Details for: MBL2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 61.9595
Cell Significance Index: 1338.6600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 27.7208
Cell Significance Index: 971.1100 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 27.2498
Cell Significance Index: 538.8200 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 25.3083
Cell Significance Index: 378.6300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 24.1872
Cell Significance Index: 791.8900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 23.6951
Cell Significance Index: 475.7100 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 21.2824
Cell Significance Index: 530.8800 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 19.1013
Cell Significance Index: 398.6600 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 18.0687
Cell Significance Index: 367.6600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 15.8078
Cell Significance Index: 503.4600 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 14.2303
Cell Significance Index: 280.0800 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 14.0394
Cell Significance Index: 242.7500 - Cell Name: hepatoblast (CL0005026)
Fold Change: 4.4116
Cell Significance Index: 74.2000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.6074
Cell Significance Index: 16.2800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.5447
Cell Significance Index: 9.1800 - Cell Name: plasmablast (CL0000980)
Fold Change: 0.5388
Cell Significance Index: 5.0000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1953
Cell Significance Index: 38.7600 - Cell Name: thymocyte (CL0000893)
Fold Change: 0.1820
Cell Significance Index: 2.3000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.1294
Cell Significance Index: 1.9100 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.0998
Cell Significance Index: 0.5800 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 0.0948
Cell Significance Index: 0.2500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0808
Cell Significance Index: 1.1600 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.0184
Cell Significance Index: 0.2400 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.0159
Cell Significance Index: 0.1600 - Cell Name: microglial cell (CL0000129)
Fold Change: 0.0119
Cell Significance Index: 0.1400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: 0.0028
Cell Significance Index: 0.1100 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: 0.0015
Cell Significance Index: 0.0300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0013
Cell Significance Index: 0.1500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0007
Cell Significance Index: -0.5400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0011
Cell Significance Index: -0.6000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0018
Cell Significance Index: -0.3700 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0029
Cell Significance Index: -0.0700 - Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.0070
Cell Significance Index: -0.0800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0093
Cell Significance Index: -0.5200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0108
Cell Significance Index: -0.2300 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0159
Cell Significance Index: -0.2200 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.0187
Cell Significance Index: -0.2000 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0210
Cell Significance Index: -0.3100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0230
Cell Significance Index: -1.2000 - Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.0248
Cell Significance Index: -0.2800 - Cell Name: endothelial cell (CL0000115)
Fold Change: -0.0260
Cell Significance Index: -0.3200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0316
Cell Significance Index: -5.6900 - Cell Name: chromaffin cell (CL0000166)
Fold Change: -0.0322
Cell Significance Index: -0.3600 - Cell Name: lymphocyte (CL0000542)
Fold Change: -0.0323
Cell Significance Index: -0.4400 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: -0.0324
Cell Significance Index: -0.4600 - Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.0331
Cell Significance Index: -0.3300 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0334
Cell Significance Index: -0.8100 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0363
Cell Significance Index: -0.4800 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.0365
Cell Significance Index: -0.4200 - Cell Name: acinar cell (CL0000622)
Fold Change: -0.0398
Cell Significance Index: -0.5000 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.0458
Cell Significance Index: -0.3900 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.0467
Cell Significance Index: -0.6000 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.0473
Cell Significance Index: -0.4500 - Cell Name: Schwann cell precursor (CL0002375)
Fold Change: -0.0490
Cell Significance Index: -0.3900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0519
Cell Significance Index: -5.3000 - Cell Name: neural cell (CL0002319)
Fold Change: -0.0531
Cell Significance Index: -0.6200 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.0540
Cell Significance Index: -0.5700 - Cell Name: Schwann cell (CL0002573)
Fold Change: -0.0563
Cell Significance Index: -0.6300 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0583
Cell Significance Index: -0.6400 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0593
Cell Significance Index: -1.1600 - Cell Name: astrocyte (CL0000127)
Fold Change: -0.0603
Cell Significance Index: -0.6900 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0605
Cell Significance Index: -0.9800 - Cell Name: cardiac neuron (CL0010022)
Fold Change: -0.0612
Cell Significance Index: -0.7400 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0624
Cell Significance Index: -0.7600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0626
Cell Significance Index: -1.3700 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0627
Cell Significance Index: -0.8600 - Cell Name: pericyte (CL0000669)
Fold Change: -0.0634
Cell Significance Index: -0.7600 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0640
Cell Significance Index: -1.6300 - Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0640
Cell Significance Index: -0.3800 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.0650
