Details for: HSP90B2P

Gene ID: 7190

Symbol: HSP90B2P

Ensembl ID: ENSG00000259706

Description: heat shock protein 90 beta family member 2, pseudogene

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 8.7381
    Cell Significance Index: 146.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.8757
    Cell Significance Index: 1389.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.4849
    Cell Significance Index: 312.7500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.6167
    Cell Significance Index: 7.3300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.4807
    Cell Significance Index: 6.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4310
    Cell Significance Index: 5.8800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2315
    Cell Significance Index: 3.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2084
    Cell Significance Index: 35.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1359
    Cell Significance Index: 84.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1144
    Cell Significance Index: 3.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0903
    Cell Significance Index: 5.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0889
    Cell Significance Index: 10.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0868
    Cell Significance Index: 9.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0746
    Cell Significance Index: 2.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0478
    Cell Significance Index: 1.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0062
    Cell Significance Index: 0.2900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0046
    Cell Significance Index: 0.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0006
    Cell Significance Index: -0.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0071
    Cell Significance Index: -0.3700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0208
    Cell Significance Index: -0.3500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0324
    Cell Significance Index: -0.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0435
    Cell Significance Index: -0.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0598
    Cell Significance Index: -2.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1120
    Cell Significance Index: -3.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1717
    Cell Significance Index: -3.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1789
    Cell Significance Index: -10.9700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.2048
    Cell Significance Index: -2.7300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.2152
    Cell Significance Index: -2.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2310
    Cell Significance Index: -3.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2359
    Cell Significance Index: -5.1100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2471
    Cell Significance Index: -2.9400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2685
    Cell Significance Index: -4.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2956
    Cell Significance Index: -10.8500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3026
    Cell Significance Index: -7.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3096
    Cell Significance Index: -10.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3180
    Cell Significance Index: -10.1900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.3734
    Cell Significance Index: -4.3000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3825
    Cell Significance Index: -4.5600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3838
    Cell Significance Index: -4.8500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3865
    Cell Significance Index: -4.0000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.3882
    Cell Significance Index: -3.8300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4295
    Cell Significance Index: -5.4200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.4310
    Cell Significance Index: -5.9600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4380
    Cell Significance Index: -10.9400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.4431
    Cell Significance Index: -4.0700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4526
    Cell Significance Index: -6.5100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.4604
    Cell Significance Index: -5.8300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.4919
    Cell Significance Index: -5.4700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.5051
    Cell Significance Index: -8.1800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.5092
    Cell Significance Index: -5.4100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.5110
    Cell Significance Index: -5.3900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.5190
    Cell Significance Index: -7.2900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.5257
    Cell Significance Index: -6.6200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.5271
    Cell Significance Index: -6.6200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5289
    Cell Significance Index: -6.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5423
    Cell Significance Index: -11.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5563
    Cell Significance Index: -11.5400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.5657
    Cell Significance Index: -9.6700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.5679
    Cell Significance Index: -6.8500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.5681
    Cell Significance Index: -7.4300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.5683
    Cell Significance Index: -6.4200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.5696
    Cell Significance Index: -6.8300
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.5706
    Cell Significance Index: -5.4400
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.5766
    Cell Significance Index: -5.2100
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.5788
    Cell Significance Index: -6.5900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.5790
    Cell Significance Index: -6.7300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.5833
    Cell Significance Index: -8.0100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.5929
    Cell Significance Index: -6.4600
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.5942
    Cell Significance Index: -6.7500
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.5953
    Cell Significance Index: -6.2400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.5985
    Cell Significance Index: -7.6700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.6048
    Cell Significance Index: -7.7700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.6061
    Cell Significance Index: -7.4500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.6080
    Cell Significance Index: -7.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6187
    Cell Significance Index: -9.2700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.6280
    Cell Significance Index: -7.8400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.6312
    Cell Significance Index: -10.7200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.6336
    Cell Significance Index: -7.9400
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.6371
    Cell Significance Index: -6.8700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6397
    Cell Significance Index: -8.5000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.6414
    Cell Significance Index: -6.4800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.6429
    Cell Significance Index: -6.8400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6453
    Cell Significance Index: -7.3900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.6467
    Cell Significance Index: -8.1900
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.6490
    Cell Significance Index: -7.2100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.6500
    Cell Significance Index: -7.5400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6509
    Cell Significance Index: -11.2200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.6519
    Cell Significance Index: -7.6700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.6534
    Cell Significance Index: -8.5300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.6551
    Cell Significance Index: -8.5500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.6562
    Cell Significance Index: -7.7200
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.6567
    Cell Significance Index: -6.9000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.6632
    Cell Significance Index: -7.7100
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.6633
    Cell Significance Index: -7.6800
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.6646
    Cell Significance Index: -8.3400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.6648
    Cell Significance Index: -6.3200
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.6667
    Cell Significance Index: -7.2400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.6695
    Cell Significance Index: -7.4800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.6723
    Cell Significance Index: -7.3800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.6740
    Cell Significance Index: -8.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSP90B2P is a pseudogene, meaning it lacks a functional gene or has a non-functional gene due to mutations or deletions. However, its expression in multiple cell types suggests that it may be involved in regulating cellular processes, such as protein folding, kinase activity, and mitochondrial function. The pseudogene's association with thermally induced stress response pathways, including ATP-dependent protein folding and ATP hydrolysis activity, implies that it may play a role in protecting cells against stress-induced damage. **Pathways and Functions:** HSP90B2P is implicated in several critical cellular pathways, including: 1. **ATP-dependent protein folding chaperone**: HSP90B2P is involved in the folding of proteins, which is essential for maintaining protein homeostasis within cells. 2. **ATP binding and hydrolysis**: The pseudogene's association with ATP-dependent pathways suggests that it may regulate energy metabolism and cellular energy homeostasis. 3. **Mitochondrial inner membrane**: HSP90B2P's expression in cardiac muscle myoblasts and pancreatic A cells, which are involved in energy metabolism, implies that it may play a role in regulating mitochondrial function. 4. **Protein kinase binding**: The pseudogene's interaction with protein kinases suggests that it may regulate signaling pathways involved in cellular proliferation, differentiation, and survival. **Clinical Significance:** While HSP90B2P is a pseudogene, its expression in various cell types and involvement in cellular homeostasis pathways suggest that it may have implications for human disease. Potential clinical applications of HSP90B2P include: 1. **Cardiovascular disease**: HSP90B2P's expression in cardiac muscle myoblasts and its association with mitochondrial function may make it a potential therapeutic target for cardiovascular disease. 2. **Pancreatic disorders**: The pseudogene's expression in pancreatic A cells and its involvement in energy metabolism may make it a potential therapeutic target for pancreatic disorders, such as type 2 diabetes. 3. **Immunological disorders**: HSP90B2P's expression in lymphoid lineage-restricted progenitor cells and its association with protein kinase binding may make it a potential therapeutic target for immunological disorders, such as autoimmune diseases. In conclusion, HSP90B2P, a pseudogene with significant expression in various cell types, may play a crucial role in maintaining cellular homeostasis and regulating cellular processes. Further research is necessary to elucidate the functional significance of HSP90B2P and its potential implications for human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.