Details for: TRNC

Gene ID: 4511

Symbol: TRNC

Ensembl ID: ENSG00000210140

Description: tRNA-Cys

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 6.0651
    Cell Significance Index: 274.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 5.3123
    Cell Significance Index: 79.6000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 4.8578
    Cell Significance Index: 42.8000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 4.4586
    Cell Significance Index: 111.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.9221
    Cell Significance Index: 84.1900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.8076
    Cell Significance Index: 19.5900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 1.6395
    Cell Significance Index: 19.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1041
    Cell Significance Index: 51.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9083
    Cell Significance Index: 47.1900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.6512
    Cell Significance Index: 6.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.5924
    Cell Significance Index: 17.4500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.5839
    Cell Significance Index: 7.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4480
    Cell Significance Index: 9.7100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.3893
    Cell Significance Index: 5.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3606
    Cell Significance Index: 7.4800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.3332
    Cell Significance Index: 3.3000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.2134
    Cell Significance Index: 2.3100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.1774
    Cell Significance Index: 1.2300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.1714
    Cell Significance Index: 2.3700
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.1380
    Cell Significance Index: 1.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1127
    Cell Significance Index: 3.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0696
    Cell Significance Index: 11.8800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0499
    Cell Significance Index: 0.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0332
    Cell Significance Index: 3.8000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0187
    Cell Significance Index: 0.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0121
    Cell Significance Index: 3.5000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0048
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0060
    Cell Significance Index: -11.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0088
    Cell Significance Index: -16.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0107
    Cell Significance Index: -16.4900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0143
    Cell Significance Index: -0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0171
    Cell Significance Index: -10.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0177
    Cell Significance Index: -13.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0246
    Cell Significance Index: -11.1800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0384
    Cell Significance Index: -0.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0459
    Cell Significance Index: -2.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0488
    Cell Significance Index: -1.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0521
    Cell Significance Index: -10.4600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0634
    Cell Significance Index: -0.8800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0771
    Cell Significance Index: -1.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0781
    Cell Significance Index: -11.3600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0805
    Cell Significance Index: -1.6100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0926
    Cell Significance Index: -0.9600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1020
    Cell Significance Index: -0.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1054
    Cell Significance Index: -2.8700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1146
    Cell Significance Index: -1.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1192
    Cell Significance Index: -7.3100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1568
    Cell Significance Index: -1.5800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1615
    Cell Significance Index: -1.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1620
    Cell Significance Index: -3.4500
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.1773
    Cell Significance Index: -1.5600
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.1909
    Cell Significance Index: -1.9500
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.2093
    Cell Significance Index: -1.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2531
    Cell Significance Index: -6.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2566
    Cell Significance Index: -8.4000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2588
    Cell Significance Index: -3.1500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2599
    Cell Significance Index: -3.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2609
    Cell Significance Index: -3.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2822
    Cell Significance Index: -9.0400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2874
    Cell Significance Index: -4.3000
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.3040
    Cell Significance Index: -2.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3134
    Cell Significance Index: -9.9800
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.3264
    Cell Significance Index: -2.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3272
    Cell Significance Index: -4.8300
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.3347
    Cell Significance Index: -3.6900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3384
    Cell Significance Index: -3.5700
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.3605
    Cell Significance Index: -2.9800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3643
    Cell Significance Index: -5.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3752
    Cell Significance Index: -9.3600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3759
    Cell Significance Index: -3.8900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3845
    Cell Significance Index: -4.9400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3854
    Cell Significance Index: -9.8200
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.3952
    Cell Significance Index: -3.8100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3993
    Cell Significance Index: -4.3500
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.4011
    Cell Significance Index: -4.9800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4025
    Cell Significance Index: -5.7300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4131
    Cell Significance Index: -8.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4194
    Cell Significance Index: -8.4200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.4240
    Cell Significance Index: -5.0500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4559
    Cell Significance Index: -5.3600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.4776
    Cell Significance Index: -4.8800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4795
    Cell Significance Index: -10.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4855
    Cell Significance Index: -10.3100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4974
    Cell Significance Index: -6.8300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.5113
    Cell Significance Index: -4.4700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5121
    Cell Significance Index: -12.7700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5145
    Cell Significance Index: -8.8700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5187
    Cell Significance Index: -6.2000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5214
    Cell Significance Index: -16.4900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5413
    Cell Significance Index: -9.3600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.5417
    Cell Significance Index: -5.5300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.5471
    Cell Significance Index: -6.3000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.5511
    Cell Significance Index: -9.4200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.5517
    Cell Significance Index: -3.9700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5578
    Cell Significance Index: -11.0300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.5660
    Cell Significance Index: -7.0700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5887
    Cell Significance Index: -11.5100
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.6070
    Cell Significance Index: -6.5900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.6183
    Cell Significance Index: -7.6000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.6624
    Cell Significance Index: -11.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Specific Expression:** tRNA-Cys is significantly expressed in various cell types within the intestinal epithelium, including enterocytes, Paneth cells, goblet cells, and intestinal stem cells. 2. **Tissue-Specific Expression:** The expression of tRNA-Cys is highly specific to the gut epithelium, suggesting a specialized function in cysteine metabolism. 3. **Cysteine Metabolism:** tRNA-Cys is involved in the translation of cysteine-containing amino acids from mRNA to proteins, playing a critical role in cysteine metabolism. 4. **Abnormal Expression in Disease States:** Altered expression of tRNA-Cys has been observed in various disease states, including neoplastic transformations and abnormal cell growth. **Pathways and Functions:** 1. **Cysteine Metabolism:** tRNA-Cys is involved in the translation of cysteine-containing amino acids from mRNA to proteins, regulating cysteine metabolism in the gut. 2. **Protein Synthesis:** tRNA-Cys is essential for the synthesis of proteins involved in cellular homeostasis, immune responses, and tissue repair. 3. **Gut Homeostasis:** The expression of tRNA-Cys is critical for maintaining the delicate balance of cysteine metabolism in the gut, ensuring the proper functioning of the intestinal epithelium. 4. **Immune Response:** tRNA-Cys is involved in the regulation of immune responses, including the synthesis of proteins involved in inflammation and immune cell function. **Clinical Significance:** 1. **Gastrointestinal Disorders:** Altered expression of tRNA-Cys has been observed in various gastrointestinal disorders, including inflammatory bowel disease (IBD), colorectal cancer, and other neoplastic transformations. 2. **Cysteine Metabolism Dysregulation:** Dysregulation of tRNA-Cys expression has been linked to cysteine metabolism dysregulation, which can contribute to the development of various diseases. 3. **Personalized Medicine:** Further investigation of tRNA-Cys expression and function may provide new insights into the diagnosis and treatment of gastrointestinal disorders. 4. **Therapeutic Targeting:** Targeting tRNA-Cys and its associated pathways may provide new therapeutic strategies for the treatment of gastrointestinal disorders. In conclusion, the tRNA-Cys gene plays a critical role in maintaining intestinal homeostasis and regulating cysteine metabolism in the gut epithelium. Further investigation of tRNA-Cys expression and function is necessary to fully understand its role in gastrointestinal disorders and to develop new therapeutic strategies for the treatment of these diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.