Details for: MBL2

Gene ID: 4153

Symbol: MBL2

Ensembl ID: ENSG00000165471

Description: mannose binding lectin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 61.9595
    Cell Significance Index: 1338.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 27.7208
    Cell Significance Index: 971.1100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 27.2498
    Cell Significance Index: 538.8200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 25.3083
    Cell Significance Index: 378.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 24.1872
    Cell Significance Index: 791.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 23.6951
    Cell Significance Index: 475.7100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 21.2824
    Cell Significance Index: 530.8800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 19.1013
    Cell Significance Index: 398.6600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 18.0687
    Cell Significance Index: 367.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 15.8078
    Cell Significance Index: 503.4600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 14.2303
    Cell Significance Index: 280.0800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 14.0394
    Cell Significance Index: 242.7500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 4.4116
    Cell Significance Index: 74.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6074
    Cell Significance Index: 16.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5447
    Cell Significance Index: 9.1800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.5388
    Cell Significance Index: 5.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1953
    Cell Significance Index: 38.7600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1820
    Cell Significance Index: 2.3000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1294
    Cell Significance Index: 1.9100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0998
    Cell Significance Index: 0.5800
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.0948
    Cell Significance Index: 0.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0808
    Cell Significance Index: 1.1600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0184
    Cell Significance Index: 0.2400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0159
    Cell Significance Index: 0.1600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.0119
    Cell Significance Index: 0.1400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0028
    Cell Significance Index: 0.1100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0015
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0013
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0011
    Cell Significance Index: -0.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0018
    Cell Significance Index: -0.3700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0029
    Cell Significance Index: -0.0700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0070
    Cell Significance Index: -0.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0093
    Cell Significance Index: -0.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0159
    Cell Significance Index: -0.2200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0187
    Cell Significance Index: -0.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0210
    Cell Significance Index: -0.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0230
    Cell Significance Index: -1.2000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0248
    Cell Significance Index: -0.2800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0260
    Cell Significance Index: -0.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0316
    Cell Significance Index: -5.6900
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0322
    Cell Significance Index: -0.3600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0323
    Cell Significance Index: -0.4400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0324
    Cell Significance Index: -0.4600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0331
    Cell Significance Index: -0.3300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0334
    Cell Significance Index: -0.8100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0363
    Cell Significance Index: -0.4800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0365
    Cell Significance Index: -0.4200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0398
    Cell Significance Index: -0.5000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0458
    Cell Significance Index: -0.3900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0467
    Cell Significance Index: -0.6000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0473
    Cell Significance Index: -0.4500
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.0490
    Cell Significance Index: -0.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0519
    Cell Significance Index: -5.3000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0531
    Cell Significance Index: -0.6200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0540
    Cell Significance Index: -0.5700
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0563
    Cell Significance Index: -0.6300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0583
    Cell Significance Index: -0.6400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0593
    Cell Significance Index: -1.1600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0603
    Cell Significance Index: -0.6900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0605
    Cell Significance Index: -0.9800
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: -0.0612
    Cell Significance Index: -0.7400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0624
    Cell Significance Index: -0.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0626
    Cell Significance Index: -1.3700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0627
