IGKV1 33 | ENSG00000242076 | NCBI 28933

Details for: IGKV1 33

Gene ID: 28933

Symbol: IGKV1 33

Ensembl ID: ENSG00000242076

Description: immunoglobulin kappa variable 1-33

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.6149
Cell Significance Index: 6.8700
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.2022
Cell Significance Index: 2.9400
Cell Name: neuron associated cell (CL0000095)
Fold Change: 0.0010
Cell Significance Index: 0.0400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0022
Cell Significance Index: -0.4400
Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
Fold Change: -0.0077
Cell Significance Index: -0.0700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0228
Cell Significance Index: -0.6100
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0232
Cell Significance Index: -0.3200
Cell Name: vein endothelial cell (CL0002543)
Fold Change: -0.0261
Cell Significance Index: -0.2800
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0288
Cell Significance Index: -0.4200
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.0295
Cell Significance Index: -0.3700
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0407
Cell Significance Index: -0.5400
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.0448
Cell Significance Index: -0.5300
Cell Name: B-1b B cell (CL0000821)
Fold Change: -0.0498
Cell Significance Index: -0.2500
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.0541
Cell Significance Index: -0.3600
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0567
Cell Significance Index: -2.0800
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: -0.0620
Cell Significance Index: -0.6800
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.0685
Cell Significance Index: -0.6200
Cell Name: plasma cell (CL0000786)
Fold Change: -0.0707
Cell Significance Index: -0.7900
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0726
Cell Significance Index: -1.0000
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0844
Cell Significance Index: -2.1500
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.0862
Cell Significance Index: -1.1100
Cell Name: B-2 B cell (CL0000822)
Fold Change: -0.0880
Cell Significance Index: -0.7800
Cell Name: neutrophil (CL0000775)
Fold Change: -0.0913
Cell Significance Index: -1.1400
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: -0.0930
Cell Significance Index: -0.9100
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0935
Cell Significance Index: -1.2100
Cell Name: mast cell (CL0000097)
Fold Change: -0.0950
Cell Significance Index: -1.2500
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0959
Cell Significance Index: -1.6400
Cell Name: naive B cell (CL0000788)
Fold Change: -0.0969
Cell Significance Index: -1.0200
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.0980
Cell Significance Index: -1.0300
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1049
Cell Significance Index: -2.5400
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.1068
Cell Significance Index: -1.7300
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.1083
Cell Significance Index: -0.9900
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1115
Cell Significance Index: -2.1800
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.1181
Cell Significance Index: -1.3900
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.1212
Cell Significance Index: -1.3100
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.1308
Cell Significance Index: -1.1100
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.1318
Cell Significance Index: -1.7200
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.1333
Cell Significance Index: -1.1000
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.1347
Cell Significance Index: -1.4300
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.1359
Cell Significance Index: -1.6700
Cell Name: memory B cell (CL0000787)
Fold Change: -0.1372
Cell Significance Index: -1.4600
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.1397
Cell Significance Index: -1.7000
Cell Name: stromal cell (CL0000499)
Fold Change: -0.1419
Cell Significance Index: -1.4500
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.1439
Cell Significance Index: -1.7100
Cell Name: B-1 B cell (CL0000819)
Fold Change: -0.1446
Cell Significance Index: -1.2600
Cell Name: club cell (CL0000158)
Fold Change: -0.1450
Cell Significance Index: -1.5800
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.1453
Cell Significance Index: -1.6000
Cell Name: fibroblast (CL0000057)
Fold Change: -0.1459
Cell Significance Index: -1.3700
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.1460
Cell Significance Index: -1.5400
Cell Name: monocyte (CL0000576)
Fold Change: -0.1486
Cell Significance Index: -1.7100
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.1487
Cell Significance Index: -1.5800
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.1505
Cell Significance Index: -1.7100
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: -0.1507
Cell Significance Index: -1.6100
Cell Name: B cell (CL0000236)
Fold Change: -0.1549
Cell Significance Index: -1.8300
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.1590
Cell Significance Index: -1.7100
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.1612
Cell Significance Index: -1.5900
Cell Name: macrophage (CL0000235)
Fold Change: -0.1626
Cell Significance Index: -1.6600
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -0.1675
Cell Significance Index: -1.0900
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: -0.1680
Cell Significance Index: -1.5800
Cell Name: B-1a B cell (CL0000820)
Fold Change: -0.1731
Cell Significance Index: -0.9200
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: -0.1753
Cell Significance Index: -1.6100
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.1760
Cell Significance Index: -2.3100
Cell Name: neuron (CL0000540)
Fold Change: -0.1783
Cell Significance Index: -1.6900
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.1816
Cell Significance Index: -1.6000
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: -0.1821
Cell Significance Index: -1.5800
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.1855
Cell Significance Index: -2.0600