Cell Significance Index: -0.7200 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.0653
Cell Significance Index: -0.6200 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.0655
Cell Significance Index: -0.9000 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.0661
Cell Significance Index: -0.7900 - Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.0672
Cell Significance Index: -0.7800 - Cell Name: naive B cell (CL0000788)
Fold Change: -0.0674
Cell Significance Index: -0.7100 - Cell Name: erythroblast (CL0000765)
Fold Change: -0.0688
Cell Significance Index: -0.8200 - Cell Name: ciliated cell (CL0000064)
Fold Change: -0.0692
Cell Significance Index: -0.7500 - Cell Name: glial cell (CL0000125)
Fold Change: -0.0694
Cell Significance Index: -0.7600 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0696
Cell Significance Index: -0.9100 - Cell Name: diffuse bipolar 6 cell (CL4033032)
Fold Change: -0.0710
Cell Significance Index: -0.8200 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.0719
Cell Significance Index: -0.7300 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.0720
Cell Significance Index: -0.5600 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0734
Cell Significance Index: -0.7600 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.0757
Cell Significance Index: -0.6400 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0769
Cell Significance Index: -0.9700 - Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.0777
Cell Significance Index: -0.6800 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0781
Cell Significance Index: -1.3400 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.0791
Cell Significance Index: -0.7600 - Cell Name: naive T cell (CL0000898)
Fold Change: -0.0804
Cell Significance Index: -0.7300 - Cell Name: Mueller cell (CL0000636)
Fold Change: -0.0806
Cell Significance Index: -0.6200 - Cell Name: obsolete animal cell (CL0000548)
Fold Change: -0.0838
Cell Significance Index: -0.8500 - Cell Name: progenitor cell (CL0011026)
Fold Change: -0.0857
Cell Significance Index: -0.9100 - Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.0884
Cell Significance Index: -0.7300 - Cell Name: basal cell (CL0000646)
Fold Change: -0.0895
Cell Significance Index: -1.0700 - Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.0908
Cell Significance Index: -0.7300 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: -0.0916
Cell Significance Index: -0.3500 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.0936
Cell Significance Index: -1.1300 - Cell Name: paneth cell (CL0000510)
Fold Change: -0.0936
Cell Significance Index: -0.9700 - Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0948
Cell Significance Index: -1.2600 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0955
Cell Significance Index: -1.4500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2678755508
Symbol: MBL2_HUMAN
Name: Collectin-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2450948
Title: A human mannose-binding protein is an acute-phase reactant that shares sequence homology with other vertebrate lectins.
PubMed ID: 2450948
PubMed ID: 2477486
Title: The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10.
PubMed ID: 2477486
PubMed ID: 2590164
Title: Structure and evolutionary origin of the gene encoding a human serum mannose-binding protein.
PubMed ID: 2590164
DOI: 10.1042/bj2620763
PubMed ID: 9743385
Title: Different molecular events result in low protein levels of mannan-binding lectin in populations from South-East Africa and South America.
PubMed ID: 9743385
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12175909
Title: Restricted polymorphisms of the mannose-binding lectin gene in a population of Papua New Guinea.
PubMed ID: 12175909
PubMed ID: 7982896
Title: Structure and function of mannan-binding proteins isolated from human liver and serum.
PubMed ID: 7982896
PubMed ID: 9087411
Title: A second serine protease associated with mannan-binding lectin that activates complement.
PubMed ID: 9087411
DOI: 10.1038/386506a0
PubMed ID: 14515269
Title: Mannose-binding lectin engagement with late apoptotic and necrotic cells.
PubMed ID: 14515269
PubMed ID: 15145932
Title: Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin.
PubMed ID: 15145932
PubMed ID: 16116208
Title: Mannan-binding protein blocks the activation of metalloproteases meprin alpha and beta.
PubMed ID: 16116208
PubMed ID: 18006063
Title: Comparative study of the human ficolins reveals unique features of Ficolin-3 (Hakata antigen).
PubMed ID: 18006063
PubMed ID: 23460739
Title: Deciphering complement receptor type 1 interactions with recognition proteins of the lectin complement pathway.
PubMed ID: 23460739
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 29563915
Title: C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules.
PubMed ID: 29563915
PubMed ID: 35102342
Title: Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules.
PubMed ID: 35102342
PubMed ID: 7634089
Title: Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil.
PubMed ID: 7634089
DOI: 10.1038/nsb1194-789
PubMed ID: 1675710
Title: Molecular basis of opsonic defect in immunodeficient children.
PubMed ID: 1675710
PubMed ID: 1304173
Title: High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene.
PubMed ID: 1304173
DOI: 10.1093/hmg/1.9.709
PubMed ID: 1303250
Title: Distinct and overlapping functions of allelic forms of human mannose binding protein.
PubMed ID: 1303250
DOI: 10.1038/ng0992-50
PubMed ID: 10447262
Title: Genotyping of the three major allelic variants of the human mannose-binding lectin gene by denaturing gradient gel electrophoresis.
PubMed ID: 10447262
DOI: 10.1002/(sici)1098-1004(1999)14:1<80::aid-humu10>3.0.co;2-j
PubMed ID: 15994813
Title: Mannose binding lectin genotypes influence recovery from hepatitis B virus infection.
PubMed ID: 15994813
PubMed ID: 21695215
Title: Variant G57E of mannose binding lectin associated with protection against tuberculosis caused by Mycobacterium africanum but not by M. tuberculosis.
PubMed ID: 21695215
Sequence Information:
- Length: 248
- Mass: 26144
- Checksum: C1F2AAED46D0F774
- Sequence:
MSLFPSLPLL LLSMVAASYS ETVTCEDAQK TCPAVIACSS PGINGFPGKD GRDGTKGEKG EPGQGLRGLQ GPPGKLGPPG NPGPSGSPGP KGQKGDPGKS PDGDSSLAAS ERKALQTEMA RIKKWLTFSL GKQVGNKFFL TNGEIMTFEK VKALCVKFQA SVATPRNAAE NGAIQNLIKE EAFLGITDEK TEGQFVDLTG NRLTYTNWNE GEPNNAGSDE DCVLLLKNGQ WNDVPCSTSH LAVCEFPI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.