Details for: PRRC2B
Gene ID: 84726
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PRRC2B
Ensembl ID: ENSG00000288701
Description: proline rich coiled-coil 2B
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 22.69rCSI 33.56%PRS 84.94
-
CSI 17.16rCSI 27.59%PRS 65.18
-
CSI 16.56rCSI 26.3%PRS 89.15
-
CSI 15.88rCSI 26.65%PRS 63.61
-
CSI 14.25rCSI 20.45%PRS 71.2
-
CSI 12.3rCSI 29.89%PRS 61.62
-
CSI 11.79rCSI 16.04%PRS 89.19
-
CSI 11.43rCSI 20.18%PRS 63.05
-
CSI 11.4rCSI 13.62%PRS 63.79
-
CSI 10.71rCSI 33.46%PRS 65.32
-
CSI 10.49rCSI 15.83%PRS 86.09
-
CSI 9.65rCSI 19.83%PRS 68.63
-
CSI 8.95rCSI 22.69%PRS 71.92
-
CSI 8.83rCSI 9.09%PRS 91.46
-
CSI 8.2rCSI 7.57%PRS 82.7
-
CSI 8.02rCSI 25.1%PRS 67.66
-
CSI 7.54rCSI 27.13%PRS 61.6
-
CSI 7.44rCSI 28.13%PRS 64.21
-
CSI 7.4rCSI 9.21%PRS 61.55
-
CSI 7.08rCSI 7.59%PRS 82.66
-
CSI 7.02rCSI 8.12%PRS 73.7
-
CSI 7.02rCSI 16.88%PRS 92.58
-
CSI 6.85rCSI 5.31%PRS 84.89
-
CSI 6.76rCSI 13.72%PRS 60.09
-
CSI 6.71rCSI 14.83%PRS 67.28
-
CSI 6.68rCSI 19%PRS 77.02
-
CSI 6.43rCSI 52.29%PRS 75.76
-
CSI 6.24rCSI 8.53%PRS 80.81
-
CSI 6.13rCSI 9.37%PRS 84.66
-
CSI 5.56rCSI 32.76%PRS 64.28
-
CSI 5.47rCSI 4.44%PRS 80.53
-
CSI 5.41rCSI 5.67%PRS 84.25
-
CSI 5.23rCSI 21.09%PRS 81.14
-
CSI 5.2rCSI 6.62%PRS 86.06
-
CSI 4.99rCSI 6.4%PRS 71.5
-
CSI 4.79rCSI 16.41%PRS 67.5
-
CSI 4.78rCSI 5.24%PRS 83.09
-
CSI 4.74rCSI 6.34%PRS 79.5
-
CSI 4.73rCSI 7.23%PRS 81.33
-
CSI 4.63rCSI 6.79%PRS 75.87
-
CSI 4.61rCSI 4.44%PRS 74.79
-
CSI 4.51rCSI 3.89%PRS 81.96
-
CSI 4.3rCSI 5.54%PRS 64.83
-
CSI 4.28rCSI 6.64%PRS 84.94
-
CSI 4.25rCSI 7.45%PRS 75.59
-
CSI 4.16rCSI 6.4%PRS 70.47
-
CSI 4.13rCSI 16.64%PRS 82.91
-
CSI 4.12rCSI 4.78%PRS 80.99
-
CSI 4.1rCSI 6.01%PRS 89.83
-
CSI 3.89rCSI 3.89%PRS 75.13
-
CSI 3.85rCSI 6.79%PRS 86.07
-
CSI 3.85rCSI 8.88%PRS 69.44
-
CSI 3.78rCSI 6.55%PRS 73.09
-
CSI 3.64rCSI 24.76%PRS 73.88
-
CSI 3.63rCSI 12.15%PRS 65.33
-
CSI 3.54rCSI 3.25%PRS 88.28
