Details for: TNP1

Gene ID: 7141

Symbol: TNP1

Ensembl ID: ENSG00000118245

Description: transition protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 18.45
    Marker Score: 57013.5
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 9.57
    Marker Score: 97011.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6851
  • Cell Name: pericyte (CL0000669)
    Fold Change: 3.45
    Marker Score: 2018
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3185
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.73
    Marker Score: 1438
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.55
    Marker Score: 1414
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10815
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.62
    Marker Score: 3068
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.49
    Marker Score: 622
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.26
    Marker Score: 713
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7555
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3659
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.11
    Marker Score: 17364
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32731
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.89
    Marker Score: 514
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.86
    Marker Score: 408
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 741
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 404
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.72
    Marker Score: 4301
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.63
    Marker Score: 1282
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.53
    Marker Score: 233.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.51
    Marker Score: 304
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 284
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.33
    Marker Score: 220
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.21
    Marker Score: 245.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.17
    Marker Score: 229.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.07
    Marker Score: 39.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.05
    Marker Score: 323
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.05
    Marker Score: 13.5
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.05
    Marker Score: 14.5
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.04
    Marker Score: 10.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.03
    Marker Score: 36.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.03
    Marker Score: 11.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.03
    Marker Score: 61
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.03
    Marker Score: 9.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.02
    Marker Score: 8.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.02
    Marker Score: 12.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 14.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.02
    Marker Score: 10.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.02
    Marker Score: 35
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.02
    Marker Score: 14.5
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 14.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.02
    Marker Score: 30
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.02
    Marker Score: 14.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.01
    Marker Score: 14.5
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.01
    Marker Score: 7.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.01
    Marker Score: 14.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 12.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.01
    Marker Score: 8.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0
    Marker Score: 9.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0
    Marker Score: 35
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0
    Marker Score: 7.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0
    Marker Score: 18
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0
    Marker Score: 14.5
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0
    Marker Score: 14.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 41
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 55
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 11.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0
    Marker Score: 9

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Other Information

**Key Characteristics** 1. **Cellular localization**: TNP1 is expressed in cells involved in reproductive and hematopoietic systems, including spermatids, microglial cells, and hematopoietic stem cells. 2. **Protein function**: TNP1 is a nuclear protein that interacts with chromatin and regulates the assembly and disassembly of nucleosomes, which are essential for DNA packaging and transcription. 3. **Regulatory role**: TNP1 is involved in the negative regulation of DNA-templated transcription, suggesting its role in preventing aberrant gene expression. 4. **Disease association**: While there is no direct association with specific diseases, alterations in TNP1 expression have been linked to various conditions, including cancer and neurological disorders. **Pathways and Functions** 1. **Chromatin remodeling**: TNP1 interacts with chromatin remodeling complexes, such as SWI/SNF, to regulate the assembly and disassembly of nucleosomes. 2. **DNA binding**: TNP1 binds to single-strand breaks and regulates the repair of DNA damage. 3. **Sperm development**: TNP1 plays a crucial role in the elongation and condensation of sperm DNA, ensuring proper sperm function. 4. **Protein processing**: TNP1 is involved in the regulation of protein processing, including the assembly and disassembly of protein complexes. 5. **Single-strand break repair**: TNP1 regulates the repair of single-strand breaks, which is essential for maintaining genome stability. **Clinical Significance** 1. **Reproductive disorders**: Alterations in TNP1 expression have been linked to male infertility and reproductive disorders, highlighting its importance in sperm development and function. 2. **Cancer**: TNP1 is overexpressed in various types of cancer, suggesting its potential role in tumorigenesis and cancer progression. 3. **Neurological disorders**: TNP1 is also expressed in cells involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease, highlighting its potential role in these conditions. 4. **Immunological disorders**: TNP1 is expressed in cells involved in the immune system, suggesting its potential role in immunological disorders, such as autoimmune diseases. In conclusion, TNP1 is a multifunctional gene that plays a crucial role in various cellular processes, including chromatin remodeling, DNA binding, and regulation of transcription. Its expression is linked to reproductive and hematopoietic systems, highlighting its importance in maintaining genome stability and proper cellular function. Further studies are needed to fully understand the clinical significance of TNP1 and its potential role in various diseases.

Genular Protein ID: 2114363894

Symbol: STP1_HUMAN

Name: Spermatid nuclear transition protein 1

UniProtKB Accession Codes:

P09430

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3412903

Title: The nucleotide sequence of human transition protein 1 cDNA.

PubMed ID: 3412903

DOI: 10.1093/nar/16.15.7723

PubMed ID: 2249851

Title: Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2.

PubMed ID: 2249851

DOI: 10.1016/0888-7543(90)90289-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9809674

Title: Expression of mRNA and protein of nucleoproteins during human spermiogenesis.

PubMed ID: 9809674

DOI: 10.1093/molehr/4.10.939

Sequence Information:

  • Length: 55
  • Mass: 6424
  • Checksum: E29C58EB2AADF3BB
  • Sequence:
    • MSTSRKLKSH GMRRSKSRSP HKGVKRGGSK RKYRKGNLKS RKRGDDANRN YRSHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.