Details for: ADAM3B

Gene ID: 1596

Symbol: ADAM3B

Ensembl ID: ENSG00000260089

Description: ADAM metallopeptidase domain 3B (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 2.5836
    Cell Significance Index: 33.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0223
    Cell Significance Index: -3.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0543
    Cell Significance Index: -6.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1183
    Cell Significance Index: -6.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1548
    Cell Significance Index: -3.3900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2045
    Cell Significance Index: -3.2400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2935
    Cell Significance Index: -2.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3011
    Cell Significance Index: -13.6500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4142
    Cell Significance Index: -5.9600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.4517
    Cell Significance Index: -4.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4538
    Cell Significance Index: -12.1600
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.4778
    Cell Significance Index: -6.0200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.5137
    Cell Significance Index: -6.5000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.5412
    Cell Significance Index: -7.5100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.6727
    Cell Significance Index: -8.5000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.6982
    Cell Significance Index: -8.3500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.7330
    Cell Significance Index: -8.4300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.7420
    Cell Significance Index: -12.4800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.7554
    Cell Significance Index: -8.6000
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.7693
    Cell Significance Index: -8.5400
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.7714
    Cell Significance Index: -8.7600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.7742
    Cell Significance Index: -9.0000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.7761
    Cell Significance Index: -9.5400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.7802
    Cell Significance Index: -8.5000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.8043
    Cell Significance Index: -10.1500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.8056
    Cell Significance Index: -9.2200
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.8101
    Cell Significance Index: -9.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8156
    Cell Significance Index: -11.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8169
    Cell Significance Index: -12.0600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.8202
    Cell Significance Index: -8.7100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.8237
    Cell Significance Index: -9.5700
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.8534
    Cell Significance Index: -9.3500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.8535
    Cell Significance Index: -11.8000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.8617
    Cell Significance Index: -8.0900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.8676
    Cell Significance Index: -11.9200
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.8712
    Cell Significance Index: -11.8500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.8722
    Cell Significance Index: -12.2500
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.8846
    Cell Significance Index: -9.6000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.9481
    Cell Significance Index: -10.1700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.9680
    Cell Significance Index: -13.9000
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.9714
    Cell Significance Index: -12.4400
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.9783
    Cell Significance Index: -10.3100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.9924
    Cell Significance Index: -10.7600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.9979
    Cell Significance Index: -12.1400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -1.0074
    Cell Significance Index: -12.0800
  • Cell Name: T cell (CL0000084)
    Fold Change: -1.0333
    Cell Significance Index: -12.2000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -1.0336
    Cell Significance Index: -12.3000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -1.0352
    Cell Significance Index: -11.7600
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -1.0449
    Cell Significance Index: -11.8500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -1.0475
    Cell Significance Index: -11.6500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -1.0594
    Cell Significance Index: -10.2100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -1.0705
    Cell Significance Index: -11.9600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -1.0727
    Cell Significance Index: -13.4600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -1.0955
    Cell Significance Index: -13.7600
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -1.1000
    Cell Significance Index: -11.5300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -1.1007
    Cell Significance Index: -13.7900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -1.1226
    Cell Significance Index: -11.4700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -1.1244
    Cell Significance Index: -13.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.1389
    Cell Significance Index: -11.7900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -1.1413
    Cell Significance Index: -11.9200
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.1478
    Cell Significance Index: -10.8800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -1.1651
    Cell Significance Index: -11.9000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -1.1701
    Cell Significance Index: -12.0700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -1.1923
    Cell Significance Index: -14.8900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.2172
    Cell Significance Index: -14.7600
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -1.2261
    Cell Significance Index: -12.9400
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -1.2272
    Cell Significance Index: -13.5200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -1.2458
    Cell Significance Index: -13.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.2466
    Cell Significance Index: -14.8600
  • Cell Name: club cell (CL0000158)
    Fold Change: -1.2556
    Cell Significance Index: -13.6800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -1.2749
    Cell Significance Index: -13.8500
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -1.3049
    Cell Significance Index: -14.9600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -1.3074
    Cell Significance Index: -13.5300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -1.3145
    Cell Significance Index: -14.8500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -1.3261
    Cell Significance Index: -14.3700
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -1.4075
    Cell Significance Index: -11.9100
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -1.4350
    Cell Significance Index: -13.3200
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: -1.5135
    Cell Significance Index: -12.3900
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: -1.5689
    Cell Significance Index: -13.8500
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -1.5862
    Cell Significance Index: -14.3500
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -1.5918
    Cell Significance Index: -14.9200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.5956
    Cell Significance Index: -13.1700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -1.7017
    Cell Significance Index: -14.9900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -1.7183
    Cell Significance Index: -13.2200
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: -1.7670
    Cell Significance Index: -13.9400
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -1.8018
    Cell Significance Index: -14.5900
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -1.9362
    Cell Significance Index: -12.1800
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -2.0039
    Cell Significance Index: -13.7600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -2.1136
    Cell Significance Index: -13.1100
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -2.2357
    Cell Significance Index: -13.2000
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: -2.2740
    Cell Significance Index: -12.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** ADAM3B is classified as a pseudogene, meaning it lacks functional coding potential due to multiple non-sense mutations and insertions. 2. **Widespread expression:** ADAM3B is significantly expressed in various cell types within the CNS, including astrocytes, ependymal cells, neurons, and their subtypes. 3. **Cell-type specificity:** ADAM3B expression is cell-type specific, suggesting that it may play a role in regulating specific cellular processes or interactions. 4. **Evolutionary conservation:** Despite its pseudogene status, ADAM3B exhibits evolutionary conservation, indicating that it may have retained some functional potential. **Pathways and Functions:** 1. **Cell-cell interactions:** ADAM3B may play a role in regulating cell-cell interactions, such as adhesion and signaling, which are critical for CNS development and function. 2. **Neurotransmitter regulation:** ADAM3B may influence the regulation of neurotransmitters, such as glutamate and GABA, which are essential for neuronal communication. 3. **Inflammation and immune responses:** ADAM3B may modulate inflammatory responses and immune cell interactions within the CNS. 4. **Tissue repair and maintenance:** ADAM3B may contribute to tissue repair and maintenance processes, such as gliosis and neurogenesis. **Clinical Significance:** 1. **Neurological disorders:** ADAM3B dysregulation may contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **CNS injuries:** ADAM3B may play a role in regulating CNS injuries, such as stroke and traumatic brain injury. 3. **Neurodevelopmental disorders:** ADAM3B may influence neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 4. **Cancer:** ADAM3B has been implicated in cancer, particularly in the context of glioblastoma and other CNS tumors. In conclusion, ADAM3B is a complex gene with far-reaching implications for our understanding of CNS biology and disease. Further research is needed to elucidate the functional significance of ADAM3B and its role in regulating various cellular processes within the CNS.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.