-
CSI 3.47rCSI 5.54%PRS 84.82
-
CSI 3.46rCSI 6.48%PRS 69.83
-
CSI 3.36rCSI 3.48%PRS 84.94
-
CSI 3.35rCSI 13.79%PRS 88.12
-
CSI 3.33rCSI 7.59%PRS 72.9
-
CSI 3.3rCSI 7.88%PRS 77.32
-
CSI 3.29rCSI 8.32%PRS 86.01
-
CSI 3.23rCSI 8.88%PRS 87.53
-
CSI 3.16rCSI 7.07%PRS 87.85
-
CSI 3.16rCSI 2.62%PRS 82.04
-
CSI 3.15rCSI 3.91%PRS 81.94
-
CSI 3.05rCSI 8.84%PRS 71.02
-
CSI 2.98rCSI 7.87%PRS 87.45
-
CSI 2.97rCSI 9.64%PRS 79.33
-
CSI 2.93rCSI 4.62%PRS 82.63
-
CSI 2.86rCSI 16.47%PRS 77.84
-
CSI 2.85rCSI 3.42%PRS 79.26
-
CSI 2.83rCSI 40.21%PRS 72.49
-
CSI 2.71rCSI 4.83%PRS 89.14
-
CSI 2.67rCSI 6.41%PRS 84
-
CSI 2.66rCSI 5.17%PRS 84.03
-
CSI 2.62rCSI 3.12%PRS 94.23
-
CSI 2.59rCSI 2.45%PRS 79.71
-
CSI 2.38rCSI 8.97%PRS 64.35
-
CSI 2.36rCSI 2.86%PRS 88.16
-
CSI 2.26rCSI 4.49%PRS 76.96
-
CSI 2.24rCSI 6.05%PRS 85.44
-
CSI 2.17rCSI 4.32%PRS 91.62
-
CSI 2.13rCSI 3.43%PRS 71.57
-
CSI 2.05rCSI 3.33%PRS 76.09
-
CSI 2.03rCSI 41.27%PRS 71.1
-
CSI 2rCSI 2.32%PRS 84.78
-
CSI 1.96rCSI 4.47%PRS 74.83
-
CSI 1.95rCSI 39.64%PRS 72.24
-
CSI 1.81rCSI 4.72%PRS 75.87
-
CSI 1.78rCSI 2.93%PRS 84.73
-
CSI 1.77rCSI 9.89%PRS 84.06
-
CSI 1.61rCSI 2.33%PRS 92.51
-
CSI 1.44rCSI 3.18%PRS 88.03
-
CSI 1.38rCSI 2.35%PRS 92.43
-
CSI 1.36rCSI 6.38%PRS 91.29
-
CSI 1.32rCSI 3.83%PRS 80.57
-
CSI 1.27rCSI 5.64%PRS 90.32
-
CSI 1.25rCSI 3.5%PRS 87.51
-
CSI 0.3rCSI 2.3%PRS 87.5%
-
CSI 0.3rCSI 3.8%PRS 88.6%
-
CSI 0.4rCSI 3.3%PRS 69.5%
-
CSI 0.6rCSI 6.8%PRS 88.5%
-
CSI 0.8rCSI 8.4%PRS 86.3%
-
CSI 0.8rCSI 4.9%PRS 73.2%
-
CSI 1.1rCSI 4.3%PRS 88.6%
-
CSI 1.2rCSI 7.3%PRS 72.8%
-
CSI 1.3rCSI 3.5%PRS 87.5%
-
CSI 1.3rCSI 5.6%PRS 90.3%
-
CSI 1.3rCSI 3.8%PRS 80.6%
-
CSI 1.4rCSI 6.4%PRS 91.3%
-
CSI 1.4rCSI 2.4%PRS 92.4%
-
CSI 1.4rCSI 3.2%PRS 88.0%
-
CSI 1.6rCSI 2.3%PRS 92.5%
-
CSI 1.8rCSI 9.9%PRS 84.1%
-
CSI 1.8rCSI 2.9%PRS 84.7%
-
CSI 1.8rCSI 4.7%PRS 75.9%
-
CSI 2.0rCSI 39.6%PRS 72.2%
-
CSI 2.0rCSI 4.5%PRS 74.8%
-
CSI 2.0rCSI 2.3%PRS 84.8%
-
