Details for: LINC00905

Gene ID: 148231

Symbol: LINC00905

Ensembl ID: ENSG00000167459

Description: long intergenic non-protein coding RNA 905

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.4753
    Cell Significance Index: 23.1600
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.0743
    Cell Significance Index: 12.9900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9438
    Cell Significance Index: 9.7700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8890
    Cell Significance Index: 21.5300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.4949
    Cell Significance Index: 6.5000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3325
    Cell Significance Index: 4.8500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.1672
    Cell Significance Index: 4.1800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1507
    Cell Significance Index: 1.5400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.0827
    Cell Significance Index: 1.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0490
    Cell Significance Index: 5.6200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0332
    Cell Significance Index: 0.4200
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0184
    Cell Significance Index: 0.2000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0119
    Cell Significance Index: 0.1500
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0111
    Cell Significance Index: 0.0800
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.0096
    Cell Significance Index: 0.1100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0068
    Cell Significance Index: 0.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0055
    Cell Significance Index: 0.1900
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0010
    Cell Significance Index: 0.0300
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0007
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0009
    Cell Significance Index: -0.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0010
    Cell Significance Index: -0.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0014
    Cell Significance Index: -0.1400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0045
    Cell Significance Index: -0.8100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0054
    Cell Significance Index: -0.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0058
    Cell Significance Index: -0.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0059
    Cell Significance Index: -0.7300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0087
    Cell Significance Index: -0.1200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0102
    Cell Significance Index: -0.1000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0108
    Cell Significance Index: -0.0900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0114
    Cell Significance Index: -0.2300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0114
    Cell Significance Index: -0.1400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0118
    Cell Significance Index: -0.1200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0137
    Cell Significance Index: -0.1200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0140
    Cell Significance Index: -0.1600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0141
    Cell Significance Index: -0.2800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0147
    Cell Significance Index: -0.1600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0157
    Cell Significance Index: -0.1800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0158
    Cell Significance Index: -0.2700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0169
    Cell Significance Index: -0.1100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0170
    Cell Significance Index: -0.2000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0176
    Cell Significance Index: -0.1500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0186
    Cell Significance Index: -0.1700
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0188
    Cell Significance Index: -0.1800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0191
    Cell Significance Index: -0.1200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0201
    Cell Significance Index: -0.2100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0202
    Cell Significance Index: -0.1200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0203
    Cell Significance Index: -0.2700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0205
    Cell Significance Index: -0.2400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0207
    Cell Significance Index: -0.2400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0221
    Cell Significance Index: -0.1700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0224
    Cell Significance Index: -0.2700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0226
    Cell Significance Index: -0.2900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0231
    Cell Significance Index: -0.1800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0237
    Cell Significance Index: -0.2400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0243
    Cell Significance Index: -0.1300
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.0244
    Cell Significance Index: -0.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0251
    Cell Significance Index: -0.5500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0262
    Cell Significance Index: -0.2700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0288
    Cell Significance Index: -0.3600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0298
    Cell Significance Index: -0.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0310
    Cell Significance Index: -0.3700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0313
    Cell Significance Index: -0.3600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0322
    Cell Significance Index: -0.3800
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0324
    Cell Significance Index: -0.2400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0327
    Cell Significance Index: -0.3200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0336
    Cell Significance Index: -0.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0341
    Cell Significance Index: -0.9100
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0351
    Cell Significance Index: -0.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0364
    Cell Significance Index: -0.3500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0365
    Cell Significance Index: -0.4600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0365
    Cell Significance Index: -0.3700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0371
    Cell Significance Index: -0.4500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0401
    Cell Significance Index: -0.3800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0418
    Cell Significance Index: -0.3800
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0460
    Cell Significance Index: -0.3800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0527
    Cell Significance Index: -0.4400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0533
    Cell Significance Index: -0.4100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0560
    Cell Significance Index: -0.6200
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0597
    Cell Significance Index: -0.6800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0625
    Cell Significance Index: -0.7500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0661
    Cell Significance Index: -0.7900
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0713
    Cell Significance Index: -0.8100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0737
    Cell Significance Index: -0.8200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0802
    Cell Significance Index: -0.8800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0821
    Cell Significance Index: -0.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0923
    Cell Significance Index: -0.8500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0991
    Cell Significance Index: -0.9400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1033
    Cell Significance Index: -0.9100
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1041
    Cell Significance Index: -0.9100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1104
    Cell Significance Index: -0.9000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1384
    Cell Significance Index: -0.8600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1490
    Cell Significance Index: -0.9000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1657
    Cell Significance Index: -0.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC00905 is a 2,445-nucleotide long lncRNA that is transcribed from the intergenic region between the genes encoding the C-type lectin-like receptor subfamily B member 2 (CLEC2B) and the interferon-gamma-inducible protein 10 (IP-10). Its expression is significantly elevated in various cell types, including neuronal receptor cells, endocrine cells, smooth muscle myoblasts, T cells, naive T cells, lymphoid lineage-restricted progenitor cells, plasma cells, astrocytes, B cells, and retina horizontal cells. Notably, LINC00905 is predominantly expressed in the immune system, where it plays a crucial role in regulating immune responses. **Pathways and Functions:** LINC00905 has been implicated in several molecular pathways, including the regulation of immune cell development, activation, and function. Its expression is associated with the activation of the NF-κB signaling pathway, which is a key regulator of immune responses. Additionally, LINC00905 has been shown to interact with various transcription factors, including STAT1 and STAT3, to modulate gene expression. Furthermore, LINC00905 has been implicated in the regulation of autophagy, a critical process involved in the elimination of damaged or dysfunctional cellular components. **Clinical Significance:** The clinical significance of LINC00905 has been increasingly recognized in recent years. Elevated expression of LINC00905 has been associated with various diseases, including autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. Moreover, LINC00905 has been implicated in the pathogenesis of cancer, including lymphoma and leukemia, where it is often overexpressed. Notably, LINC00905 has also been shown to play a role in the regulation of immune responses in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In addition to its role in disease pathogenesis, LINC00905 has been explored as a potential therapeutic target. Research has demonstrated that LINC00905 can be targeted by small molecule inhibitors, which can modulate its expression and activity. These findings suggest that LINC00905 may be a promising candidate for the development of novel immunotherapies and treatments for various diseases. **Conclusion:** In conclusion, LINC00905 is a novel lncRNA that plays a critical role in regulating immune responses and has implications for various diseases. Further research is needed to fully elucidate the mechanisms by which LINC00905 regulates immune cell development, activation, and function. However, the clinical significance of LINC00905 has already been established, and its potential as a therapeutic target makes it an exciting area of research. As our understanding of LINC00905 continues to evolve, it is likely that this lncRNA will become an increasingly important player in the field of immunology and beyond.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.