Details for: GTF2IRD1

Gene ID: 9569

Symbol: GTF2IRD1

Ensembl ID: ENSG00000006704

Description: GTF2I repeat domain containing 1

Associated with

  • Cytosol
    (GO:0005829)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transition between slow and fast fiber
    (GO:0014886)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 6.27
    Marker Score: 83,428
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.4
    Marker Score: 11,017
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.42
    Marker Score: 4,605
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.19
    Marker Score: 3,863
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.79
    Marker Score: 6,122
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.7
    Marker Score: 11,299
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.53
    Marker Score: 1,480
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.5
    Marker Score: 8,896
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.39
    Marker Score: 1,391
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.35
    Marker Score: 9,733
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.25
    Marker Score: 658
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.24
    Marker Score: 85,144
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.23
    Marker Score: 1,721
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.18
    Marker Score: 16,714
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.16
    Marker Score: 1,047
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.14
    Marker Score: 47,930
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.14
    Marker Score: 32,031
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.04
    Marker Score: 75,372
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.99
    Marker Score: 7,712
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.92
    Marker Score: 607
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.87
    Marker Score: 40,005
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.77
    Marker Score: 2,002
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.76
    Marker Score: 738
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.7
    Marker Score: 1,874
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.62
    Marker Score: 513
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.61
    Marker Score: 13,830
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.54
    Marker Score: 3,620
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.53
    Marker Score: 94,158
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.53
    Marker Score: 554
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.5
    Marker Score: 839
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.5
    Marker Score: 431
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.48
    Marker Score: 3,002
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,358
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.47
    Marker Score: 29,192
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.45
    Marker Score: 13,755
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.44
    Marker Score: 692
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.44
    Marker Score: 6,639
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.42
    Marker Score: 2,199
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.42
    Marker Score: 13,378
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.42
    Marker Score: 387
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.4
    Marker Score: 442
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.35
    Marker Score: 519
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.35
    Marker Score: 21,093
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.33
    Marker Score: 772
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.33
    Marker Score: 1,651
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.3
    Marker Score: 595
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.21
    Marker Score: 842
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.15
    Marker Score: 361
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.14
    Marker Score: 596
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.11
    Marker Score: 6,662
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.1
    Marker Score: 1,186
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.08
    Marker Score: 736
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.04
    Marker Score: 920
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,786
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,011
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.96
    Marker Score: 476
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.95
    Marker Score: 349
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.94
    Marker Score: 1,813
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.93
    Marker Score: 981
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,733
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.9
    Marker Score: 542
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1,459
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,081
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.87
    Marker Score: 1,230
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.85
    Marker Score: 290
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.85
    Marker Score: 474
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.84
    Marker Score: 555
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.84
    Marker Score: 170
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.84
    Marker Score: 270
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.83
    Marker Score: 3,379
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 631
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.82
    Marker Score: 2,351
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.8
    Marker Score: 2,833
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.77
    Marker Score: 1,294
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.76
    Marker Score: 401
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.76
    Marker Score: 421
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.76
    Marker Score: 361
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.75
    Marker Score: 191
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3,122
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 676
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.7
    Marker Score: 311
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.68
    Marker Score: 853
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.67
    Marker Score: 660
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.65
    Marker Score: 541
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.65
    Marker Score: 1,097
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.64
    Marker Score: 512
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.62
    Marker Score: 162
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.62
    Marker Score: 1,082
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.62
    Marker Score: 2,279
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.6
    Marker Score: 1,256
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.6
    Marker Score: 691

