Details for: OPALIN

Gene ID: 93377

Symbol: OPALIN

Ensembl ID: ENSG00000197430

Description: oligodendrocytic myelin paranodal and inner loop protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7561
    Cell Significance Index: 18.3200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0382
    Cell Significance Index: 0.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0110
    Cell Significance Index: 7.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0012
    Cell Significance Index: -0.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0013
    Cell Significance Index: -0.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0035
    Cell Significance Index: -6.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0040
    Cell Significance Index: -6.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0049
    Cell Significance Index: -6.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0084
    Cell Significance Index: -6.2000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0086
    Cell Significance Index: -0.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0111
    Cell Significance Index: -6.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0123
    Cell Significance Index: -7.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0130
    Cell Significance Index: -7.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0171
    Cell Significance Index: -7.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0205
    Cell Significance Index: -5.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0337
    Cell Significance Index: -6.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0352
    Cell Significance Index: -7.4200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0357
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0408
    Cell Significance Index: -6.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0423
    Cell Significance Index: -1.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0435
    Cell Significance Index: -7.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0447
    Cell Significance Index: -1.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0520
    Cell Significance Index: -7.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0614
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0641
    Cell Significance Index: -7.3400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0736
    Cell Significance Index: -1.1200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0837
    Cell Significance Index: -1.2500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0926
    Cell Significance Index: -1.3500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0967
    Cell Significance Index: -0.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1027
    Cell Significance Index: -6.3100
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1092
    Cell Significance Index: -1.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1105
    Cell Significance Index: -7.1300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1110
    Cell Significance Index: -2.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1113
    Cell Significance Index: -8.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1196
    Cell Significance Index: -6.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1207
    Cell Significance Index: -5.3400
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1300
    Cell Significance Index: -1.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1314
    Cell Significance Index: -6.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1422
    Cell Significance Index: -4.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1429
    Cell Significance Index: -5.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1608
    Cell Significance Index: -4.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1694
    Cell Significance Index: -5.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1705
    Cell Significance Index: -5.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1890
    Cell Significance Index: -6.6400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1891
    Cell Significance Index: -5.9800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1999
    Cell Significance Index: -2.1900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2039
    Cell Significance Index: -5.8200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2043
    Cell Significance Index: -2.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2075
    Cell Significance Index: -4.4400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2136
    Cell Significance Index: -1.4500
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.2159
    Cell Significance Index: -2.5000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2217
    Cell Significance Index: -5.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2228
    Cell Significance Index: -5.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2318
    Cell Significance Index: -6.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2360
    Cell Significance Index: -6.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2361
    Cell Significance Index: -5.1000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2406
    Cell Significance Index: -4.8300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2423
    Cell Significance Index: -3.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2431
    Cell Significance Index: -5.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2439
    Cell Significance Index: -6.2300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2443
    Cell Significance Index: -4.9700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2506
    Cell Significance Index: -5.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2557
    Cell Significance Index: -7.3300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2564
    Cell Significance Index: -5.0700
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.2621
    Cell Significance Index: -2.0100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2671
    Cell Significance Index: -3.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2672
    Cell Significance Index: -6.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2678
    Cell Significance Index: -3.8400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2712
    Cell Significance Index: -6.9100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2754
    Cell Significance Index: -6.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2818
    Cell Significance Index: -6.1700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2916
    Cell Significance Index: -5.7400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2931
    Cell Significance Index: -7.0300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2967
    Cell Significance Index: -5.1300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2979
    Cell Significance Index: -1.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3122
    Cell Significance Index: -5.3500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.3162
    Cell Significance Index: -1.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3186
    Cell Significance Index: -6.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3202
    Cell Significance Index: -6.2500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.3224
    Cell Significance Index: -1.7000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3230
    Cell Significance Index: -6.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3342
    Cell Significance Index: -4.5600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3446
    Cell Significance Index: -5.8900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3454
    Cell Significance Index: -4.8300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3536
    Cell Significance Index: -4.6400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3565
    Cell Significance Index: -6.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3651
    Cell Significance Index: -6.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3734
    Cell Significance Index: -6.2900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.3736
    Cell Significance Index: -5.5900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3758
    Cell Significance Index: -6.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3791
    Cell Significance Index: -4.1300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.3832
    Cell Significance Index: -4.2000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3934
    Cell Significance Index: -4.0700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3955
    Cell Significance Index: -4.6500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.4084
    Cell Significance Index: -5.1600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4112
    Cell Significance Index: -6.6600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.4138
    Cell Significance Index: -5.4000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.4164
    Cell Significance Index: -5.4000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.4176
    Cell Significance Index: -5.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OPALIN, a protein encoded by the OPALIN gene, exhibits a unique oligodendrocytic myelin paranodal and inner loop structure. Its expression is predominantly found in cells involved in the central nervous system, including oligodendrocytes, interneurons, and blood vessel endothelial cells. Notably, OPALIN is also expressed in various non-neuronal cells, such as goblet cells, absorptive cells, and intestinal crypt stem cells, suggesting a broader functional scope. **Pathways and Functions:** OPALIN is intricately involved in several cellular pathways, including cell-cell contact zones, Golgi apparatus, plasma membrane, and regulation of oligodendrocyte differentiation. Its precise mechanisms of action are multifaceted: 1. **Cell-cell contact zones:** OPALIN plays a crucial role in establishing and maintaining cell-cell interactions, which are essential for the development and function of the central nervous system. 2. **Golgi apparatus:** OPALIN is involved in the processing and modification of proteins within the Golgi apparatus, ensuring proper protein folding and secretion. 3. **Plasma membrane:** OPALIN is embedded in the plasma membrane, where it regulates ion channels and transporters, influencing cellular signaling and communication. 4. **Regulation of oligodendrocyte differentiation:** OPALIN is essential for the differentiation and maturation of oligodendrocytes, the myelinating cells of the central nervous system. **Clinical Significance:** OPALIN's involvement in the central nervous system and its regulation of oligodendrocyte differentiation render it a critical protein in the context of neurological disorders. Dysregulation of OPALIN has been implicated in various conditions, including: 1. **Multiple sclerosis:** OPALIN's role in oligodendrocyte differentiation and myelination makes it a potential target for therapeutic interventions in multiple sclerosis. 2. **Neurodevelopmental disorders:** OPALIN's expression in interneurons and other non-neuronal cells suggests its involvement in neurodevelopmental processes, potentially linking it to disorders such as autism spectrum disorder or schizophrenia. 3. **Neuroinflammatory diseases:** OPALIN's participation in cell-cell contact zones and plasma membrane regulation may contribute to the pathogenesis of neuroinflammatory diseases, such as Alzheimer's disease or Parkinson's disease. In conclusion, OPALIN is a fascinating protein that has shed light on the intricate mechanisms of cellular communication and differentiation in the central nervous system. Further studies are warranted to fully elucidate the clinical significance of OPALIN and its potential as a therapeutic target for neurological disorders.

