Details for: IGHV4 61

Gene ID: 28391

Symbol: IGHV4 61

Ensembl ID: ENSG00000211970

Description: immunoglobulin heavy variable 4-61

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.2451
    Cell Significance Index: 13.9200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1632
    Cell Significance Index: 2.3700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1138
    Cell Significance Index: 1.7600
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0036
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0070
    Cell Significance Index: -5.2800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0285
    Cell Significance Index: -0.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0567
    Cell Significance Index: -5.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0628
    Cell Significance Index: -1.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0855
    Cell Significance Index: -5.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0881
    Cell Significance Index: -15.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1035
    Cell Significance Index: -13.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1067
    Cell Significance Index: -2.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1801
    Cell Significance Index: -13.4200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1989
    Cell Significance Index: -2.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2118
    Cell Significance Index: -5.4100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2153
    Cell Significance Index: -2.2000
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.2508
    Cell Significance Index: -1.6700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2660
    Cell Significance Index: -5.2000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2753
    Cell Significance Index: -3.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2792
    Cell Significance Index: -10.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2916
    Cell Significance Index: -5.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2977
    Cell Significance Index: -13.8800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3112
    Cell Significance Index: -5.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3215
    Cell Significance Index: -5.3800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3218
    Cell Significance Index: -3.8200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3316
    Cell Significance Index: -5.3700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3403
    Cell Significance Index: -8.6700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3472
    Cell Significance Index: -4.0900
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3766
    Cell Significance Index: -3.2100
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.3812
    Cell Significance Index: -3.8700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.4155
    Cell Significance Index: -5.2500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4163
    Cell Significance Index: -4.7900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.4220
    Cell Significance Index: -5.0900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4243
    Cell Significance Index: -4.7400
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.4368
    Cell Significance Index: -3.5100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.4537
    Cell Significance Index: -4.8200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4557
    Cell Significance Index: -5.9800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4682
    Cell Significance Index: -5.1400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.4740
    Cell Significance Index: -5.1100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4906
    Cell Significance Index: -5.3500
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.4918
    Cell Significance Index: -5.0600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.4928
    Cell Significance Index: -5.3900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4985
    Cell Significance Index: -6.4500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.5000
    Cell Significance Index: -4.6400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.5016
    Cell Significance Index: -5.3600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.5042
    Cell Significance Index: -4.8400
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.5082
    Cell Significance Index: -5.7600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.5085
    Cell Significance Index: -5.4000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.5094
    Cell Significance Index: -5.6400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.5154
    Cell Significance Index: -6.2700
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.5182
    Cell Significance Index: -5.2900
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.5197
    Cell Significance Index: -5.5900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.5247
    Cell Significance Index: -6.7400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.5406
    Cell Significance Index: -5.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5421
    Cell Significance Index: -6.1600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.5433
    Cell Significance Index: -5.7800
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.5516
    Cell Significance Index: -4.9200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.5518
    Cell Significance Index: -6.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5584
    Cell Significance Index: -12.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.5629
    Cell Significance Index: -5.4100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5639
    Cell Significance Index: -6.3600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.5722
    Cell Significance Index: -5.0100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.5724
    Cell Significance Index: -6.6400
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.5726
    Cell Significance Index: -5.2900
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.5743
    Cell Significance Index: -5.3500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.5745
    Cell Significance Index: -6.7900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.5746
    Cell Significance Index: -6.7900
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.5759
    Cell Significance Index: -5.1500
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.5776
    Cell Significance Index: -5.6400
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -0.5791
    Cell Significance Index: -5.9200
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.5823
    Cell Significance Index: -5.3700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.5851
    Cell Significance Index: -5.3100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.5860
    Cell Significance Index: -6.1700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.5878
    Cell Significance Index: -5.3400
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.5976
    Cell Significance Index: -5.2500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.6020
    Cell Significance Index: -7.5200
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.6056
    Cell Significance Index: -5.6200
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.6122
    Cell Significance Index: -6.8000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.6124
    Cell Significance Index: -7.2300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.6146
    Cell Significance Index: -5.7700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.6230
    Cell Significance Index: -6.9000
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.6291
    Cell Significance Index: -5.4100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.6306
    Cell Significance Index: -6.5400
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.6325
    Cell Significance Index: -5.2700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.6344
    Cell Significance Index: -8.6300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.6374
    Cell Significance Index: -5.6800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.6424
    Cell Significance Index: -10.9100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.6434
    Cell Significance Index: -9.4100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.6452
    Cell Significance Index: -6.4400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.6461
    Cell Significance Index: -6.5900
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.6474
    Cell Significance Index: -4.9400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.6500
    Cell Significance Index: -8.4900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.6510
    Cell Significance Index: -6.1600
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.6520
    Cell Significance Index: -5.3500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6540
    Cell Significance Index: -8.6900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.6570
    Cell Significance Index: -6.6200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.6583
    Cell Significance Index: -6.6500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.6584
    Cell Significance Index: -6.1300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.6616
    Cell Significance Index: -8.3100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.6619
    Cell Significance Index: -5.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin heavy chain variable region**: The IGHV4-61 gene encodes a variable region of the heavy chain of immunoglobulins, which is responsible for antigen recognition and binding. 2. **IgG class**: The IGHV4-61 gene is specifically associated with the production of IgG antibodies, which are the most abundant class of antibodies in the human body. 3. **Variable region diversity**: The IGHV4-61 gene contributes to the diversity of IgG antibodies, allowing for the recognition of a wide range of antigens. 4. **Expression in multiple cell types**: The IGHV4-61 gene is expressed in various cell types beyond B cells, including granulocyte-monocyte progenitor cells, T cells, and epithelial cells. **Pathways and Functions:** 1. **Antigen binding**: The IGHV4-61 gene plays a critical role in the binding of IgG antibodies to specific antigens, triggering an immune response. 2. **Immunoglobulin complex formation**: The IGHV4-61 gene is part of the immunoglobulin complex, which is formed by the association of Ig molecules with other immune-related proteins. 3. **Immunoglobulin-mediated immune response**: The IGHV4-61 gene contributes to the immunoglobulin-mediated immune response, which involves the recognition and elimination of pathogens and foreign substances. 4. **Cell signaling and regulation**: The IGHV4-61 gene may also play a role in cell signaling and regulation, particularly in the context of immune cell activation and differentiation. **Clinical Significance:** 1. **Immunodeficiency disorders**: Abnormalities in the IGHV4-61 gene have been associated with immunodeficiency disorders, such as X-linked agammaglobulinemia, which is characterized by a lack of IgG antibodies. 2. **Cancer**: The IGHV4-61 gene has been implicated in the development of certain types of cancer, including B-cell lymphoma and leukemia. 3. **Autoimmune diseases**: The IGHV4-61 gene may also contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus, in which the immune system mistakenly attacks the body's own tissues. 4. **Vaccine development**: Understanding the role of the IGHV4-61 gene in the immune response may inform the development of vaccines that target specific antigens and induce a robust immune response. In conclusion, the IGHV4-61 gene is a critical component of the immune system, playing a key role in the recognition and binding of antigens, the formation of immunoglobulin complexes, and the regulation of immune responses. Its expression in multiple cell types highlights its broader role in immune function and tissue homeostasis, and its abnormalities have been associated with various immunodeficiency disorders, cancers, and autoimmune diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.