Details for: CSHL1

Gene ID: 1444

Symbol: CSHL1

Ensembl ID: ENSG00000204414

Description: chorionic somatomammotropin hormone like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 21.9224
    Cell Significance Index: 157.9400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.5134
    Cell Significance Index: 3.1900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3074
    Cell Significance Index: 4.4800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0853
    Cell Significance Index: 1.7000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0712
    Cell Significance Index: 0.4300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0413
    Cell Significance Index: 0.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0405
    Cell Significance Index: 0.5800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0147
    Cell Significance Index: 0.1400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0137
    Cell Significance Index: 0.2300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0047
    Cell Significance Index: 0.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0009
    Cell Significance Index: -0.0300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0022
    Cell Significance Index: -0.0200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0024
    Cell Significance Index: -0.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0026
    Cell Significance Index: -0.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0036
    Cell Significance Index: -1.6500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0039
    Cell Significance Index: -0.1000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0040
    Cell Significance Index: -0.1100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0046
    Cell Significance Index: -0.0600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0055
    Cell Significance Index: -0.0500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0059
    Cell Significance Index: -0.1000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0061
    Cell Significance Index: -0.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0083
    Cell Significance Index: -1.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0085
    Cell Significance Index: -0.5700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0088
    Cell Significance Index: -0.0900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0103
    Cell Significance Index: -0.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0112
    Cell Significance Index: -2.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0179
    Cell Significance Index: -0.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0192
    Cell Significance Index: -0.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0200
    Cell Significance Index: -0.5700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0208
    Cell Significance Index: -0.2000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0232
    Cell Significance Index: -0.2500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0233
    Cell Significance Index: -0.3200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0236
    Cell Significance Index: -0.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0249
    Cell Significance Index: -0.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0292
    Cell Significance Index: -0.6200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0296
    Cell Significance Index: -0.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0314
    Cell Significance Index: -1.0000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0315
    Cell Significance Index: -0.3500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0330
    Cell Significance Index: -0.6500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0333
    Cell Significance Index: -0.5400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0343
    Cell Significance Index: -0.6700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0350
    Cell Significance Index: -0.7300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0382
    Cell Significance Index: -0.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0387
    Cell Significance Index: -1.7100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0415
    Cell Significance Index: -0.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0421
    Cell Significance Index: -0.9100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0437
    Cell Significance Index: -0.6000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0450
    Cell Significance Index: -0.4900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0452
    Cell Significance Index: -0.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0454
    Cell Significance Index: -1.7200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0455
    Cell Significance Index: -0.5000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0463
    Cell Significance Index: -0.5500
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0480
    Cell Significance Index: -0.4700
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0481
    Cell Significance Index: -0.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0496
    Cell Significance Index: -0.8300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0499
    Cell Significance Index: -0.5800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0502
    Cell Significance Index: -0.5200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0515
    Cell Significance Index: -0.5700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0517
    Cell Significance Index: -0.5600
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0519
    Cell Significance Index: -0.5500
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0530
    Cell Significance Index: -0.5600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0531
    Cell Significance Index: -0.7100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0534
    Cell Significance Index: -0.6500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0541
    Cell Significance Index: -0.5700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0549
    Cell Significance Index: -0.5600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0555
    Cell Significance Index: -0.7300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0556
    Cell Significance Index: -0.6400
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0562
    Cell Significance Index: -0.6500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0563
    Cell Significance Index: -0.2600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0572
    Cell Significance Index: -0.5900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0577
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0583
    Cell Significance Index: -0.5400
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0594
    Cell Significance Index: -0.6400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0601
    Cell Significance Index: -0.5600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0601
    Cell Significance Index: -0.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0607
    Cell Significance Index: -1.3300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0613
    Cell Significance Index: -0.5400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0626
    Cell Significance Index: -0.7200
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0629
    Cell Significance Index: -0.5500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0641
    Cell Significance Index: -0.5300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0643
    Cell Significance Index: -0.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0665
    Cell Significance Index: -1.3200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0670
    Cell Significance Index: -0.6800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0671
    Cell Significance Index: -0.9900
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0672
    Cell Significance Index: -0.6400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0677
    Cell Significance Index: -0.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0682
    Cell Significance Index: -1.3700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0686
    Cell Significance Index: -0.6000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0690
    Cell Significance Index: -0.7800
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0699
    Cell Significance Index: -0.5700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0710
    Cell Significance Index: -0.6400
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0713
    Cell Significance Index: -0.6500
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0722
    Cell Significance Index: -0.5500
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0771
    Cell Significance Index: -0.7000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0792
    Cell Significance Index: -1.3700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0792
    Cell Significance Index: -0.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CSHL1 is a gene that exhibits a unique structure, consisting of multiple exons and introns. Its expression is widespread, with significant levels detected in various cell types, including plasma cells, goblet cells, absorptive cells, trophoblast giant cells, and intestinal crypt stem cells. The gene's protein product, CSHL_HUMAN, shares structural homology with somatomammotropin hormones, suggesting a conserved evolutionary pathway. Notably, CSHL1 is also expressed in abnormal and neoplastic cells, highlighting its potential role in tumorigenesis. **Pathways and Functions:** CSHL1 is intricately involved in several signaling pathways, including: 1. **Growth factor activity**: CSHL1 interacts with growth factors, modulating their signaling pathways and influencing cell growth and proliferation. 2. **Growth hormone receptor signaling pathway**: The gene's product binds to the growth hormone receptor, activating a cascade of downstream signaling events that regulate cellular growth and differentiation. 3. **Positive regulation of receptor signaling pathway via Jak-Stat**: CSHL1 enhances the activity of the JAK-STAT signaling pathway, a key regulator of cell growth and survival. 4. **Positive regulation of tyrosine phosphorylation of Stat protein**: The gene's product promotes the tyrosine phosphorylation of Stat proteins, a critical step in the activation of downstream signaling pathways. 5. **Metal ion binding**: CSHL1 exhibits metal ion-binding properties, suggesting a potential role in regulating cellular metal homeostasis. These pathways and functions highlight the gene's critical role in regulating cellular growth, development, and survival. **Clinical Significance:** The clinical significance of CSHL1 is multifaceted: 1. **Growth disorders**: Abnormalities in CSHL1 expression have been linked to various growth disorders, including dwarfism and acromegaly. 2. **Cancer**: The gene's expression in abnormal and neoplastic cells suggests a potential role in tumorigenesis and cancer progression. 3. **Inflammatory diseases**: CSHL1's involvement in the regulation of immune responses and inflammation may contribute to the pathogenesis of inflammatory diseases, such as rheumatoid arthritis. 4. **Neurological disorders**: The gene's expression in the brain and nervous system may be linked to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CSHL1 is a gene of enduring significance in growth, development, and cellular regulation. Its involvement in various signaling pathways and its expression in abnormal and neoplastic cells highlight its potential role in various diseases. Further research is necessary to fully elucidate the mechanisms underlying CSHL1's functions and to explore its therapeutic potential in clinical settings.