Cell Name: immature B cell (CL0000816)
Fold Change: -0.1865
Cell Significance Index: -1.7700
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: -0.1875
Cell Significance Index: -1.7000
Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.1890
Cell Significance Index: -1.7300
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.1913
Cell Significance Index: -2.2600
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: -0.1922
Cell Significance Index: -1.5900
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.1945
Cell Significance Index: -2.2600
Cell Name: glial cell (CL0000125)
Fold Change: -0.1971
Cell Significance Index: -2.1600
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: -0.1973
Cell Significance Index: -1.5900
Cell Name: T cell (CL0000084)
Fold Change: -0.1982
Cell Significance Index: -2.3400
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.2009
Cell Significance Index: -2.3300
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.2025
Cell Significance Index: -2.3300
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.2063
Cell Significance Index: -2.1400
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.2086
Cell Significance Index: -2.3100
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.2090
Cell Significance Index: -2.3600
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: -0.2095
Cell Significance Index: -2.1700
Cell Name: goblet cell (CL0000160)
Fold Change: -0.2101
Cell Significance Index: -1.9000
Cell Name: granulocyte (CL0000094)
Fold Change: -0.2172
Cell Significance Index: -2.6200
Cell Name: plasmablast (CL0000980)
Fold Change: -0.2187
Cell Significance Index: -2.0300
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.2195
Cell Significance Index: -2.2800
Cell Name: classical monocyte (CL0000860)
Fold Change: -0.2212
Cell Significance Index: -2.0600
Cell Name: germinal center B cell (CL0000844)
Fold Change: -0.2264
Cell Significance Index: -1.6000
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.2267
Cell Significance Index: -2.3000
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.2297
Cell Significance Index: -2.4400
Cell Name: late pro-B cell (CL0002048)
Fold Change: -0.2329
Cell Significance Index: -1.7100
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.2332
Cell Significance Index: -2.0800
Cell Name: platelet (CL0000233)
Fold Change: -0.2352
Cell Significance Index: -2.4200
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.2370
Cell Significance Index: -2.3100
Cell Name: mature B cell (CL0000785)
Fold Change: -0.2412
Cell Significance Index: -1.5700
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: -0.2422
Cell Significance Index: -2.2400
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.2427
Cell Significance Index: -2.2700
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: -0.2455
Cell Significance Index: -2.4800
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.2458
Cell Significance Index: -2.3300
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.2467
Cell Significance Index: -2.6800
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.2471
Cell Significance Index: -2.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** IGKV1 33 is a kappa light chain gene, which is one of the five constant regions of the immunoglobulin kappa chain. This gene is part of the immunoglobulin gene family and is involved in the production of antibodies. The gene is expressed in various cells, including T cells, granulocyte monocyte progenitor cells, and lymphocytes, indicating its role in immune responses. The gene's expression is also found in non-immune cells, such as goblet cells and intestinal crypt stem cells, suggesting its involvement in other cellular processes. **Pathways and Functions** IGKV1 33 is involved in multiple pathways and functions, including: 1. **Adaptive Immune System**: The gene is expressed in T cells and lymphocytes, suggesting its role in adaptive immune responses. 2. **Anti-inflammatory Response**: The gene is associated with anti-inflammatory responses, particularly in the context of Leishmania parasite infection. 3. **Antigen-Activated B Cell Receptor (BCR) Signaling**: The gene is involved in signaling by the BCR, leading to the generation of second messengers. 4. **Scavenger Receptor-Mediated Ligand Binding and Uptake**: The gene is associated with binding and uptake of ligands by scavenger receptors. 5. **Complement Cascade**: The gene is involved in the regulation of the complement cascade, particularly in classical antibody-mediated complement activation. 6. **Cell Surface Interactions**: The gene is involved in cell surface interactions at the vascular wall. 7. **Phagocytosis**: The gene is associated with phagocytosis, particularly in the context of Leishmania phagocytosis. **Clinical Significance** The clinical significance of IGKV1 33 is multifaceted, with potential implications in: 1. **Infectious Diseases**: The gene's involvement in Leishmania parasite infection and phagocytosis suggests its potential role in treating infectious diseases. 2. **Autoimmune Disorders**: The gene's association with anti-inflammatory responses and immune system regulation suggests its potential role in autoimmune disorders. 3. **Cancer**: The gene's expression in non-immune cells, such as goblet cells and intestinal crypt stem cells, suggests its potential role in cancer development and progression. 4. **SARS-CoV Infections**: The gene's involvement in viral infection pathways suggests its potential role in treating SARS-CoV infections. 5. **Potential Therapeutics**: The gene's potential role in regulating the complement cascade and phagocytosis suggests its potential as a therapeutic target for various diseases. In conclusion, IGKV1 33 is a gene that plays a crucial role in immune responses, including adaptive and innate immune responses, cell surface interactions, and regulation of the complement cascade. Its clinical significance is multifaceted, with potential implications in infectious diseases, autoimmune disorders, cancer, and SARS-CoV infections. Further research is needed to fully understand the gene's functions and potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.