Gene VCL - ENSG00000035403 | NCBI Gene ID: 7414

Details for: VCL

Gene ID: 7414

Symbol: VCL

Ensembl ID: ENSG00000035403

Description: vinculin

Associated with

Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Map2k and mapk activation
(R-HSA-5674135)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Muscle contraction
(R-HSA-397014)
Neutrophil degranulation
(R-HSA-6798695)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Raf/map kinase cascade
(R-HSA-5673001)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling downstream of ras mutants
(R-HSA-9649948)
Signal transduction
(R-HSA-162582)
Smooth muscle contraction
(R-HSA-445355)
Actin binding
(GO:0003779)
Adherens junction
(GO:0005912)
Adherens junction assembly
(GO:0034333)
Alpha-catenin binding
(GO:0045294)
Apical junction assembly
(GO:0043297)
Axon extension
(GO:0048675)
Beta-catenin binding
(GO:0008013)
Cadherin binding
(GO:0045296)
Cell-cell contact zone
(GO:0044291)
Cell-cell junction
(GO:0005911)
Cell-matrix adhesion
(GO:0007160)
Cell-substrate junction
(GO:0030055)
Cell adhesion
(GO:0007155)
Cell projection
(GO:0042995)
Costamere
(GO:0043034)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Dystroglycan binding
(GO:0002162)
Epithelial cell-cell adhesion
(GO:0090136)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular vesicle
(GO:1903561)
Fascia adherens
(GO:0005916)
Ficolin-1-rich granule lumen
(GO:1904813)
Focal adhesion
(GO:0005925)
Lamellipodium assembly
(GO:0030032)
Maintenance of blood-brain barrier
(GO:0035633)
Morphogenesis of an epithelium
(GO:0002009)
Negative regulation of cell migration
(GO:0030336)
Plasma membrane
(GO:0005886)
Platelet aggregation
(GO:0070527)
Podosome ring
(GO:0061826)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein localization to cell surface
(GO:0034394)
Regulation of establishment of endothelial barrier
(GO:1903140)
Regulation of focal adhesion assembly
(GO:0051893)
Regulation of protein localization to adherens junction
(GO:1904702)
Sarcolemma
(GO:0042383)
Secretory granule lumen
(GO:0034774)
Specific granule lumen
(GO:0035580)
Structural molecule activity
(GO:0005198)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 3.59
Marker Score: 80264
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 3.31
Marker Score: 8282
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 3.09
Marker Score: 2948
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.75
Marker Score: 1040
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.74
Marker Score: 6004.5
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.66
Marker Score: 5109
Cell Name: cardiac neuron (CL0010022)
Fold Change: 2.65
Marker Score: 3301
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.6
Marker Score: 2244
Cell Name: contractile cell (CL0000183)
Fold Change: 2.54
Marker Score: 1376
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.43
Marker Score: 1350
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.25
Marker Score: 2930
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.19
Marker Score: 2525
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.17
Marker Score: 9062
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.12
Marker Score: 4980
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 2.07
Marker Score: 527
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.07
Marker Score: 653
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.06
Marker Score: 1355
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 2.02
Marker Score: 844
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.97
Marker Score: 4809
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.97
Marker Score: 6993
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.92
Marker Score: 21673
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.89
Marker Score: 1347
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.89
Marker Score: 4712
Cell Name: supporting cell (CL0000630)
Fold Change: 1.88
Marker Score: 3532
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.86
Marker Score: 2561
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.83
Marker Score: 10881
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.83
Marker Score: 2659
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.82
Marker Score: 2250
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.77
Marker Score: 2608
Cell Name: pericyte (CL0000669)
Fold Change: 1.68
Marker Score: 984
Cell Name: decidual cell (CL2000002)
Fold Change: 1.67
Marker Score: 7198
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.65
Marker Score: 56245
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.65
Marker Score: 4056.5
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.64
Marker Score: 2380
Cell Name: lactocyte (CL0002325)
Fold Change: 1.64
Marker Score: 26314
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.64
