Details for: IGHV3 72

Gene ID: 28410

Symbol: IGHV3 72

Ensembl ID: ENSG00000225698

Description: immunoglobulin heavy variable 3-72

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 801
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,816
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.01
    Marker Score: 2,570
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,338
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1,475
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,295
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 508
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.63
    Marker Score: 1,960
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.3
    Marker Score: 402
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.25
    Marker Score: 347
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.19
    Marker Score: 53
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.12
    Marker Score: 95
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.12
    Marker Score: 73
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 121
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1
    Marker Score: 66
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.08
    Marker Score: 34
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 38
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.07
    Marker Score: 83
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 134
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.06
    Marker Score: 30
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.05
    Marker Score: 53
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.05
    Marker Score: 62
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.05
    Marker Score: 76
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.04
    Marker Score: 55
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.04
    Marker Score: 32
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.04
    Marker Score: 478
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 41
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 32
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.03
    Marker Score: 74
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.02
    Marker Score: 100
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.02
    Marker Score: 51
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.02
    Marker Score: 51
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.02
    Marker Score: 41
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.01
    Marker Score: 13

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHV3-72 gene exhibits several distinct characteristics that make it an essential component of the immune system. These include: 1. **Variable region:** The IGHV3-72 gene encodes the variable region of the heavy chain, which is responsible for recognizing and binding to specific antigens. 2. **Diversity:** The IGHV3-72 gene is part of the V(H) gene family, which is responsible for generating the vast diversity of antibodies in the human genome. 3. **Expression:** The IGHV3-72 gene is expressed in various cell types, including granulocyte-monocyte progenitor cells, goblet cells, and epithelial cells of the colon. 4. **Antibody production:** The IGHV3-72 gene is involved in the production of IgM and IgD antibodies, which are critical for the early recognition and response to pathogens. **Pathways and Functions:** The IGHV3-72 gene is involved in several key pathways and functions, including: 1. **Antigen binding:** The IGHV3-72 gene encodes the variable region of the heavy chain, which recognizes and binds to specific antigens. 2. **Immune response:** The IGHV3-72 gene plays a critical role in the early recognition and response to pathogens, facilitating the activation of immune cells and the production of antibodies. 3. **Plasma membrane:** The IGHV3-72 gene is expressed on the surface of plasma cells, which are specialized cells that produce and secrete antibodies. 4. **Immunoglobulin complex:** The IGHV3-72 gene is part of the immunoglobulin complex, which is a complex of antibodies that recognizes and binds to specific antigens. **Clinical Significance:** The IGHV3-72 gene has significant clinical implications, including: 1. **Autoimmune diseases:** Abnormal expression of the IGHV3-72 gene has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** The IGHV3-72 gene is often overexpressed in certain types of cancer, including lymphoma and leukemia. 3. **Immunodeficiency:** Mutations in the IGHV3-72 gene can lead to immunodeficiency, making individuals susceptible to infections. 4. **Vaccine development:** The IGHV3-72 gene has been targeted for vaccine development, as it is involved in the production of antibodies against specific pathogens. In conclusion, the IGHV3-72 gene is a critical component of the immune system, playing a pivotal role in the production of antibodies and the recognition and response to pathogens. Its expression is widespread across various cell types, and its dysregulation has significant clinical implications, including autoimmune diseases, cancer, immunodeficiency, and vaccine development. Further research into the IGHV3-72 gene is necessary to fully understand its immunological significance and to develop effective therapeutic strategies for its dysregulation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.