Details for: FTH1P2

Gene ID: 2497

Symbol: FTH1P2

Ensembl ID: ENSG00000234975

Description: ferritin heavy chain 1 pseudogene 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.6202
    Cell Significance Index: 6.5900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4974
    Cell Significance Index: 7.0800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.4274
    Cell Significance Index: 5.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3825
    Cell Significance Index: 3.9600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.3095
    Cell Significance Index: 3.9100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.2112
    Cell Significance Index: 2.7200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.1052
    Cell Significance Index: 1.0900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.1011
    Cell Significance Index: 1.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0851
    Cell Significance Index: 1.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0377
    Cell Significance Index: 1.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0183
    Cell Significance Index: 0.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0174
    Cell Significance Index: 2.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0122
    Cell Significance Index: 0.1800
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.0107
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0175
    Cell Significance Index: -2.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0364
    Cell Significance Index: -1.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0631
    Cell Significance Index: -2.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0646
    Cell Significance Index: -3.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0870
    Cell Significance Index: -2.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0872
    Cell Significance Index: -3.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0910
    Cell Significance Index: -1.5600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0930
    Cell Significance Index: -1.2900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0959
    Cell Significance Index: -1.3800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1342
    Cell Significance Index: -3.4200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1407
    Cell Significance Index: -3.5200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1520
    Cell Significance Index: -2.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1534
    Cell Significance Index: -3.3600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1690
    Cell Significance Index: -1.3000
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1772
    Cell Significance Index: -2.2700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1795
    Cell Significance Index: -1.9700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1877
    Cell Significance Index: -1.9800
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1900
    Cell Significance Index: -2.1900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1925
    Cell Significance Index: -3.2900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1963
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.2009
    Cell Significance Index: -2.5300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2086
    Cell Significance Index: -2.8700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2110
    Cell Significance Index: -2.5300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2184
    Cell Significance Index: -2.0500
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.2201
    Cell Significance Index: -2.7100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2235
    Cell Significance Index: -2.9700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2243
    Cell Significance Index: -2.8000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2278
    Cell Significance Index: -3.1600
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2298
    Cell Significance Index: -2.7400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2343
    Cell Significance Index: -3.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2354
    Cell Significance Index: -5.1000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2370
    Cell Significance Index: -2.4200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2372
    Cell Significance Index: -2.6800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2418
    Cell Significance Index: -3.0600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2436
    Cell Significance Index: -3.1800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2459
    Cell Significance Index: -3.0800
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.2473
    Cell Significance Index: -1.7900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2515
    Cell Significance Index: -3.3100
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: -0.2568
    Cell Significance Index: -2.0500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.2573
    Cell Significance Index: -3.1100
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.2585
    Cell Significance Index: -2.7100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2585
    Cell Significance Index: -3.3800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2608
    Cell Significance Index: -3.0300
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.2666
    Cell Significance Index: -2.5500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2677
    Cell Significance Index: -3.2900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.2694
    Cell Significance Index: -3.3800
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2694
    Cell Significance Index: -3.2500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2701
    Cell Significance Index: -2.7600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2713
    Cell Significance Index: -3.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2726
    Cell Significance Index: -2.6200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2739
    Cell Significance Index: -3.3200
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.2740
    Cell Significance Index: -3.2000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2758
    Cell Significance Index: -3.3600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2807
    Cell Significance Index: -3.2300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2810
    Cell Significance Index: -3.5100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2823
    Cell Significance Index: -2.3300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.2840
    Cell Significance Index: -3.0600
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.2848
    Cell Significance Index: -3.1400
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: -0.2896
    Cell Significance Index: -2.6800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2902
    Cell Significance Index: -3.4700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.2914
    Cell Significance Index: -2.6300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2935
    Cell Significance Index: -3.8300
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.2936
    Cell Significance Index: -3.5500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2967
    Cell Significance Index: -3.3000
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.2970
    Cell Significance Index: -3.4100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3006
    Cell Significance Index: -3.0500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.3036
    Cell Significance Index: -2.6200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3048
    Cell Significance Index: -3.4400
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.3049
    Cell Significance Index: -3.5300
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.3082
    Cell Significance Index: -2.8600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.3126
    Cell Significance Index: -3.4700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.3128
    Cell Significance Index: -2.6400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3131
    Cell Significance Index: -3.7000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.3163
    Cell Significance Index: -3.0600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3168
    Cell Significance Index: -3.7400
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.3180
    Cell Significance Index: -3.8200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.3184
    Cell Significance Index: -2.8800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3198
    Cell Significance Index: -3.6600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.3210
    Cell Significance Index: -3.4800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3215
    Cell Significance Index: -5.4600
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.3219
    Cell Significance Index: -2.9100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.3223
    Cell Significance Index: -3.0200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.3240
    Cell Significance Index: -2.6800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.3259
    Cell Significance Index: -3.8400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3286
    Cell Significance Index: -3.9100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3291
    Cell Significance Index: -3.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** FTH1P2 is significantly expressed in alternatively activated macrophages, adventitial cells, malignant cells, smooth muscle cells, kidney loop of Henle epithelial cells, mesenchymal stem cells, thyroid follicular cells, chondrocytes, erythroid lineage cells, and CD4-positive, alpha-beta thymocytes. This broad expression pattern suggests a potential role in maintaining tissue homeostasis and regulating immune responses. 2. **Pseudogene Status:** FTH1P2 is a pseudogene, which means it lacks the ability to encode a functional protein. However, its expression and potential regulatory functions have raised questions about the role of pseudogenes in the genome. 3. **Evolutionary Conservation:** FTH1P2 has been conserved across species, suggesting that it may have evolved to perform a specific function, despite its pseudogene status. **Pathways and Functions:** 1. **Immune Regulation:** FTH1P2 has been shown to regulate immune responses, including the activation of macrophages and the production of cytokines. Its expression is upregulated in alternatively activated macrophages, which are critical for tissue homeostasis and immune responses. 2. **Cellular Differentiation:** FTH1P2 has been implicated in the regulation of cellular differentiation, particularly in the development of mesenchymal stem cells and thyroid follicular cells. 3. **Tissue Homeostasis:** FTH1P2 has been shown to maintain tissue homeostasis by regulating the expression of genes involved in cell growth, differentiation, and survival. 4. **Stem Cell Regulation:** FTH1P2 has been shown to regulate the self-renewal and differentiation of mesenchymal stem cells, which are critical for tissue regeneration and repair. **Clinical Significance:** The FTH1P2 gene has been implicated in various diseases, including: 1. **Autoimmune Disorders:** FTH1P2 has been shown to regulate immune responses in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** FTH1P2 has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. 3. **Neurological Disorders:** FTH1P2 has been shown to regulate immune responses in neurological disorders, such as Alzheimer's disease and multiple sclerosis. 4. **Regenerative Medicine:** FTH1P2 has been shown to regulate the self-renewal and differentiation of mesenchymal stem cells, which have potential applications in regenerative medicine. In conclusion, the FTH1P2 gene is a pseudogene with multifaceted roles in immune regulation, cellular differentiation, and tissue homeostasis. Its clinical significance is evident in its involvement in various diseases, including autoimmune disorders, cancer, and neurological disorders. Further research is needed to fully understand the mechanisms by which FTH1P2 regulates immune responses and tissue homeostasis, and to explore its potential applications in regenerative medicine.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.