Marker Score: 34966
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.61
Marker Score: 1079
Cell Name: acinar cell (CL0000622)
Fold Change: 1.61
Marker Score: 1133
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.6
Marker Score: 1927
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.59
Marker Score: 1712
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.54
Marker Score: 53484
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.54
Marker Score: 746
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.53
Marker Score: 5677
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.53
Marker Score: 7530
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.51
Marker Score: 55881
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.51
Marker Score: 93035
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.51
Marker Score: 1534
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.5
Marker Score: 6229
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.49
Marker Score: 1593
Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.48
Marker Score: 385
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.48
Marker Score: 542
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.47
Marker Score: 1002
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.46
Marker Score: 13860
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 1.45
Marker Score: 1103.5
Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 166328
Cell Name: fat cell (CL0000136)
Fold Change: 1.44
Marker Score: 807
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.43
Marker Score: 14736
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.42
Marker Score: 2386
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.41
Marker Score: 697
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.41
Marker Score: 1086.5
Cell Name: neuron (CL0000540)
Fold Change: 1.4
Marker Score: 5692
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.39
Marker Score: 733
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.37
Marker Score: 3453
Cell Name: neural cell (CL0002319)
Fold Change: 1.36
Marker Score: 658
Cell Name: podocyte (CL0000653)
Fold Change: 1.36
Marker Score: 504
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.35
Marker Score: 583
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.35
Marker Score: 11595
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.34
Marker Score: 800
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.34
Marker Score: 778
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.33
Marker Score: 2053
Cell Name: basal cell (CL0000646)
Fold Change: 1.31
Marker Score: 1691
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.31
Marker Score: 371
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.31
Marker Score: 1853
Cell Name: club cell (CL0000158)
Fold Change: 1.31
Marker Score: 1527
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.3
Marker Score: 20269
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.29
Marker Score: 2282
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.29
Marker Score: 1981
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.28
Marker Score: 1054
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.28
Marker Score: 25479
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.28
Marker Score: 746
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.28
Marker Score: 730
Cell Name: platelet (CL0000233)
Fold Change: 1.27
Marker Score: 575
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.25
Marker Score: 471
Cell Name: muscle cell (CL0000187)
Fold Change: 1.24
Marker Score: 352
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 1.24
Marker Score: 1087
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.24
Marker Score: 1300
Cell Name: stromal cell (CL0000499)
Fold Change: 1.23
Marker Score: 1442
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.23
Marker Score: 2970
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.22
Marker Score: 964
Cell Name: secretory cell (CL0000151)
Fold Change: 1.21
Marker Score: 2212
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.21
Marker Score: 564
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.2
Marker Score: 10567
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 1.19
Marker Score: 1179
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.18
Marker Score: 15625
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.18
Marker Score: 1301
Cell Name: fast muscle cell (CL0000190)
Fold Change: 1.18
Marker Score: 355
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.17
Marker Score: 2666
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.17
Marker Score: 290
Cell Name: astrocyte (CL0000127)
Fold Change: 1.17
Marker Score: 1010
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.16
Marker Score: 1186

