Details for: OR8G5

Gene ID: 219865

Symbol: OR8G5

Ensembl ID: ENSG00000255298

Description: olfactory receptor family 8 subfamily G member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3715
    Cell Significance Index: 5.4200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1060
    Cell Significance Index: 1.1900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0563
    Cell Significance Index: 0.6800
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.0468
    Cell Significance Index: 0.5000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0458
    Cell Significance Index: 0.6700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0338
    Cell Significance Index: 0.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0288
    Cell Significance Index: 0.7700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0263
    Cell Significance Index: 0.3600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0205
    Cell Significance Index: 0.1600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0105
    Cell Significance Index: 0.1000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0075
    Cell Significance Index: 0.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0006
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0004
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0005
    Cell Significance Index: -0.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0008
    Cell Significance Index: -0.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0009
    Cell Significance Index: -0.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0016
    Cell Significance Index: -0.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0024
    Cell Significance Index: -0.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0040
    Cell Significance Index: -0.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0042
    Cell Significance Index: -0.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0047
    Cell Significance Index: -0.4900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0051
    Cell Significance Index: -0.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0063
    Cell Significance Index: -0.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0074
    Cell Significance Index: -0.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0075
    Cell Significance Index: -0.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0080
    Cell Significance Index: -0.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0086
    Cell Significance Index: -0.2300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0094
    Cell Significance Index: -0.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0111
    Cell Significance Index: -0.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0122
    Cell Significance Index: -0.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0123
    Cell Significance Index: -0.4700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0162
    Cell Significance Index: -0.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0165
    Cell Significance Index: -0.3500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0166
    Cell Significance Index: -0.2100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0173
    Cell Significance Index: -0.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0175
    Cell Significance Index: -0.5000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0175
    Cell Significance Index: -0.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0176
    Cell Significance Index: -0.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0183
    Cell Significance Index: -0.4800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0194
    Cell Significance Index: -0.3900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0196
    Cell Significance Index: -0.4100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0198
    Cell Significance Index: -0.2600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0201
    Cell Significance Index: -0.4000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0203
    Cell Significance Index: -0.4000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0217
    Cell Significance Index: -0.5300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0240
    Cell Significance Index: -0.4700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0242
    Cell Significance Index: -0.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0250
    Cell Significance Index: -0.6000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0251
    Cell Significance Index: -0.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0252
    Cell Significance Index: -0.3000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0255
    Cell Significance Index: -0.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0256
    Cell Significance Index: -0.5000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0260
    Cell Significance Index: -0.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0265
    Cell Significance Index: -0.6400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0265
    Cell Significance Index: -0.4500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0274
    Cell Significance Index: -0.3900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0281
    Cell Significance Index: -0.4800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0283
    Cell Significance Index: -0.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0289
    Cell Significance Index: -0.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0296
    Cell Significance Index: -0.5000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0299
    Cell Significance Index: -0.3800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0304
    Cell Significance Index: -0.3800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0309
    Cell Significance Index: -0.4100
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.0315
    Cell Significance Index: -0.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0318
    Cell Significance Index: -0.4700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0320
    Cell Significance Index: -0.4600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0321
    Cell Significance Index: -0.3000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0321
    Cell Significance Index: -0.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0322
    Cell Significance Index: -0.4400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0322
    Cell Significance Index: -0.4900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0328
    Cell Significance Index: -0.5300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0330
    Cell Significance Index: -0.3600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0337
    Cell Significance Index: -0.4400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0338
    Cell Significance Index: -0.4000
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0341
    Cell Significance Index: -0.3700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0342
    Cell Significance Index: -0.4500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0343
    Cell Significance Index: -0.3300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0343
    Cell Significance Index: -0.5300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0345
    Cell Significance Index: -0.4500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0345
    Cell Significance Index: -0.4600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0349
    Cell Significance Index: -0.4100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0361
    Cell Significance Index: -0.5000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0362
    Cell Significance Index: -0.4400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0365
    Cell Significance Index: -0.4200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0365
    Cell Significance Index: -0.4700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0367
    Cell Significance Index: -0.4600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0367
    Cell Significance Index: -0.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0368
    Cell Significance Index: -0.3000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0368
    Cell Significance Index: -0.5000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0369
    Cell Significance Index: -0.4600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0371
    Cell Significance Index: -0.5200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0373
    Cell Significance Index: -0.4200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0378
    Cell Significance Index: -0.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR8G5 is a G protein-coupled receptor that is specifically expressed in various cell types, including progenitor cells, oligodendrocyte precursor cells, microglial cells, blood vessel endothelial cells, and goblet cells. Its expression is widespread, with significant presence in the central nervous system, particularly in the cerebral cortex and olfactory bulb. OR8G5 is also found in the peripheral nervous system, where it interacts with odorant molecules to trigger sensory responses. **Pathways and Functions:** OR8G5 is involved in several signaling pathways that are essential for the sensory perception of smell. These include: 1. **Detection of chemical stimulus:** OR8G5 binds to specific odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **G protein-coupled receptor activity:** OR8G5 activates G proteins, which in turn activate downstream effectors, leading to changes in cellular activity. 3. **G protein-coupled receptor signaling pathway:** OR8G5 is part of a larger signaling pathway that involves multiple G protein-coupled receptors, leading to complex cellular responses. 4. **Olfactory signaling pathway:** OR8G5 plays a key role in the olfactory signaling pathway, which involves the detection of odorant molecules by olfactory receptors and the transmission of signals to the brain. **Clinical Significance:** OR8G5 has significant implications for our understanding of human health and disease. Research has shown that alterations in OR8G5 expression can lead to changes in olfactory perception, which can have significant consequences for individuals with olfactory disorders. For example, changes in OR8G5 expression have been linked to: 1. **Olfactory dysfunction:** Alterations in OR8G5 expression can lead to reduced olfactory function, which can affect quality of life and daily activities. 2. **Neurodegenerative diseases:** OR8G5 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where olfactory dysfunction is a common feature. 3. **Cancer:** OR8G5 has been shown to play a role in cancer development and progression, particularly in the context of olfactory epithelial tumors. In conclusion, OR8G5 is a critical gene involved in the sensory perception of smell, with significant implications for our understanding of human health and disease. Further research is needed to fully elucidate the functions and clinical significance of OR8G5, but this gene is undoubtedly an important player in the complex world of olfactory perception.