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Functional classification:** GTF2IRD1 is classified as a transcription factor, which is a protein that regulates gene expression by binding to specific DNA sequences. 2. **Repetition domain:** The gene's name, GTF2IRD1, suggests the presence of a GTF2I repeat domain, which is a characteristic feature of transcription factors involved in regulating gene expression. 3. **Significant expression in various tissues:** GTF2IRD1 is expressed in a wide range of cell types, including cardiac muscle cells, skeletal muscle fibers, and lens epithelial cells, indicating its potential role in tissue development and maintenance. 4. **RNA polymerase II-dependent transcription:** The gene's association with RNA polymerase II-dependent transcription suggests its involvement in the regulation of genes that are transcribed by this enzyme. **Pathways and Functions:** 1. **Transcriptional regulation:** GTF2IRD1 is involved in regulating gene expression by binding to specific DNA sequences and modulating the activity of RNA polymerase II. 2. **DNA-binding transcription factor activity:** The protein produced by GTF2IRD1 has DNA-binding transcription factor activity, which allows it to interact with specific DNA sequences and regulate gene expression. 3. **Negative regulation of transcription:** GTF2IRD1 can act as a negative regulator of transcription by binding to specific DNA sequences and inhibiting the activity of RNA polymerase II. 4. **Regulation of DNA-templated transcription:** The gene's role in regulating DNA-templated transcription suggests its involvement in the coordinated expression of genes in response to developmental cues. **Clinical Significance:** 1. **Cardiac muscle diseases:** Alterations in GTF2IRD1 expression have been linked to cardiac muscle diseases, such as dilated cardiomyopathy and hypertrophic cardiomyopathy. 2. **Muscle disorders:** The gene's expression in skeletal muscle fibers suggests its potential role in muscle disorders, such as muscular dystrophy. 3. **Lens disorders:** GTF2IRD1 expression in lens epithelial cells and secondary lens fibers suggests its potential role in lens disorders, such as cataracts and glaucoma. 4. **Neurological disorders:** The gene's expression in chandelier PVB GABAergic cortical interneurons suggests its potential role in neurological disorders, such as epilepsy and schizophrenia. In conclusion, GTF2IRD1 is a transcription factor that plays a crucial role in regulating gene expression in various tissues. Its clinical significance lies in its potential role in cardiac muscle diseases, muscle disorders, lens disorders, and neurological disorders. Further research is needed to fully elucidate the gene's functions and its implications for human disease.

Genular Protein ID: 3390161256

Symbol: GT2D1_HUMAN

Name: General transcription factor II-I repeat domain-containing protein 1

UniProtKB Accession Codes:

Q9UHL9 O95444 Q6DSU6 Q75MX7 Q86UM3 Q8WVC4 Q9UHK8 Q9UI91

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 4 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9774679

Title: Identification of a novel slow-muscle-fiber enhancer binding protein, MUSTRD1.

PubMed ID: 9774679

DOI: 10.1128/mcb.18.11.6641

PubMed ID: 10198167

Title: Identification of a putative transcription factor gene (WBSCR11) that is commonly deleted in Williams-Beuren syndrome.

PubMed ID: 10198167

DOI: 10.1006/geno.1999.5784

PubMed ID: 10573005

Title: A transcription factor involved in skeletal muscle gene expression is deleted in patients with Williams syndrome.

PubMed ID: 10573005

DOI: 10.1038/sj.ejhg.5200396

PubMed ID: 10575229

Title: Identification of GTF2IRD1, a putative transcription factor within the Williams-Beuren syndrome deletion at 7q11.23.

PubMed ID: 10575229

DOI: 10.1159/000015322

PubMed ID: 10642537

Title: Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I.

PubMed ID: 10642537

DOI: 10.1042/bj3450749

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11438732

Title: Repression of TFII-I-dependent transcription by nuclear exclusion.