Hover over a box to see details here...

**Key Characteristics:** 1. **Cell Adhesion:** Vinculin is a critical component of focal adhesions, which are essential for maintaining cell-cell and cell-substrate adhesion. 2. **Cytoskeletal Interaction:** Vinculin interacts with actin filaments, facilitating the transmission of mechanical forces and enabling cells to sense and respond to their environment. 3. **Signaling Pathways:** Vinculin is involved in various signaling pathways, including those regulated by growth factors and second messengers, such as MAPK and PI3K/Akt pathways. 4. **Tissue-Specific Expression:** Vinculin is expressed in multiple cell types, including cardiac myocytes, skeletal muscle fibers, and smooth muscle cells, highlighting its importance in maintaining tissue integrity and function. **Pathways and Functions:** Vinculin's involvement in various signaling pathways underscores its critical function in regulating cellular behavior. Some of the key pathways and functions include: 1. **Focal Adhesion Assembly:** Vinculin plays a crucial role in the assembly and disassembly of focal adhesions, enabling cells to sense and respond to their environment. 2. **Cell-Cell Adhesion:** Vinculin is essential for maintaining cell-cell adhesion, particularly in epithelial cells, where it helps to regulate the formation and maintenance of adherens junctions. 3. **Cell-Matrix Adhesion:** Vinculin is involved in regulating cell-matrix adhesion, enabling cells to sense and respond to changes in the extracellular matrix. 4. **Signaling by Growth Factors:** Vinculin is involved in signaling pathways regulated by growth factors, such as EGF and FGF, which are essential for regulating cell growth and differentiation. 5. **MAPK and PI3K/Akt Signaling:** Vinculin interacts with MAPK and PI3K/Akt signaling pathways, enabling cells to respond to external stimuli and regulate cellular behavior. **Clinical Significance:** Dysregulation of vinculin has been implicated in various diseases, including: 1. **Cancer:** Vinculin's involvement in signaling pathways regulated by growth factors and second messengers makes it a potential target for cancer therapy. 2. **Cardiovascular Disease:** Vinculin's role in regulating cell-cell and cell-substrate adhesion makes it a potential target for treating cardiovascular diseases, such as atherosclerosis. 3. **Neurological Disorders:** Vinculin's involvement in signaling pathways regulated by growth factors and second messengers makes it a potential target for treating neurological disorders, such as Alzheimer's disease. In conclusion, vinculin is a critical component of cell adhesion and signaling pathways, playing a pivotal role in maintaining tissue integrity and function. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Vinculin
B3KXA2_HUMAN

Genular Protein ID: 2855648317

Symbol: VINC_HUMAN

Name: Vinculin

UniProtKB Accession Codes:

P18206 Q16450 Q5SWX2 Q7Z3B8 Q8IXU7

Database IDs:

Citations:

PubMed ID: 2116004

Title: Complete sequence of human vinculin and assignment of the gene to chromosome 10.

PubMed ID: 2116004

DOI: 10.1073/pnas.87.15.5667

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8440716

Title: Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter.

PubMed ID: 8440716

DOI: 10.1016/s0021-9258(18)53612-7

PubMed ID: 1339348

Title: An additional exon in the human vinculin gene specifically encodes meta-vinculin-specific difference peptide. Cross-species comparison reveals variable and conserved motifs in the meta-vinculin insert.

PubMed ID: 1339348

DOI: 10.1111/j.1432-1033.1992.tb16692.x

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8702989

Title: Functional analysis of Shigella VirG domains essential for interaction with vinculin and actin-based motility.

PubMed ID: 8702989

DOI: 10.1074/jbc.271.36.21878

PubMed ID: 15229287

Title: The phosphorylation of vinculin on tyrosine residues 100 and 1065, mediated by SRC kinases, affects cell spreading.

PubMed ID: 15229287

DOI: 10.1091/mbc.e04-03-0264

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18028034

Title: Human alpha-synemin interacts directly with vinculin and metavinculin.

PubMed ID: 18028034

DOI: 10.1042/bj20071188

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20484056

Title: Vinculin is a dually regulated actin filament barbed end-capping and side-binding protein.

PubMed ID: 20484056

DOI: 10.1074/jbc.m110.102830

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22613835

Title: The C-terminal tail domain of metavinculin, vinculin's splice variant, severs actin filaments.

PubMed ID: 22613835

DOI: 10.1083/jcb.201111046

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26691986

Title: Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity.

PubMed ID: 26691986

DOI: 10.1038/ng.3474

PubMed ID: 29069646

Title: The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly.

PubMed ID: 29069646

DOI: 10.1159/000484298

PubMed ID: 15070891

Title: Structural basis for amplifying vinculin activation by talin.

PubMed ID: 15070891

DOI: 10.1074/jbc.m403076200

PubMed ID: 14702644

Title: Vinculin activation by talin through helical bundle conversion.

