Details for: CARTPT

Gene ID: 9607

Symbol: CARTPT

Ensembl ID: ENSG00000164326

Description: CART prepropeptide

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3,167
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.49
    Marker Score: 4,289
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.03
    Marker Score: 2,802
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1,995
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2,216
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.71
    Marker Score: 575
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,170
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.27
    Marker Score: 1,209
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.25
    Marker Score: 2,535
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,690
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,805
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.11
    Marker Score: 2,105
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.1
    Marker Score: 579
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.03
    Marker Score: 340
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,029
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,343
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13,877
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 490
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1,605
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.75
    Marker Score: 1,192
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1,176
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 480
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.6
    Marker Score: 361
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.57
    Marker Score: 542
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 177
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 358
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.49
    Marker Score: 609
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.48
    Marker Score: 2,902
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.48
    Marker Score: 230
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.45
    Marker Score: 101
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 444
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.41
    Marker Score: 196
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.4
    Marker Score: 625
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.4
    Marker Score: 214
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.4
    Marker Score: 392
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.36
    Marker Score: 217
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.36
    Marker Score: 340
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.36
    Marker Score: 199
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.36
    Marker Score: 155
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3
    Marker Score: 366
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.29
    Marker Score: 103
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.27
    Marker Score: 121
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.27
    Marker Score: 259
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.27
    Marker Score: 78
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.26
    Marker Score: 129
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.25
    Marker Score: 130
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.24
    Marker Score: 275
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.24
    Marker Score: 84
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.24
    Marker Score: 977
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.24
    Marker Score: 110
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.23
    Marker Score: 237
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.21
    Marker Score: 99
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.2
    Marker Score: 117
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 165
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.18
    Marker Score: 439
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 103
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.18
    Marker Score: 46
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.16
    Marker Score: 43
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.15
    Marker Score: 132
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.14
    Marker Score: 45
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.14
    Marker Score: 33
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.13
    Marker Score: 274
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.13
    Marker Score: 46
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.13
    Marker Score: 376
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.12
    Marker Score: 45
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.12
    Marker Score: 207
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.12
    Marker Score: 170
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 149
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.12
    Marker Score: 45
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.12
    Marker Score: 490
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.12
    Marker Score: 48

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CARTPT gene is characterized by its involvement in multiple signaling pathways, including cell-cell signaling, cellular response to starvation, and circadian regulation of gene expression. It is also implicated in various molecular functions, such as negative regulation of appetite, negative regulation of bone resorption, and positive regulation of blood pressure. The gene's expression is widespread, with significant levels found in endothelial cells, immune cells, and neurons, underscoring its importance in maintaining tissue homeostasis. **Pathways and Functions:** The CARTPT gene is involved in several key pathways, including: 1. **Neuropeptide hormone activity:** CART is a neuropeptide hormone that regulates various physiological processes, including appetite, metabolism, and immune responses. 2. **G protein-coupled receptor signaling pathway:** CART interacts with G protein-coupled receptors, modulating downstream signaling pathways involved in cellular homeostasis. 3. **Cell-cell signaling:** CART regulates communication between cells, influencing immune responses and tissue homeostasis. 4. **Intracellular glucose homeostasis:** CART modulates glucose metabolism, influencing insulin secretion and energy homeostasis. 5. **Signal transduction:** CART interacts with various signaling molecules, including kinases and phosphatases, to regulate cellular responses. **Functions:** The CARTPT gene has several key functions, including: 1. **Negative regulation of appetite:** CART reduces appetite, modulating food intake and energy homeostasis. 2. **Negative regulation of bone resorption:** CART inhibits bone resorption, maintaining bone health and density. 3. **Negative regulation of glucagon secretion:** CART reduces glucagon secretion, regulating glucose metabolism and energy homeostasis. 4. **Negative regulation of osteoclast differentiation:** CART inhibits osteoclast differentiation, maintaining bone health and density. 5. **Regulation of insulin secretion:** CART modulates insulin secretion, influencing glucose metabolism and energy homeostasis. **Clinical Significance:** The CARTPT gene has significant clinical implications in immune regulation and disease. Dysregulation of CART signaling has been implicated in various conditions, including: 1. **Obesity:** Altered CART signaling has been linked to obesity, metabolic syndrome, and related disorders. 2. **Autoimmune diseases:** CART has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where dysregulation of CART signaling contributes to disease pathogenesis. 3. **Cancer:** CART has been shown to regulate cancer cell growth, invasion, and metastasis, highlighting its potential as a therapeutic target. 4. **Neurological disorders:** CART has been implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease, where dysregulation of CART signaling contributes to disease pathogenesis. In conclusion, the CARTPT gene plays a complex and multifaceted role in regulating immune responses, homeostasis, and disease. Further research is needed to fully elucidate the mechanisms underlying CART signaling and its clinical significance in immune regulation and disease.

Genular Protein ID: 3010885520

Symbol: CART_HUMAN

Name: Cocaine- and amphetamine-regulated transcript protein

UniProtKB Accession Codes:

Q16568 Q6FG92

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8647455

Title: Characterization of the human cDNA and genomic DNA encoding CART: a cocaine- and amphetamine-regulated transcript.

PubMed ID: 8647455

DOI: 10.1016/0378-1119(96)88651-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9590691

Title: Hypothalamic CART is a new anorectic peptide regulated by leptin.

PubMed ID: 9590691

DOI: 10.1038/29993

PubMed ID: 11478874

Title: Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold.

PubMed ID: 11478874

DOI: 10.1021/bi010433u

PubMed ID: 10905499

Title: The CART gene and human obesity: mutational analysis and population genetics.

PubMed ID: 10905499

DOI: 10.2337/diabetes.49.5.872

PubMed ID: 11522684

Title: Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family.

PubMed ID: 11522684

DOI: 10.2337/diabetes.50.9.2157

Sequence Information:

  • Length: 116
  • Mass: 12829
  • Checksum: FC396CA2C032AA83
  • Sequence:
    • MESSRVRLLP LLGAALLLML PLLGTRAQED AELQPRALDI YSAVDDASHE KELIEALQEV 
LKKLKSKRVP IYEKKYGQVP MCDAGEQCAV RKGARIGKLC DCPRGTSCNS FLLKCL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.