Details for: IGHV3 72

Gene ID: 28410

Symbol: IGHV3 72

Ensembl ID: ENSG00000225698

Description: immunoglobulin heavy variable 3-72

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0624
    Cell Significance Index: 0.9100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0620
    Cell Significance Index: 0.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0054
    Cell Significance Index: -4.0600
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0100
    Cell Significance Index: -0.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0144
    Cell Significance Index: -2.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0365
    Cell Significance Index: -0.9900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0512
    Cell Significance Index: -1.2400
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0531
    Cell Significance Index: -0.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0636
    Cell Significance Index: -8.2200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0774
    Cell Significance Index: -1.9300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1018
    Cell Significance Index: -1.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1085
    Cell Significance Index: -8.0900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1156
    Cell Significance Index: -2.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1244
    Cell Significance Index: -5.6400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1306
    Cell Significance Index: -0.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1471
    Cell Significance Index: -6.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1477
    Cell Significance Index: -3.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1544
    Cell Significance Index: -4.0600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1547
    Cell Significance Index: -2.8600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1657
    Cell Significance Index: -3.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1765
    Cell Significance Index: -4.5100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1825
    Cell Significance Index: -3.1200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1885
    Cell Significance Index: -2.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2031
    Cell Significance Index: -2.3100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2173
    Cell Significance Index: -3.5200
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.2217
    Cell Significance Index: -1.8300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2220
    Cell Significance Index: -3.7400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2238
    Cell Significance Index: -2.5000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2320
    Cell Significance Index: -2.6700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.2410
    Cell Significance Index: -2.1500
  • Cell Name: collagen secreting cell (CL0000667)
    Fold Change: -0.2422
    Cell Significance Index: -1.3500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2429
    Cell Significance Index: -2.9300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2446
    Cell Significance Index: -2.6800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2457
    Cell Significance Index: -2.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2500
    Cell Significance Index: -3.6900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2541
    Cell Significance Index: -2.8400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2579
    Cell Significance Index: -4.3800
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.2581
    Cell Significance Index: -2.6700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2637
    Cell Significance Index: -3.1300
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.2692
    Cell Significance Index: -2.7700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2709
    Cell Significance Index: -3.4800
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.2709
    Cell Significance Index: -2.7500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2751
    Cell Significance Index: -2.3500
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.2768
    Cell Significance Index: -2.8100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2865
    Cell Significance Index: -3.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2869
    Cell Significance Index: -8.2300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2881
    Cell Significance Index: -3.0600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2940
    Cell Significance Index: -3.1700
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.2972
    Cell Significance Index: -2.7000
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.3026
    Cell Significance Index: -3.2200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3030
    Cell Significance Index: -4.1600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3072
    Cell Significance Index: -3.9800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.3087
    Cell Significance Index: -2.7000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3162
    Cell Significance Index: -3.9500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3177
    Cell Significance Index: -3.9300
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.3215
    Cell Significance Index: -2.8300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3227
    Cell Significance Index: -4.6900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3234
    Cell Significance Index: -3.5800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3234
    Cell Significance Index: -4.2300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3332
    Cell Significance Index: -3.9200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.3395
    Cell Significance Index: -2.8700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3467
    Cell Significance Index: -3.3800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3488
    Cell Significance Index: -4.4200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3507
    Cell Significance Index: -3.8500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3514
    Cell Significance Index: -4.4400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.3523
    Cell Significance Index: -3.2700
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.3528
    Cell Significance Index: -3.2600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3563
    Cell Significance Index: -4.1000
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: -0.3590
    Cell Significance Index: -2.7700
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.3625
    Cell Significance Index: -3.4800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.3628
    Cell Significance Index: -3.3200
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.3644
    Cell Significance Index: -3.8200
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.3659
    Cell Significance Index: -3.9100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3709
    Cell Significance Index: -4.1800
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.3717
    Cell Significance Index: -4.0600
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.3718
    Cell Significance Index: -2.8600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3744
    Cell Significance Index: -4.4200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3761
    Cell Significance Index: -4.1700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3761
    Cell Significance Index: -3.9600
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.3761
    Cell Significance Index: -2.8700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3774
    Cell Significance Index: -4.4600
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.3839
    Cell Significance Index: -4.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3850
    Cell Significance Index: -3.7000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.3866
    Cell Significance Index: -3.9200
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.3875
    Cell Significance Index: -2.6900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.3887
    Cell Significance Index: -3.1900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3892
    Cell Significance Index: -4.5200
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.3906
    Cell Significance Index: -3.4900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3909
    Cell Significance Index: -4.6200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3918
    Cell Significance Index: -4.6300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3923
    Cell Significance Index: -4.5500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3929
    Cell Significance Index: -5.1700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3966
    Cell Significance Index: -5.5000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.3975
    Cell Significance Index: -4.2200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3995
    Cell Significance Index: -4.2500
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4011
    Cell Significance Index: -4.2600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.4028
    Cell Significance Index: -4.9000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.4038
    Cell Significance Index: -3.2700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.4040
    Cell Significance Index: -4.0700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.4058
    Cell Significance Index: -4.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHV3-72 gene exhibits several distinct characteristics that make it an essential component of the immune system. These include: 1. **Variable region:** The IGHV3-72 gene encodes the variable region of the heavy chain, which is responsible for recognizing and binding to specific antigens. 2. **Diversity:** The IGHV3-72 gene is part of the V(H) gene family, which is responsible for generating the vast diversity of antibodies in the human genome. 3. **Expression:** The IGHV3-72 gene is expressed in various cell types, including granulocyte-monocyte progenitor cells, goblet cells, and epithelial cells of the colon. 4. **Antibody production:** The IGHV3-72 gene is involved in the production of IgM and IgD antibodies, which are critical for the early recognition and response to pathogens. **Pathways and Functions:** The IGHV3-72 gene is involved in several key pathways and functions, including: 1. **Antigen binding:** The IGHV3-72 gene encodes the variable region of the heavy chain, which recognizes and binds to specific antigens. 2. **Immune response:** The IGHV3-72 gene plays a critical role in the early recognition and response to pathogens, facilitating the activation of immune cells and the production of antibodies. 3. **Plasma membrane:** The IGHV3-72 gene is expressed on the surface of plasma cells, which are specialized cells that produce and secrete antibodies. 4. **Immunoglobulin complex:** The IGHV3-72 gene is part of the immunoglobulin complex, which is a complex of antibodies that recognizes and binds to specific antigens. **Clinical Significance:** The IGHV3-72 gene has significant clinical implications, including: 1. **Autoimmune diseases:** Abnormal expression of the IGHV3-72 gene has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** The IGHV3-72 gene is often overexpressed in certain types of cancer, including lymphoma and leukemia. 3. **Immunodeficiency:** Mutations in the IGHV3-72 gene can lead to immunodeficiency, making individuals susceptible to infections. 4. **Vaccine development:** The IGHV3-72 gene has been targeted for vaccine development, as it is involved in the production of antibodies against specific pathogens. In conclusion, the IGHV3-72 gene is a critical component of the immune system, playing a pivotal role in the production of antibodies and the recognition and response to pathogens. Its expression is widespread across various cell types, and its dysregulation has significant clinical implications, including autoimmune diseases, cancer, immunodeficiency, and vaccine development. Further research into the IGHV3-72 gene is necessary to fully understand its immunological significance and to develop effective therapeutic strategies for its dysregulation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.