Details for: GTF2F2

Gene ID: 2963

Symbol: GTF2F2

Ensembl ID: ENSG00000188342

Description: general transcription factor IIF subunit 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.52
    Marker Score: 1674
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.48
    Marker Score: 56390
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.48
    Marker Score: 1557
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.43
    Marker Score: 413
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.41
    Marker Score: 5475.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.39
    Marker Score: 5663
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.34
    Marker Score: 908
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.34
    Marker Score: 3264
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.3
    Marker Score: 1632.5
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.3
    Marker Score: 648
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.27
    Marker Score: 1276
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19693
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.26
    Marker Score: 1361
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.25
    Marker Score: 11924
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.25
    Marker Score: 27966
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.24
    Marker Score: 24743.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.23
    Marker Score: 9429
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.23
    Marker Score: 2596
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.23
    Marker Score: 11547
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.22
    Marker Score: 10486
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.22
    Marker Score: 2541
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.19
    Marker Score: 72928
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.19
    Marker Score: 1576
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.18
    Marker Score: 1527
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.17
    Marker Score: 2763.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.16
    Marker Score: 20633.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.15
    Marker Score: 2622
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.15
    Marker Score: 1214
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.14
    Marker Score: 1642
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.14
    Marker Score: 11758
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.14
    Marker Score: 2015
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.13
    Marker Score: 1929
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.13
    Marker Score: 24155.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.13
    Marker Score: 39078
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.13
    Marker Score: 594
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.12
    Marker Score: 4598.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.11
    Marker Score: 1641
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.11
    Marker Score: 9558
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.11
    Marker Score: 3007
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.1
    Marker Score: 331
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.1
    Marker Score: 1009.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.1
    Marker Score: 685
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.1
    Marker Score: 1366
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.09
    Marker Score: 544
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.08
    Marker Score: 2198
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.08
    Marker Score: 1668
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.08
    Marker Score: 1303
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.07
    Marker Score: 1216
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.07
    Marker Score: 1156.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.06
    Marker Score: 1316
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.06
    Marker Score: 836
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.06
    Marker Score: 1846
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.05
    Marker Score: 1119
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.05
    Marker Score: 612
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.01
    Marker Score: 2385
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.01
    Marker Score: 3900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.01
    Marker Score: 873
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1
    Marker Score: 1046
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1
    Marker Score: 36983.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1
    Marker Score: 13201
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1
    Marker Score: 749
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71622
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47847
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.99
    Marker Score: 829
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.99
    Marker Score: 402
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.99
    Marker Score: 1054
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30372
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.98
    Marker Score: 15728
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.98
    Marker Score: 653
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.98
    Marker Score: 717
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.98
    Marker Score: 538
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.97
    Marker Score: 585
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.97
    Marker Score: 2309
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.97
    Marker Score: 310
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.96
    Marker Score: 1361
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.96
    Marker Score: 10822
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.96
    Marker Score: 14288
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.95
    Marker Score: 462
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.94
    Marker Score: 1549
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.94
    Marker Score: 642
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2385
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.94
    Marker Score: 325
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.94
    Marker Score: 594
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.93
    Marker Score: 4589
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.93
    Marker Score: 380
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.93
    Marker Score: 7266.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.93
    Marker Score: 343
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.93
    Marker Score: 5571
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.92
    Marker Score: 320
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.92
    Marker Score: 1761.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.92
    Marker Score: 651
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.91
    Marker Score: 214
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.91
    Marker Score: 216.5
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.9
    Marker Score: 908.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.9
    Marker Score: 197.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5142
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9
    Marker Score: 9129.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.9
    Marker Score: 955

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * GTF2F2 is a protein of the TGF-beta superfamily of transcription factors. * It is a key regulator of epithelial cell growth and differentiation. * It is upregulated in a variety of human cancers. **Pathways and functions:** * GTF2F2 is involved in the regulation of epithelial cell growth and differentiation. * It is a key regulator of the cell cycle, promoting cell cycle progression from G1 to S phase and inhibiting cell cycle progression from G2 to M phase. * It is also involved in the regulation of cell migration and invasion. * GTF2F2 is also involved in the regulation of apoptosis. * It is a key regulator of the development of the eye, skin, and other epithelial tissues. **Clinical significance:** * Mutations in GTF2F2 have been linked to a number of human cancers, including breast cancer, lung cancer, and colon cancer. * Inhibition of GTF2F2 has been shown to inhibit cancer cell growth and metastasis. * Therefore, GTF2F2 is a promising target for the treatment of cancer. **Additional notes:** * GTF2F2 is a highly conserved protein with a wide expression in different tissues. * It is a key regulator of epithelial cell growth and differentiation, and its expression is often upregulated in cancer. * GTF2F2 is a promising target for the treatment of cancer.

Genular Protein ID: 3700123369

Symbol: T2FB_HUMAN

Name: General transcription factor IIF subunit 2

UniProtKB Accession Codes:

P13984 A6NNS5 Q5W0H3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 32 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 39 PDBsum 37 PIR 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 32 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2477704

Title: Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II.

PubMed ID: 2477704

DOI: 10.1038/341410a0

PubMed ID: 1840667

Title: Nucleotide and amino acid sequence of RAP30.

PubMed ID: 1840667

DOI: 10.1093/nar/19.19.5436

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8504927

Title: Multiple functional domains of human transcription factor IIB: distinct interactions with two general transcription factors and RNA polymerase II.

PubMed ID: 8504927

DOI: 10.1101/gad.7.6.1021

PubMed ID: 8662660

Title: RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding.

PubMed ID: 8662660

DOI: 10.1074/jbc.271.20.11703

PubMed ID: 10454543

Title: Tat-SF1 protein associates with RAP30 and human SPT5 proteins.

PubMed ID: 10454543

DOI: 10.1128/mcb.19.9.5960

PubMed ID: 12737519

Title: Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP).

PubMed ID: 12737519

DOI: 10.1038/sj.cr.7290155

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 9689043

Title: Structural homology between the Rap30 DNA-binding domain and linker histone H5: implications for preinitiation complex assembly.

PubMed ID: 9689043

DOI: 10.1073/pnas.95.16.9117

Sequence Information:

  • Length: 249
  • Mass: 28380
  • Checksum: 05A1A9F8D31B749C
  • Sequence:
    • MAERGELDLT GAKQNTGVWL VKVPKYLSQQ WAKASGRGEV GKLRIAKTQG RTEVSFTLNE 
DLANIHDIGG KPASVSAPRE HPFVLQSVGG QTLTVFTESS SDKLSLEGIV VQRAECRPAA 
SENYMRLKRL QIEESSKPVR LSQQLDKVVT TNYKPVANHQ YNIEYERKKK EDGKRARADK 
QHVLDMLFSA FEKHQYYNLK DLVDITKQPV VYLKEILKEI GVQNVKGIHK NTWELKPEYR 
HYQGEEKSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.