Details for: TRNM

Gene ID: 4569

Symbol: TRNM

Ensembl ID: ENSG00000210112

Description: tRNA-Met

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 4.7501
    Cell Significance Index: 118.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.5577
    Cell Significance Index: 161.2600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.2074
    Cell Significance Index: 31.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.6760
    Cell Significance Index: 77.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.6568
    Cell Significance Index: 39.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.5864
    Cell Significance Index: 76.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.0686
    Cell Significance Index: 107.4600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 1.5326
    Cell Significance Index: 20.4300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.4856
    Cell Significance Index: 25.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2167
    Cell Significance Index: 56.7300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.8822
    Cell Significance Index: 9.2100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.7446
    Cell Significance Index: 8.0700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.5375
    Cell Significance Index: 5.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4611
    Cell Significance Index: 12.5500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.3370
    Cell Significance Index: 4.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2793
    Cell Significance Index: 80.3600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.2248
    Cell Significance Index: 2.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1667
    Cell Significance Index: 28.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1525
    Cell Significance Index: 17.4700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1517
    Cell Significance Index: 1.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1451
    Cell Significance Index: 1.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1177
    Cell Significance Index: 7.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0563
    Cell Significance Index: 1.2200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0512
    Cell Significance Index: 0.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0075
    Cell Significance Index: -14.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0177
    Cell Significance Index: -13.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0194
    Cell Significance Index: -12.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0206
    Cell Significance Index: -11.6300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0222
    Cell Significance Index: -0.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0336
    Cell Significance Index: -15.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0398
    Cell Significance Index: -1.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0466
    Cell Significance Index: -9.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0489
    Cell Significance Index: -1.0200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0530
    Cell Significance Index: -0.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0789
    Cell Significance Index: -11.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1240
    Cell Significance Index: -7.6000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1268
    Cell Significance Index: -1.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1385
    Cell Significance Index: -1.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1421
    Cell Significance Index: -14.8000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1699
    Cell Significance Index: -1.8400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1909
    Cell Significance Index: -2.6400
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.2029
    Cell Significance Index: -1.4600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2338
    Cell Significance Index: -2.4200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.2455
    Cell Significance Index: -3.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3111
    Cell Significance Index: -6.6300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3305
    Cell Significance Index: -6.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3366
    Cell Significance Index: -11.0200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3407
    Cell Significance Index: -4.1300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3525
    Cell Significance Index: -8.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3537
    Cell Significance Index: -12.3900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3561
    Cell Significance Index: -5.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3578
    Cell Significance Index: -11.4600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.3655
    Cell Significance Index: -3.7900
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.3753
    Cell Significance Index: -4.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3815
    Cell Significance Index: -12.1500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3830
    Cell Significance Index: -3.8400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3981
    Cell Significance Index: -9.9300
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.4015
    Cell Significance Index: -3.5100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4294
    Cell Significance Index: -4.5300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.4471
    Cell Significance Index: -5.6300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4919
    Cell Significance Index: -5.6600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.4983
    Cell Significance Index: -5.4500
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.5088
    Cell Significance Index: -5.3200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5460
    Cell Significance Index: -9.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5462
    Cell Significance Index: -14.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5524
    Cell Significance Index: -11.7300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.5527
    Cell Significance Index: -7.1000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.5571
    Cell Significance Index: -7.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5693
    Cell Significance Index: -12.3000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5806
    Cell Significance Index: -11.4800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.5821
    Cell Significance Index: -9.9500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5836
    Cell Significance Index: -12.1800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.5902
    Cell Significance Index: -12.0100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5924
    Cell Significance Index: -11.6600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.6083
    Cell Significance Index: -9.1000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6271
    Cell Significance Index: -12.5900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.6328
    Cell Significance Index: -7.4400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.6377
    Cell Significance Index: -6.5100
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.6702
    Cell Significance Index: -7.3900
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.6830
    Cell Significance Index: -6.0100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.6932
    Cell Significance Index: -8.6600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.6954
    Cell Significance Index: -8.2100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.7227
    Cell Significance Index: -8.6000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.7236
    Cell Significance Index: -7.5900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.7292
    Cell Significance Index: -8.7200
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.7391
    Cell Significance Index: -7.0700
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.7434
    Cell Significance Index: -7.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7475
    Cell Significance Index: -12.8100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.7493
    Cell Significance Index: -9.2100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.7570
    Cell Significance Index: -14.8000
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.7582
    Cell Significance Index: -10.3100
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.7663
    Cell Significance Index: -6.0100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.7666
    Cell Significance Index: -9.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7810
    Cell Significance Index: -11.5300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.7867
    Cell Significance Index: -8.3700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.7892
    Cell Significance Index: -6.6700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.7894
    Cell Significance Index: -7.6100
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.7911
    Cell Significance Index: -5.9600
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.8148
    Cell Significance Index: -8.8100
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.8154
    Cell Significance Index: -8.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Tissue-specific expression**: tRNA-Met is significantly expressed in cells of the immune system, including CD4+ and CD8+ alpha-beta thymocytes, as well as mesenchymal stem cells, enterocytes, Paneth cells, and goblet cells in the colon. 2. **Conserved expression**: The gene is also expressed in bladder urothelial cells and intestinal crypt stem cells, indicating its importance in multiple cell types. 3. **Tissue-specific localization**: tRNA-Met is primarily localized to the mitochondria, where it plays a critical role in the translation of Met codons. **Pathways and Functions:** 1. **Translation of Met codons**: tRNA-Met is essential for the translation of Met codons (AUG) into the amino acid methionine, which is a crucial building block for protein synthesis. 2. **Regulation of immune cell development**: tRNA-Met is involved in the development and maturation of immune cells, including T cells and dendritic cells, which are critical for the adaptive immune response. 3. **Maintenance of intestinal homeostasis**: tRNA-Met is also involved in the regulation of intestinal homeostasis, including the maintenance of the epithelial barrier and the regulation of the immune response in the gut. 4. **Mitochondrial function**: tRNA-Met plays a critical role in mitochondrial function, where it is involved in the regulation of energy metabolism and the production of reactive oxygen species (ROS). **Clinical Significance:** 1. **Immune-related disorders**: Alterations in tRNA-Met expression have been implicated in various immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: tRNA-Met has been shown to play a critical role in cancer development and progression, including the regulation of cell proliferation and apoptosis. 3. **Intestinal disorders**: tRNA-Met has been implicated in the regulation of intestinal homeostasis, and alterations in its expression have been associated with various intestinal disorders, including inflammatory bowel disease (IBD) and colorectal cancer. 4. **Mitochondrial dysfunction**: tRNA-Met dysfunction has been linked to various mitochondrial disorders, including neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. In conclusion, the tRNA-Met gene plays a critical role in the development and function of immune cells, as well as the maintenance of intestinal homeostasis. Its dysregulation has been implicated in various immune-related disorders and cancer, highlighting the importance of this gene in human health and disease. Further research is needed to fully elucidate the mechanisms by which tRNA-Met regulates immune cell development and intestinal homeostasis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.