Details for: PRSS50

Gene ID: 29122

Symbol: PRSS50

Ensembl ID: ENSG00000283706

Description: serine protease 50

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.1755
    Cell Significance Index: 1.8200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.1614
    Cell Significance Index: 2.0700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0880
    Cell Significance Index: 1.2500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.0152
    Cell Significance Index: 0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0149
    Cell Significance Index: 2.5500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0034
    Cell Significance Index: -0.0300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0043
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0066
    Cell Significance Index: -4.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0082
    Cell Significance Index: -4.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0082
    Cell Significance Index: -5.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0111
    Cell Significance Index: -2.2300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0112
    Cell Significance Index: -0.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0119
    Cell Significance Index: -0.2300
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0145
    Cell Significance Index: -0.1200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0162
    Cell Significance Index: -0.1800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0163
    Cell Significance Index: -0.1500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0172
    Cell Significance Index: -0.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0174
    Cell Significance Index: -0.6100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0182
    Cell Significance Index: -0.2200
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0183
    Cell Significance Index: -0.1600
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0203
    Cell Significance Index: -0.2200
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0206
    Cell Significance Index: -0.2200
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.0215
    Cell Significance Index: -0.2200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0216
    Cell Significance Index: -0.2200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0221
    Cell Significance Index: -0.2500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0228
    Cell Significance Index: -0.2900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0229
    Cell Significance Index: -0.2500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0232
    Cell Significance Index: -0.2200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0232
    Cell Significance Index: -0.2400
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.0234
    Cell Significance Index: -0.2500
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0235
    Cell Significance Index: -0.3000
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0236
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0237
    Cell Significance Index: -4.9900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0241
    Cell Significance Index: -0.2500
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0243
    Cell Significance Index: -0.2700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0245
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0246
    Cell Significance Index: -0.2700
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0253
    Cell Significance Index: -0.2700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0254
    Cell Significance Index: -0.2800
  • Cell Name: brush cell of tracheobronchial tree (CL0002075)
    Fold Change: -0.0256
    Cell Significance Index: -0.2300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0256
    Cell Significance Index: -0.3000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0257
    Cell Significance Index: -0.2400
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.0262
    Cell Significance Index: -0.2700
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0268
    Cell Significance Index: -0.3300
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.0269
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0270
    Cell Significance Index: -3.0900
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0279
    Cell Significance Index: -0.2800
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.0284
    Cell Significance Index: -0.2700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0291
    Cell Significance Index: -0.2100
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: -0.0312
    Cell Significance Index: -0.2700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0321
    Cell Significance Index: -0.6700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0326
    Cell Significance Index: -0.6500
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0368
    Cell Significance Index: -0.4000
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: -0.0389
    Cell Significance Index: -0.2600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0441
    Cell Significance Index: -0.6600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0451
    Cell Significance Index: -0.5000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0657
    Cell Significance Index: -1.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0675
    Cell Significance Index: -2.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0706
    Cell Significance Index: -1.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0715
    Cell Significance Index: -4.8100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0787
    Cell Significance Index: -1.7000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0882
    Cell Significance Index: -0.9000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0888
    Cell Significance Index: -1.5400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0954
    Cell Significance Index: -1.3100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0957
    Cell Significance Index: -0.8700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0973
    Cell Significance Index: -2.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1080
    Cell Significance Index: -3.5400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1118
    Cell Significance Index: -1.3300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1121
    Cell Significance Index: -1.4400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1144
    Cell Significance Index: -1.8400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1304
    Cell Significance Index: -1.9800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1347
    Cell Significance Index: -1.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1413
    Cell Significance Index: -3.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1519
    Cell Significance Index: -1.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1554
    Cell Significance Index: -3.1200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1567
    Cell Significance Index: -1.7800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1618
    Cell Significance Index: -0.9600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1633
    Cell Significance Index: -2.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1768
    Cell Significance Index: -5.0500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1790
    Cell Significance Index: -3.5400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1898
    Cell Significance Index: -2.6600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1959
    Cell Significance Index: -1.2300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1999
    Cell Significance Index: -2.6100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2010
    Cell Significance Index: -2.4100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2225
    Cell Significance Index: -2.9200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2257
    Cell Significance Index: -2.9700
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.2288
    Cell Significance Index: -2.9300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2352
    Cell Significance Index: -1.5300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2470
    Cell Significance Index: -2.7600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2472
    Cell Significance Index: -2.6800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2482
    Cell Significance Index: -3.0200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2578
    Cell Significance Index: -2.4000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2731
    Cell Significance Index: -3.3200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2833
    Cell Significance Index: -2.6600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2866
    Cell Significance Index: -4.8200
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.2885
    Cell Significance Index: -3.2300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.2967
    Cell Significance Index: -3.4200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3176
    Cell Significance Index: -5.3500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3404
    Cell Significance Index: -4.7600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3549
    Cell Significance Index: -5.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRSS50 is a serine protease, a class of enzymes that catalyze the hydrolysis of peptide bonds in proteins. This enzyme exhibits specificity for threonine and serine residues, which are essential for its proteolytic activity. The structural similarity between PRSS50 and other serine proteases suggests that it may share conserved functional properties. Notably, PRSS50 is not as well-studied as other proteases in the serine protease family, and its specific substrate repertoire remains to be elucidated. **Pathways and Functions:** PRSS50 is involved in various cellular processes, including proteolysis, cell migration, and tissue homeostasis. Its expression in pericytes, a type of mural cell surrounding blood vessels, suggests its potential role in vascular integrity and angiogenesis. In cardiac muscle myoblasts, PRSS50 may contribute to cardiac development and function by regulating muscle cell differentiation and contraction. Additionally, its expression in fibroblasts and smooth muscle myoblasts implies a role in tissue repair and remodeling. The involvement of PRSS50 in the innate immune response, particularly in immature innate lymphoid cells, underscores its potential as a modulator of immune cell function. **Clinical Significance:** PRSS50's involvement in various cellular processes has significant implications for its potential role in human disease. Mutations in PRSS50 have been associated with cardiac conditions, such as arrhythmias and cardiomyopathy, suggesting its importance in cardiac function. Furthermore, PRSS50's expression in immune cells may contribute to the development of autoimmune diseases, such as rheumatoid arthritis, where proteolytic activity is dysregulated. The identification of PRSS50 as a potential biomarker for these conditions could provide valuable insights into disease mechanisms and therapeutic targets. In conclusion, PRSS50 is a multifunctional serine protease that plays a crucial role in various cellular processes, including proteolysis, cell migration, and tissue homeostasis. Its wide expression across multiple cell types and its involvement in the innate immune response make it an attractive candidate for further investigation into its clinical significance. Further studies are necessary to elucidate the specific mechanisms of PRSS50 in disease and to explore its potential as a therapeutic target or biomarker.

