Details for: ASCL3

Gene ID: 56676

Symbol: ASCL3

Ensembl ID: ENSG00000176009

Description: achaete-scute family bHLH transcription factor 3

Associated with

  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Salivary gland development
    (GO:0007431)
  • Sensory epithelium regeneration
    (GO:0070654)
  • Tissue homeostasis
    (GO:0001894)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.4806
    Cell Significance Index: 17.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.2552
    Cell Significance Index: 26.0700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.1071
    Cell Significance Index: 2.1800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0620
    Cell Significance Index: 1.0600
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.0437
    Cell Significance Index: 0.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0021
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0038
    Cell Significance Index: -2.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0054
    Cell Significance Index: -0.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0084
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0087
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0113
    Cell Significance Index: -2.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0131
    Cell Significance Index: -1.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0339
    Cell Significance Index: -1.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0493
    Cell Significance Index: -1.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0502
    Cell Significance Index: -1.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0541
    Cell Significance Index: -1.7700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0545
    Cell Significance Index: -1.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0577
    Cell Significance Index: -1.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0602
    Cell Significance Index: -1.3000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0605
    Cell Significance Index: -1.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0617
    Cell Significance Index: -1.3500
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.0644
    Cell Significance Index: -0.5900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0668
    Cell Significance Index: -1.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0674
    Cell Significance Index: -1.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0675
    Cell Significance Index: -3.7900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0680
    Cell Significance Index: -0.9400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0698
    Cell Significance Index: -1.7400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0706
    Cell Significance Index: -1.2200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0743
    Cell Significance Index: -1.5500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0760
    Cell Significance Index: -1.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0831
    Cell Significance Index: -1.3900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0853
    Cell Significance Index: -1.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0856
    Cell Significance Index: -2.1800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0858
    Cell Significance Index: -1.1100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0879
    Cell Significance Index: -0.9100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0938
    Cell Significance Index: -1.8700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1108
    Cell Significance Index: -1.0500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1134
    Cell Significance Index: -1.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1138
    Cell Significance Index: -1.6800
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: -0.1170
    Cell Significance Index: -1.0300
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1201
    Cell Significance Index: -1.2700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1214
    Cell Significance Index: -1.6700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1223
    Cell Significance Index: -1.8300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1234
    Cell Significance Index: -1.6100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1274
    Cell Significance Index: -1.7900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1288
    Cell Significance Index: -1.2800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1293
    Cell Significance Index: -2.0000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1309
    Cell Significance Index: -2.1200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1401
    Cell Significance Index: -1.7700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1405
    Cell Significance Index: -2.0400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1424
    Cell Significance Index: -2.9700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1480
    Cell Significance Index: -1.7400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1572
    Cell Significance Index: -1.7200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1629
    Cell Significance Index: -2.1300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1639
    Cell Significance Index: -1.9500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1644
    Cell Significance Index: -2.2800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1645
    Cell Significance Index: -1.7500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1661
    Cell Significance Index: -1.8100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1665
    Cell Significance Index: -2.4400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1688
    Cell Significance Index: -1.8100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1692
    Cell Significance Index: -1.8900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1693
    Cell Significance Index: -3.3100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1694
    Cell Significance Index: -2.0200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1710
    Cell Significance Index: -2.2500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1716
    Cell Significance Index: -1.8500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1760
    Cell Significance Index: -2.3100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1774
    Cell Significance Index: -2.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1796