PubMed ID: 14702644

DOI: 10.1038/nature02281

PubMed ID: 15988023

Title: Structural dynamics of alpha-actinin-vinculin interactions.

PubMed ID: 15988023

DOI: 10.1128/mcb.25.14.6112-6122.2005

PubMed ID: 11815424

Title: Metavinculin mutations alter actin interaction in dilated cardiomyopathy.

PubMed ID: 11815424

DOI: 10.1161/hc0402.102930

PubMed ID: 16236538

Title: Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathy.

PubMed ID: 16236538

DOI: 10.1016/j.ymgme.2005.08.006

PubMed ID: 16712796

Title: A missense mutation in a ubiquitously expressed protein, vinculin, confers susceptibility to hypertrophic cardiomyopathy.

PubMed ID: 16712796

DOI: 10.1016/j.bbrc.2006.04.151

Sequence Information:

Length: 1134
Mass: 123799
Checksum: BFBD687DA836B0FA
Sequence:

MPVFHTRTIE SILEPVAQQI SHLVIMHEEG EVDGKAIPDL TAPVAAVQAA VSNLVRVGKE 
TVQTTEDQIL KRDMPPAFIK VENACTKLVQ AAQMLQSDPY SVPARDYLID GSRGILSGTS 
DLLLTFDEAE VRKIIRVCKG ILEYLTVAEV VETMEDLVTY TKNLGPGMTK MAKMIDERQQ 
ELTHQEHRVM LVNSMNTVKE LLPVLISAMK IFVTTKNSKN QGIEEALKNR NFTVEKMSAE 
INEIIRVLQL TSWDEDAWAS KDTEAMKRAL ASIDSKLNQA KGWLRDPSAS PGDAGEQAIR 
QILDEAGKVG ELCAGKERRE ILGTCKMLGQ MTDQVADLRA RGQGSSPVAM QKAQQVSQGL 
DVLTAKVENA ARKLEAMTNS KQSIAKKIDA AQNWLADPNG GPEGEEQIRG ALAEARKIAE 
LCDDPKERDD ILRSLGEISA LTSKLADLRR QGKGDSPEAR ALAKQVATAL QNLQTKTNRA 
VANSRPAKAA VHLEGKIEQA QRWIDNPTVD DRGVGQAAIR GLVAEGHRLA NVMMGPYRQD 
LLAKCDRVDQ LTAQLADLAA RGEGESPQAR ALASQLQDSL KDLKARMQEA MTQEVSDVFS 
DTTTPIKLLA VAATAPPDAP NREEVFDERA ANFENHSGKL GATAEKAAAV GTANKSTVEG 
IQASVKTARE LTPQVVSAAR ILLRNPGNQA AYEHFETMKN QWIDNVEKMT GLVDEAIDTK 
SLLDASEEAI KKDLDKCKVA MANIQPQMLV AGATSIARRA NRILLVAKRE VENSEDPKFR 
EAVKAASDEL SKTISPMVMD AKAVAGNISD PGLQKSFLDS GYRILGAVAK VREAFQPQEP 
DFPPPPPDLE QLRLTDELAP PKPPLPEGEV PPPRPPPPEE KDEEFPEQKA GEVINQPMMM 
AARQLHDEAR KWSSKPGIPA AEVGIGVVAE ADAADAAGFP VPPDMEDDYE PELLLMPSNQ 
PVNQPILAAA QSLHREATKW SSKGNDIIAA AKRMALLMAE MSRLVRGGSG TKRALIQCAK 
DIAKASDEVT RLAKEVAKQC TDKRIRTNLL QVCERIPTIS TQLKILSTVK ATMLGRTNIS 
DEESEQATEM LVHNAQNLMQ SVKETVREAE AASIKIRTDA GFTLRWVRKT PWYQ

Genular Protein ID: 3599347235

Symbol: B3KXA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KXA2

Database IDs:

Sequence Information:

Length: 1006
Mass: 110306
Checksum: BA2C56F9404FF44C
Sequence:

