Details for: OR10D3

Gene ID: 26497

Symbol: OR10D3

Ensembl ID: ENSG00000197309

Description: olfactory receptor family 10 subfamily D member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.0806
    Cell Significance Index: 52.6600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2127
    Cell Significance Index: 29.3800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.1776
    Cell Significance Index: 12.5100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.5955
    Cell Significance Index: 6.6000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3986
    Cell Significance Index: 5.8100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1970
    Cell Significance Index: 2.8600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1528
    Cell Significance Index: 2.0100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0450
    Cell Significance Index: 0.5700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.0368
    Cell Significance Index: 0.4800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0362
    Cell Significance Index: 0.3500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0077
    Cell Significance Index: 0.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0040
    Cell Significance Index: 0.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0003
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0012
    Cell Significance Index: -0.2500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0040
    Cell Significance Index: -0.0800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0051
    Cell Significance Index: -1.0300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0057
    Cell Significance Index: -0.0700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0059
    Cell Significance Index: -0.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0083
    Cell Significance Index: -1.4900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0096
    Cell Significance Index: -0.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0103
    Cell Significance Index: -0.1000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0111
    Cell Significance Index: -0.1400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0150
    Cell Significance Index: -0.1800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0164
    Cell Significance Index: -0.2700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0165
    Cell Significance Index: -0.2200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0205
    Cell Significance Index: -0.1100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0220
    Cell Significance Index: -0.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0223
    Cell Significance Index: -0.3200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0230
    Cell Significance Index: -0.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0232
    Cell Significance Index: -1.5600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0243
    Cell Significance Index: -0.3600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0268
    Cell Significance Index: -0.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0274
    Cell Significance Index: -1.5400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0275
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0289
    Cell Significance Index: -0.2700
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0293
    Cell Significance Index: -0.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0315
    Cell Significance Index: -1.4800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0321
    Cell Significance Index: -0.3400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0334
    Cell Significance Index: -0.3900
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0335
    Cell Significance Index: -0.3400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0364
    Cell Significance Index: -0.3200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0364
    Cell Significance Index: -0.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0367
    Cell Significance Index: -1.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0380
    Cell Significance Index: -1.0900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0385
    Cell Significance Index: -0.3300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0390
    Cell Significance Index: -0.3300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0390
    Cell Significance Index: -0.3700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0400
    Cell Significance Index: -0.3200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0405
    Cell Significance Index: -0.5100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0417
    Cell Significance Index: -0.2900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0424
    Cell Significance Index: -0.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0435
    Cell Significance Index: -1.3900
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0474
    Cell Significance Index: -0.3400
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0487
    Cell Significance Index: -0.4700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0495
    Cell Significance Index: -0.3300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0508
    Cell Significance Index: -0.6200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0513
    Cell Significance Index: -1.2800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0516
    Cell Significance Index: -0.6100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0517
    Cell Significance Index: -0.6800
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0524
    Cell Significance Index: -0.6300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0544
    Cell Significance Index: -0.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0547
    Cell Significance Index: -1.5600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0555
    Cell Significance Index: -1.2000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0558
    Cell Significance Index: -0.6500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0570
    Cell Significance Index: -0.7600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0575
    Cell Significance Index: -0.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0593
    Cell Significance Index: -1.5600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0607
    Cell Significance Index: -0.6200
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0611
    Cell Significance Index: -0.6300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0621
    Cell Significance Index: -0.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0636
    Cell Significance Index: -1.3500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0644
    Cell Significance Index: -1.2600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0661
    Cell Significance Index: -0.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0683
    Cell Significance Index: -1.3500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0692
    Cell Significance Index: -0.7500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0697
    Cell Significance Index: -1.0600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0697
    Cell Significance Index: -0.8300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0706
    Cell Significance Index: -0.8300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0707
    Cell Significance Index: -1.4200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0727
    Cell Significance Index: -0.9800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0743
    Cell Significance Index: -0.8100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0749
    Cell Significance Index: -0.9600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0759
    Cell Significance Index: -1.0800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0782
    Cell Significance Index: -1.5400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0783
    Cell Significance Index: -0.8600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0787
    Cell Significance Index: -1.0500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0804
    Cell Significance Index: -1.3900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0812
    Cell Significance Index: -0.5100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0820
    Cell Significance Index: -0.7700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0835
    Cell Significance Index: -1.1100
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0835
    Cell Significance Index: -0.9700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0871
    Cell Significance Index: -1.0700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0874
    Cell Significance Index: -1.0000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0910
    Cell Significance Index: -1.0800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0917
    Cell Significance Index: -0.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0944
    Cell Significance Index: -1.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR10D3 shares several key characteristics with other olfactory receptors. It belongs to the GPCR superfamily, which is characterized by its ability to activate G proteins upon binding to ligands. The OR10D3 receptor is also expressed on the plasma membrane, where it can interact with its ligands and initiate downstream signaling cascades. Furthermore, OR10D3 is involved in the sensory perception of smell, which is mediated by its ability to detect chemical stimuli. However, OR10D3's unique expression profile in hematopoietic cells sets it apart from other olfactory receptors. Its presence in these cells suggests a potential role in modulating immune responses, inflammation, or hematopoiesis. This raises intriguing questions about the functional significance of OR10D3 in the context of hematopoiesis and its potential impact on human health. **Pathways and Functions:** OR10D3 is involved in several signaling pathways, including: 1. **Detection of chemical stimulus involved in sensory perception of smell:** OR10D3 detects chemical stimuli, which triggers a signaling cascade that ultimately leads to the perception of smell. 2. **G protein-coupled receptor activity:** OR10D3 activates G proteins, which in turn modulate downstream signaling pathways. 3. **G protein-coupled receptor signaling pathway:** OR10D3's activation of G proteins leads to the activation of various downstream signaling molecules, including MAP kinases and phospholipases. 4. **Olfactory receptor activity:** OR10D3's ability to detect chemical stimuli is essential for the perception of smell. 5. **Olfactory signaling pathway:** OR10D3's signaling pathway is involved in the transmission of sensory information from the olfactory system to the central nervous system. **Clinical Significance:** The discovery of OR10D3's expression in hematopoietic cells has significant implications for our understanding of human health and disease. Potential clinical applications of OR10D3 include: 1. **Immunomodulation:** OR10D3's presence in hematopoietic cells suggests a potential role in modulating immune responses. This could lead to the development of novel immunotherapies or treatments for immune-related disorders. 2. **Hematopoiesis:** OR10D3's expression in hematopoietic cells may influence hematopoiesis, the process of blood cell formation. This could have implications for the treatment of anemia, leukemia, or other hematological disorders. 3. **Cancer:** OR10D3's expression in some cancer cells has been reported, suggesting a potential role in cancer development or progression. Further investigation is needed to fully understand the relationship between OR10D3 and cancer. In conclusion, OR10D3 is a novel olfactory receptor with widespread expression in the hematopoietic system. Its unique expression profile and potential functional significance in hematopoiesis and immunomodulation make it an exciting area of research with significant clinical implications. Further investigation is needed to fully understand the role of OR10D3 in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.