    Cell Significance Index: -0.8600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0634
    Cell Significance Index: -0.7600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0640
    Cell Significance Index: -1.6300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0640
    Cell Significance Index: -0.3800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0650
    Cell Significance Index: -0.7200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0653
    Cell Significance Index: -0.6200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0655
    Cell Significance Index: -0.9000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0661
    Cell Significance Index: -0.7900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0672
    Cell Significance Index: -0.7800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0674
    Cell Significance Index: -0.7100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0688
    Cell Significance Index: -0.8200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0692
    Cell Significance Index: -0.7500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0694
    Cell Significance Index: -0.7600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0696
    Cell Significance Index: -0.9100
  • Cell Name: diffuse bipolar 6 cell (CL4033032)
    Fold Change: -0.0710
    Cell Significance Index: -0.8200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0719
    Cell Significance Index: -0.7300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0720
    Cell Significance Index: -0.5600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0734
    Cell Significance Index: -0.7600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0757
    Cell Significance Index: -0.6400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0769
    Cell Significance Index: -0.9700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0777
    Cell Significance Index: -0.6800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0781
    Cell Significance Index: -1.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0791
    Cell Significance Index: -0.7600
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0804
    Cell Significance Index: -0.7300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0806
    Cell Significance Index: -0.6200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0838
    Cell Significance Index: -0.8500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0857
    Cell Significance Index: -0.9100
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0884
    Cell Significance Index: -0.7300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0895
    Cell Significance Index: -1.0700
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0908
    Cell Significance Index: -0.7300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0916
    Cell Significance Index: -0.3500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0936
    Cell Significance Index: -1.1300
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0936
    Cell Significance Index: -0.9700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0948
    Cell Significance Index: -1.2600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0955
    Cell Significance Index: -1.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The MBL2 gene is located on chromosome 10q23.3 and consists of six exons that encode a 106-amino acid protein, also known as Collectin-1. The protein has a mannose-binding domain, which recognizes and binds to carbohydrate molecules on the surface of pathogens, such as bacteria and viruses. MBL2 is produced by various cell types, including immune cells, endothelial cells, and epithelial cells, and is secreted into the bloodstream, where it can interact with pathogens and trigger the complement cascade. **Pathways and Functions** MBL2 is involved in several key immune pathways, including: 1. **Complement Activation**: MBL2 binds to carbohydrate molecules on the surface of pathogens, triggering the activation of the complement system, which leads to the formation of the membrane attack complex (MAC) and the opsonization of pathogens. 2. **Antiviral Innate Immune Response**: MBL2 recognizes viral particles and triggers the activation of the interferon (IFN) pathway, leading to the production of antiviral cytokines and the activation of immune cells. 3. **Antibacterial Innate Immune Response**: MBL2 binds to bacterial surface components, such as lipopolysaccharides (LPS), triggering the activation of the complement system and the production of pro-inflammatory cytokines. 4. **Endothelial Cell Function**: MBL2 is expressed on endothelial cells, where it plays a role in the regulation of vascular permeability and the recruitment of immune cells to sites of infection. **Clinical Significance** Variations in the MBL2 gene have been associated with several clinical conditions, including: 1. **Increased Susceptibility to Infections**: MBL2 deficiency or polymorphisms have been linked to an increased risk of recurrent infections, particularly with encapsulated bacteria such as Streptococcus pneumoniae and Haemophilus influenzae. 2. **Autoimmune Diseases**: MBL2 polymorphisms have been associated with an increased risk of autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). 3. **Cancer**: MBL2 polymorphisms have been linked to an increased risk of certain cancers, including lung, breast, and colon cancer. 4. **COVID-19**: MBL2 has been shown to play a role in the recognition and elimination of SARS-CoV-2, and polymorphisms in the MBL2 gene have been associated with an increased risk of severe COVID-19. In conclusion, the MBL2 gene is a critical component of the innate immune system, playing a pivotal role in the recognition and elimination of pathogens. Variations in the MBL2 gene have been associated with an increased susceptibility to infections, autoimmune diseases, and certain cancers, highlighting its importance in human health and disease.

