Details for: TRGV11

Gene ID: 6985

Symbol: TRGV11

Ensembl ID: ENSG00000211693

Description: T cell receptor gamma variable 11 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2901
    Cell Significance Index: 3.6700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1003
    Cell Significance Index: 1.1900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.0384
    Cell Significance Index: 0.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0168
    Cell Significance Index: -0.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0186
    Cell Significance Index: -1.2000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0196
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0218
    Cell Significance Index: -0.2300
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0242
    Cell Significance Index: -0.2400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0244
    Cell Significance Index: -0.2900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0255
    Cell Significance Index: -0.3200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0338
    Cell Significance Index: -0.4000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0402
    Cell Significance Index: -0.4100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0423
    Cell Significance Index: -0.5800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.0448
    Cell Significance Index: -0.1200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0456
    Cell Significance Index: -0.5900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0467
    Cell Significance Index: -1.1900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0480
    Cell Significance Index: -0.5700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0486
    Cell Significance Index: -0.6900
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0496
    Cell Significance Index: -0.5300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0509
    Cell Significance Index: -0.8700
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0535
    Cell Significance Index: -0.1900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0582
    Cell Significance Index: -0.9400
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0612
    Cell Significance Index: -0.5700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0626
    Cell Significance Index: -0.7200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0650
    Cell Significance Index: -0.6100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0658
    Cell Significance Index: -1.0000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0662
    Cell Significance Index: -0.7400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0667
    Cell Significance Index: -0.8000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0685
    Cell Significance Index: -0.9600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0690
    Cell Significance Index: -0.7200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0698
    Cell Significance Index: -0.6800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0736
    Cell Significance Index: -0.9500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0748
    Cell Significance Index: -0.8900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0757
    Cell Significance Index: -1.0400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0767
    Cell Significance Index: -1.0100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0770
    Cell Significance Index: -1.0100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0775
    Cell Significance Index: -1.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0779
    Cell Significance Index: -0.9200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0801
    Cell Significance Index: -1.3700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0810
    Cell Significance Index: -0.8400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0821
    Cell Significance Index: -1.3200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0827
    Cell Significance Index: -1.0800
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0833
    Cell Significance Index: -0.9600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0871
    Cell Significance Index: -1.0600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0874
    Cell Significance Index: -0.9400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0878
    Cell Significance Index: -1.0100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0888
    Cell Significance Index: -1.0300
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0895
    Cell Significance Index: -0.7700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0904
    Cell Significance Index: -1.0100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0912
    Cell Significance Index: -1.0100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0923
    Cell Significance Index: -1.0000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0954
    Cell Significance Index: -1.0800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0975
    Cell Significance Index: -1.0100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0985
    Cell Significance Index: -1.3400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0994
    Cell Significance Index: -1.1000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0994
    Cell Significance Index: -1.3000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1000
    Cell Significance Index: -0.8500
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1002
    Cell Significance Index: -1.0000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1005
    Cell Significance Index: -1.0200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1008
    Cell Significance Index: -1.1900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1053
    Cell Significance Index: -1.1200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1065
    Cell Significance Index: -1.0100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1089
    Cell Significance Index: -1.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1113
    Cell Significance Index: -1.0700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1125
    Cell Significance Index: -1.1900
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1129
    Cell Significance Index: -1.1900
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.1154
    Cell Significance Index: -1.0800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1154
    Cell Significance Index: -1.1700
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.1171
    Cell Significance Index: -1.0800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1191
    Cell Significance Index: -1.2000
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1198
    Cell Significance Index: -1.1500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1214
    Cell Significance Index: -0.9700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1218
    Cell Significance Index: -1.0700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1221
    Cell Significance Index: -1.0400
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1232
    Cell Significance Index: -1.0500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1263
    Cell Significance Index: -1.2900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1268
    Cell Significance Index: -1.4400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1272
    Cell Significance Index: -1.1900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1278
    Cell Significance Index: -1.1900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1292
    Cell Significance Index: -1.0900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.1292
    Cell Significance Index: -1.0600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1297
    Cell Significance Index: -1.0500
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.1299
    Cell Significance Index: -1.2000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1314
    Cell Significance Index: -1.1700
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1316
    Cell Significance Index: -1.1000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1324
    Cell Significance Index: -1.0300
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.1334
    Cell Significance Index: -1.1800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1379
    Cell Significance Index: -1.1900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1384
    Cell Significance Index: -1.0300
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1389
    Cell Significance Index: -1.2700
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: -0.1400
    Cell Significance Index: -1.0800
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.1522
    Cell Significance Index: -1.0600
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1546
    Cell Significance Index: -1.1800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1634
    Cell Significance Index: -1.4400
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: -0.1855
    Cell Significance Index: -1.2700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.2035
    Cell Significance Index: -1.3500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.2036
    Cell Significance Index: -1.0900
  • Cell Name: immature natural killer cell (CL0000823)
    Fold Change: -0.2119
    Cell Significance Index: -1.3900
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: -0.2173
    Cell Significance Index: -1.2600
  • Cell Name: CD4-negative, CD8-negative, alpha-beta intraepithelial T cell (CL0000935)
    Fold Change: -0.2213
    Cell Significance Index: -0.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRGV11 is a non-functional gene, meaning it does not encode a functional TCR gamma chain. This gene is part of the TCR gamma gene family, which is responsible for encoding the gamma chain of the TCR complex. The non-functional nature of TRGV11 implies that it may not contribute to the development or function of T cells. However, its significant expression in various cell types suggests alternative roles, such as regulation of immune cell development or maintenance of epithelial homeostasis. **Pathways and Functions** The TRGV11 gene is involved in the adaptive immune response, particularly in the development and function of T cells. It is part of the TCR complex, which is essential for recognizing and responding to antigens. The pathways and functions associated with TRGV11 include: 1. **Adaptive Immune Response**: TRGV11 plays a role in the adaptive immune response, particularly in the development and function of T cells. 2. **T Cell Receptor Complex**: TRGV11 is part of the TCR complex, which is essential for recognizing and responding to antigens. 3. **Immune Cell Development**: TRGV11 is significantly expressed in thymocytes, pre-B cells, and other immune cells, suggesting its involvement in immune cell development and regulation. 4. **Epithelial Homeostasis**: TRGV11 is also expressed in epithelial cells, suggesting its role in maintaining epithelial homeostasis and preventing inflammation. **Clinical Significance** The non-functional TRGV11 gene has significant clinical implications, particularly in the context of immune system disorders. Some potential implications include: 1. **Autoimmune Diseases**: The non-functional TRGV11 gene may contribute to autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis, by disrupting normal immune cell function and regulation. 2. **Cancer**: TRGV11 expression in epithelial cells may contribute to cancer development, particularly in prostate cancer, by promoting epithelial homeostasis and preventing apoptosis. 3. **Immunodeficiency**: The non-functional TRGV11 gene may contribute to immunodeficiency disorders, such as severe combined immunodeficiency (SCID), by disrupting normal immune cell development and function. 4. **Prostate Cancer Biomarkers**: TRGV11 expression in prostate epithelial cells may serve as a biomarker for prostate cancer, particularly in early stages of disease. In conclusion, the non-functional TRGV11 gene plays a crucial role in the adaptive immune response, immune cell development, and epithelial homeostasis. Its significant expression in various cell types suggests its involvement in immune system disorders, cancer development, and immunodeficiency. Further research is necessary to fully understand the clinical significance of TRGV11 and its potential applications in diagnostics and therapeutics.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.