GRM7 | ENSG00000196277 | NCBI 2917

Details for: GRM7

Gene ID: 2917

Symbol: GRM7

Ensembl ID: ENSG00000196277

Description: glutamate metabotropic receptor 7

Associated with

Class c/3 (metabotropic glutamate/pheromone receptors)
(R-HSA-420499)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Adenylate cyclase-inhibiting g protein-coupled glutamate receptor signaling pathway
(GO:0007196)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Adenylate cyclase inhibitor activity
(GO:0010855)
Asymmetric synapse
(GO:0032279)
Axon
(GO:0030424)
Axon development
(GO:0061564)
Behavioral fear response
(GO:0001662)
Calcium ion binding
(GO:0005509)
Cell cortex
(GO:0005938)
Chemical synaptic transmission
(GO:0007268)
Dendrite
(GO:0030425)
Dendritic shaft
(GO:0043198)
Glutamate binding
(GO:0016595)
Glutamate receptor activity
(GO:0008066)
Glycosylation
(GO:0070085)
G protein-coupled glutamate receptor signaling pathway
(GO:0007216)
Group iii metabotropic glutamate receptor activity
(GO:0001642)
Membrane
(GO:0016020)
Negative regulation of glutamate secretion
(GO:0014050)
Pdz domain binding
(GO:0030165)
Plasma membrane
(GO:0005886)
Postsynaptic membrane
(GO:0045211)
Presynaptic active zone
(GO:0048786)
Protein dimerization activity
(GO:0046983)
Receptor complex
(GO:0043235)
Regulation of synaptic transmission, glutamatergic
(GO:0051966)
Sensory perception of sound
(GO:0007605)
Serine binding
(GO:0070905)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.92
Cell Significance Index: 3
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.37
Cell Significance Index: 2
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.27
Cell Significance Index: 2
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 1
Cell Significance Index: 1
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 1
Cell Significance Index: 1
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 1
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1
Cell Significance Index: 1
Cell Name: chandelier cell (CL4023083)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuron (CL0000540)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: secretory cell (CL0000151)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neural cell (CL0002319)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: peg cell (CL4033014)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: malignant cell (CL0001064)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: flat midget bipolar cell (CL4033033)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast (CL0000057)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basophilic erythroblast (CL0000549)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: astrocyte (CL0000127)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: germ cell (CL0000586)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: melanocyte (CL0000148)
Fold Change: 0.99
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** GRM7 is a G protein-coupled receptor that belongs to the family of metabotropic glutamate receptors. It is characterized by its ability to bind to glutamate, a major excitatory neurotransmitter, and activate G protein-coupled signaling pathways. GRM7 is highly expressed in the central nervous system, particularly in the cerebral cortex, hippocampus, and brainstem. Its expression is also observed in other tissues, including the lung, where it plays a role in regulating alveolar fluid secretion. **Pathways and Functions:** GRM7 is involved in various signaling pathways, including adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway, adenylate cyclase inhibitor activity, and regulation of synaptic transmission. Upon binding to glutamate, GRM7 activates a G protein-coupled signaling cascade that inhibits adenylate cyclase activity, leading to a decrease in cAMP levels. This decrease in cAMP levels has been shown to modulate synaptic transmission, neuronal excitability, and neuronal plasticity. GRM7 has also been implicated in the regulation of various physiological processes, including sensory perception of sound, behavioral fear response, and regulation of synaptic transmission. In the context of synaptic transmission, GRM7 has been shown to modulate the release of glutamate and GABA, two major neurotransmitters involved in excitatory and inhibitory neurotransmission, respectively. **Clinical Significance:** Dysregulation of GRM7 has been implicated in various neurological and psychiatric disorders, including schizophrenia, bipolar disorder, and anxiety disorders. Studies have shown that GRM7 is differentially expressed in the brains of individuals with these disorders, suggesting that altered GRM7 function may contribute to the pathophysiology of these conditions. Furthermore, GRM7 has been shown to play a role in the regulation of synaptic plasticity, a process essential for learning and memory. Alterations in GRM7 function have been linked to impaired synaptic plasticity, which may contribute to the cognitive deficits observed in individuals with neurological and psychiatric disorders. In addition, GRM7 has been implicated in the regulation of pain perception and anxiety. Studies have shown that GRM7 is involved in the regulation of pain signaling pathways and that alterations in GRM7 function may contribute to the development of anxiety disorders. **Conclusion:** In conclusion, GRM7 is a critical component of glutamatergic signaling pathways, playing a key role in regulating synaptic transmission, neuronal excitability, and neuronal plasticity. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the importance of GRM7 in maintaining normal brain function. Further research is needed to fully elucidate the mechanisms by which GRM7 regulates glutamatergic signaling and to explore its potential as a therapeutic target for the treatment of neurological and psychiatric disorders. **References:** * [Insert relevant references to support the discussion] Note: As an expert immunologist, I have taken a more general approach to discussing GRM7, focusing on its role in glutamatergic signaling and its implications in various physiological and pathological processes. However, please note that GRM7 is a gene that is primarily studied in the context of neuroscience and molecular biology, and the discussion above may not be as relevant to immunology as it would be to other fields.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.