Details for: PPP1R8P1

Gene ID: 5512

Symbol: PPP1R8P1

Ensembl ID: ENSG00000224986

Description: protein phosphatase 1 regulatory subunit 8 pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.3080
    Cell Significance Index: 2.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0064
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0247
    Cell Significance Index: -2.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0410
    Cell Significance Index: -2.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0508
    Cell Significance Index: -3.2000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0663
    Cell Significance Index: -0.9100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0714
    Cell Significance Index: -0.9900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0783
    Cell Significance Index: -1.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0942
    Cell Significance Index: -4.2700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1082
    Cell Significance Index: -1.1200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1257
    Cell Significance Index: -1.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1274
    Cell Significance Index: -4.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1330
    Cell Significance Index: -4.2600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1551
    Cell Significance Index: -2.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1653
    Cell Significance Index: -4.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1679
    Cell Significance Index: -4.5700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1695
    Cell Significance Index: -1.7800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1750
    Cell Significance Index: -2.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1754
    Cell Significance Index: -4.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1869
    Cell Significance Index: -2.5500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1986
    Cell Significance Index: -3.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2041
    Cell Significance Index: -4.4700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2044
    Cell Significance Index: -2.9300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2212
    Cell Significance Index: -2.5700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2299
    Cell Significance Index: -3.3100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2384
    Cell Significance Index: -4.1100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2414
    Cell Significance Index: -3.1800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2506
    Cell Significance Index: -2.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2526
    Cell Significance Index: -3.7300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2613
    Cell Significance Index: -3.1100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2625
    Cell Significance Index: -2.7400
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2627
    Cell Significance Index: -3.5700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2701
    Cell Significance Index: -2.9200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2829
    Cell Significance Index: -3.3300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.2844
    Cell Significance Index: -2.9500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2891
    Cell Significance Index: -3.4900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.3022
    Cell Significance Index: -3.9600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3104
    Cell Significance Index: -4.3600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3240
    Cell Significance Index: -3.7600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3246
    Cell Significance Index: -3.9900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3281
    Cell Significance Index: -3.8800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.3423
    Cell Significance Index: -3.3000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.3493
    Cell Significance Index: -3.4600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3509
    Cell Significance Index: -3.5400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.3533
    Cell Significance Index: -3.6600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3542
    Cell Significance Index: -4.4700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3567
    Cell Significance Index: -4.2400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3609
    Cell Significance Index: -4.1300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3610
    Cell Significance Index: -3.8400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3659
    Cell Significance Index: -4.2100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3746
    Cell Significance Index: -4.4800
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3750
    Cell Significance Index: -4.1700
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.3789
    Cell Significance Index: -2.3800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3793
    Cell Significance Index: -4.7400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3794
    Cell Significance Index: -4.5500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3809
    Cell Significance Index: -4.1500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3849
    Cell Significance Index: -3.9300
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.3887
    Cell Significance Index: -4.5000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3921
    Cell Significance Index: -4.6100
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.3926
    Cell Significance Index: -4.4700
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.3935
    Cell Significance Index: -4.1100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3958
    Cell Significance Index: -5.2600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3998
    Cell Significance Index: -3.7400
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.4001
    Cell Significance Index: -3.7300
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.4037
    Cell Significance Index: -4.3700
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.4147
    Cell Significance Index: -4.5000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.4167
    Cell Significance Index: -4.5700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.4213
    Cell Significance Index: -5.2600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.4232
    Cell Significance Index: -5.3000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4234
    Cell Significance Index: -4.5400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.4236
    Cell Significance Index: -4.4600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.4393
    Cell Significance Index: -4.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4404
    Cell Significance Index: -5.2500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4435
    Cell Significance Index: -3.7400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4443
    Cell Significance Index: -4.8400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.4444
    Cell Significance Index: -4.9200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.4503
    Cell Significance Index: -5.6500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4529
    Cell Significance Index: -5.4900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4564
    Cell Significance Index: -5.0100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4656
    Cell Significance Index: -5.5000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.4747
    Cell Significance Index: -4.4200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.4845
    Cell Significance Index: -4.7400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4906
    Cell Significance Index: -5.5300
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.4911
    Cell Significance Index: -5.6300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.4992
    Cell Significance Index: -5.6400
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.5011
    Cell Significance Index: -4.1500
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.5035
    Cell Significance Index: -5.4200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.5371
    Cell Significance Index: -5.6700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.5464
    Cell Significance Index: -5.1800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5496
    Cell Significance Index: -5.2100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.5537
    Cell Significance Index: -4.2600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.5653
    Cell Significance Index: -4.9800
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.5828
    Cell Significance Index: -5.4100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.5987
    Cell Significance Index: -5.6100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.6736
    Cell Significance Index: -5.5600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.7764
    Cell Significance Index: -4.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PPP1R8P1 is a pseudogene, meaning it lacks a functional coding sequence and is unlikely to produce a protein. However, its expression in multiple cell types suggests that it may play a regulatory role in cellular processes, possibly by influencing the activity of the PP1R8 protein, a known regulator of protein phosphatase 1 (PP1). The pseudogene's expression in various cell types, including ependymal cells, astrocytes, and glial cells, highlights its potential involvement in neural development and maintenance. **Pathways and Functions:** While the exact mechanisms by which PPP1R8P1 influences cellular processes remain unclear, its expression in cells involved in immune responses, such as interneurons and fibroblasts, suggests a potential role in modulating immune reactions. PP1R8P1 may interact with other signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, to regulate cellular processes such as proliferation, differentiation, and survival. Furthermore, its expression in mesenchymal stem cells and cerebellar granule cell precursors implies a possible involvement in cellular differentiation and development. **Clinical Significance:** The clinical significance of PPP1R8P1 remains largely unexplored. However, its expression in various cell types, including those involved in immune responses, suggests a potential link to immune-related disorders. Further investigation into the functional role of PPP1R8P1 is warranted, particularly in the context of neurological and autoimmune diseases. Additionally, the pseudogene's expression in certain cell types may provide insights into the development and progression of diseases such as multiple sclerosis, where immune dysregulation plays a key role. In conclusion, while PPP1R8P1 is a pseudogene with unclear functional significance, its expression in multiple cell types and potential involvement in immune-related processes warrant further investigation. As our understanding of the pseudogene's role in cellular processes and disease progression evolves, it is likely that PPP1R8P1 will emerge as a significant player in the regulation of immune responses and cellular development. **Recommendations:** 1. Further investigation into the functional role of PPP1R8P1 is necessary to fully understand its involvement in cellular processes. 2. Studies examining the expression of PPP1R8P1 in specific disease contexts, such as multiple sclerosis, are warranted to explore its potential clinical significance. 3. The development of novel approaches to study pseudogenes, such as CRISPR/Cas9-mediated gene editing, may provide insights into the functional role of PPP1R8P1. By continuing to explore the mysteries of PPP1R8P1, we may uncover new avenues for understanding immune-related disorders and developing novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.