Details for: E2F3
Gene ID: 1871
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: E2F3
Ensembl ID: ENSG00000112242
Description: E2F transcription factor 3
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 12.91rCSI 46.47%PRS 63.96
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CSI 11.28rCSI 10.86%PRS 82.43
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CSI 9.28rCSI 22.56%PRS 63.97
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CSI 7.2rCSI 13.08%PRS 74.9
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CSI 7.12rCSI 8.22%PRS 75.38
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CSI 6.33rCSI 5.12%PRS 85.09
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CSI 5.58rCSI 14.16%PRS 74.18
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CSI 5.53rCSI 16.43%PRS 90.65
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CSI 5.37rCSI 8.56%PRS 74.78
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CSI 4.86rCSI 18.49%PRS 74.5
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CSI 4.83rCSI 20.95%PRS 87.23
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CSI 4.75rCSI 3.66%PRS 86.13
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CSI 4.73rCSI 12.55%PRS 87.41
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CSI 4.62rCSI 14.45%PRS 67.66
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CSI 4.54rCSI 18.33%PRS 83.11
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CSI 4.26rCSI 3.93%PRS 84.31
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CSI 4.2rCSI 4.32%PRS 92.55
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CSI 4.2rCSI 5.07%PRS 89.7
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CSI 4.11rCSI 3.4%PRS 85.25
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CSI 4.05rCSI 8.95%PRS 69.57
-
CSI 4.01rCSI 6.6%PRS 86.46
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CSI 3.7rCSI 9.88%PRS 75.5
-
CSI 3.66rCSI 2.85%PRS 94.21
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CSI 3.57rCSI 8.01%PRS 92.9
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CSI 3.55rCSI 4.93%PRS 81.43
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CSI 3.44rCSI 4.94%PRS 73.39
-
CSI 3.36rCSI 5.13%PRS 89.19
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CSI 3.18rCSI 2.22%PRS 86.38
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CSI 3.17rCSI 2.38%PRS 88.37
-
CSI 2.98rCSI 7.18%PRS 93.71
-
CSI 2.95rCSI 1.96%PRS 85.44
-
CSI 2.95rCSI 2.05%PRS 93.06
-
CSI 2.93rCSI 12.16%PRS 80.25
-
CSI 2.93rCSI 3.65%PRS 90.83
-
CSI 2.92rCSI 5.06%PRS 75.26
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CSI 2.86rCSI 10.7%PRS 76.05
-
CSI 2.76rCSI 5.55%PRS 74.19
-
CSI 2.72rCSI 17.01%PRS 75.29
-
CSI 2.71rCSI 4.87%PRS 76.78
-
CSI 2.7rCSI 2.13%PRS 72.91
-
CSI 2.62rCSI 5.76%PRS 86.33
-
CSI 2.59rCSI 4.43%PRS 88.09
-
CSI 2.58rCSI 2.33%PRS 81.56
-
CSI 2.56rCSI 5.86%PRS 83.84
-
CSI 2.49rCSI 6.48%PRS 84.09
-
