Details for: RNU5D 1

Gene ID: 26830

Symbol: RNU5D 1

Ensembl ID: ENSG00000200169

Description: RNA, U5D small nuclear 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.2995
    Cell Significance Index: 39.8000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 1.4780
    Cell Significance Index: 17.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8208
    Cell Significance Index: 23.6500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.2377
    Cell Significance Index: 2.4700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.1673
    Cell Significance Index: 1.7800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.1606
    Cell Significance Index: 1.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0726
    Cell Significance Index: 3.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0553
    Cell Significance Index: 2.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0473
    Cell Significance Index: 2.9000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0431
    Cell Significance Index: 0.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0054
    Cell Significance Index: 0.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0031
    Cell Significance Index: -5.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0031
    Cell Significance Index: -4.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0035
    Cell Significance Index: -4.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0059
    Cell Significance Index: -1.0000
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0066
    Cell Significance Index: -0.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0085
    Cell Significance Index: -0.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0091
    Cell Significance Index: -5.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0118
    Cell Significance Index: -3.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0162
    Cell Significance Index: -7.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0190
    Cell Significance Index: -2.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0203
    Cell Significance Index: -1.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0291
    Cell Significance Index: -0.6300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0339
    Cell Significance Index: -0.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0349
    Cell Significance Index: -7.0000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0373
    Cell Significance Index: -0.6500
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0396
    Cell Significance Index: -0.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0399
    Cell Significance Index: -5.8100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0404
    Cell Significance Index: -0.8000
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0487
    Cell Significance Index: -0.6000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0537
    Cell Significance Index: -0.3900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0560
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0596
    Cell Significance Index: -0.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0689
    Cell Significance Index: -1.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0725
    Cell Significance Index: -7.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0762
    Cell Significance Index: -1.0400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1153
    Cell Significance Index: -1.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1169
    Cell Significance Index: -6.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1308
    Cell Significance Index: -4.1900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1320
    Cell Significance Index: -1.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1417
    Cell Significance Index: -3.5400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1551
    Cell Significance Index: -2.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1773
    Cell Significance Index: -6.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1775
    Cell Significance Index: -2.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1894
    Cell Significance Index: -6.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2002
    Cell Significance Index: -5.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2008
    Cell Significance Index: -5.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2074
    Cell Significance Index: -6.1100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2093
    Cell Significance Index: -2.9800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2147
    Cell Significance Index: -2.1900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2149
    Cell Significance Index: -3.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2155
    Cell Significance Index: -4.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2245
    Cell Significance Index: -7.1500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2264
    Cell Significance Index: -7.1600
  • Cell Name: mature conventional dendritic cell (CL0000841)
    Fold Change: -0.2280
    Cell Significance Index: -0.9100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.2284
    Cell Significance Index: -3.0500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2313
    Cell Significance Index: -2.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2320
    Cell Significance Index: -5.9100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2320
    Cell Significance Index: -2.4600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2333
    Cell Significance Index: -2.9300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2387
    Cell Significance Index: -3.3100
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2579
    Cell Significance Index: -2.3200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.2624
    Cell Significance Index: -3.3900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2634
    Cell Significance Index: -3.4500
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.2787
    Cell Significance Index: -2.9400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2874
    Cell Significance Index: -6.2100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.2902
    Cell Significance Index: -2.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2926
    Cell Significance Index: -6.2100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2984
    Cell Significance Index: -5.1000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3175
    Cell Significance Index: -4.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3179
    Cell Significance Index: -6.9600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3192
    Cell Significance Index: -4.1000
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.3225
    Cell Significance Index: -2.4300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3254
    Cell Significance Index: -3.0300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3387
    Cell Significance Index: -4.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3419
    Cell Significance Index: -6.7600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.3525
    Cell Significance Index: -3.8200
  • Cell Name: immature natural killer cell (CL0000823)
    Fold Change: -0.3598
    Cell Significance Index: -2.3600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3683
    Cell Significance Index: -4.1500
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.3692
    Cell Significance Index: -3.5200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3724
    Cell Significance Index: -4.5300
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.3785
    Cell Significance Index: -4.7000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3802
    Cell Significance Index: -4.4100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3845
    Cell Significance Index: -4.5400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3868
    Cell Significance Index: -5.7100
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.3888
    Cell Significance Index: -3.5100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3899
    Cell Significance Index: -4.6400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3992
    Cell Significance Index: -4.4600
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.4015
    Cell Significance Index: -5.0800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.4037
    Cell Significance Index: -4.7700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.4092
    Cell Significance Index: -4.4300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4102
    Cell Significance Index: -4.7200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4106
    Cell Significance Index: -6.6500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.4148
    Cell Significance Index: -4.3300
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: -0.4172
    Cell Significance Index: -3.1600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.4194
    Cell Significance Index: -4.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.4214
    Cell Significance Index: -4.0500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.4219
    Cell Significance Index: -5.7400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.4253
    Cell Significance Index: -4.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU5D1 is a small nuclear RNA (snRNA) that belongs to the U5 family of snRNAs, which play a crucial role in the assembly and function of spliceosomal complexes. The gene is highly expressed in cells involved in immune responses, including goblet cells, which are essential for mucin production and immune barrier function. Notably, RNU5D1 is also expressed in neoplastic cells, suggesting its potential involvement in cancer progression. Furthermore, its expression is also observed in abnormal cells, implying a possible role in cellular stress and damage response. **Pathways and Functions:** The expression of RNU5D1 is intricately linked to the formation and function of spliceosomal complexes, which are essential for the processing and editing of pre-mRNA. Specifically, RNU5D1 is involved in the assembly of the U4/U6/U5 tri-snRNP complex, which plays a critical role in the recognition of splice sites and the catalysis of splicing reactions. Additionally, RNU5D1 is also implicated in the formation of the quadruple snRNP complex, which is required for the efficient assembly of spliceosomes. While the precise mechanisms of RNU5D1's function remain unclear, its expression in goblet cells suggests a possible role in the regulation of mucin production and immune barrier function. Furthermore, its expression in neoplastic cells implies a possible role in cancer progression and metastasis. **Clinical Significance:** The clinical significance of RNU5D1 is an area of active research, with potential implications for the diagnosis and treatment of immune-related disorders. Notably, the expression of RNU5D1 has been observed in various types of cancer, including colon cancer, suggesting its potential as a biomarker for disease diagnosis and prognosis. Furthermore, RNU5D1's involvement in the regulation of mucin production and immune barrier function suggests its potential as a therapeutic target for the treatment of inflammatory bowel diseases (IBD) and other immune-related disorders. Additionally, its expression in neoplastic cells implies a possible role in cancer progression, highlighting the need for further research into the molecular mechanisms underlying its function. In conclusion, RNU5D1 is a gene that warrants further investigation into its role in the immune system and its potential applications in the diagnosis and treatment of immune-related disorders. While its precise function and pathways remain unclear, its widespread expression in various cell types and its involvement in spliceosomal complexes suggest a complex and multifaceted role in immune system regulation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.