MPPAFIKVEN ACTKLVQAAQ MLQSDPYSVP ARDYLIDGSR GILSGTSDLL LTFDEAEVRK 
IIRVCKGILE YLTVAEVVET MEDLVTYTKN LGPGMTKMAK MIDERQQELT HQEHRVMLVN 
SMNTVKELLP VLISAMKIFV TTKNSKNQGI EEALKNRNFT VEKMSAEINE IIRVLQLTSW 
DEDAWASKDT EAMKRALASI DSKLNQAKGW LRDPSASPGD AGEQAIRQIL DEAGKVGELC 
AGKERREILG TCKMLEQMTD QVADLRARGQ GSSPVAMQKA QQVSQGLDVL TAKVENAARK 
LEAMTNSKQS IAKKIDAAQN WLADPNGGPE GEEQIRGALA EARKIAELCD DPKERDDILR 
SLGEISALTS KLADLRRQGK GDSPEARALA KQVATALQNL QTKTNRAVAN SRPAKAAVHL 
EGKIEQAQRW IDNPTVDDRG VGQAAIRGLV AEGHRLANVM MGPYRQDLLA KCDRVDQLTA 
QLADLAARGE GESPQARALA SQLQDSLKDL KARMQEAMTQ EVSDVFSDTT TPIKLLAVAA 
TAPPDAPNRE EVFDERAANF ENHSGKLGAT AEKAAAVGTA NKSTVEGIQA SVKTARELTP 
QVVSAARILL RNPGNQAAYE HFETMKNQWI DNVEKMTGLV DEAIDTKSLL DASEEAIKKD 
LDKCKVAMAN IQPQMLVAGA TSIARRANRI LLAAKREVEN SEDPKFREAV KAASDELSKT 
ISPMVMDAKA VAGNISDPGL QKSFLDSGYR ILGAVAKVRE AFQPQEPDFP PPPPDLEQLR 
LTDELAPPKP PLPEGEVPPP RPPPPEEKDE EFPEQKAGEV INQPMMMAAR QLHDEARKWS 
SKGNDIIAAA KRMALLMAEM SRLVRGGSGT KRALIQCAKD IAKASDEVTR LAKEVAKQCT 
DKRIRTNLLQ VCERIPTIST QLKILSTVKA TMLGRTNISD EESEQATEML VHNAQNLMQS 
VKETVRELKL LQSKFEQMLD LHCAGLERLP GTSRHLAEPG WHRNLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: VCL

Associated with

Cells (max top 100)

Other Information

Complete sequence of human vinculin and assignment of the gene to chromosome 10. PubMed ID: 2116004

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter. PubMed ID: 8440716

An additional exon in the human vinculin gene specifically encodes meta-vinculin-specific difference peptide. Cross-species comparison reveals variable and conserved motifs in the meta-vinculin insert. PubMed ID: 1339348

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Functional analysis of Shigella VirG domains essential for interaction with vinculin and actin-based motility. PubMed ID: 8702989

The phosphorylation of vinculin on tyrosine residues 100 and 1065, mediated by SRC kinases, affects cell spreading. PubMed ID: 15229287

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Human alpha-synemin interacts directly with vinculin and metavinculin. PubMed ID: 18028034

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Vinculin is a dually regulated actin filament barbed end-capping and side-binding protein. PubMed ID: 20484056

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

The C-terminal tail domain of metavinculin, vinculin's splice variant, severs actin filaments. PubMed ID: 22613835

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity. PubMed ID: 26691986

The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly. PubMed ID: 29069646

Structural basis for amplifying vinculin activation by talin. PubMed ID: 15070891

Vinculin activation by talin through helical bundle conversion. PubMed ID: 14702644

Structural dynamics of alpha-actinin-vinculin interactions. PubMed ID: 15988023

Metavinculin mutations alter actin interaction in dilated cardiomyopathy. PubMed ID: 11815424

Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathy. PubMed ID: 16236538

A missense mutation in a ubiquitously expressed protein, vinculin, confers susceptibility to hypertrophic cardiomyopathy. PubMed ID: 16712796