Genular Protein ID: 3994439182

Symbol: TSP50_HUMAN

Name: Probable threonine protease PRSS50

UniProtKB Accession Codes:

Q9UI38

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10397268

Title: Isolation of a novel gene, TSP50, by a hypomethylated DNA fragment in human breast cancer.

PubMed ID: 10397268

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17283160

Title: TSP50 encodes a testis-specific protease and is negatively regulated by p53.

PubMed ID: 17283160

DOI: 10.1158/0008-5472.can-06-3688

Sequence Information:

  • Length: 385
  • Mass: 43088
  • Checksum: F5B39D6E12798AE5
  • Sequence:
    • MGRWCQTVAR GQRPRTSAPS RAGALLLLLL LLRSAGCWGA GEAPGALSTA DPADQSVQCV 
PKATCPSSRP RLLWQTPTTQ TLPSTTMETQ FPVSEGKVDP YRSCGFSYEQ DPTLRDPEAV 
ARRWPWMVSV RANGTHICAG TIIASQWVLT VAHCLIWRDV IYSVRVGSPW IDQMTQTASD 
VPVLQVIMHS RYRAQRFWSW VGQANDIGLL KLKQELKYSN YVRPICLPGT DYVLKDHSRC 
TVTGWGLSKA DGMWPQFRTI QEKEVIILNN KECDNFYHNF TKIPTLVQII KSQMMCAEDT 
HREKFCYELT GEPLVCSMEG TWYLVGLVSW GAGCQKSEAP PIYLQVSSYQ HWIWDCLNGQ 
ALALPAPSRT LLLALPLPLS LLAAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.