Details for: GAK

Gene ID: 2580

Symbol: GAK

Ensembl ID: ENSG00000178950

Description: cyclin G associated kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.76
    Marker Score: 1198
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.63
    Marker Score: 1091
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.62
    Marker Score: 1791
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.54
    Marker Score: 764
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.52
    Marker Score: 3207
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.51
    Marker Score: 9620
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5
    Marker Score: 92063
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.45
    Marker Score: 3568
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.45
    Marker Score: 4545
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.39
    Marker Score: 11954
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.35
    Marker Score: 12841
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.35
    Marker Score: 1417
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.33
    Marker Score: 13731.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.33
    Marker Score: 1957
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.3
    Marker Score: 639
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.29
    Marker Score: 47419.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.28
    Marker Score: 12000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.27
    Marker Score: 6074
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.26
    Marker Score: 1363
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.26
    Marker Score: 1939
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.25
    Marker Score: 1238.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.24
    Marker Score: 24572
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.23
    Marker Score: 26335
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.23
    Marker Score: 575
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.22
    Marker Score: 4206
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.21
    Marker Score: 707.5
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.21
    Marker Score: 349
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.21
    Marker Score: 378
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.19
    Marker Score: 2813
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.18
    Marker Score: 44953
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.17
    Marker Score: 17533.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.17
    Marker Score: 4514.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.14
    Marker Score: 283
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.14
    Marker Score: 2497
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.11
    Marker Score: 3941
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.11
    Marker Score: 4098.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.11
    Marker Score: 463
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.1
    Marker Score: 8465
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1
    Marker Score: 1097
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.09
    Marker Score: 2706
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.08
    Marker Score: 2464.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.06
    Marker Score: 2040
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.06
    Marker Score: 558
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.06
    Marker Score: 4430
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.05
    Marker Score: 1129
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.04
    Marker Score: 58315
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.03
    Marker Score: 615
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.02
    Marker Score: 888
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.02
    Marker Score: 377
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.02
    Marker Score: 977
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1
    Marker Score: 486
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1
    Marker Score: 2264
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71621
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47845
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.99
    Marker Score: 33592
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30376
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.98
    Marker Score: 1643
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.98
    Marker Score: 1384
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.98
    Marker Score: 4053.5
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.97
    Marker Score: 1116
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.97
    Marker Score: 15527
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15126
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.97
    Marker Score: 642
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.96
    Marker Score: 392
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.95
    Marker Score: 1229
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.95
    Marker Score: 729
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.94
    Marker Score: 382
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.94
    Marker Score: 271
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.94
    Marker Score: 1710
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2386
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.94
    Marker Score: 8133
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.93
    Marker Score: 1124.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.93
    Marker Score: 3790
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.93
    Marker Score: 9389
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.92
    Marker Score: 297
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.92
    Marker Score: 844
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.91
    Marker Score: 393
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.91
    Marker Score: 1307
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5163
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9
    Marker Score: 216
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.9
    Marker Score: 861
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.9
    Marker Score: 283
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2683
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.89
    Marker Score: 611
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.89
    Marker Score: 244
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.89
    Marker Score: 1078
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.88
    Marker Score: 279
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1423
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.88
    Marker Score: 878.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.87
    Marker Score: 191.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.87
    Marker Score: 926
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.87
    Marker Score: 326
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.87
    Marker Score: 6456
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.87
    Marker Score: 250
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.86
    Marker Score: 409
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.86
    Marker Score: 598.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309

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Other Information

**Key characteristics:** - GAK is a serine/threonine kinase. - It is a key regulator of the cell cycle. - It is expressed in a variety of cell types, including squamous epithelial cells, nasal mucosa goblet cells, corneal epithelial cells, central nervous system macrophages, pancreatic acinar cells, foveolar cells of the stomach, L2/3-6 intratelencephalic projecting glutamatergic neurons, glandular epithelial cells, and colon epithelial cells. **Pathways and functions:** - GAK is involved in a variety of cellular processes, including cell cycle entry, cell cycle exit, and cell migration. - It is a key regulator of the cell cycle. - It is involved in the regulation of cell cycle entry by binding to the Cyclin-dependent kinase 1 (CDK1) complex and inhibiting its activity. - It is also involved in cell cycle exit by binding to the CDK inhibitor protein p53 and inhibiting its activity. - It is involved in cell migration by binding to the microtubule-associated protein MAP1 and promoting its interaction with the microtubule motor protein kinesin-1. **Clinical significance:** - Mutations in the GAK gene have been linked to a number of human diseases, including cancer and neurodegenerative disorders. - GAK inhibitors are being investigated as a potential treatment for cancer and other diseases that are characterized by uncontrolled cell growth.

Genular Protein ID: 508127034

Symbol: GAK_HUMAN

Name: Cyclin-G-associated kinase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9299234

Title: Structure, expression, and chromosomal localization of human GAK.

PubMed ID: 9299234

DOI: 10.1006/geno.1997.4873

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10625686

Title: Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells.