    Cell Significance Index: -3.3200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1806
    Cell Significance Index: -2.2200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1820
    Cell Significance Index: -1.9200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1821
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1834
    Cell Significance Index: -2.3100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1859
    Cell Significance Index: -2.1000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1884
    Cell Significance Index: -2.4600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1886
    Cell Significance Index: -2.0000
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1897
    Cell Significance Index: -2.1600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1915
    Cell Significance Index: -2.4600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1933
    Cell Significance Index: -2.0000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1974
    Cell Significance Index: -1.9700
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1983
    Cell Significance Index: -2.2500
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.2018
    Cell Significance Index: -2.2400
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.2021
    Cell Significance Index: -2.3000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2057
    Cell Significance Index: -2.0400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2084
    Cell Significance Index: -1.7200
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.2088
    Cell Significance Index: -2.3000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2118
    Cell Significance Index: -2.8200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2149
    Cell Significance Index: -2.5700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.2149
    Cell Significance Index: -1.7400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2151
    Cell Significance Index: -1.9900
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.2230
    Cell Significance Index: -2.3600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.2382
    Cell Significance Index: -2.3500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2437
    Cell Significance Index: -2.0600
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.2492
    Cell Significance Index: -2.3500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2509
    Cell Significance Index: -2.6700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2561
    Cell Significance Index: -1.5200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2570
    Cell Significance Index: -3.6800
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2628
    Cell Significance Index: -1.9100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2647
    Cell Significance Index: -3.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ASCL3 is a transcription factor that belongs to the achaete-scute family of bHLH proteins. These proteins are known for their ability to regulate gene expression by binding to specific DNA sequences and influencing the transcriptional activity of target genes. ASCL3 exhibits a unique ability to modulate its activity in response to different cellular contexts, making it a versatile regulator of transcription. **Pathways and Functions:** ASCL3 is involved in multiple signaling pathways that regulate gene expression, including: 1. **Chromatin remodeling:** ASCL3 interacts with chromatin-modifying enzymes to regulate gene expression by modifying chromatin structure and accessibility. 2. **DNA-binding transcription factor activity:** ASCL3 recognizes specific DNA sequences and recruits co-factors to modulate transcriptional activity. 3. **Regulation of transcription by RNA polymerase II:** ASCL3 influences the activity of RNA polymerase II, a key enzyme responsible for transcription. 4. **Protein binding and dimerization:** ASCL3 interacts with other proteins to form dimers, which can modulate its activity and influence transcriptional outcomes. ASCL3 plays a critical role in the development and homeostasis of various cell types, including: 1. **Retinal development:** ASCL3 regulates the expression of genes involved in retinal development, including those required for photoreceptor differentiation. 2. **Sensory epithelium regeneration:** ASCL3 promotes the regeneration of sensory epithelial cells, which are essential for maintaining sensory function. 3. **Tissue homeostasis:** ASCL3 maintains the balance of gene expression in tissues, ensuring proper cellular function and preventing disease. **Clinical Significance:** Dysregulation of ASCL3 has been implicated in various diseases, including: 1. **Retinal degeneration:** Mutations in ASCL3 have been associated with retinal degeneration, a leading cause of blindness in older adults. 2. **Neurological disorders:** ASCL3 has been linked to neurological disorders, such as Parkinson's disease and Alzheimer's disease, where dysregulation of transcriptional pathways contributes to disease progression. 3. **Cancer:** ASCL3 has been implicated in cancer, where its dysregulation can contribute to tumor development and progression. In conclusion, ASCL3 is a critical regulator of gene expression in various tissues, including the nervous system. Its dysregulation has been implicated in several diseases, highlighting the need for further research into the molecular mechanisms underlying ASCL3 function and its implications in human disease.

Genular Protein ID: 2583494236

Symbol: ASCL3_HUMAN

Name: Class A basic helix-loop-helix protein 42

UniProtKB Accession Codes:

Q9NQ33 Q8WYQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 2 Ensembl 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11528127

Title: Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7.

PubMed ID: 11528127

DOI: 10.1159/000056999

PubMed ID: 11784080

Title: Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice.

PubMed ID: 11784080

DOI: 10.1006/dbio.2001.0473

PubMed ID: 15475265

Title: Hash4, a novel human achaete-scute homologue found in fetal skin.

PubMed ID: 15475265

DOI: 10.1016/j.ygeno.2004.07.004

Sequence Information:

  • Length: 181
  • Mass: 20928
  • Checksum: 72040CC569B4CD33
  • Sequence:
    • MMDNRGNSSL PDKLPIFPDS ARLPLTRSFY LEPMVTFHVH PEAPVSSPYS EELPRLPFPS 
DSLILGNYSE PCPFSFPMPY PNYRGCEYSY GPAFTRKRNE RERQRVKCVN EGYAQLRHHL 
PEEYLEKRLS KVETLRAAIK YINYLQSLLY PDKAETKNNP GKVSSMIATT SHHADPMFRI 
V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.