CSI 2.0rCSI 41.3%PRS 71.1%
-
CSI 2.1rCSI 3.3%PRS 76.1%
-
CSI 2.1rCSI 3.4%PRS 71.6%
-
CSI 2.2rCSI 4.3%PRS 91.6%
-
CSI 2.2rCSI 6.1%PRS 85.4%
-
CSI 2.3rCSI 4.5%PRS 77.0%
-
CSI 2.4rCSI 2.9%PRS 88.2%
-
CSI 2.4rCSI 9.0%PRS 64.4%
-
CSI 2.6rCSI 2.5%PRS 79.7%
-
CSI 2.6rCSI 3.1%PRS 94.2%
-
CSI 2.7rCSI 5.2%PRS 84.0%
-
CSI 2.7rCSI 6.4%PRS 84.0%
-
CSI 2.7rCSI 4.8%PRS 89.1%
-
CSI 2.8rCSI 40.2%PRS 72.5%
-
CSI 2.9rCSI 3.4%PRS 79.3%
-
CSI 2.9rCSI 16.5%PRS 77.8%
-
CSI 2.9rCSI 4.6%PRS 82.6%
-
CSI 3.0rCSI 9.6%PRS 79.3%
-
CSI 3.0rCSI 7.9%PRS 87.5%
-
CSI 3.1rCSI 8.8%PRS 71.0%
-
CSI 3.2rCSI 3.9%PRS 81.9%
-
CSI 3.2rCSI 2.6%PRS 82.0%
-
CSI 3.2rCSI 7.1%PRS 87.9%
-
CSI 3.2rCSI 8.9%PRS 87.5%
-
CSI 3.3rCSI 8.3%PRS 86.0%
-
CSI 3.3rCSI 7.9%PRS 77.3%
-
CSI 3.3rCSI 7.6%PRS 72.9%
-
CSI 3.4rCSI 13.8%PRS 88.1%
-
CSI 3.4rCSI 3.5%PRS 84.9%
-
CSI 3.5rCSI 6.5%PRS 69.8%
-
CSI 3.5rCSI 5.5%PRS 84.8%
-
CSI 3.5rCSI 3.3%PRS 88.3%
-
CSI 3.6rCSI 12.2%PRS 65.3%
-
CSI 3.6rCSI 24.8%PRS 73.9%
-
CSI 3.8rCSI 6.6%PRS 73.1%
-
CSI 3.9rCSI 8.9%PRS 69.4%
-
CSI 3.9rCSI 6.8%PRS 86.1%
-
CSI 3.9rCSI 3.9%PRS 75.1%
-
CSI 4.1rCSI 6.0%PRS 89.8%
-
CSI 4.1rCSI 4.8%PRS 81.0%
-
CSI 4.1rCSI 16.6%PRS 82.9%
-
CSI 4.2rCSI 6.4%PRS 70.5%
-
CSI 4.3rCSI 7.5%PRS 75.6%
-
CSI 4.3rCSI 6.6%PRS 84.9%
-
CSI 4.3rCSI 5.5%PRS 64.8%
-
CSI 4.5rCSI 3.9%PRS 82.0%
-
CSI 4.6rCSI 4.4%PRS 74.8%
-
CSI 4.6rCSI 6.8%PRS 75.9%
-
CSI 4.7rCSI 7.2%PRS 81.3%
-
CSI 4.7rCSI 6.3%PRS 79.5%
-
CSI 4.8rCSI 5.2%PRS 83.1%
-
CSI 4.8rCSI 16.4%PRS 67.5%
-
CSI 5.0rCSI 6.4%PRS 71.5%
-
CSI 5.2rCSI 6.6%PRS 86.1%
-
CSI 5.2rCSI 21.1%PRS 81.1%
-
CSI 5.4rCSI 5.7%PRS 84.3%
-
CSI 5.5rCSI 4.4%PRS 80.5%
-
CSI 5.6rCSI 32.8%PRS 64.3%
-
CSI 6.1rCSI 9.4%PRS 84.7%
-
CSI 6.2rCSI 8.5%PRS 80.8%
-
CSI 6.4rCSI 52.3%PRS 75.8%
-
CSI 6.7rCSI 19.0%PRS 77.0%
-
CSI 6.7rCSI 14.8%PRS 67.3%
-
CSI 6.8rCSI 13.7%PRS 60.1%
-
CSI 6.9rCSI 5.3%PRS 84.9%
-
CSI 7.0rCSI 16.9%PRS 92.6%
-
CSI 7.0rCSI 8.1%PRS 73.7%
-
CSI 7.1rCSI 7.6%PRS 82.7%
