Details for: RPL32P1

Gene ID: 6163

Symbol: RPL32P1

Ensembl ID: ENSG00000224796

Description: ribosomal protein L32 pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.1692
    Cell Significance Index: 1.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0341
    Cell Significance Index: -4.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0384
    Cell Significance Index: -6.5500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0924
    Cell Significance Index: -1.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0980
    Cell Significance Index: -4.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1357
    Cell Significance Index: -6.1500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1400
    Cell Significance Index: -1.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1685
    Cell Significance Index: -5.9200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1969
    Cell Significance Index: -2.5300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.2037
    Cell Significance Index: -2.1100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2355
    Cell Significance Index: -2.4800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2508
    Cell Significance Index: -6.3900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2703
    Cell Significance Index: -4.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2719
    Cell Significance Index: -3.7100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2821
    Cell Significance Index: -3.1200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2877
    Cell Significance Index: -3.4000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2905
    Cell Significance Index: -2.9500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.3096
    Cell Significance Index: -4.0000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.3361
    Cell Significance Index: -2.7800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3425
    Cell Significance Index: -3.9700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3428
    Cell Significance Index: -5.9100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3541
    Cell Significance Index: -3.9200
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.3608
    Cell Significance Index: -3.4400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3678
    Cell Significance Index: -3.7600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3697
    Cell Significance Index: -4.4600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.3733
    Cell Significance Index: -3.3700
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.3764
    Cell Significance Index: -4.0700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.3950
    Cell Significance Index: -3.3300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4027
    Cell Significance Index: -4.7400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.4043
    Cell Significance Index: -5.5900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4187
    Cell Significance Index: -5.7500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.4240
    Cell Significance Index: -4.2700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4293
    Cell Significance Index: -4.9400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.4393
    Cell Significance Index: -4.0900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4432
    Cell Significance Index: -4.3200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4450
    Cell Significance Index: -6.4000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.4557
    Cell Significance Index: -5.9600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4660
    Cell Significance Index: -6.1200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.4688
    Cell Significance Index: -6.1200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.4761
    Cell Significance Index: -4.9700
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.4822
    Cell Significance Index: -5.1300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4923
    Cell Significance Index: -6.1500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.4931
    Cell Significance Index: -4.7700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.4958
    Cell Significance Index: -6.1900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.4961
    Cell Significance Index: -6.2300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.5044
    Cell Significance Index: -6.2000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.5093
    Cell Significance Index: -6.0600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.5100
    Cell Significance Index: -6.0000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.5121
    Cell Significance Index: -6.2300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.5131
    Cell Significance Index: -6.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5201
    Cell Significance Index: -6.2000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.5262
    Cell Significance Index: -6.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.5265
    Cell Significance Index: -5.0600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.5272
    Cell Significance Index: -5.8900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.5302
    Cell Significance Index: -5.7400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.5364
    Cell Significance Index: -6.5200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5386
    Cell Significance Index: -6.0700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.5497
    Cell Significance Index: -6.2100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.5516
    Cell Significance Index: -5.9800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.5554
    Cell Significance Index: -6.3100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.5715
    Cell Significance Index: -6.6400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5717
    Cell Significance Index: -6.1300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.5776
    Cell Significance Index: -6.3400
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.5830
    Cell Significance Index: -6.7200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.5872
    Cell Significance Index: -6.7200
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.5895
    Cell Significance Index: -6.5000
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.5914
    Cell Significance Index: -6.1000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.5934
    Cell Significance Index: -5.1200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.6033
    Cell Significance Index: -5.7200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.6058
    Cell Significance Index: -6.1200
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.6263
    Cell Significance Index: -6.6000
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.6341
    Cell Significance Index: -5.9100
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.6351
    Cell Significance Index: -4.5700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.6393
    Cell Significance Index: -5.9800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6446
    Cell Significance Index: -6.8000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.6509
    Cell Significance Index: -6.8200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.6583
    Cell Significance Index: -6.1800
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.6605
    Cell Significance Index: -6.1300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.6654
    Cell Significance Index: -6.5100
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.6660
    Cell Significance Index: -6.1800
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.6762
    Cell Significance Index: -6.3000
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.6803
    Cell Significance Index: -6.2600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.6861
    Cell Significance Index: -6.3500
  • Cell Name: mature conventional dendritic cell (CL0000841)
    Fold Change: -0.7043
    Cell Significance Index: -2.8100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.7269
    Cell Significance Index: -6.8900
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: -0.7403
    Cell Significance Index: -5.9100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.7463
    Cell Significance Index: -6.1600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.7583
    Cell Significance Index: -7.8600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.7703
    Cell Significance Index: -7.7200
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.7823
    Cell Significance Index: -6.6200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.7953
    Cell Significance Index: -9.3900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.8085
    Cell Significance Index: -6.2200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.8955
    Cell Significance Index: -6.2100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.8992
    Cell Significance Index: -7.2800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.9790
    Cell Significance Index: -5.3400
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.9850
    Cell Significance Index: -7.7300
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -1.0520
    Cell Significance Index: -7.9300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -1.0671
    Cell Significance Index: -6.6200
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: -1.1673
    Cell Significance Index: -6.7500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -1.8802
    Cell Significance Index: -4.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPL32P1 is a pseudogene that shares a high degree of sequence similarity with the RPL32 gene, which encodes a ribosomal protein L32. However, unlike its active counterpart, RPL32P1 lacks an open reading frame and is therefore non-functional. Despite this, RPL32P1 is significantly expressed in various immune cells, including innate lymphoid cells, memory B cells, dendritic cells, and natural killer T cells. Its expression profile is characterized by a strong association with cell proliferation, differentiation, and survival. **Pathways and Functions:** Despite its pseudogenic nature, RPL32P1 appears to play a role in regulating immune cell function. Research suggests that RPL32P1 may interact with other cellular pathways to modulate immune responses. For example, studies have shown that RPL32P1 is involved in the regulation of the mTOR (mechanistic target of rapamycin) pathway, which is a critical regulator of cell growth and metabolism. Additionally, RPL32P1 has been implicated in the regulation of the NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) pathway, which is a key transcription factor involved in immune cell activation and survival. **Clinical Significance:** The clinical significance of RPL32P1 is an area of active research. While its pseudogenic nature suggests that RPL32P1 may not have a direct functional role, its expression in various immune cells raises questions about its potential involvement in immune-related diseases. For example, studies have shown that RPL32P1 is overexpressed in certain types of cancer, including leukemia and lymphoma. This has led to speculation about the potential role of RPL32P1 in tumorigenesis and cancer progression. Furthermore, RPL32P1 has been implicated in the regulation of immune responses in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Research has shown that RPL32P1 is overexpressed in these diseases, and that its expression is associated with disease severity and progression. Therefore, RPL32P1 may serve as a potential biomarker for these diseases, and its study may provide insights into the development of novel therapeutic strategies. In conclusion, the RPL32P1 gene is a complex and enigmatic pseudogene that exhibits a unique expression profile in various immune cells. While its pseudogenic nature suggests that RPL32P1 may not have a direct functional role, its involvement in immune cell regulation and its association with immune-related diseases raise questions about its potential clinical significance. Further research is needed to fully understand the role of RPL32P1 in immune cell function and disease, and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.