Genular Protein ID: 15357865

Symbol: OPALI_HUMAN

Name: Opalin

UniProtKB Accession Codes:

Q96PE5 A8MX69 A8MYG4 B4DK96 B4DKH0 Q5W102

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 10 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11814680

Title: Identification and characterization of a novel human brain-specific gene, homologous to S. scrofa tmp83.5, in the chromosome 10q24 critical region for temporal lobe epilepsy and spastic paraplegia.

PubMed ID: 11814680

DOI: 10.1016/s0378-1119(01)00846-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 30837646

Title: TMEM10 Promotes Oligodendrocyte Differentiation and is Expressed by Oligodendrocytes in Human Remyelinating Multiple Sclerosis Plaques.

PubMed ID: 30837646

DOI: 10.1038/s41598-019-40342-x

Sequence Information:

  • Length: 141
  • Mass: 15683
  • Checksum: 86DE9B7AF4C89B85
  • Sequence:
    • MSFSLNFTLP ANTTSSPVTG GKETDCGPSL GLAAGIPLLV ATALLVALLF TLIHRRRSSI 
EAMEESDRPC EISEIDDNPK ISENPRRSPT HEKNTMGAQE AHIYVKTVAG SEEPVHDRYR 
PTIEMERRRG LWWLVPRLSL E

Genular Protein ID: 2385501847

Symbol: A0A0A0MS47_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MS47

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 129
  • Mass: 14389
  • Checksum: 554E64E8A30008A5
  • Sequence:
    • MTSSPVTGGK ETDCGPSLGL AAGIPLLVAT ALLVALLFTL IHRRRSSIEA MEESDRPCEI 
SEIDDNPKIS ENPRRSPTHE KNTMGAQEAH IYVKTVAGSE EPVHDRYRPT IEMERRRGLW 
WLVPRLSLE

Genular Protein ID: 4219688326

Symbol: A0A0A0MTN4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MTN4

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 79
  • Mass: 9301
  • Checksum: 30BD0A7B2D09192F
  • Sequence:
    • MEESDRPCEI SEIDDNPKIS ENPRRSPTHE KNTMGAQEAH IYVKTVAGSE EPVHDRYRPT 
IEMERRRGLW WLVPRLSLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.