Details for: TPD52L3

Gene ID: 89882

Symbol: TPD52L3

Ensembl ID: ENSG00000170777

Description: TPD52 like 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2563
    Cell Significance Index: 4.3100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.2560
    Cell Significance Index: 3.0600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.1660
    Cell Significance Index: 5.2500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1376
    Cell Significance Index: 1.7800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.1153
    Cell Significance Index: 1.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0386
    Cell Significance Index: 0.5500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0290
    Cell Significance Index: 0.4700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0240
    Cell Significance Index: 0.2900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.0155
    Cell Significance Index: 0.1800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0116
    Cell Significance Index: 0.1100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0099
    Cell Significance Index: 0.1100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0084
    Cell Significance Index: 0.1000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0047
    Cell Significance Index: 0.0500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0035
    Cell Significance Index: 0.0300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0012
    Cell Significance Index: -0.7400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0033
    Cell Significance Index: -0.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0035
    Cell Significance Index: -0.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0037
    Cell Significance Index: -0.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0048
    Cell Significance Index: -0.1400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0049
    Cell Significance Index: -0.0400
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0076
    Cell Significance Index: -0.0900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0098
    Cell Significance Index: -0.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0116
    Cell Significance Index: -0.3100
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0157
    Cell Significance Index: -0.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0164
    Cell Significance Index: -0.3600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0218
    Cell Significance Index: -0.2300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0251
    Cell Significance Index: -0.6400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0253
    Cell Significance Index: -0.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0263
    Cell Significance Index: -0.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0270
    Cell Significance Index: -0.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0276
    Cell Significance Index: -0.7900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0283
    Cell Significance Index: -0.4300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0285
    Cell Significance Index: -0.7100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0315
    Cell Significance Index: -0.3600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0338
    Cell Significance Index: -0.6600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0371
    Cell Significance Index: -0.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0396
    Cell Significance Index: -0.8400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0417
    Cell Significance Index: -0.5000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0422
    Cell Significance Index: -0.5800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0423
    Cell Significance Index: -0.8500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0427
    Cell Significance Index: -0.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0430
    Cell Significance Index: -0.8500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0431
    Cell Significance Index: -0.5000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0431
    Cell Significance Index: -0.5200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0432
    Cell Significance Index: -0.5100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0450
    Cell Significance Index: -0.5700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0460
    Cell Significance Index: -0.6700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0466
    Cell Significance Index: -0.7500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0467
    Cell Significance Index: -0.6900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0470
    Cell Significance Index: -0.4800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0472
    Cell Significance Index: -0.4200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0483
    Cell Significance Index: -0.6200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0488
    Cell Significance Index: -0.5400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0489
    Cell Significance Index: -0.6600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0490
    Cell Significance Index: -0.4600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0492
    Cell Significance Index: -0.8500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0492
    Cell Significance Index: -0.5100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0508
    Cell Significance Index: -0.6000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0513
    Cell Significance Index: -0.6800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0521
    Cell Significance Index: -0.7300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0523
    Cell Significance Index: -0.6600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0529
    Cell Significance Index: -0.5800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0529
    Cell Significance Index: -0.6900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0529
    Cell Significance Index: -0.6300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0538
    Cell Significance Index: -0.6200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0541
    Cell Significance Index: -0.7100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0560
    Cell Significance Index: -0.6100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0561
    Cell Significance Index: -0.6900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0567
    Cell Significance Index: -0.6700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0567
    Cell Significance Index: -0.7400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0567
    Cell Significance Index: -0.6900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0568
    Cell Significance Index: -0.7100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0573
    Cell Significance Index: -0.6400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0574
    Cell Significance Index: -0.6600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0577
    Cell Significance Index: -0.6200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0599
    Cell Significance Index: -0.8600
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0608
    Cell Significance Index: -0.6500
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0612
    Cell Significance Index: -0.4400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0634
    Cell Significance Index: -0.6800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0652
    Cell Significance Index: -0.8400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0665
    Cell Significance Index: -0.7300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0669
    Cell Significance Index: -0.7600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0680
    Cell Significance Index: -0.6900
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.0685
    Cell Significance Index: -0.5800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0687
    Cell Significance Index: -0.7300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0693
    Cell Significance Index: -0.7300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0695
    Cell Significance Index: -0.6800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0701
    Cell Significance Index: -0.7600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0704
    Cell Significance Index: -0.6000
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0706
    Cell Significance Index: -0.7900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0707
    Cell Significance Index: -0.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0718
    Cell Significance Index: -0.6900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0726
    Cell Significance Index: -0.9600
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0736
    Cell Significance Index: -0.8000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0750
    Cell Significance Index: -0.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TPD52L3 gene is a member of the tumor protein family, which is known for its involvement in various cellular processes, including cell growth, differentiation, and apoptosis. The gene's protein product, TPD55, has been annotated in the Human Protein Reference Database (HPRD) and has been associated with the cytoplasmic localization. The expression profile of TPD52L3 is characterized by its significant expression in cells of the nervous system, immune system, and epithelial tissues. Notably, the gene's expression pattern is not limited to healthy cells, as it is also detected in neoplastic and abnormal cells, suggesting its potential role in cancer and other diseases. **Pathways and Functions:** The molecular pathways and functions associated with TPD52L3 are not well characterized, but its involvement in cytoplasmic protein binding suggests potential roles in regulating protein-protein interactions and signaling pathways. The gene's expression in various cell types, including those of the nervous system and immune system, implies that TPD52L3 may play a role in modulating immune responses and neuronal function. Further investigation is needed to elucidate the specific molecular mechanisms underlying the gene's functions. **Clinical Significance:** The clinical significance of TPD52L3 is an area of active research, with potential implications for the diagnosis and treatment of various diseases. The gene's expression in neoplastic and abnormal cells suggests that TPD52L3 may serve as a biomarker for cancer diagnosis and monitoring. Additionally, the gene's involvement in immune regulation and neuronal function implies that it may play a role in the pathogenesis of autoimmune and neurodegenerative diseases. Further study is needed to fully appreciate the clinical significance of TPD52L3 and its potential applications in personalized medicine. In conclusion, TPD52L3 is a gene of interest that warrants further investigation due to its unique expression profile and potential implications in immune regulation and disease progression. Further research is needed to elucidate the molecular mechanisms underlying the gene's functions and to explore its clinical significance in various diseases.