CSI 2.43rCSI 14.32%PRS 66.56
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CSI 2.39rCSI 4.95%PRS 79.97
-
CSI 2.34rCSI 4.39%PRS 72.07
-
CSI 2.34rCSI 2.9%PRS 63.91
-
CSI 2.28rCSI 3.4%PRS 82.56
-
CSI 2.28rCSI 54.54%PRS 64.02
-
CSI 2.26rCSI 3.6%PRS 76.55
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CSI 2.25rCSI 54.36%PRS 64.6
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CSI 2.23rCSI 5.45%PRS 75.53
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CSI 2.22rCSI 1.92%PRS 86.6
-
CSI 2.22rCSI 2.02%PRS 93.06
-
CSI 2.2rCSI 1.95%PRS 80.81
-
CSI 2.2rCSI 3.53%PRS 67.42
-
CSI 2.17rCSI 8.22%PRS 66.57
-
CSI 2.14rCSI 3.44%PRS 73.68
-
CSI 2.12rCSI 1.95%PRS 89.82
-
CSI 2.1rCSI 3.52%PRS 66
-
CSI 2rCSI 1.34%PRS 94.02
-
CSI 1.98rCSI 2.99%PRS 87.84
-
CSI 1.94rCSI 2.31%PRS 66.07
-
CSI 1.91rCSI 1.84%PRS 77.2
-
CSI 1.9rCSI 2.75%PRS 87.77
-
CSI 1.85rCSI 2.3%PRS 83.68
-
CSI 1.84rCSI 4.12%PRS 66.89
-
CSI 1.82rCSI 3.62%PRS 78.91
-
CSI 1.8rCSI 2.31%PRS 79.28
-
CSI 1.78rCSI 3.66%PRS 70.38
-
CSI 1.73rCSI 2.64%PRS 83.06
-
CSI 1.7rCSI 2.13%PRS 90.33
-
CSI 1.61rCSI 2.07%PRS 67.17
-
CSI 1.5rCSI 2.29%PRS 86.28
-
CSI 1.44rCSI 1.79%PRS 81.25
-
CSI 1.43rCSI 1.88%PRS 92.01
-
CSI 1.38rCSI 2%PRS 93.56
-
CSI 1.37rCSI 7.77%PRS 69.4
-
CSI 1.33rCSI 4.17%PRS 69.93
-
CSI 1.33rCSI 2.74%PRS 79.3
-
CSI 1.32rCSI 2.96%PRS 89.36
-
CSI 1.28rCSI 1.97%PRS 81.9
-
CSI 1.26rCSI 5.55%PRS 71.64
-
CSI 1.24rCSI 6.92%PRS 83.34
-
CSI 1.14rCSI 2.46%PRS 70.52
-
CSI 1.06rCSI 1.88%PRS 65.53
-
CSI 1.04rCSI 1.97%PRS 89.86
-
CSI 1.04rCSI 4.56%PRS 89.57
-
CSI 1rCSI 3.21%PRS 79.87
-
CSI 0.87rCSI 2.09%PRS 70.15
-
CSI 0.87rCSI 2.87%PRS 69.16
-
CSI 0.78rCSI 6.31%PRS 77.79
-
CSI 0.61rCSI 5.25%PRS 71.7
-
CSI 0.57rCSI 4.22%PRS 71.18
-
CSI 0.57rCSI 11.56%PRS 74.05
-
CSI 0.56rCSI 2.19%PRS 95.09
-
CSI 0.44rCSI 2.54%PRS 87.27
-
CSI 0.4rCSI 5.64%PRS 74.42
-
CSI 0.4rCSI 7.8%PRS 73.1%
-
CSI 0.4rCSI 5.6%PRS 74.4%
-
CSI 0.4rCSI 2.5%PRS 87.3%
-
CSI 0.6rCSI 2.2%PRS 95.1%
-
CSI 0.6rCSI 11.6%PRS 74.1%
-
CSI 0.6rCSI 4.2%PRS 71.2%
-
CSI 0.6rCSI 5.3%PRS 71.7%
-
CSI 0.8rCSI 6.3%PRS 77.8%
-
CSI 0.9rCSI 2.9%PRS 69.2%
-
CSI 0.9rCSI 2.1%PRS 70.2%
-
CSI 1.0rCSI 3.2%PRS 79.9%
-
CSI 1.0rCSI 4.6%PRS 89.6%
-
CSI 1.0rCSI 2.0%PRS 89.9%
-
CSI 1.1rCSI 1.9%PRS 65.5%
-
CSI 1.1rCSI 2.5%PRS 70.5%
-
CSI 1.2rCSI 6.9%PRS 83.3%
-
CSI 1.3rCSI 5.6%PRS 71.6%
-
CSI 1.3rCSI 2.0%PRS 81.9%
-
CSI 1.3rCSI 3.0%PRS 89.4%
-
CSI 1.3rCSI 2.7%PRS 79.3%
-
CSI 1.3rCSI 4.2%PRS 69.9%
-
CSI 1.4rCSI 7.8%PRS 69.4%
-
CSI 1.4rCSI 2.0%PRS 93.6%
-
CSI 1.4rCSI 1.9%PRS 92.0%
-
CSI 1.4rCSI 1.8%PRS 81.3%
-
CSI 1.5rCSI 2.3%PRS 86.3%
-
CSI 1.6rCSI 2.1%PRS 67.2%
-
CSI 1.7rCSI 2.1%PRS 90.3%
-
CSI 1.7rCSI 2.6%PRS 83.1%
-
CSI 1.8rCSI 3.7%PRS 70.4%
-
CSI 1.8rCSI 2.3%PRS 79.3%
-
CSI 1.8rCSI 3.6%PRS 78.9%
-
CSI 1.8rCSI 4.1%PRS 66.9%
-
CSI 1.9rCSI 2.3%PRS 83.7%
-
CSI 1.9rCSI 2.8%PRS 87.8%
-
CSI 1.9rCSI 1.8%PRS 77.2%
-
CSI 1.9rCSI 2.3%PRS 66.1%
-
CSI 2.0rCSI 3.0%PRS 87.8%
