Details for: CSHL1

Gene ID: 1444

Symbol: CSHL1

Ensembl ID: ENSG00000204414

Description: chorionic somatomammotropin hormone like 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2222
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.96
    Marker Score: 312
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.85
    Marker Score: 468.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1335
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1202
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.74
    Marker Score: 706
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.73
    Marker Score: 861
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.71
    Marker Score: 1222
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 538
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.6
    Marker Score: 348
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.58
    Marker Score: 1091
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.52
    Marker Score: 503
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.48
    Marker Score: 994
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.42
    Marker Score: 379
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.37
    Marker Score: 194
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.37
    Marker Score: 389
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.32
    Marker Score: 190
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.31
    Marker Score: 626
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.26
    Marker Score: 230
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.25
    Marker Score: 3877
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.25
    Marker Score: 658
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.22
    Marker Score: 147
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.2
    Marker Score: 366
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.18
    Marker Score: 84
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.16
    Marker Score: 167
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.15
    Marker Score: 49
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.14
    Marker Score: 179
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.13
    Marker Score: 102
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.09
    Marker Score: 555
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.09
    Marker Score: 209
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.08
    Marker Score: 43
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 49
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 66
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.06
    Marker Score: 48
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.05
    Marker Score: 195
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.05
    Marker Score: 81
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.04
    Marker Score: 49
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.04
    Marker Score: 55
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.04
    Marker Score: 36.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.03
    Marker Score: 47
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.03
    Marker Score: 38.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.02
    Marker Score: 49
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.02
    Marker Score: 47
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.02
    Marker Score: 49
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.02
    Marker Score: 65
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.02
    Marker Score: 45
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 46
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.01
    Marker Score: 46
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.01
    Marker Score: 48.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.01
    Marker Score: 37.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.01
    Marker Score: 47
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.01
    Marker Score: 42
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.01
    Marker Score: 32
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.01
    Marker Score: 46
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.01
    Marker Score: 44
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.01
    Marker Score: 49.5
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.01
    Marker Score: 56
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.01
    Marker Score: 49
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0
    Marker Score: 46
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0
    Marker Score: 49
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0
    Marker Score: 40
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0
    Marker Score: 46
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 41
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0
    Marker Score: 32
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0
    Marker Score: 44
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 49
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0
    Marker Score: 36
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 39
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 31
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0
    Marker Score: 45

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Other Information

## Summary CSHL1 is a protein that is involved in the development of the central nervous system. It is expressed in many different cell types, including plasma cells, goblet cells, absorptive cells, trophoblast giant cells, intestinal crypt stem cells of the colon, transit amplifying cells, abnormal cells, neoplastic cells, mast cells, and erythrocytes. ## Key characteristics * CSHL1 is a protein that is produced by the chorionic somatomammotropin (CSL) gene. * It is a transmembrane protein that is expressed in the central nervous system. * It is a key regulator of the development of the central nervous system. * It is involved in the regulation of growth, differentiation, and apoptosis. ## Pathways and functions * CSHL1 is involved in the regulation of the development of the central nervous system. * It is a key regulator of the growth and differentiation of neurons. * It is involved in the regulation of synaptic plasticity. * It is involved in the development of the blood-brain barrier. ## Clinical significance * Mutations in the CSHL1 gene have been linked to a number of neurological disorders, including cerebral palsy, epilepsy, and autism. * CSHL1 is a potential therapeutic target for these disorders. ## Conclusion CSHL1 is a key regulator of the development and function of the central nervous system. Its mutations have a significant impact on the development of the central nervous system and have been linked to a number of neurological disorders.

Genular Protein ID: 3065434324

Symbol: CSHL_HUMAN

Name: Chorionic somatomammotropin hormone-like 1

UniProtKB Accession Codes:

Q14406 D3DU26 D3DU27 Q0VDB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2744760

Title: The human growth hormone locus: nucleotide sequence, biology, and evolution.

PubMed ID: 2744760

DOI: 10.1016/0888-7543(89)90271-1

PubMed ID: 8083227

Title: Complex alternative splicing partially inactivates the human chorionic somatomammotropin-like (hCS-L) gene.

PubMed ID: 8083227

DOI: 10.1016/s0021-9258(17)31642-3

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 222
  • Mass: 25391
  • Checksum: E450E16D4731813A
  • Sequence:
    • MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA IDTYQEFISS 
WGMEAYITKE QKYSFLHDSQ TSFCFSDSIP TSSNMEETQQ KSNLELLHIS LLLIESRLEP 
VRFLRSTFTN NLVYDTSDSD DYHLLKDLEE GIQMLMGRLE DGSHLTGQTL KQTYSKFDTN 
SHNHDALLKN YGLLHCFRKD MDKVETFLRM VQCRSVEGSC GF

Genular Protein ID: 4220788636

Symbol: A0A384N655_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A384N655

Database IDs:

ARBA 3 AlphaFoldDB 1 CTD 1 ChEBI 2 DNASU 1 EMBL 2 GO 4 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 199
  • Mass: 22649
  • Checksum: 119656E87AFD55C3
  • Sequence:
    • MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA IDTYQEFISS 
WGMDSIPTSS NMEETQQKSN LELLHISLLL IESRLEPVRF LRSTFTNNLV YDTSDSDDYH 
LLKDLEEGIQ MLMGRLEDGS HLTGQTLKQT YSKFDTNSHN HDALLKNYGL LHCFRKDMDK 
VETFLRMVQC RSVEGSCGF

Genular Protein ID: 3860370245

Symbol: A0A0B4J1R0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0B4J1R0

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 160
  • Mass: 18235
  • Checksum: C2AC558E00594113
  • Sequence:
    • MAAGSRTSLL LAFALLCLPW LQEADSIPTS SNMEETQQKS NLELLHISLL LIESRLEPVR 
FLRSTFTNNL VYDTSDSDDY HLLKDLEEGI QMLMGRLEDG SHLTGQTLKQ TYSKFDTNSH 
NHDALLKNYG LLHCFRKDMD KVETFLRMVQ CRSVEGSCGF

Genular Protein ID: 3409514799

Symbol: I6L999_HUMAN

Name: N/A

UniProtKB Accession Codes:

I6L999

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 4 Gene3D 1 GenomeRNAi 1 HOGENOM 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 1 RefSeq 2 RuleBase 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 128
  • Mass: 14875
  • Checksum: 3EA9C8B73EBF67D5
  • Sequence:
    • MEETQQKSNL ELLHISLLLI ESRLEPVRFL RSTFTNNLVY DTSDSDDYHL LKDLEEGIQM 
LMGRLEDGSH LTGQTLKQTY SKFDTNSHNH DALLKNYGLL HCFRKDMDKV ETFLRMVQCR 
SVEGSCGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.