Details for: OR1F1

Gene ID: 4992

Symbol: OR1F1

Ensembl ID: ENSG00000168124

Description: olfactory receptor family 1 subfamily F member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 8.2442
    Cell Significance Index: 210.0500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 4.9258
    Cell Significance Index: 79.7800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.3345
    Cell Significance Index: 57.0000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.9904
    Cell Significance Index: 27.3000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.6102
    Cell Significance Index: 20.8400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.2416
    Cell Significance Index: 13.1900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1164
    Cell Significance Index: 1.6900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.0769
    Cell Significance Index: 1.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0156
    Cell Significance Index: 0.2300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0004
    Cell Significance Index: -0.0900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0036
    Cell Significance Index: -0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0050
    Cell Significance Index: -1.8100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0062
    Cell Significance Index: -0.0400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0065
    Cell Significance Index: -0.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0071
    Cell Significance Index: -2.0300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0167
    Cell Significance Index: -0.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0180
    Cell Significance Index: -0.6300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0190
    Cell Significance Index: -0.2500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0245
    Cell Significance Index: -0.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0258
    Cell Significance Index: -0.8500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0269
    Cell Significance Index: -0.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0295
    Cell Significance Index: -0.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0356
    Cell Significance Index: -2.1900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0359
    Cell Significance Index: -0.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0454
    Cell Significance Index: -1.0000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0585
    Cell Significance Index: -1.1800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0602
    Cell Significance Index: -0.7900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0697
    Cell Significance Index: -1.3900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0704
    Cell Significance Index: -0.6200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0716
    Cell Significance Index: -0.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0740
    Cell Significance Index: -1.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0887
    Cell Significance Index: -1.2700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0887
    Cell Significance Index: -1.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0888
    Cell Significance Index: -2.1300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0921
    Cell Significance Index: -0.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0926
    Cell Significance Index: -2.0000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0939
    Cell Significance Index: -1.9600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0981
    Cell Significance Index: -1.0400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0992
    Cell Significance Index: -0.9900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1029
    Cell Significance Index: -1.4000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1065
    Cell Significance Index: -1.1100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1077
    Cell Significance Index: -2.1200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1088
    Cell Significance Index: -1.1700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1092
    Cell Significance Index: -1.0100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1092
    Cell Significance Index: -1.2900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1099
    Cell Significance Index: -1.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1111
    Cell Significance Index: -1.2100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1174
    Cell Significance Index: -1.3000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1200
    Cell Significance Index: -1.4600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1232
    Cell Significance Index: -1.5000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1239
    Cell Significance Index: -1.3600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1245
    Cell Significance Index: -1.3500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1246
    Cell Significance Index: -2.1600
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1278
    Cell Significance Index: -1.4200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1316
    Cell Significance Index: -1.6000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1336
    Cell Significance Index: -1.5500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1340
    Cell Significance Index: -1.4900
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1342
    Cell Significance Index: -1.3900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1347
    Cell Significance Index: -1.2400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1353
    Cell Significance Index: -1.2600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1384
    Cell Significance Index: -1.2100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1385
    Cell Significance Index: -1.1800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1460
    Cell Significance Index: -1.6300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1482
    Cell Significance Index: -1.4100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1485
    Cell Significance Index: -1.7000
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.1506
    Cell Significance Index: -1.6100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1510
    Cell Significance Index: -1.4900
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.1517
    Cell Significance Index: -1.6100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1533
    Cell Significance Index: -1.5200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1536
    Cell Significance Index: -1.5700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1555
    Cell Significance Index: -1.8600
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.1596
    Cell Significance Index: -1.6400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1603
    Cell Significance Index: -1.9700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1613
    Cell Significance Index: -1.7500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1637
    Cell Significance Index: -3.2000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1655
    Cell Significance Index: -2.1600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1667
    Cell Significance Index: -1.9600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1681
    Cell Significance Index: -1.3900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1690
    Cell Significance Index: -3.4400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1710
    Cell Significance Index: -2.0500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1712
    Cell Significance Index: -2.1600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1739
    Cell Significance Index: -1.1100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1836
    Cell Significance Index: -2.1700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1869
    Cell Significance Index: -2.1200
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.1931
    Cell Significance Index: -2.4100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1935
    Cell Significance Index: -2.0600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1939
    Cell Significance Index: -2.4100
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1994
    Cell Significance Index: -2.2700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1995
    Cell Significance Index: -2.2100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2005
    Cell Significance Index: -2.1500
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.2014
    Cell Significance Index: -2.2000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2037
    Cell Significance Index: -2.0800
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.2073
    Cell Significance Index: -2.4000
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.2103
    Cell Significance Index: -2.3400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2108
    Cell Significance Index: -2.3800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2115
    Cell Significance Index: -2.8100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2133
    Cell Significance Index: -2.2500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2236
    Cell Significance Index: -2.4500
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.2237
    Cell Significance Index: -2.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR1F1 is a G protein-coupled receptor that detects chemical stimuli, thereby contributing to the perception of smell. 2. **Cellular Expression:** The gene is expressed in a variety of cell types, including progenitor cells, erythrocytes, microglial cells, and hematopoietic stem cells, suggesting its role in multiple physiological processes. 3. **Signaling Pathways:** OR1F1 is involved in olfactory signaling pathways, including detection of chemical stimulus, expression and translocation of olfactory receptors, and G protein-coupled receptor activity. 4. **Protein Structure:** The OR1F1 protein is a G protein-coupled receptor that consists of seven transmembrane domains, which are essential for ligand binding and signal transduction. **Pathways and Functions:** 1. **Olfactory Signaling Pathway:** OR1F1 plays a crucial role in detecting chemical stimuli and facilitating the sensory perception of smell. This process involves the binding of odorant molecules to the olfactory receptor, triggering a signaling cascade that ultimately leads to the perception of a specific odor. 2. **G Protein-Coupled Receptor Activity:** OR1F1 is a G protein-coupled receptor that utilizes the G protein-coupled receptor signaling pathway to transmit signals from the receptor to downstream effectors. 3. **Expression and Translocation of Olfactory Receptors:** OR1F1 is involved in the expression and translocation of olfactory receptors, which is essential for the proper functioning of the olfactory system. 4. **Signal Transduction:** OR1F1 utilizes signal transduction pathways to transmit signals from the receptor to downstream effectors, ultimately leading to the perception of a specific odor. **Clinical Significance:** 1. **Olfactory Disorders:** Dysfunctions in the OR1F1 gene have been associated with olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Neurological Disorders:** Alterations in OR1F1 expression have been linked to various neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer Research:** OR1F1 has been identified as a potential biomarker for cancer, as its expression is altered in various types of cancer. 4. **Pharmacological Applications:** OR1F1 has been explored as a target for the development of novel therapeutic agents, including olfactory stimulants and treatments for olfactory disorders. In conclusion, the OR1F1 gene plays a critical role in the human olfactory system, and its dysfunctions have been associated with various clinical disorders. Further research into the mechanisms of OR1F1 and its signaling pathways is essential for the development of novel therapeutic agents and our understanding of the complex relationships between olfaction and various diseases.

