Details for: TRNP

Gene ID: 4571

Symbol: TRNP

Ensembl ID: ENSG00000210196

Description: tRNA-Pro

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 8.1036
    Cell Significance Index: 367.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 5.6987
    Cell Significance Index: 85.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.6382
    Cell Significance Index: 169.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.1739
    Cell Significance Index: 91.4500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 2.5439
    Cell Significance Index: 27.5700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.3353
    Cell Significance Index: 32.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.1045
    Cell Significance Index: 31.0700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.9474
    Cell Significance Index: 48.6400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.7218
    Cell Significance Index: 15.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.0367
    Cell Significance Index: 177.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0220
    Cell Significance Index: 53.0900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.5716
    Cell Significance Index: 5.5300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.4807
    Cell Significance Index: 4.5700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.4623
    Cell Significance Index: 7.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.4404
    Cell Significance Index: 50.4600
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.3191
    Cell Significance Index: 2.7900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.3113
    Cell Significance Index: 3.3700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.2920
    Cell Significance Index: 3.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2668
    Cell Significance Index: 5.7800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.2414
    Cell Significance Index: 2.4200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.1623
    Cell Significance Index: 1.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1204
    Cell Significance Index: 4.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1147
    Cell Significance Index: 2.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0878
    Cell Significance Index: 25.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0080
    Cell Significance Index: -15.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0108
    Cell Significance Index: -19.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0132
    Cell Significance Index: -20.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0148
    Cell Significance Index: -20.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0201
    Cell Significance Index: -14.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0219
    Cell Significance Index: -12.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0232
    Cell Significance Index: -14.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0296
    Cell Significance Index: -18.5000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0411
    Cell Significance Index: -0.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0414
    Cell Significance Index: -2.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0445
    Cell Significance Index: -20.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0482
    Cell Significance Index: -9.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0896
    Cell Significance Index: -2.8700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0977
    Cell Significance Index: -1.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0990
    Cell Significance Index: -14.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1022
    Cell Significance Index: -3.5800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1148
    Cell Significance Index: -1.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1161
    Cell Significance Index: -3.8000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1318
    Cell Significance Index: -1.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1455
    Cell Significance Index: -15.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1535
    Cell Significance Index: -9.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1640
    Cell Significance Index: -4.0900
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.1695
    Cell Significance Index: -2.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2050
    Cell Significance Index: -5.5800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2160
    Cell Significance Index: -2.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2760
    Cell Significance Index: -8.1300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3465
    Cell Significance Index: -4.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3517
    Cell Significance Index: -11.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3625
    Cell Significance Index: -7.7200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3854
    Cell Significance Index: -8.1800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4006
    Cell Significance Index: -8.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4089
    Cell Significance Index: -10.5100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4228
    Cell Significance Index: -8.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4392
    Cell Significance Index: -11.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4527
    Cell Significance Index: -9.7800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4689
    Cell Significance Index: -9.3500
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.4792
    Cell Significance Index: -6.0400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4986
    Cell Significance Index: -10.0100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5229
    Cell Significance Index: -7.5200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.5260
    Cell Significance Index: -6.6000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5578
    Cell Significance Index: -8.8500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.5697
    Cell Significance Index: -7.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5937
    Cell Significance Index: -8.1000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.5986
    Cell Significance Index: -12.1800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6188
    Cell Significance Index: -12.1800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.6609
    Cell Significance Index: -8.4900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.6648
    Cell Significance Index: -8.3500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6756
    Cell Significance Index: -13.2100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.6759
    Cell Significance Index: -10.1100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.6849
    Cell Significance Index: -7.1500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.6856
    Cell Significance Index: -11.7200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.7058
    Cell Significance Index: -7.7200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.7185
    Cell Significance Index: -9.4100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.7325
    Cell Significance Index: -7.3800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7391
    Cell Significance Index: -18.4300
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.7500
    Cell Significance Index: -11.2200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.8241
    Cell Significance Index: -9.6900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.8333
    Cell Significance Index: -10.4100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.8433
    Cell Significance Index: -12.1100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.8469
    Cell Significance Index: -10.4100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.8496
    Cell Significance Index: -10.1100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.8514
    Cell Significance Index: -12.1200
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.8553
    Cell Significance Index: -8.4700
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.8616
    Cell Significance Index: -9.5000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.8816
    Cell Significance Index: -9.3000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.8832
    Cell Significance Index: -15.0000
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.8840
    Cell Significance Index: -9.0300
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.9015
    Cell Significance Index: -11.1000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.9052
    Cell Significance Index: -9.6300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.9077
    Cell Significance Index: -10.4500
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.9158
    Cell Significance Index: -7.5700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.9186
    Cell Significance Index: -10.9900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.9214
    Cell Significance Index: -12.0500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.9270
    Cell Significance Index: -12.7300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.9292
    Cell Significance Index: -12.1300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.9512
    Cell Significance Index: -11.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRNP is a small non-coding RNA molecule that is significantly expressed in diverse cell types, including Paneth cells of the colon, enterocytes of the epithelial lining of the large intestine, duct epithelial cells, CD4-positive T cells, alpha-beta thymocytes, acinar cells of the salivary gland, innate lymphoid cells, hepatocytes, goblet cells, and mesenchymal stem cells. Its widespread expression highlights its multifaceted role in maintaining tissue homeostasis and immune function. **Pathways and Functions:** TRNP's functions are multifaceted and involve various cellular processes: 1. **Tissue-specific expression:** TRNP is differentially expressed in various tissues, suggesting its involvement in tissue-specific functions. Its presence in Paneth cells, for example, may contribute to the maintenance of intestinal homeostasis. 2. **Immune regulation:** TRNP may play a role in regulating immune responses by modulating the activity of immune cells, such as T cells and innate lymphoid cells. Its expression in CD4-positive T cells and alpha-beta thymocytes suggests a potential role in T cell development and function. 3. **Cellular differentiation:** TRNP may be involved in the regulation of cellular differentiation processes, particularly in the development of goblet cells and acinar cells. Its expression in these cell types may contribute to the maintenance of epithelial homeostasis. 4. **Regulation of gene expression:** TRNP may act as a regulatory element that modulates the expression of other genes, potentially influencing cellular processes such as proliferation, differentiation, and survival. **Clinical Significance:** The significance of TRNP in human disease is multifaceted: 1. **Gastrointestinal disorders:** Abnormal expression of TRNP in Paneth cells and enterocytes may contribute to gastrointestinal disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). 2. **Immunodeficiency:** Dysregulation of TRNP expression in immune cells may lead to immunodeficiency, increasing the susceptibility to infections and autoimmune diseases. 3. **Cancer:** TRNP's role in cellular differentiation and regulation of gene expression may contribute to the development and progression of certain cancers, such as colorectal cancer. 4. **Tissue-specific disorders:** TRNP's expression in specific tissues, such as the salivary gland, may contribute to the development of tissue-specific disorders, such as salivary gland dysfunction. In conclusion, TRNP is a complex gene with multiple roles in maintaining tissue homeostasis and regulating immune responses. Further research is necessary to elucidate the precise mechanisms by which TRNP functions and to explore its clinical significance in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.