Genular Protein ID: 2678755508

Symbol: MBL2_HUMAN

Name: Collectin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2450948

Title: A human mannose-binding protein is an acute-phase reactant that shares sequence homology with other vertebrate lectins.

PubMed ID: 2450948

DOI: 10.1084/jem.167.3.1034

PubMed ID: 2477486

Title: The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10.

PubMed ID: 2477486

DOI: 10.1084/jem.170.4.1175

PubMed ID: 2590164

Title: Structure and evolutionary origin of the gene encoding a human serum mannose-binding protein.

PubMed ID: 2590164

DOI: 10.1042/bj2620763

PubMed ID: 9743385

Title: Different molecular events result in low protein levels of mannan-binding lectin in populations from South-East Africa and South America.

PubMed ID: 9743385

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12175909

Title: Restricted polymorphisms of the mannose-binding lectin gene in a population of Papua New Guinea.

PubMed ID: 12175909

DOI: 10.1016/s0027-5107(02)00142-2

PubMed ID: 7982896

Title: Structure and function of mannan-binding proteins isolated from human liver and serum.

PubMed ID: 7982896

DOI: 10.1093/oxfordjournals.jbchem.a124471

PubMed ID: 9087411

Title: A second serine protease associated with mannan-binding lectin that activates complement.

PubMed ID: 9087411

DOI: 10.1038/386506a0

PubMed ID: 14515269

Title: Mannose-binding lectin engagement with late apoptotic and necrotic cells.

PubMed ID: 14515269

DOI: 10.1002/eji.200323888

PubMed ID: 15145932

Title: Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin.

PubMed ID: 15145932

DOI: 10.1074/jbc.m403763200

PubMed ID: 16116208

Title: Mannan-binding protein blocks the activation of metalloproteases meprin alpha and beta.

PubMed ID: 16116208

DOI: 10.4049/jimmunol.175.5.3177

PubMed ID: 18006063

Title: Comparative study of the human ficolins reveals unique features of Ficolin-3 (Hakata antigen).

PubMed ID: 18006063

DOI: 10.1016/j.molimm.2007.10.006

PubMed ID: 23460739

Title: Deciphering complement receptor type 1 interactions with recognition proteins of the lectin complement pathway.

PubMed ID: 23460739

DOI: 10.4049/jimmunol.1202451

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29563915

Title: C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules.

PubMed ID: 29563915

DOI: 10.3389/fimmu.2018.00453

PubMed ID: 35102342

Title: Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules.

PubMed ID: 35102342

DOI: 10.1038/s41590-021-01114-w

PubMed ID: 7634089

Title: Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil.

PubMed ID: 7634089

DOI: 10.1038/nsb1194-789

PubMed ID: 1675710

Title: Molecular basis of opsonic defect in immunodeficient children.

PubMed ID: 1675710

DOI: 10.1016/0140-6736(91)93263-9

PubMed ID: 1304173

Title: High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene.

PubMed ID: 1304173

DOI: 10.1093/hmg/1.9.709

PubMed ID: 1303250

Title: Distinct and overlapping functions of allelic forms of human mannose binding protein.

PubMed ID: 1303250

DOI: 10.1038/ng0992-50

PubMed ID: 10447262

Title: Genotyping of the three major allelic variants of the human mannose-binding lectin gene by denaturing gradient gel electrophoresis.

PubMed ID: 10447262

DOI: 10.1002/(sici)1098-1004(1999)14:1<80::aid-humu10>3.0.co;2-j

PubMed ID: 15994813

Title: Mannose binding lectin genotypes influence recovery from hepatitis B virus infection.

PubMed ID: 15994813

DOI: 10.1128/jvi.79.14.9192-9196.2005

PubMed ID: 21695215

Title: Variant G57E of mannose binding lectin associated with protection against tuberculosis caused by Mycobacterium africanum but not by M. tuberculosis.

PubMed ID: 21695215

DOI: 10.1371/journal.pone.0020908

Sequence Information:

  • Length: 248
  • Mass: 26144
  • Checksum: C1F2AAED46D0F774
  • Sequence:
  • MSLFPSLPLL LLSMVAASYS ETVTCEDAQK TCPAVIACSS PGINGFPGKD GRDGTKGEKG 
    EPGQGLRGLQ GPPGKLGPPG NPGPSGSPGP KGQKGDPGKS PDGDSSLAAS ERKALQTEMA 
    RIKKWLTFSL GKQVGNKFFL TNGEIMTFEK VKALCVKFQA SVATPRNAAE NGAIQNLIKE 
    EAFLGITDEK TEGQFVDLTG NRLTYTNWNE GEPNNAGSDE DCVLLLKNGQ WNDVPCSTSH 
    LAVCEFPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.