Details for: TRNH

Gene ID: 4564

Symbol: TRNH

Ensembl ID: ENSG00000210176

Description: tRNA-His

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 23.5146
    Cell Significance Index: 180.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 6.7620
    Cell Significance Index: 306.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 5.3710
    Cell Significance Index: 80.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 3.9866
    Cell Significance Index: 99.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.4990
    Cell Significance Index: 72.0000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 2.3022
    Cell Significance Index: 24.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6871
    Cell Significance Index: 78.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.6710
    Cell Significance Index: 24.6700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.8909
    Cell Significance Index: 11.5100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.8588
    Cell Significance Index: 10.4100
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.7458
    Cell Significance Index: 6.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7061
    Cell Significance Index: 36.6800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.5776
    Cell Significance Index: 7.7000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.5140
    Cell Significance Index: 6.4500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.4186
    Cell Significance Index: 4.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3113
    Cell Significance Index: 9.1700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1825
    Cell Significance Index: 2.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1237
    Cell Significance Index: 2.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1222
    Cell Significance Index: 2.5400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.1020
    Cell Significance Index: 1.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0914
    Cell Significance Index: 15.6200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0429
    Cell Significance Index: 0.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0101
    Cell Significance Index: 1.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0076
    Cell Significance Index: 2.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0039
    Cell Significance Index: -2.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0058
    Cell Significance Index: -10.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0084
    Cell Significance Index: -12.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0095
    Cell Significance Index: -12.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0116
    Cell Significance Index: -0.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0143
    Cell Significance Index: -9.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0263
    Cell Significance Index: -11.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0364
    Cell Significance Index: -1.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0387
    Cell Significance Index: -7.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0425
    Cell Significance Index: -1.4900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0455
    Cell Significance Index: -1.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0465
    Cell Significance Index: -1.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0467
    Cell Significance Index: -1.2700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0582
    Cell Significance Index: -0.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0589
    Cell Significance Index: -1.4700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0637
    Cell Significance Index: -0.6600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0704
    Cell Significance Index: -1.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0755
    Cell Significance Index: -10.9800
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0757
    Cell Significance Index: -0.9400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0808
    Cell Significance Index: -1.5900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0839
    Cell Significance Index: -1.4500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0924
    Cell Significance Index: -1.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1023
    Cell Significance Index: -6.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1076
    Cell Significance Index: -2.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1108
    Cell Significance Index: -2.1900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1136
    Cell Significance Index: -1.1500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1147
    Cell Significance Index: -1.6500
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1179
    Cell Significance Index: -1.3000
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.1244
    Cell Significance Index: -1.3500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1614
    Cell Significance Index: -1.7700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1619
    Cell Significance Index: -1.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1762
    Cell Significance Index: -4.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1773
    Cell Significance Index: -3.7800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1838
    Cell Significance Index: -2.5500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1856
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1882
    Cell Significance Index: -2.3700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2113
    Cell Significance Index: -2.9300
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2239
    Cell Significance Index: -3.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2323
    Cell Significance Index: -7.4400
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.2364
    Cell Significance Index: -2.0800
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2525
    Cell Significance Index: -2.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2551
    Cell Significance Index: -3.4800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2673
    Cell Significance Index: -4.2400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2755
    Cell Significance Index: -7.0200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2958
    Cell Significance Index: -3.8000
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.3225
    Cell Significance Index: -2.4300
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.3292
    Cell Significance Index: -3.2600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.3474
    Cell Significance Index: -4.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3722
    Cell Significance Index: -7.9000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.3738
    Cell Significance Index: -3.9700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.3749
    Cell Significance Index: -2.6000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3791
    Cell Significance Index: -4.1300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3887
    Cell Significance Index: -4.1000
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.4264
    Cell Significance Index: -4.5000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4369
    Cell Significance Index: -6.0000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4395
    Cell Significance Index: -5.4900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4405
    Cell Significance Index: -7.5300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.4452
    Cell Significance Index: -3.6800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4490
    Cell Significance Index: -7.7400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4622
    Cell Significance Index: -6.5800
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.4689
    Cell Significance Index: -4.7900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.5044
    Cell Significance Index: -6.2000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5080
    Cell Significance Index: -6.4100
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.5114
    Cell Significance Index: -3.6800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.5165
    Cell Significance Index: -4.9100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.5269
    Cell Significance Index: -4.7900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.5314
    Cell Significance Index: -5.4300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.5389
    Cell Significance Index: -6.5000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.5405
    Cell Significance Index: -5.7500
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.5466
    Cell Significance Index: -6.7300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.5554
    Cell Significance Index: -6.5300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.5560
    Cell Significance Index: -6.4600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.5570
    Cell Significance Index: -9.4600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.5672
    Cell Significance Index: -6.7500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5795
    Cell Significance Index: -11.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **tRNA-His is a transfer RNA gene**: TRNH is a type of transfer RNA (tRNA) that plays a crucial role in protein synthesis, specifically in the incorporation of histidine residues into proteins. 2. **Widespread expression in the intestine**: TRNH is significantly expressed in various cell types within the large intestine, including epithelial cells, immune cells, and stem cells. 3. **Diversity of cell types**: TRNH is expressed in a range of cell types, including enterocytes, plasma cells, Paneth cells, goblet cells, absorptive cells, intestinal crypt stem cells, transit amplifying cells, and mast cells, highlighting its importance in maintaining intestinal homeostasis. 4. **Association with disease states**: TRNH is also found in abnormal and neoplastic cells, suggesting its involvement in disease processes. **Pathways and Functions:** 1. **Protein synthesis**: TRNH is involved in the incorporation of histidine residues into proteins, which is essential for various cellular processes, including cell signaling, immune response, and tissue homeostasis. 2. **Immune regulation**: TRNH is expressed in immune cells, such as plasma cells and mast cells, and is involved in the regulation of the immune response, including the activation of immune cells and the production of cytokines. 3. **Gut-associated lymphoid tissue (GALT) function**: TRNH is essential for the proper functioning of GALT, which is critical for maintaining intestinal homeostasis and regulating the immune response. 4. **Cell signaling**: TRNH may be involved in cell signaling pathways, including the regulation of cell growth, differentiation, and survival. **Clinical Significance:** 1. **Gastrointestinal disorders**: Alterations in TRNH expression have been linked to various gastrointestinal disorders, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and colorectal cancer. 2. **Immune system dysregulation**: TRNH is involved in the regulation of the immune response, and alterations in its expression may contribute to immune system dysregulation, which is a hallmark of various diseases, including autoimmune disorders and cancer. 3. **Cancer development**: TRNH is expressed in abnormal and neoplastic cells, suggesting its involvement in cancer development and progression. 4. **Therapeutic targets**: Understanding the functions and regulation of TRNH may lead to the identification of new therapeutic targets for the treatment of gastrointestinal disorders and immune system dysregulation. In conclusion, TRNH is a critical gene that plays a vital role in maintaining intestinal homeostasis and regulating the immune response. Further research is needed to fully understand the functions and regulation of TRNH, as well as its clinical significance in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.