Details for: IGHV3 66

Gene ID: 28412

Symbol: IGHV3 66

Ensembl ID: ENSG00000211972

Description: immunoglobulin heavy variable 3-66

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.5069
    Cell Significance Index: 5.6700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1926
    Cell Significance Index: 2.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0464
    Cell Significance Index: -4.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0630
    Cell Significance Index: -1.7200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0761
    Cell Significance Index: -1.1100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0801
    Cell Significance Index: -1.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0879
    Cell Significance Index: -5.6700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1275
    Cell Significance Index: -3.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1318
    Cell Significance Index: -3.5300
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.1333
    Cell Significance Index: -1.1000
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1605
    Cell Significance Index: -1.8200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1687
    Cell Significance Index: -1.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1859
    Cell Significance Index: -4.7500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2367
    Cell Significance Index: -6.0300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2414
    Cell Significance Index: -4.7200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2650
    Cell Significance Index: -4.5300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2692
    Cell Significance Index: -3.3300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2851
    Cell Significance Index: -3.9100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2873
    Cell Significance Index: -3.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2927
    Cell Significance Index: -5.4100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2945
    Cell Significance Index: -4.7700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3029
    Cell Significance Index: -3.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3093
    Cell Significance Index: -14.4200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3179
    Cell Significance Index: -3.7400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.3220
    Cell Significance Index: -3.2900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3223
    Cell Significance Index: -4.1700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.3289
    Cell Significance Index: -2.1900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3294
    Cell Significance Index: -3.7900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3643
    Cell Significance Index: -3.8700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3647
    Cell Significance Index: -4.3300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3672
    Cell Significance Index: -4.6400
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.3684
    Cell Significance Index: -3.7400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3790
    Cell Significance Index: -3.9900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3825
    Cell Significance Index: -4.5200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3931
    Cell Significance Index: -4.4500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.4098
    Cell Significance Index: -4.4900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4106
    Cell Significance Index: -4.8800
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.4148
    Cell Significance Index: -4.4300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.4155
    Cell Significance Index: -4.4800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.4318
    Cell Significance Index: -3.6800
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.4344
    Cell Significance Index: -4.5200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4359
    Cell Significance Index: -4.8700
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.4393
    Cell Significance Index: -4.8800
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.4403
    Cell Significance Index: -4.5300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4436
    Cell Significance Index: -4.8700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.4482
    Cell Significance Index: -4.7600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.4525
    Cell Significance Index: -5.5000
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.4549
    Cell Significance Index: -4.8600
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.4582
    Cell Significance Index: -4.5200
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.4610
    Cell Significance Index: -4.6800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4616
    Cell Significance Index: -4.5000
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.4698
    Cell Significance Index: -4.5100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.4748
    Cell Significance Index: -6.9200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.4892
    Cell Significance Index: -4.5400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.4901
    Cell Significance Index: -5.2700
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.4914
    Cell Significance Index: -4.5400
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.4923
    Cell Significance Index: -4.5300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.4950
    Cell Significance Index: -5.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.4984
    Cell Significance Index: -4.7900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.5013
    Cell Significance Index: -6.8200
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.5015
    Cell Significance Index: -4.4800
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.5041
    Cell Significance Index: -4.7700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.5045
    Cell Significance Index: -4.5000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.5122
    Cell Significance Index: -4.4800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.5128
    Cell Significance Index: -6.0600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.5132