PubMed ID: 10625686

DOI: 10.1074/jbc.275.2.1365

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1311
  • Mass: 143191
  • Checksum: 0ACE45DF57A5F981
  • Sequence:
  • MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL RVRRVLAEGG FAFVYEAQDV 
    GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL 
    LLTELCKGQL VEFLKKMESR GPLSCDTVLK IFYQTCRAVQ HMHRQKPPII HRDLKVENLL 
    LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR NTTPMYRTPE IIDLYSNFPI 
    GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKYSIPP HDTQYTVFHS LIRAMLQVNP 
    EERLSIAEVV HQLQEIAAAR NVNPKSPITE LLEQNGGYGS ATLSRGPPPP VGPAGSGYSG 
    GLALAEYDQP YGGFLDILRG GTERLFTNLK DTSSKVIQSV ANYAKGDLDI SYITSRIAVM 
    SFPAEGVESA LKNNIEDVRL FLDSKHPGHY AVYNLSPRTY RPSRFHNRVS ECGWAARRAP 
    HLHTLYNICR NMHAWLRQDH KNVCVVHCMD GRAASAVAVC SFLCFCRLFS TAEAAVYMFS 
    MKRCPPGIWP SHKRYIEYMC DMVAEEPITP HSKPILVRAV VMTPVPLFSK QRSGCRPFCE 
    VYVGDERVAS TSQEYDKMRD FKIEDGKAVI PLGVTVQGDV LIVIYHARST LGGRLQAKMA 
    SMKMFQIQFH TGFVPRNATT VKFAKYDLDA CDIQEKYPDL FQVNLEVEVE PRDRPSREAP 
    PWENSSMRGL NPKILFSSRE EQQDILSKFG KPELPRQPGS TAQYDAGAGS PEAEPTDSDS 
    PPSSSADASR FLHTLDWQEE KEAETGAENA SSKESESALM EDRDESEVSD EGGSPISSEG 
    QEPRADPEPP GLAAGLVQQD LVFEVETPAV LPEPVPQEDG VDLLGLHSEV GAGPAVPPQA 
    CKAPSSNTDL LSCLLGPPEA ASQGPPEDLL SEDPLLLASP APPLSVQSTP RGGPPAAADP 
    FGPLLPSSGN NSQPCSNPDL FGEFLNSDSV TVPPSFPSAH SAPPPSCSAD FLHLGDLPGE 
    PSKMTASSSN PDLLGGWAAW TETAASAVAP TPATEGPLFS PGGQPAPCGS QASWTKSQNP 
    DPFADLGDLS SGLQGSPAGF PPGGFIPKTA TTPKGSSSWQ TSRPPAQGAS WPPQAKPPPK 
    ACTQPRPNYA SNFSVIGARE ERGVRAPSFA QKPKVSENDF EDLLSNQGFS SRSDKKGPKT 
    IAEMRKQDLA KDTDPLKLKL LDWIEGKERN IRALLSTLHT VLWDGESRWT PVGMADLVAP 
    EQVKKHYRRA VLAVHPDKAA GQPYEQHAKM IFMELNDAWS EFENQGSRPL F

Genular Protein ID: 310995840

Symbol: B4DS37_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1213
  • Mass: 132145
  • Checksum: 53C8B50F2E9663C4
  • Sequence:
  • MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL RVRRVLAEGQ LVEFLKKMES 
    RGPLSCDTVL KIFYQTCRAV QHMHRQKPPI IHRDLKVENL LLSNQGTIKL CDFGSATTIS 
    HYPDYSWSAQ RRALVEEEIT RNTTPMYRTP EIIDLYSNFP IGEKQDIWAL GCILYLLCFR 
    QHPFEDGAKL RIVNGAMLQV NPEERLSIAE VVHQLQEIAA ARNVNPKSPI TELLEQNGGY 
    GSATLSRGPP PPVGPAGSGY SGGLALAEYD QPYGGFLDIL RGGTERLFTN LKDTSSKVIQ 
    SVANYAKGDL DISYITSRIA VMSFPAEGVE SALKNNIEDV RLFLDSKHPG HYAVYNLSPR 
    TYRPSRFHNR VSECGWAARR APHLHTLYNI CRNMHAWPRQ DHKNVCVVHC MDGRAASAVA 
    VCSFLCFCRL FSTAEAAVYM FSMKRCPPGI WPSHKRYIEY MCDMVAEEPI TPHSKLILVR 
    AVVMTPVPLF SKQRSGCRPF CEVYVGDERV ASTSQEYDKM RDFKIEDGKA VIPLGVTVQG 
    DVLIVIYHAR STLGGRLQAK MASMKMFQIQ FHTGFVPRNA TTVKFAKYDL DACDIQEKYP 
    DLFQVNLEVE VEPRDRPSRE APPWENSSMR GLNPKILFSS REEQQDILSK FGKPELPRQP 
    GSTAQYDAGA GSPEAEPTDS DSPPSSSADA SRFLHTLDWQ EEKEAETGAE NASSKESESA 
    LMEDRDESEV SDEGGSPISS EGQEPRADPE PPGLAAGLVQ QDLVFEVETP AVLPEPVPQE 
    DGVDLLGLHS EVGAGPAVPP QACKAPSSNT DLLSCLLGPP EAASQGPPED LLSEDPLLLA 
    SPAPPLSVQS TPRGGPPAAA DPFGPLLPSS GNNSQPCSNP DLFGEFLNSD SVTVPPSFPS 
    AHSAPPPSCS ADFLHLGDLP GEPSKMTASS SNPDLLGGWA AWTETAASAV APTPATEGPL 
    LSPGGQPAPC GSQASWTKSQ NPDPFADLGD LSSGLQGSPA GFPPGGFIPK TATTPKGSSS 
    WQTSRPPAQG ASWPPQAKPP PKACTQPRPN YASNFSVIGA REERGVRAPS FAQKPKVSEN 
    DFEDLLSNQG FSSRSDKKGP KTIAEMRKQD LAKDTDPLKL KLLDWIEGKE RNIRALLSTL 
    HTVLWDGESR WTPVGMADLV APEQVKKHYR RAVLAVHPDK AAGQPYEQHA KMIFMELNDA 
    WSEFENQGSR PLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.