Genular Protein ID: 4002559355

Symbol: TPD55_HUMAN

Name: Tumor protein D55

UniProtKB Accession Codes:

Q96J77 Q5TCR3 Q5TCR4 Q5TCR5 Q8N4P5 Q8WWF7 Q96M09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 GO 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 4 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16631610

Title: A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins.

PubMed ID: 16631610

DOI: 10.1016/j.bbrc.2006.03.208

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 140
  • Mass: 15503
  • Checksum: 759F26E983B1EFAD
  • Sequence:
    • MPHARTETSV GTYESHSTSE LEDLTEPEQR ELKTKLTKLE AEIVTLRHVL AAKERRCGEL 
KRKLGLTALV GLRQNLSKSW LDVQVSNTYV KQKTSAALST MGTLICRKLG GVKKSATFRS 
FEGLMGTIKS KVSGGKRAWP

Genular Protein ID: 3650930537

Symbol: A0A140VKH0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VKH0

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 2

Sequence Information:

  • Length: 136
  • Mass: 15234
  • Checksum: FC4B618301A9C324
  • Sequence:
    • MPHARTETSV GTYESHSTSE LEDLTEPEQR ELKTKLTKLE AEIVTLRHVL AAKERRCGEL 
KRKLGLTALV GLRQNLSKSW LDVQVSNTYV KQKTSAALST MGTLICRKLG GVKKSATLRS 
FEGLIFNKYT LNQGRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.