Genular Protein ID: 3065434324

Symbol: CSHL_HUMAN

Name: Chorionic somatomammotropin hormone-like 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2744760

Title: The human growth hormone locus: nucleotide sequence, biology, and evolution.

PubMed ID: 2744760

DOI: 10.1016/0888-7543(89)90271-1

PubMed ID: 8083227

Title: Complex alternative splicing partially inactivates the human chorionic somatomammotropin-like (hCS-L) gene.

PubMed ID: 8083227

DOI: 10.1016/s0021-9258(17)31642-3

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 222
  • Mass: 25391
  • Checksum: E450E16D4731813A
  • Sequence:
  • MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA IDTYQEFISS 
    WGMEAYITKE QKYSFLHDSQ TSFCFSDSIP TSSNMEETQQ KSNLELLHIS LLLIESRLEP 
    VRFLRSTFTN NLVYDTSDSD DYHLLKDLEE GIQMLMGRLE DGSHLTGQTL KQTYSKFDTN 
    SHNHDALLKN YGLLHCFRKD MDKVETFLRM VQCRSVEGSC GF

Genular Protein ID: 4220788636

Symbol: A0A384N655_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 199
  • Mass: 22649
  • Checksum: 119656E87AFD55C3
  • Sequence:
  • MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA IDTYQEFISS 
    WGMDSIPTSS NMEETQQKSN LELLHISLLL IESRLEPVRF LRSTFTNNLV YDTSDSDDYH 
    LLKDLEEGIQ MLMGRLEDGS HLTGQTLKQT YSKFDTNSHN HDALLKNYGL LHCFRKDMDK 
    VETFLRMVQC RSVEGSCGF

Genular Protein ID: 3409514799

Symbol: I6L999_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 128
  • Mass: 14875
  • Checksum: 3EA9C8B73EBF67D5
  • Sequence:
  • MEETQQKSNL ELLHISLLLI ESRLEPVRFL RSTFTNNLVY DTSDSDDYHL LKDLEEGIQM 
    LMGRLEDGSH LTGQTLKQTY SKFDTNSHNH DALLKNYGLL HCFRKDMDKV ETFLRMVQCR 
    SVEGSCGF

Genular Protein ID: 3860370245

Symbol: A0A0B4J1R0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 160
  • Mass: 18235
  • Checksum: C2AC558E00594113
  • Sequence:
  • MAAGSRTSLL LAFALLCLPW LQEADSIPTS SNMEETQQKS NLELLHISLL LIESRLEPVR 
    FLRSTFTNNL VYDTSDSDDY HLLKDLEEGI QMLMGRLEDG SHLTGQTLKQ TYSKFDTNSH 
    NHDALLKNYG LLHCFRKDMD KVETFLRMVQ CRSVEGSCGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.