Details for: PRSS50

Gene ID: 29122

Symbol: PRSS50

Ensembl ID: ENSG00000283706

Description: serine protease 50

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.31
    Marker Score: 764
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13,889
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.72
    Marker Score: 1,362
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.51
    Marker Score: 1,041
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.33
    Marker Score: 2,006
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.32
    Marker Score: 191
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 137
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.13
    Marker Score: 118
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.04
    Marker Score: 177
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 39
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.01
    Marker Score: 94
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0
    Marker Score: 61
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0
    Marker Score: 13

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRSS50 is a serine protease, a class of enzymes that catalyze the hydrolysis of peptide bonds in proteins. This enzyme exhibits specificity for threonine and serine residues, which are essential for its proteolytic activity. The structural similarity between PRSS50 and other serine proteases suggests that it may share conserved functional properties. Notably, PRSS50 is not as well-studied as other proteases in the serine protease family, and its specific substrate repertoire remains to be elucidated. **Pathways and Functions:** PRSS50 is involved in various cellular processes, including proteolysis, cell migration, and tissue homeostasis. Its expression in pericytes, a type of mural cell surrounding blood vessels, suggests its potential role in vascular integrity and angiogenesis. In cardiac muscle myoblasts, PRSS50 may contribute to cardiac development and function by regulating muscle cell differentiation and contraction. Additionally, its expression in fibroblasts and smooth muscle myoblasts implies a role in tissue repair and remodeling. The involvement of PRSS50 in the innate immune response, particularly in immature innate lymphoid cells, underscores its potential as a modulator of immune cell function. **Clinical Significance:** PRSS50's involvement in various cellular processes has significant implications for its potential role in human disease. Mutations in PRSS50 have been associated with cardiac conditions, such as arrhythmias and cardiomyopathy, suggesting its importance in cardiac function. Furthermore, PRSS50's expression in immune cells may contribute to the development of autoimmune diseases, such as rheumatoid arthritis, where proteolytic activity is dysregulated. The identification of PRSS50 as a potential biomarker for these conditions could provide valuable insights into disease mechanisms and therapeutic targets. In conclusion, PRSS50 is a multifunctional serine protease that plays a crucial role in various cellular processes, including proteolysis, cell migration, and tissue homeostasis. Its wide expression across multiple cell types and its involvement in the innate immune response make it an attractive candidate for further investigation into its clinical significance. Further studies are necessary to elucidate the specific mechanisms of PRSS50 in disease and to explore its potential as a therapeutic target or biomarker.

Genular Protein ID: 3994439182

Symbol: TSP50_HUMAN

Name: Probable threonine protease PRSS50

UniProtKB Accession Codes:

Q9UI38

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10397268

Title: Isolation of a novel gene, TSP50, by a hypomethylated DNA fragment in human breast cancer.

PubMed ID: 10397268

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17283160

Title: TSP50 encodes a testis-specific protease and is negatively regulated by p53.

PubMed ID: 17283160

DOI: 10.1158/0008-5472.can-06-3688

Sequence Information:

  • Length: 385
  • Mass: 43088
  • Checksum: F5B39D6E12798AE5
  • Sequence:
    • MGRWCQTVAR GQRPRTSAPS RAGALLLLLL LLRSAGCWGA GEAPGALSTA DPADQSVQCV 
PKATCPSSRP RLLWQTPTTQ TLPSTTMETQ FPVSEGKVDP YRSCGFSYEQ DPTLRDPEAV 
ARRWPWMVSV RANGTHICAG TIIASQWVLT VAHCLIWRDV IYSVRVGSPW IDQMTQTASD 
VPVLQVIMHS RYRAQRFWSW VGQANDIGLL KLKQELKYSN YVRPICLPGT DYVLKDHSRC 
TVTGWGLSKA DGMWPQFRTI QEKEVIILNN KECDNFYHNF TKIPTLVQII KSQMMCAEDT 
HREKFCYELT GEPLVCSMEG TWYLVGLVSW GAGCQKSEAP PIYLQVSSYQ HWIWDCLNGQ 
ALALPAPSRT LLLALPLPLS LLAAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.