Gene MSTN - ENSG00000138379 | NCBI Gene ID: 2660

Details for: MSTN

Gene ID: 2660

Symbol: MSTN

Ensembl ID: ENSG00000138379

Description: myostatin

Associated with

Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of cell cycle genes
(R-HSA-9617828)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Rna polymerase ii transcription
(R-HSA-73857)
Cellular response to dexamethasone stimulus
(GO:0071549)
Cellular response to hypoxia
(GO:0071456)
Cytokine activity
(GO:0005125)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Heparin binding
(GO:0008201)
Identical protein binding
(GO:0042802)
Muscle cell cellular homeostasis
(GO:0046716)
Muscle organ development
(GO:0007517)
Myoblast migration involved in skeletal muscle regeneration
(GO:0014839)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of muscle hypertrophy
(GO:0014741)
Negative regulation of myoblast differentiation
(GO:0045662)
Negative regulation of myoblast proliferation
(GO:2000818)
Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051898)
Negative regulation of satellite cell differentiation
(GO:1902725)
Negative regulation of skeletal muscle satellite cell proliferation
(GO:1902723)
Negative regulation of skeletal muscle tissue growth
(GO:0048632)
Ovulation cycle process
(GO:0022602)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of lamellipodium assembly
(GO:0010592)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Response to electrical stimulus
(GO:0051602)
Response to estrogen
(GO:0043627)
Response to ethanol
(GO:0045471)
Response to gravity
(GO:0009629)
Response to muscle activity
(GO:0014850)
Response to testosterone
(GO:0033574)
Signaling receptor binding
(GO:0005102)
Skeletal muscle atrophy
(GO:0014732)
Skeletal muscle satellite cell differentiation
(GO:0014816)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythrocyte (CL0000232)
Fold Change: 4.68
Marker Score: 2591
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.43
Marker Score: 2446
Cell Name: megakaryocyte (CL0000556)
Fold Change: 1.92
Marker Score: 1090
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1174
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.57
Marker Score: 1568
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 858
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.25
Marker Score: 659
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 488
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7693
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4820
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.1
Marker Score: 504
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71832
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48057
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5353
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 375
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.88
Marker Score: 1673
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.88
Marker Score: 579
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5288
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.85
Marker Score: 355
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1265
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 711
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 398
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 463
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.71
Marker Score: 1441
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.61
Marker Score: 485
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.56
Marker Score: 8751
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 174
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.52
Marker Score: 349
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.49
Marker Score: 294
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 278
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.42
Marker Score: 184
Cell Name: mast cell (CL0000097)
Fold Change: 0.4
Marker Score: 230.5
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.27
Marker Score: 129
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.27
Marker Score: 202
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.24
Marker Score: 2478
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.23
Marker Score: 67
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.2
Marker Score: 246
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.17
Marker Score: 242
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.15
Marker Score: 256
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.15
Marker Score: 1263
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.15
Marker Score: 51
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.15
Marker Score: 303
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.14
Marker Score: 75
Cell Name: neural cell (CL0002319)
Fold Change: 0.14
Marker Score: 67
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.13
Marker Score: 37
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.13
Marker Score: 120
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.11
Marker Score: 236.5
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.11
Marker Score: 4233.5
Cell Name: neuron (CL0000540)
Fold Change: 0.11
Marker Score: 453
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.11
Marker Score: 1021
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.1
Marker Score: 42
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.1
Marker Score: 49
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1
Marker Score: 5966
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 0.1
Marker Score: 29
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.09
Marker Score: 67.5
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.09
Marker Score: 376
Cell Name: muscle precursor cell (CL0000680)
Fold Change: 0.09
Marker Score: 23
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.09
Marker Score: 17
Cell Name: astrocyte (CL0000127)
Fold Change: 0.09
Marker Score: 75
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.09
Marker Score: 66
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.09
Marker Score: 132
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.08
Marker Score: 52
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.08
Marker Score: 308
Cell Name: stromal cell (CL0000499)
Fold Change: 0.08
Marker Score: 90
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.07
Marker Score: 31
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.07
Marker Score: 160
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.07
Marker Score: 18.5
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.07
Marker Score: 17
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.07
Marker Score: 1067
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.07
Marker Score: 18
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.07
Marker Score: 206
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.07
Marker Score: 17
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.07
Marker Score: 15
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 0.07
Marker Score: 17
Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.07
Marker Score: 20
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.07
Marker Score: 188
Cell Name: tendon cell (CL0000388)
Fold Change: 0.07
Marker Score: 16
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.06
Marker Score: 32
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.06
Marker Score: 185
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.06
Marker Score: 485
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.06
Marker Score: 2324
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 15
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.06
Marker Score: 20
Cell Name: interneuron (CL0000099)
Fold Change: 0.06
Marker Score: 28
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.06
Marker Score: 18
Cell Name: pericyte (CL0000669)
Fold Change: 0.06
Marker Score: 35
Cell Name: ionocyte (CL0005006)
Fold Change: 0.06
Marker Score: 18
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.06
Marker Score: 73
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.06
Marker Score: 18
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.06
Marker Score: 534
Cell Name: muscle cell (CL0000187)
Fold Change: 0.05
Marker Score: 15

Hover over a box to see details here...