PubMed ID: 11438732

DOI: 10.1073/pnas.141222298

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 959
  • Mass: 106057
  • Checksum: 7DA3097879701540
  • Sequence:
    • MALLGKRCDV PTNGCGPDRW NSAFTRKDEI ITSLVSALDS MCSALSKLNA EVACVAVHDE 
SAFVVGTEKG RMFLNARKEL QSDFLRFCRG PPWKDPEAEH PKKVQRGEGG GRSLPRSSLE 
HGSDVYLLRK MVEEVFDVLY SEALGRASVV PLPYERLLRE PGLLAVQGLP EGLAFRRPAE 
YDPKALMAIL EHSHRIRFKL KRPLEDGGRD SKALVELNGV SLIPKGSRDC GLHGQAPKVP 
PQDLPPTATS SSMASFLYST ALPNHAIREL KQEAPSCPLA PSDLGLSRPM PEPKATGAQD 
FSDCCGQKPT GPGGPLIQNV HASKRILFSI VHDKSEKWDA FIKETEDINT LRECVQILFN 
SRYAEALGLD HMVPVPYRKI ACDPEAVEIV GIPDKIPFKR PCTYGVPKLK RILEERHSIH 
FIIKRMFDER IFTGNKFTKD TTKLEPASPP EDTSAEVSRA TVLDLAGNAR SDKGSMSEDC 
GPGTSGELGG LRPIKIEPED LDIIQVTVPD PSPTSEEMTD SMPGHLPSED SGYGMEMLTD 
KGLSEDARPE ERPVEDSHGD VIRPLRKQVE LLFNTRYAKA IGISEPVKVP YSKFLMHPEE 
LFVVGLPEGI SLRRPNCFGI AKLRKILEAS NSIQFVIKRP ELLTEGVKEP IMDSQGTASS 
LGFSPPALPP ERDSGDPLVD ESLKRQGFQE NYDARLSRID IANTLREQVQ DLFNKKYGEA 
LGIKYPVQVP YKRIKSNPGS VIIEGLPPGI PFRKPCTFGS QNLERILAVA DKIKFTVTRP 
FQGLIPKPDE DDANRLGEKV ILREQVKELF NEKYGEALGL NRPVLVPYKL IRDSPDAVEV 
TGLPDDIPFR NPNTYDIHRL EKILKAREHV RMVIINQLQP FAEICNDAKV PAKDSSIPKR 
KRKRVSEGNS VSSSSSSSSS SSSNPDSVAS ANQISLVQWP MYMVDYAGLN VQLPGPLNY

Genular Protein ID: 2041266636

Symbol: E9PFE2_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PFE2

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 PANTHER 2 PIRSF 1 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 960
  • Mass: 106049
  • Checksum: E08A2EF95D7859D2
  • Sequence:
    • MALLGKRCDV PTNGCGPDRW NSAFTRKDEI ITSLVSALDS MCSALSKLNA EVACVAVHDE 
SAFVVGTEKG RMFLNARKEL QSDFLRFCRG PPWKDPEAEH PKKVQRGEGG GRSLPRSSLE 
HGSDVYLLRK MVEEVFDVLY SEALGRASVV PLPYERLLRE PGLLAVQGLP EGLAFRRPAE 
YDPKALMAIL EHSHRIRFKL KRPLEDGGRD SKALVELNGV SLIPKGSRDC GLHGQAPKVP 
PQDLPPTATS SSMASFLYST ALPNHAIREL KQEAPSCPLA PSDLGLSRPM PEPKATGAQD 
FSDCCGQKPT GPGGPLIQNV HASKRILFSI VHDKSEKWDA FIKETEDINT LRECVQILFN 
SRYAEALGLD HMVPVPYRKI ACDPEAVEIV GIPDKIPFKR PCTYGVPKLK RILEERHSIH 
FIIKRMFDER IFTGNKFTKD TTKLEPASPP EDTSAEVSRA TVLDLAGNAR SDKGSMSEDC 
GPGTSGELGG LRPIKIEPED LDIIQVTVPD PSPTSEEMTD SMPGHLPSED SGYGMEMLTD 
KGLSEDARPE ERPVEDSHGD VIRPLRKQVE LLFNTRYAKA IGISEPVKVP YSKFLMHPEE 
LFVVGLPEGI SLRRPNCFGI AKLRKILEAS NSIQFVIKRP ELLTEGVKEP IMDSQERDSG 
DPLVDESLKR QGFQENYDAR LSRIDIANTL REQVQDLFNK KYGEALGIKY PVQVPYKRIK 
SNPGSVIIEG LPPGIPFRKP CTFGSQNLER ILAVADKIKF TVTRPFQGLI PKPDEDDANR 
LGEKVILREQ VKELFNEKYG EALGLNRPVL VPYKLIRDSP DAVEVTGLPD DIPFRNPNTY 
DIHRLEKILK AREHVRMVII NQLQPFAEIC NDAKVPAKDS SIPKRKRKRV SEGNSVSSSS 
SSSSSSSSNP DSVASANQIS LVVKLHRFGL RHSSLWPSPL CLAGPSTLGC GPRGRGGTGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.