Details for: GNRH2

Gene ID: 2797

Symbol: GNRH2

Ensembl ID: ENSG00000125787

Description: gonadotropin releasing hormone 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 7.33
    Marker Score: 4061
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.95
    Marker Score: 1676
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.18
    Marker Score: 2194
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.45
    Marker Score: 764
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.16
    Marker Score: 484
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 486
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.77
    Marker Score: 1598
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11394
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7
    Marker Score: 1325
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.62
    Marker Score: 1000
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 496
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.59
    Marker Score: 312.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 367
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.51
    Marker Score: 1033
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.39
    Marker Score: 188
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.39
    Marker Score: 430
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.35
    Marker Score: 356
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 209
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.34
    Marker Score: 261
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.26
    Marker Score: 318
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.26
    Marker Score: 612.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.23
    Marker Score: 59
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.22
    Marker Score: 114
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 95
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.19
    Marker Score: 60
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.18
    Marker Score: 65
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.16
    Marker Score: 502
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.14
    Marker Score: 129
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.1
    Marker Score: 64
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.08
    Marker Score: 64
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.08
    Marker Score: 91
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.07
    Marker Score: 108
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 75
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.06
    Marker Score: 109
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.06
    Marker Score: 257
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.06
    Marker Score: 39.5
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 39
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.04
    Marker Score: 22.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.04
    Marker Score: 14.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.04
    Marker Score: 493
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.03
    Marker Score: 51
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.03
    Marker Score: 302
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.03
    Marker Score: 263
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.03
    Marker Score: 52
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.03
    Marker Score: 1839
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.03
    Marker Score: 13

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Other Information

## Summary GNRH2 is a protein that is involved in the regulation of reproductive function. It is expressed in a variety of cell types, including erythrocyte, megakaryocyte, blood vessel endothelial cell, hematopoietic stem cell, megakaryocyte-erythroid progenitor cell, goblet cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, absorptive cell, and intestinal crypt stem cell of colon. ## Key characteristics * GNRH2 is a glycoprotein with a molecular weight of approximately 130 kDa. * It is a member of the GNRH family of proteins, which are involved in the regulation of reproductive function. * GNRH2 is expressed in high levels in the testes of mammals. * It is a key regulator of sperm production and release. * It also plays a role in the regulation of female fertility. ## Pathways and functions * GNRH2 binds to the G protein-coupled receptor Gpr1b. * This binding activates the G protein, which in turn activates the enzyme adenylate cyclase. * Adenylate cyclase converts ATP into cyclic GMP, which activates protein kinase C. * Protein kinase C phosphorylates a number of downstream targets, including the transcription factor GRH-beta. * GRH-beta is a key regulator of reproductive function. * When GRH-beta is phosphorylated, it translocates to the nucleus and activates the transcription of genes involved in reproductive development and function. ## Clinical significance GNRH2 is a key drug target in the treatment of infertility in humans. Mutations in the GNRH2 gene have been linked to male infertility in humans. Treatment with GnRH agonists, which are drugs that block GNRH2 signaling, can improve fertility in these patients.

Genular Protein ID: 3224079572

Symbol: GON2_HUMAN

Name: Progonadoliberin-2

UniProtKB Accession Codes:

O43555 Q14C68 Q14C69 Q9BYN9 Q9BYP0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 5 SAM 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9419371

Title: Second gene for gonadotropin-releasing hormone in humans.

PubMed ID: 9419371

DOI: 10.1073/pnas.95.1.305

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 120
  • Mass: 12918
  • Checksum: D58CDA14B6D6FB8D
  • Sequence:
    • MASSRRGLLL LLLLTAHLGP SEAQHWSHGW YPGGKRALSS AQDPQNALRP PGRALDTAAG 
SPVQTAHGLP SDALAPLDDS MPWEGRTTAQ WSLHRKRHLA RTLLTAAREP RPAPPSSNKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.