    Cell Significance Index: -5.4600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.5168
    Cell Significance Index: -4.1300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.5220
    Cell Significance Index: -6.0700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.5251
    Cell Significance Index: -4.7400
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.5263
    Cell Significance Index: -4.2300
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.5324
    Cell Significance Index: -4.9100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.5332
    Cell Significance Index: -4.8800
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.5391
    Cell Significance Index: -4.5500
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.5406
    Cell Significance Index: -4.7500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.5414
    Cell Significance Index: -6.1500
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.5438
    Cell Significance Index: -4.8200
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.5470
    Cell Significance Index: -4.8700
  • Cell Name: collagen secreting cell (CL0000667)
    Fold Change: -0.5482
    Cell Significance Index: -3.0500
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.5532
    Cell Significance Index: -6.1000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.5558
    Cell Significance Index: -4.6900
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.5562
    Cell Significance Index: -4.5400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.5573
    Cell Significance Index: -6.7800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.5585
    Cell Significance Index: -3.9300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.5588
    Cell Significance Index: -6.7400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.5704
    Cell Significance Index: -7.5800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.5751
    Cell Significance Index: -5.7400
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.5755
    Cell Significance Index: -5.6200
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.5762
    Cell Significance Index: -6.0400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.5791
    Cell Significance Index: -7.5600
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.5801
    Cell Significance Index: -4.7600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.5819
    Cell Significance Index: -6.1700
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.5848
    Cell Significance Index: -6.0600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.5874
    Cell Significance Index: -6.7600
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.5913
    Cell Significance Index: -4.5400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.5924
    Cell Significance Index: -7.0000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.5927
    Cell Significance Index: -7.8000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.5939
    Cell Significance Index: -5.5300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.5947
    Cell Significance Index: -7.6400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.5955
    Cell Significance Index: -6.0000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.6002
    Cell Significance Index: -6.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location and Expression:** The IGHV3-66 gene is located on the immunoglobulin heavy chain locus (IgH) and is expressed in a variety of cell types, including those involved in immune responses, such as endothelial cells, goblet cells, and granulocyte-monocyte progenitor cells. 2. **Gene Structure:** The IGHV3-66 gene consists of a variable (V) region, a diversity (D) region, and a joining (J) region, which are essential for the assembly of the antibody heavy chain. 3. **Antigen-Binding Function:** The IGHV3-66 gene encodes a specific heavy chain that recognizes and binds to specific antigens, facilitating the immune system's ability to respond to pathogens. 4. **Immunoglobulin Class:** The IGHV3-66 gene is associated with the production of IgM antibodies, which are the first line of defense against infections. **Pathways and Functions:** 1. **Antigen-Binding Pathway:** The IGHV3-66 gene is involved in the antigen-binding process, which is essential for the immune system's ability to recognize and respond to pathogens. 2. **Immunoglobulin Complex Formation:** The IGHV3-66 gene plays a crucial role in the formation of immunoglobulin complexes, which are essential for the immune system's ability to eliminate pathogens. 3. **Immunoglobulin-Mediated Immune Response:** The IGHV3-66 gene is involved in the immunoglobulin-mediated immune response, which is a key mechanism of defense against infections. 4. **Cell Signaling:** The IGHV3-66 gene is also involved in cell signaling pathways, which are essential for the regulation of immune responses. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations in the IGHV3-66 gene have been associated with immunodeficiency disorders, such as X-linked agammaglobulinemia (XLA), which is characterized by a deficiency in IgM antibodies. 2. **Cancer Association:** The IGHV3-66 gene has been associated with certain types of cancer, such as follicular lymphoma and diffuse large B-cell lymphoma, which are characterized by the dysregulation of the immune system. 3. **Autoimmune Diseases:** The IGHV3-66 gene has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, which are characterized by the dysregulation of the immune system. 4. **Transplantation and Immunotherapy:** The IGHV3-66 gene has been used as a target for immunotherapy and transplantation, as it is involved in the recognition and elimination of foreign antigens. In conclusion, the IGHV3-66 gene plays a crucial role in the immune system's ability to recognize and respond to pathogens. Its dysregulation has been implicated in various diseases, including immunodeficiency disorders, cancer, autoimmune diseases, and transplantation-related complications. Further research is necessary to fully understand the mechanisms by which the IGHV3-66 gene regulates immune responses and to develop effective therapeutic strategies for diseases associated with its dysregulation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.