: -2.4500
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.2039
    Cell Significance Index: -2.3500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.2043
    Cell Significance Index: -1.5200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2049
    Cell Significance Index: -2.3800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.2069
    Cell Significance Index: -2.3500
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.2092
    Cell Significance Index: -2.3900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2099
    Cell Significance Index: -3.0700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2111
    Cell Significance Index: -2.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SSTR4 is a GPCR that belongs to the class A/1 rhodopsin-like receptors. It is characterized by its high affinity for somatostatin peptides, which are neuropeptides that regulate various physiological processes. The receptor is activated by binding to somatostatin, leading to the activation of G proteins and subsequent signaling cascades. SSTR4 is also known to be involved in the regulation of adenylate cyclase activity, arachidonic acid secretion, and the Erk1/2 cascade. **Pathways and Functions** SSTR4 is involved in various signaling pathways, including: 1. **G protein-coupled receptor signaling pathway**: SSTR4 activates G proteins, which in turn regulate adenylate cyclase activity, arachidonic acid secretion, and the Erk1/2 cascade. 2. **Cell migration**: SSTR4 is involved in regulating cell migration, particularly in progenitor cells and oligodendrocyte precursor cells. 3. **Neurodevelopment**: SSTR4 plays a role in neuronal development, including the regulation of neuron projection and the formation of the forebrain. 4. **Neurotransmission**: SSTR4 is also involved in regulating neurotransmission, particularly in the regulation of arachidonic acid secretion. **Clinical Significance** SSTR4 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: SSTR4 has been shown to play a role in the regulation of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: SSTR4 has been implicated in the regulation of cell proliferation and differentiation in various types of cancer, including breast cancer and colon cancer. 3. **Inflammatory disorders**: SSTR4 has been shown to play a role in regulating inflammatory responses, particularly in the regulation of arachidonic acid secretion. 4. **Cardiovascular disease**: SSTR4 has been implicated in the regulation of cardiovascular disease, particularly in the regulation of endothelial function. In conclusion, SSTR4 is a complex receptor that plays a crucial role in various physiological processes, including cell migration, neuronal development, and signaling pathways. Its involvement in various diseases highlights the potential of SSTR4 as a therapeutic target for the treatment of neurodegenerative disorders, cancer, inflammatory disorders, and cardiovascular disease.

Genular Protein ID: 4268537829

Symbol: SSR4_HUMAN

Name: Somatostatin receptor type 4

UniProtKB Accession Codes:

P31391 Q17RM1 Q17RM3 Q9UIY1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 10 EMDB 2 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8512564

Title: Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4.

PubMed ID: 8512564

DOI: 10.1006/bbrc.1993.1673

PubMed ID: 8483934

Title: Cloning and characterization of a fourth human somatostatin receptor.

PubMed ID: 8483934

DOI: 10.1073/pnas.90.9.4196

PubMed ID: 8373420

Title: Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.

PubMed ID: 8373420

DOI: 10.1006/bbrc.1993.2122

PubMed ID: 8100352

Title: Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.

PubMed ID: 8100352

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 388
  • Mass: 42003
  • Checksum: DFCD9393620EDFC9
  • Sequence:
    • MSAPSTLPPG GEEGLGTAWP SAANASSAPA EAEEAVAGPG DARAAGMVAI QCIYALVCLV 
GLVGNALVIF VILRYAKMKT ATNIYLLNLA VADELFMLSV PFVASSAALR HWPFGSVLCR 
AVLSVDGLNM FTSVFCLTVL SVDRYVAVVH PLRAATYRRP SVAKLINLGV WLASLLVTLP 
IAIFADTRPA RGGQAVACNL QWPHPAWSAV FVVYTFLLGF LLPVLAIGLC YLLIVGKMRA 
VALRAGWQQR RRSEKKITRL VLMVVVVFVL CWMPFYVVQL LNLFVTSLDA TVNHVSLILS 
YANSCANPIL YGFLSDNFRR FFQRVLCLRC CLLEGAGGAE EEPLDYYATA LKSKGGAGCM 
CPPLPCQQEA LQPEPGRKRI PLTRTTTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.