-
CSI 7.4rCSI 9.2%PRS 61.6%
-
CSI 7.4rCSI 28.1%PRS 64.2%
-
CSI 7.5rCSI 27.1%PRS 61.6%
-
CSI 8.0rCSI 25.1%PRS 67.7%
-
CSI 8.2rCSI 7.6%PRS 82.7%
-
CSI 8.8rCSI 9.1%PRS 91.5%
-
CSI 9.0rCSI 22.7%PRS 71.9%
-
CSI 9.7rCSI 19.8%PRS 68.6%
-
CSI 10.5rCSI 15.8%PRS 86.1%
-
CSI 10.7rCSI 33.5%PRS 65.3%
-
CSI 11.4rCSI 13.6%PRS 63.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2349912190
Symbol: PRC2B_HUMAN
Name: Protein PRRC2B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 9628581
Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9628581
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18318008
Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
PubMed ID: 18318008
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
Sequence Information:
- Length: 2229
- Mass: 242967
- Checksum: 0F5F13DAC0217A6D
- Sequence:
MSDRLGQITK GKDGKSKYST LSLFDKYKGK SVDAIRSSVI PRHGLQSLGK VAAARRMPPP ANLPSLKSEN KGNDPNIVIV PKDGTGWANK QDQQDPKSSS ATASQPPESL PQPGLQKSVS NLQKPTQSIS QENTNSVPGG PKSWAQLNGK PVGHEGGLRG SSRLLSFSPE EFPTLKAAGG QDKAGKEKGV LDLSYGPGPS LRPQNVTSWR EGGGRHIISA TSLSTSPTEL GSRNSSTGDG APSSACTSDS KDPSLRPAQP VRKGASQFMG NVYHPPTYHD MLPAFMCSPK SSENQGTVER GSFPLPQLRL EPRVPFRQFQ MNDQDGKENR LGLSRPLRPL RQLVERAPRP TIINAENLKG LDDLDADADD GWAGLHEEVD YSEKLKFSDD EEEEEVVKDG RPKWNSWDPR RQRQLSMSSA DSADAKRTRE EGKDWAEAVG ASRVVRKAPD PQPPPRKLHG WAPGPDYQKS SMGSMFRQQS IEDKEDKPPP RQKFIQSEMS EAVERARKRR EEEERRAREE RLAACAAKLK QLDQKCKQAR KAGEARKQAE KEVPWSPSAE KASPQENGPA VHKGSPEFPA QETPTTFPEE APTVSPAVAQ SNSSEEEARE AGSPAQEFKY QKSLPPRFQR QQQQQQQEQL YKMQHWQPVY PPPSHPQRTF YPHHPQMLGF DPRWMMMPSY MDPRITPTRT PVDFYPSALH PSGLMKPMMP QESLNGTGCR SEDQNCVPPL QERKVTPIDS PPVWSPEGYM ALQSKGYPLP HPKSSDTLAM DMRVRNESSF SASLGRAGGV SAQRDLFEER GEEYLSAFDK KAQADFDSCI SSQRIGQELL FPPQENVQDA GAPGGHTQNL RCSPLEPDFV PDEKKPECGS WDVSHQPETA DTAHGVERET PREGTAFNIS SWDKNGSPNK QPSSEPEWTP EPRSSSSQHP EQTGRTRRSG PIKKPVLKAL KVEDKEKELE KIKQELGEES TRLAKEKEQS