Genular Protein ID: 632977059

Symbol: OR8G5_HUMAN

Name: Olfactory receptor 8G5

UniProtKB Accession Codes:

Q8NG78 B2RND3 Q6IEU6

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 GO 6 Gene3D 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 InParanoid 1 InterPro 3 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 7 SMR 1 STRING 1 SUPFAM 1 UCSC 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 346
  • Mass: 38798
  • Checksum: 4CE6344D67DB9C0D
  • Sequence:
    • MIIYKQGITF LQKENNNTIH LNTMFFLSPA ETHQRMAAEN HSFVTKFILV GLTEKSELQL 
PLFLVFLGIY VVTVLGNLGM ITLIGLSSHL HTPMYCFLSS LSFIDFCHST VITPKMLVNF 
VTEKNIISYP ECMTQLYFFL VFAIAECHML AAMAYDGYVA ICSPLLYSII ISNKACFSLI 
LVVYVIGLIC ASAHIGCMFR VQFCKFDVIN HYFCDLISIL KLSCSSTYIN ELLILIFSGI 
NILVPSLTIL SSYIFIIASI LRIRYTEGRS KAFSTCSSHI SAVSVFFGSA AFMYLQPSSV 
SSMDQGKVSS VFYTIVVPML NPLIYSLRNK DVHVALKKTL GKRTFL

Genular Protein ID: 2966485742

Symbol: A0A126GW95_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A126GW95

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 Pfam 1 Proteomes 2 RefSeq 7 SAM 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 311
  • Mass: 34636
  • Checksum: 3965961AD1EC9ECD
  • Sequence:
    • MAAENHSFVT KFILVGLTEK SELQLPLFLV FLGIYVVTVL GNLGMITLIG LSSHLHTPMY 
CFLSSLSFID FCHSTVITPK MLVNFVTEKN IISYPECMTQ LYFFLVFAIA ECHMLAAMAY 
DGYVAICSPL LYSIIISNKA CFSLILVVYV IGLICASAHI GCMFRVQFCK FDVINHYFCD 
LISILKLSCS STYINELLIL IFSGINILVP SLTILSSYIF IIASILRIRY TEGRSKAFST 
CSSHISAVSV FFGSAAFMYL QPSSVSSMDQ GKVSSVFYTI VVPMLNPLIY SLRNKDVHVA 
LKKTLGKRTF L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.