**Key characteristics:** - Myostatin is a secreted glycoprotein. - It is a potent inhibitor of muscle growth. - It binds to the GDF-8 receptor. - It inhibits the activation of the GDF-8 receptor. - It is expressed in various cell types in skeletal muscle. **Pathways and functions:** - Myostatin inhibits muscle growth by binding to the GDF-8 receptor and preventing its activation. - It also inhibits the expression of genes involved in muscle growth, such as IGF-1 and myosin heavy chain. - Myostatin plays a critical role in controlling muscle mass and metabolism. **Clinical significance:** - Mutations in the MSTN gene have been linked to several human diseases, including osteoporosis, cardiovascular disease, and cancer. - Inhibitors of myostatin have been investigated as potential therapeutic agents for these diseases. - However, the clinical efficacy of these inhibitors is still being evaluated. **Additional information:** - Myostatin is a highly conserved protein, with a similar protein found in other vertebrates. - It is a secreted protein that is produced and released into the extracellular environment. - Myostatin has been shown to have both pro- and anti-hypertrophic effects on muscle cells.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Growth/differentiation factor 8

Genular Protein ID: 789880757

Symbol: GDF8_HUMAN

Name: Growth/differentiation factor 8

UniProtKB Accession Codes:

O14793 A1C2J7 A1C2K0 Q6B0H2

Database IDs:

Citations:

PubMed ID: 9356471

Title: Double muscling in cattle due to mutations in the myostatin gene.

PubMed ID: 9356471

DOI: 10.1073/pnas.94.23.12457

PubMed ID: 9843994

Title: Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting.

PubMed ID: 9843994

DOI: 10.1073/pnas.95.25.14938

PubMed ID: 17186467

Title: Human adaptive evolution at myostatin (GDF8), a regulator of muscle growth.

PubMed ID: 17186467

DOI: 10.1086/509707

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12595574

Title: Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains.

PubMed ID: 12595574

DOI: 10.1210/me.2002-0366

PubMed ID: 15215484

Title: Myostatin mutation associated with gross muscle hypertrophy in a child.

PubMed ID: 15215484

DOI: 10.1056/nejmoa040933

PubMed ID: 17878677

Title: Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development.

PubMed ID: 17878677

DOI: 10.2152/jmi.54.276

PubMed ID: 27625211

Title: Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.

PubMed ID: 27625211

DOI: 10.1080/19420862.2016.1215786

PubMed ID: 28257634

Title: Structural basis for potency differences between GDF8 and GDF11.

PubMed ID: 28257634

DOI: 10.1186/s12915-017-0350-1

Sequence Information:

Length: 375
Mass: 42750
Checksum: EBFF6129725E6AFA
Sequence:

MQKLQLCVYI YLFMLIVAGP VDLNENSEQK ENVEKEGLCN ACTWRQNTKS SRIEAIKIQI 
LSKLRLETAP NISKDVIRQL LPKAPPLREL IDQYDVQRDD SSDGSLEDDD YHATTETIIT 
MPTESDFLMQ VDGKPKCCFF KFSSKIQYNK VVKAQLWIYL RPVETPTTVF VQILRLIKPM 
KDGTRYTGIR SLKLDMNPGT GIWQSIDVKT VLQNWLKQPE SNLGIEIKAL DENGHDLAVT 
FPGPGEDGLN PFLEVKVTDT PKRSRRDFGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA 
PKRYKANYCS GECEFVFLQK YPHTHLVHQA NPRGSAGPCC TPTKMSPINM LYFNGKEQII 
YGKIPAMVVD RCGCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: MSTN

Associated with

Cells (max top 100)

Other Information

Double muscling in cattle due to mutations in the myostatin gene. PubMed ID: 9356471

Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. PubMed ID: 9843994

Human adaptive evolution at myostatin (GDF8), a regulator of muscle growth. PubMed ID: 17186467

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. PubMed ID: 12595574

Myostatin mutation associated with gross muscle hypertrophy in a child. PubMed ID: 15215484

Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development. PubMed ID: 17878677

Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody. PubMed ID: 27625211

Structural basis for potency differences between GDF8 and GDF11. PubMed ID: 28257634