PTAEKDEDEE NDASLANSST TTLEDKGPGH ATFGREATKF EEEEKPDKAW EARPPRESSD VPPMKRNNWI FIDEEQAFGV RGQARGRGRG FREFTFRGRP AGGNGSGLCG GGVLGARSIY CSSQRSGRGR GLREFARPED CPRAKPRRRV ASETHSEGSE YEELPKRRRQ RGSENGNEGS LLEREESTLK KGDCRDSWRS NKGCSEDHSG LDAKSRGPRA FGRALPPRLS NCGYGRRTFV SKESPHWQSK SPGSSWQEYG PSDTCGSRRP TDRDYVPDSY RHPDAFGGRG FEDSRAEDKR SFFQDEHVAD SENAENRPFR RRRPPRQDKP PRFRRLRQER ESLGLWGPEE EPHLLAGQWP GRPKLCSGDK SGTVGRRSPE LSYQNSSDHA NEEWETASES SDFSERRERR EGPGSEPDSQ VDGGLSGASL GEKKELAKRS FSSQRPVVDR QSRKLEPGGF GEKPVRPGGG DTSPRYESQQ NGTPLKVKRS PDEALPGGLS GCSSGSGHSP YALERAAHAS ADLPEASSKK AEKEAKLAAP RAGEQGEAMK QFDLNYGSAI IENCGSSPGE ESEVGSMVGE GFIEVLTKKQ RRLLEEERRK KEQAVQVPVK GRGLSSRIPP RFAKKQNNLC LEQGDVTVPG SSLGTEIWES SSQALPVQAP ANDSWRKAVT AFSSTETGSA EQGFKSSQGD SGVDLSAESR ESSATSSQRS SPYGTLKPEE MSGPGLAEPK ADSHKEQAPK PSEQKDSEQG SGQSKEHRPG PIGNERSLKN RKGSEGAERL QGAVVPPVNG VEIHVDSVLP VPPIEFGVSP KDSDFSLPPG SASGPTGSPV VKLQDALASN AGLTQSIPIL RRDHHIQRAI GLSPMSFPTA DLTLKMESAR KAWENSPSLP EQSSPGGAGS GIQPPSSVGA SSGVNYSSFG GVSMPPMPVA SVAPSASMPG SHLPPLYLDG HVFASQPRLV PQTIPQQQSY QQAAAAQQIP ISLHTSLQAQ AQLGLRGGLP VSQSQEIFSS LQPFRSQVYM HPSLSPPSTM ILSGGTALKP PYSAFPGMQP LEMVKPQSGS PYQPMSGNQA LVYEGQLSQA AGLGASQMLD SQLPQLTMPL PRYGSGQQPL ILPQSIQLPP GQSLSVGAPR RIPPPGSQPP VLNTSREPSQ MEMKGFHFAD SKQNVPSGGP VPSPQTYRPS SASPSGKPSG SAVNMGSVQG HYVQQAKQRV DEKPSLGAVK LQEAPSAASQ MKRTGAIKPR AVKVEESKA
Genular Protein ID: 821692677
Symbol: Q9BU62_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 339
- Mass: 36378
- Checksum: F6DF9BCBDDCEAC14
- Sequence:
MSDRLGQITK GKDGKSKYST LSLFDKYKGK SVDAIRSSVI PRHGLQSLGK VAAARRMPPP ANLPSLKSEN KGNDPNIVIV PKDGTGWANK QDQQDPKSSS ATASQPPESL PQPGLQKSVS NLQKPTQSIS QENTNSVPGG PKSWAQLNGK PVGHEGGLRG SSRLLSFSPE EFPTLKAAGG QDKAGKEKGV LDLSYGPGPS LRPQNVTSWR EGGGRHIISA TSLSTSPTEL GSRNSSTGDG APSSACTSDS KDPSLRPAQP VRKGASQFMG NVYHPPTYHD MLPAFMCSPK SSENQGTVER GSFPLPQLRL EPRVPFRQFQ MNDQDWNYGA RLVNMTFNE