Details for: FEZ2

Gene ID: 9637

Symbol: FEZ2

Ensembl ID: ENSG00000171055

Description: fasciculation and elongation protein zeta 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 4.12
    Marker Score: 5,547
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.98
    Marker Score: 4,815
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.22
    Marker Score: 8,059
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.57
    Marker Score: 1,504
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.16
    Marker Score: 9,033
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.08
    Marker Score: 657
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.95
    Marker Score: 7,531
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.93
    Marker Score: 5,252
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.85
    Marker Score: 1,005
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.85
    Marker Score: 595
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.82
    Marker Score: 904
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.78
    Marker Score: 1,060
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.75
    Marker Score: 1,556
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.75
    Marker Score: 107,622
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.71
    Marker Score: 1,713
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.7
    Marker Score: 17,113
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.7
    Marker Score: 25,416
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.67
    Marker Score: 3,345
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.67
    Marker Score: 3,047
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.64
    Marker Score: 55,548
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.63
    Marker Score: 13,990
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.62
    Marker Score: 15,384
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.59
    Marker Score: 6,481
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.57
    Marker Score: 59,675
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.56
    Marker Score: 6,144
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.56
    Marker Score: 910
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.55
    Marker Score: 1,457
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.51
    Marker Score: 8,963
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.5
    Marker Score: 3,295
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.49
    Marker Score: 436
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.49
    Marker Score: 1,565
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.48
    Marker Score: 1,026
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.47
    Marker Score: 1,155
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.46
    Marker Score: 37,424
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,686
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.45
    Marker Score: 524
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.44
    Marker Score: 2,119
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.42
    Marker Score: 784
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.41
    Marker Score: 10,787
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.4
    Marker Score: 477
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.39
    Marker Score: 2,149
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.39
    Marker Score: 5,985
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.37
    Marker Score: 435
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.36
    Marker Score: 762
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.36
    Marker Score: 1,750
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.34
    Marker Score: 1,204
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.34
    Marker Score: 1,481
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.34
    Marker Score: 1,948
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.34
    Marker Score: 2,375
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.34
    Marker Score: 705
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.32
    Marker Score: 1,427
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.32
    Marker Score: 17,402
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.3
    Marker Score: 12,191
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.29
    Marker Score: 3,100
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.29
    Marker Score: 1,615
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.29
    Marker Score: 27,459
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.28
    Marker Score: 1,334
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.27
    Marker Score: 14,267
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.26
    Marker Score: 3,079
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.25
    Marker Score: 1,269
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.25
    Marker Score: 1,403
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.24
    Marker Score: 604
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.24
    Marker Score: 1,069
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.24
    Marker Score: 458
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.24
    Marker Score: 1,119
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.23
    Marker Score: 7,998
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.23
    Marker Score: 2,491
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.22
    Marker Score: 1,318
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.22
    Marker Score: 3,824
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.21
    Marker Score: 1,304
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.21
    Marker Score: 4,669
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.2
    Marker Score: 23,961
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.2
    Marker Score: 1,103
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.19
    Marker Score: 304
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.18
    Marker Score: 2,789
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.18
    Marker Score: 1,121
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.17
    Marker Score: 683
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.17
    Marker Score: 1,237
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.16
    Marker Score: 639
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.16
    Marker Score: 1,228
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.15
    Marker Score: 25,755
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.15
    Marker Score: 995
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.14
    Marker Score: 2,194
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.14
    Marker Score: 1,646
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.14
    Marker Score: 343
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.14
    Marker Score: 273
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.13
    Marker Score: 1,746
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.13
    Marker Score: 469
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.13
    Marker Score: 265
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.13
    Marker Score: 11,632
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.12
    Marker Score: 4,316
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.11
    Marker Score: 1,268
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.1
    Marker Score: 428
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.1
    Marker Score: 1,263
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.09
    Marker Score: 2,051
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.09
    Marker Score: 264
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.09
    Marker Score: 549
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.08
    Marker Score: 2,254
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.07
    Marker Score: 304
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.07
    Marker Score: 321

