Details for: PRLHR

Gene ID: 2834

Symbol: PRLHR

Ensembl ID: ENSG00000119973

Description: prolactin releasing hormone receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.96
    Marker Score: 2189
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1179
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1509
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.33
    Marker Score: 2514
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.29
    Marker Score: 2632
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 863
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.2
    Marker Score: 1146
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 493
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7691
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4823
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 509
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 515
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48058
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 469
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 380
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13739
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 494
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.71
    Marker Score: 2733
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.67
    Marker Score: 402
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.67
    Marker Score: 1071
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 512
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.56
    Marker Score: 2184
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 177.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.51
    Marker Score: 3897
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.47
    Marker Score: 17774
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.44
    Marker Score: 202
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.43
    Marker Score: 229
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.43
    Marker Score: 416
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.42
    Marker Score: 202.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 195
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.41
    Marker Score: 15074
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.41
    Marker Score: 226
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.41
    Marker Score: 432.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.38
    Marker Score: 158
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.35
    Marker Score: 563
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.35
    Marker Score: 7006
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.35
    Marker Score: 197
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.33
    Marker Score: 195
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.32
    Marker Score: 108
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.31
    Marker Score: 4689
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.3
    Marker Score: 297
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.28
    Marker Score: 307.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 116
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.22
    Marker Score: 189
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.19
    Marker Score: 193
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.18
    Marker Score: 80
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.17
    Marker Score: 351
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.16
    Marker Score: 109
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.16
    Marker Score: 85
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.15
    Marker Score: 58
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.14
    Marker Score: 183
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.13
    Marker Score: 54
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.13
    Marker Score: 67
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 77
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.1
    Marker Score: 117
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.1
    Marker Score: 444
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.08
    Marker Score: 134.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.08
    Marker Score: 59
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.08
    Marker Score: 39
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.07
    Marker Score: 44
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.07
    Marker Score: 17.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.06
    Marker Score: 65
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 53
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.06
    Marker Score: 73
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.05
    Marker Score: 77
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.05
    Marker Score: 322
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.05
    Marker Score: 220
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 19

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Other Information

**Key characteristics:** * PRLHR is a single-pass transmembrane protein that is expressed in the plasma membrane of cells. * It is a member of the GPCR superfamily, which is a group of G proteins that are involved in a variety of cellular processes, including growth, differentiation, and metabolism. * PRLHR is a ligand-gated ion channel, which means that it opens when a ligand binds to it. * When PRLHR is activated, it binds to the G protein GPCR alpha-subunit, which triggers a cascade of events that ultimately lead to the activation of the MAPK signaling pathway. **Pathways and functions:** * PRLHR is involved in the regulation of feeding behavior. When PRLHR is activated, it promotes the release of prolactin from pituitary gland cells. Prolactin is a hormone that stimulates milk production in women who are breastfeeding. * PRLHR is also involved in the regulation of female pregnancy. When PRLHR is activated during pregnancy, it promotes the growth of the fetus and the maintenance of uterine blood flow. * In addition to its role in feeding behavior and female pregnancy, PRLHR is also involved in the regulation of gastrointestinal secretions. When PRLHR is activated, it promotes the secretion of gastric and intestinal juices. **Clinical significance:** Mutations in the PRLHR gene have been linked to a number of human diseases, including prolactinomas, breast milk protein (BMP) deficiency, and infertility. PRLHR mutations can also cause other symptoms, such as growth hormone deficiency, hypothyroidism, and diabetes.

Genular Protein ID: 4073627365

Symbol: PRLHR_HUMAN

Name: Prolactin-releasing peptide receptor

UniProtKB Accession Codes:

P49683 O75194 Q502U8 Q5VXR9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8666380

Title: Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.

PubMed ID: 8666380

DOI: 10.1006/geno.1995.9996

PubMed ID: 9607765

Title: A prolactin-releasing peptide in the brain.

PubMed ID: 9607765

DOI: 10.1038/30515

PubMed ID: 11923475

Title: Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region.

PubMed ID: 11923475

DOI: 10.1210/mend.16.4.0819

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10498338

Title: Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor.

PubMed ID: 10498338

DOI: 10.1016/s0167-0115(99)00028-2

PubMed ID: 11641419

Title: The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering.

PubMed ID: 11641419

DOI: 10.1124/mol.60.5.916

Sequence Information:

  • Length: 370
  • Mass: 41121
  • Checksum: 47F71490A080C81F
  • Sequence:
    • MASSTTRGPR VSDLFSGLPP AVTTPANQSA EASAGNGSVA GADAPAVTPF QSLQLVHQLK 
GLIVLLYSVV VVVGLVGNCL LVLVIARVRR LHNVTNFLIG NLALSDVLMC TACVPLTLAY 
AFEPRGWVFG GGLCHLVFFL QPVTVYVSVF TLTTIAVDRY VVLVHPLRRR ISLRLSAYAV 
LAIWALSAVL ALPAAVHTYH VELKPHDVRL CEEFWGSQER QRQLYAWGLL LVTYLLPLLV 
ILLSYVRVSV KLRNRVVPGC VTQSQADWDR ARRRRTFCLL VVIVVVFAVC WLPLHVFNLL 
RDLDPHAIDP YAFGLVQLLC HWLAMSSACY NPFIYAWLHD SFREELRKLL VAWPRKIAPH 
GQNMTVSVVI

Genular Protein ID: 559776937

Symbol: A5JUU5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A5JUU5

Database IDs:

ARBA 7 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 6 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 370
  • Mass: 41107
  • Checksum: 08E9E57FBE6FC809
  • Sequence:
    • MASSTTRGPR VSDLFSGLPP AVTTPANQSA EASAGNGSVA GADAPAVTPF QSLQLVHQLK 
GLIVLLYSVV VVVGLVGNCL LVLVIARVRR LHNVTNFLIG NLALSDVLMC TACVPLTLAY 
AFEPRGWVFG GGLCHLVFFL QPVTVYVSVF TLTTIAVDRY VVLVHPLRRR ISLRLSAYAV 
LAIWALSAVL ALPAAVHTYH VELKPHDVRL CEEFWGSQER QRQLYAWGLL LVTYLLPLLV 
ILLSYVRVSV KLRNRVVPGC VTQSQADWDR ARRRRTFCLL VVVVVVFAVC WLPLHVFNLL 
RDLDPHAIDP YAFGLVQLLC HWLAMSSACY NPFIYAWLHD SFREELRKLL VAWPRKIAPH 
GQNMTVSVVI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.