Details for: TRBV29 1

Gene ID: 28558

Symbol: TRBV29 1

Ensembl ID: ENSG00000232869

Description: T cell receptor beta variable 29-1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7433
    Cell Significance Index: 11.5000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.5605
    Cell Significance Index: 4.5400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2843
    Cell Significance Index: 1.5500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1182
    Cell Significance Index: 1.6800
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0009
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0070
    Cell Significance Index: -5.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0240
    Cell Significance Index: -3.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0269
    Cell Significance Index: -5.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0280
    Cell Significance Index: -3.2100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0615
    Cell Significance Index: -0.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0627
    Cell Significance Index: -6.4000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0801
    Cell Significance Index: -1.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1106
    Cell Significance Index: -5.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1124
    Cell Significance Index: -3.0600
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1215
    Cell Significance Index: -0.8700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1526
    Cell Significance Index: -2.1200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1605
    Cell Significance Index: -1.9300
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1689
    Cell Significance Index: -1.7800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1746
    Cell Significance Index: -1.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1813
    Cell Significance Index: -4.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2043
    Cell Significance Index: -5.2200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2075
    Cell Significance Index: -2.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2108
    Cell Significance Index: -5.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2120
    Cell Significance Index: -5.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2309
    Cell Significance Index: -6.8000
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.2318
    Cell Significance Index: -2.2700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2488
    Cell Significance Index: -2.5800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2572
    Cell Significance Index: -2.8800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2583
    Cell Significance Index: -5.0500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2596
    Cell Significance Index: -3.5000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2729
    Cell Significance Index: -3.5000
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2765
    Cell Significance Index: -2.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2813
    Cell Significance Index: -5.2000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2833
    Cell Significance Index: -3.6400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2881
    Cell Significance Index: -3.6400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2985
    Cell Significance Index: -5.0700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3123
    Cell Significance Index: -7.6200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3176
    Cell Significance Index: -3.7500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3257
    Cell Significance Index: -3.2900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3266
    Cell Significance Index: -4.7600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3272
    Cell Significance Index: -5.2500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.3328
    Cell Significance Index: -3.2200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.3352
    Cell Significance Index: -5.3900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3384
    Cell Significance Index: -5.1400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3413
    Cell Significance Index: -4.6800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3444
    Cell Significance Index: -4.7300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3458
    Cell Significance Index: -5.6000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.3461
    Cell Significance Index: -3.7600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3469
    Cell Significance Index: -5.9300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3507
    Cell Significance Index: -4.1500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3617
    Cell Significance Index: -3.6700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.3738
    Cell Significance Index: -5.0900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3740
    Cell Significance Index: -4.4200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3845
    Cell Significance Index: -5.3900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.3851
    Cell Significance Index: -3.2500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3876
    Cell Significance Index: -4.8000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3931
    Cell Significance Index: -4.5600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3953
    Cell Significance Index: -4.2500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.3956
    Cell Significance Index: -3.3700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3961
    Cell Significance Index: -5.2800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.4000
    Cell Significance Index: -1.5100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4016
    Cell Significance Index: -3.7700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.4169
    Cell Significance Index: -4.1800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4177
    Cell Significance Index: -5.5500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4184
    Cell Significance Index: -5.2800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.4207
    Cell Significance Index: -3.6300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.4251
    Cell Significance Index: -4.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4258
    Cell Significance Index: -7.3400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.4278
    Cell Significance Index: -5.6300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4290
    Cell Significance Index: -5.6300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.4311
    Cell Significance Index: -4.4700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.4330
    Cell Significance Index: -5.1400
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.4361
    Cell Significance Index: -3.7500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.4378
    Cell Significance Index: -5.2100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.4402
    Cell Significance Index: -5.3100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.4413
    Cell Significance Index: -3.8600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.4421
    Cell Significance Index: -3.5800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4543
    Cell Significance Index: -4.9500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4621
    Cell Significance Index: -5.9800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.4631
    Cell Significance Index: -4.9100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4662
    Cell Significance Index: -5.7300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4663
    Cell Significance Index: -4.5500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.4682
    Cell Significance Index: -5.1300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.4749
    Cell Significance Index: -5.2600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4762
    Cell Significance Index: -5.4800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.4767
    Cell Significance Index: -5.1400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.4794
    Cell Significance Index: -4.8900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.4804
    Cell Significance Index: -4.8400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4809
    Cell Significance Index: -4.9100
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.4818
    Cell Significance Index: -5.2700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.4824
    Cell Significance Index: -5.7000
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.4825
    Cell Significance Index: -5.2700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.4828
    Cell Significance Index: -4.1200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.4846
    Cell Significance Index: -5.2800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.4857
    Cell Significance Index: -6.3400
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.4857
    Cell Significance Index: -5.1900
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.4870
    Cell Significance Index: -5.0100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.4875
    Cell Significance Index: -4.5600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.4886
    Cell Significance Index: -5.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location and Expression:** TRBV29-1 is located on chromosome 7q35.3 and is expressed in a range of cell types, including hematopoietic cells, goblet cells, granulocyte-monocyte progenitor cells, and neoplastic cells. 2. **T Cell Receptor (TCR) Family:** TRBV29-1 belongs to the TCR beta family, which is responsible for recognizing and binding to specific antigens. 3. **Adaptive Immune Response:** TRBV29-1 plays a critical role in the adaptive immune response, which involves the activation of immune cells, such as T cells and B cells, in response to antigen presentation. 4. **Cell Surface Receptor Signaling Pathways:** TRBV29-1 is involved in cell surface receptor signaling pathways, which regulate various cellular processes, including proliferation, differentiation, and survival. 5. **Plasma Membrane Interactions:** TRBV29-1 interacts with the plasma membrane, influencing cell-cell interactions and signaling events. **Pathways and Functions:** 1. **Adaptive Immune Response Pathway:** TRBV29-1 is involved in the adaptive immune response pathway, which includes the recognition of antigens, activation of immune cells, and the production of antibodies. 2. **Cell Surface Receptor Signaling Pathway:** TRBV29-1 is part of the cell surface receptor signaling pathway, which regulates various cellular processes, including proliferation, differentiation, and survival. 3. **Plasma Membrane Interactions:** TRBV29-1 interacts with the plasma membrane, influencing cell-cell interactions and signaling events. 4. **T Cell Receptor Complex:** TRBV29-1 is a component of the T cell receptor complex, which recognizes and binds to specific antigens. **Clinical Significance:** The TRBV29-1 gene has been linked to various immune-related disorders, including: 1. **Autoimmune Diseases:** TRBV29-1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where the adaptive immune response is dysregulated. 2. **Cancer:** TRBV29-1 has been found to be overexpressed in certain types of cancer, such as leukemia and lymphoma, where the immune system is compromised. 3. **Infectious Diseases:** TRBV29-1 has been linked to infectious diseases, such as HIV and tuberculosis, where the adaptive immune response is impaired. 4. **Immunodeficiency Disorders:** TRBV29-1 has been implicated in immunodeficiency disorders, such as severe combined immunodeficiency (SCID), where the immune system is severely compromised. In conclusion, TRBV29-1 is a critical component of the adaptive immune response, playing a key role in recognizing and responding to antigens. Its dysregulation has been linked to various immune-related disorders, highlighting the importance of understanding the mechanisms of TRBV29-1 in the context of immune function and disease. Further research is needed to fully elucidate the role of TRBV29-1 in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.