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FEZ2 is a fasciculation and elongation protein that belongs to the FEZ family of proteins, which are known to play critical roles in regulating cellular morphology and migration. The FEZ2 protein is characterized by its ability to interact with various cellular components, including proteins and signaling pathways, to regulate its activity. Notably, FEZ2 acts as a negative regulator of autophagosome assembly, which is essential for maintaining cellular homeostasis and preventing excessive cellular damage. **Pathways and Functions:** FEZ2 is involved in several key pathways, including: 1. **Axon Guidance:** FEZ2 plays a crucial role in regulating axon guidance, which is essential for the development and maintenance of the nervous system. FEZ2 interacts with other proteins to regulate the formation and maintenance of axonal connections. 2. **Negative Regulation of Autophagosome Assembly:** FEZ2 acts as a negative regulator of autophagosome assembly, which is essential for maintaining cellular homeostasis and preventing excessive cellular damage. 3. **Signal Transduction:** FEZ2 interacts with various signaling pathways to regulate its activity and influence cellular behavior. **Clinical Significance:** FEZ2 has been significantly expressed in various cell types, including anterior lens cells, skeletal muscle fibers, and neural progenitor cells. The dysregulation of FEZ2 has been implicated in several neurological and developmental disorders, including: 1. **Autophagy-related disorders:** FEZ2 dysregulation has been linked to autophagy-related disorders, such as autophagy-related protein 5 (ATG5) deficiency. 2. **Neurodegenerative disorders:** FEZ2 dysregulation has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Developmental disorders:** FEZ2 dysregulation has been linked to developmental disorders, such as neural tube defects and congenital heart defects. In conclusion, FEZ2 is a critical gene that plays a significant role in regulating cellular processes, including axon guidance, negative regulation of autophagosome assembly, and signal transduction. The dysregulation of FEZ2 has been implicated in several neurological and developmental disorders, highlighting its importance in maintaining cellular homeostasis and preventing excessive cellular damage. Further research is necessary to fully elucidate the role of FEZ2 in human disease and to explore potential therapeutic strategies for its dysregulation.

Genular Protein ID: 810530227

Symbol: FEZ2_HUMAN

Name: Fasciculation and elongation protein zeta-2

UniProtKB Accession Codes:

Q9UHY8 Q5EBN3 Q76LN0 Q99690

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14697253

Title: Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1.

PubMed ID: 14697253

DOI: 10.1016/j.bbrc.2003.12.006

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 9096408

Title: The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation.

PubMed ID: 9096408

DOI: 10.1073/pnas.94.7.3414

PubMed ID: 16484223

Title: FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region.

PubMed ID: 16484223

DOI: 10.1074/jbc.m513280200

PubMed ID: 20812761

Title: Human FEZ1 protein forms a disulfide bond mediated dimer: implications for cargo transport.

PubMed ID: 20812761

DOI: 10.1021/pr100314q

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 353
  • Mass: 39666
  • Checksum: 4F55D0FC1A6B3421
  • Sequence:
    • MAADGDWQDF YEFQEPARSL LDQENCNASP EPGAEAGAEA GGGADGFPAP ACSLEEKLSL 
CFRPSDPGAE PPRTAVRPIT ERSLLQGDEI WNALTDNYGN VMPVDWKSSH TRTLHLLTLN 
LSEKGVSDSL LFDTSDDEEL REQLDMHSII VSCVNDEPLF TADQVIEEIE EMMQESPDPE 
DDETPTQSDR LSMLSQEIQT LKRSSTGSYE ERVKRLSVSE LNEILEEIET AIKEYSEELV 
QQLALRDELE FEKEVKNSFI SVLIEVQNKQ KEHKETAKKK KKLKNGSSQN GKNERSHMPG 
TYLTTVIPYE KKNGPPSVED LQILTKILRA MKEDSEKVPS LLTDYILKVL CPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.