Details for: IGKV2D 26

Gene ID: 28884

Symbol: IGKV2D 26

Ensembl ID: ENSG00000211623

Description: immunoglobulin kappa variable 2D-26

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 12.6844
    Cell Significance Index: 216.8300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.6661
    Cell Significance Index: 7.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1474
    Cell Significance Index: 2.1400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1248
    Cell Significance Index: 1.4800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.0851
    Cell Significance Index: 1.0100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0842
    Cell Significance Index: 1.1600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0521
    Cell Significance Index: 0.6600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.0154
    Cell Significance Index: 0.2600
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0137
    Cell Significance Index: 0.1800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0010
    Cell Significance Index: 0.0400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0027
    Cell Significance Index: -0.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0037
    Cell Significance Index: -0.2500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0160
    Cell Significance Index: -0.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0168
    Cell Significance Index: -0.4800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0179
    Cell Significance Index: -0.1900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0246
    Cell Significance Index: -0.3500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0267
    Cell Significance Index: -0.4300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0268
    Cell Significance Index: -0.3900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0269
    Cell Significance Index: -0.3700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0294
    Cell Significance Index: -0.7500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0298
    Cell Significance Index: -0.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0301
    Cell Significance Index: -1.9400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0309
    Cell Significance Index: -0.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0335
    Cell Significance Index: -0.9000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0335
    Cell Significance Index: -0.4700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0353
    Cell Significance Index: -0.4200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0362
    Cell Significance Index: -0.3700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0362
    Cell Significance Index: -0.4400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0367
    Cell Significance Index: -0.4400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0370
    Cell Significance Index: -0.4800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0376
    Cell Significance Index: -0.3900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0382
    Cell Significance Index: -0.5800
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0390
    Cell Significance Index: -0.4500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0391
    Cell Significance Index: -0.5100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0414
    Cell Significance Index: -0.4800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0425
    Cell Significance Index: -0.5500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0433
    Cell Significance Index: -0.4100
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.0448
    Cell Significance Index: -0.4300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0456
    Cell Significance Index: -0.5000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0457
    Cell Significance Index: -0.7400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0473
    Cell Significance Index: -0.4800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0483
    Cell Significance Index: -0.5400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0508
    Cell Significance Index: -0.4900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0521
    Cell Significance Index: -0.5900
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0528
    Cell Significance Index: -0.4600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0549
    Cell Significance Index: -0.7100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0559
    Cell Significance Index: -0.6600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0566
    Cell Significance Index: -0.7000
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.0637
    Cell Significance Index: -0.4500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0652
    Cell Significance Index: -0.7500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0655
    Cell Significance Index: -0.8600
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0689
    Cell Significance Index: -0.6500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0707
    Cell Significance Index: -0.7600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0707
    Cell Significance Index: -0.4900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0725
    Cell Significance Index: -0.5900
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0733
    Cell Significance Index: -0.6500
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.0749
    Cell Significance Index: -0.5500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0763
    Cell Significance Index: -0.8500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0809
    Cell Significance Index: -1.9600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0836
    Cell Significance Index: -1.6400
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0862
    Cell Significance Index: -0.8800
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0876
    Cell Significance Index: -0.7600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0915
    Cell Significance Index: -0.4900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0951
    Cell Significance Index: -1.2600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0959
    Cell Significance Index: -1.0100
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0991
    Cell Significance Index: -0.6600
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0996
    Cell Significance Index: -0.8000
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1045
    Cell Significance Index: -0.6800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1054
    Cell Significance Index: -1.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1055
    Cell Significance Index: -1.9500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1086
    Cell Significance Index: -1.1100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1092
    Cell Significance Index: -1.0900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1099
    Cell Significance Index: -1.0400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1100
    Cell Significance Index: -1.1700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1104
    Cell Significance Index: -1.2700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1109
    Cell Significance Index: -1.3100
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.1233
    Cell Significance Index: -0.6600
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1236
    Cell Significance Index: -1.1300
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.1267
    Cell Significance Index: -0.6000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1310
    Cell Significance Index: -1.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1337
    Cell Significance Index: -1.2900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1347
    Cell Significance Index: -1.5900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1361
    Cell Significance Index: -1.2000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1376
    Cell Significance Index: -0.9000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1380
    Cell Significance Index: -1.1700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1418
    Cell Significance Index: -1.7100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1422
    Cell Significance Index: -1.5000
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.1439
    Cell Significance Index: -0.7200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1439
    Cell Significance Index: -1.4700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1472
    Cell Significance Index: -1.6300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1482
    Cell Significance Index: -1.6700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1564
    Cell Significance Index: -1.5800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1584
    Cell Significance Index: -1.4700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1590
    Cell Significance Index: -1.4800
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1614
    Cell Significance Index: -1.6600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1638
    Cell Significance Index: -1.6500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1661
    Cell Significance Index: -1.6900
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1680
    Cell Significance Index: -1.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin Kappa (IgK) Family**: IGKV2D-26 belongs to the IgK family, which is responsible for producing kappa light chains of immunoglobulins. 2. **Variable Region**: The variable region of IGKV2D-26 is critical for generating diversity in the B cell receptor, allowing for the recognition of a wide range of antigens. 3. **High Expression in Immune Cells**: IGKV2D-26 is highly expressed in immune cells, including erythrocytes, macrophages, mast cells, and dendritic cells, indicating its widespread involvement in immune function. 4. **Adaptive Immune Response**: IGKV2D-26 is involved in the adaptive immune response, which is a specific and targeted response to pathogens, as opposed to the innate immune response, which provides immediate defense against infection. **Pathways and Functions:** 1. **Immunoglobulin Production**: IGKV2D-26 is essential for the production of immunoglobulins, which are proteins that recognize and bind to specific antigens, marking them for destruction. 2. **B Cell Receptor Diversity**: The variable region of IGKV2D-26 contributes to the generation of B cell receptor diversity, allowing for the recognition of a wide range of antigens. 3. **Antigen Recognition**: IGKV2D-26 plays a role in the recognition of antigens by B cells, which is critical for the initiation of the adaptive immune response. 4. **Immune Cell Activation**: IGKV2D-26 is involved in the activation of immune cells, including B cells and dendritic cells, which is necessary for the initiation of an immune response. **Clinical Significance:** 1. **Immunodeficiency Disorders**: Mutations in IGKV2D-26 have been associated with immunodeficiency disorders, such as agammaglobulinemia, which is characterized by a lack of immunoglobulins and impaired immune function. 2. **Autoimmune Diseases**: Altered expression or function of IGKV2D-26 has been implicated in autoimmune diseases, such as rheumatoid arthritis, where the immune system mistakenly attacks healthy tissues. 3. **Cancer**: IGKV2D-26 has been found to be overexpressed in certain types of cancer, such as multiple myeloma, where it contributes to the development of cancerous cells. 4. **Vaccine Development**: Understanding the role of IGKV2D-26 in the adaptive immune response has implications for the development of vaccines, which can be designed to target specific immune cells and stimulate the production of immunoglobulins. In conclusion, the Immunoglobulin Kappa Variable 2D-26 gene plays a critical role in the adaptive immune response, generating B cell receptor diversity and contributing to the production of immunoglobulins. Its widespread expression in immune cells highlights its importance in immune function, and its dysregulation has been implicated in various diseases, including immunodeficiency disorders, autoimmune diseases, and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.