Genular Protein ID: 1250742630

Symbol: OR1F1_HUMAN

Name: Olfactory receptor 1F1

UniProtKB Accession Codes:

O43749 O15246 Q6IFL5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 7 Ensembl 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9288094

Title: A candidate gene for familial Mediterranean fever.

PubMed ID: 9288094

DOI: 10.1038/ng0997-25

PubMed ID: 9653642

Title: A transcriptional map of the FMF region.

PubMed ID: 9653642

DOI: 10.1006/geno.1998.5313

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9500546

Title: Distribution of olfactory receptor genes in the human genome.

PubMed ID: 9500546

DOI: 10.1038/ng0398-243

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 312
  • Mass: 34866
  • Checksum: 5C1E1708A18B10E4
  • Sequence:
    • MSGTNQSSVS EFLLLGLSRQ PQQQHLLFVF FLSMYLATVL GNLLIILSVS IDSCLHTPMY 
FFLSNLSFVD ICFSFTTVPK MLANHILETQ TISFCGCLTQ MYFVFMFVDM DNFLLAVMAY 
DHFVAVCHPL HYTAKMTHQL CALLVAGLWV VANLNVLLHT LLMAPLSFCA DNAITHFFCD 
VTPLLKLSCS DTHLNEVIIL SEGALVMITP FLCILASYMH ITCTVLKVPS TKGRWKAFST 
CGSHLAVVLL FYSTIIAVYF NPLSSHSAEK DTMATVLYTV VTPMLNPFIY SLRNRYLKGA 
LKKVVGRVVF SV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.