-
CSI 2.0rCSI 1.3%PRS 94.0%
-
CSI 2.1rCSI 3.5%PRS 66.0%
-
CSI 2.1rCSI 2.0%PRS 89.8%
-
CSI 2.1rCSI 3.4%PRS 73.7%
-
CSI 2.2rCSI 8.2%PRS 66.6%
-
CSI 2.2rCSI 3.5%PRS 67.4%
-
CSI 2.2rCSI 2.0%PRS 80.8%
-
CSI 2.2rCSI 2.0%PRS 93.1%
-
CSI 2.2rCSI 1.9%PRS 86.6%
-
CSI 2.2rCSI 5.5%PRS 75.5%
-
CSI 2.3rCSI 54.4%PRS 64.6%
-
CSI 2.3rCSI 3.6%PRS 76.6%
-
CSI 2.3rCSI 54.5%PRS 64.0%
-
CSI 2.3rCSI 3.4%PRS 82.6%
-
CSI 2.3rCSI 2.9%PRS 63.9%
-
CSI 2.3rCSI 4.4%PRS 72.1%
-
CSI 2.4rCSI 5.0%PRS 80.0%
-
CSI 2.4rCSI 14.3%PRS 66.6%
-
CSI 2.5rCSI 6.5%PRS 84.1%
-
CSI 2.6rCSI 5.9%PRS 83.8%
-
CSI 2.6rCSI 2.3%PRS 81.6%
-
CSI 2.6rCSI 4.4%PRS 88.1%
-
CSI 2.6rCSI 5.8%PRS 86.3%
-
CSI 2.7rCSI 2.1%PRS 72.9%
-
CSI 2.7rCSI 4.9%PRS 76.8%
-
CSI 2.7rCSI 17.0%PRS 75.3%
-
CSI 2.8rCSI 5.6%PRS 74.2%
-
CSI 2.9rCSI 10.7%PRS 76.1%
-
CSI 2.9rCSI 5.1%PRS 75.3%
-
CSI 2.9rCSI 3.7%PRS 90.8%
-
CSI 2.9rCSI 12.2%PRS 80.3%
-
CSI 3.0rCSI 2.1%PRS 93.1%
-
CSI 3.0rCSI 2.0%PRS 85.4%
-
CSI 3.0rCSI 7.2%PRS 93.7%
-
CSI 3.2rCSI 2.4%PRS 88.4%
-
CSI 3.2rCSI 2.2%PRS 86.4%
-
CSI 3.4rCSI 5.1%PRS 89.2%
-
CSI 3.4rCSI 4.9%PRS 73.4%
-
CSI 3.6rCSI 4.9%PRS 81.4%
-
CSI 3.6rCSI 8.0%PRS 92.9%
-
CSI 3.7rCSI 2.9%PRS 94.2%
-
CSI 3.7rCSI 9.9%PRS 75.5%
-
CSI 4.0rCSI 6.6%PRS 86.5%
-
CSI 4.1rCSI 9.0%PRS 69.6%
-
CSI 4.1rCSI 3.4%PRS 85.3%
-
CSI 4.2rCSI 5.1%PRS 89.7%
-
CSI 4.2rCSI 4.3%PRS 92.6%
-
CSI 4.3rCSI 3.9%PRS 84.3%
-
CSI 4.5rCSI 18.3%PRS 83.1%
-
CSI 4.6rCSI 14.5%PRS 67.7%
-
CSI 4.7rCSI 12.6%PRS 87.4%
-
CSI 4.8rCSI 3.7%PRS 86.1%
-
CSI 4.8rCSI 21.0%PRS 87.2%
-
CSI 4.9rCSI 18.5%PRS 74.5%
-
CSI 5.4rCSI 8.6%PRS 74.8%
-
CSI 5.5rCSI 16.4%PRS 90.7%
-
CSI 5.6rCSI 14.2%PRS 74.2%
-
CSI 6.3rCSI 5.1%PRS 85.1%
-
CSI 7.1rCSI 8.2%PRS 75.4%
-
CSI 7.2rCSI 13.1%PRS 74.9%
-
CSI 9.3rCSI 22.6%PRS 64.0%
-
CSI 11.3rCSI 10.9%PRS 82.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 239456170
Symbol: E2F3_HUMAN
Name: Transcription factor E2F3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8246996
Title: The retinoblastoma protein binds to a family of E2F transcription factors.
PubMed ID: 8246996
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 7584044
Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.
PubMed ID: 7584044
PubMed ID: 15716352
Title: EAPP, a novel E2F binding protein that modulates E2F-dependent transcription.
PubMed ID: 15716352
Sequence Information:
- Length: 465
- Mass: 49162
- Checksum: 4641565842CA99EC
- Sequence:
MRKGIQPALE QYLVTAGGGE GAAVVAAAAA ASMDKRALLA SPGFAAAAAA AAAPGAYIQI LTTNTSTTSC SSSLQSGAVA AGPLLPSAPG AEQTAGSLLY TTPHGPSSRA GLLQQPPALG RGGSGGGGGP PAKRRLELGE SGHQYLSDGL KTPKGKGRAA LRSPDSPKTP KSPSEKTRYD TSLGLLTKKF IQLLSQSPDG VLDLNKAAEV LKVQKRRIYD ITNVLEGIHL IKKKSKNNVQ WMGCSLSEDG GMLAQCQGLS KEVTELSQEE KKLDELIQSC TLDLKLLTED SENQRLAYVT YQDIRKISGL KDQTVIVVKA PPETRLEVPD SIESLQIHLA STQGPIEVYL CPEETETHSP MKTNNQDHNG NIPKPASKDL ASTNSGHSDC SVSMGNLSPL ASPANLLQQT EDQIPSNLEG PFVNLLPPLL QEDYLLSLGE EEGISDLFDA YDLEKLPLVE DFMCS