E2F3 | ENSG00000112242 | NCBI 1871

Details for: E2F3

Gene ID: 1871

Symbol: E2F3

Ensembl ID: ENSG00000112242

Description: E2F transcription factor 3

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic g1/s transition in cancer due to rb1 defects
(R-HSA-9659787)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cyclin d associated events in g1
(R-HSA-69231)
Defective binding of rb1 mutants to e2f1,(e2f2, e2f3)
(R-HSA-9661069)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
G1 phase
(R-HSA-69236)
G2 phase
(R-HSA-68911)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Oncogene induced senescence
(R-HSA-2559585)
Oxidative stress induced senescence
(R-HSA-2559580)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Signaling by notch
(R-HSA-157118)
Signal transduction
(R-HSA-162582)
Chromatin
(GO:0000785)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Dna-binding transcription activator activity
(GO:0001216)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
G1/s transition of mitotic cell cycle
(GO:0000082)
Negative regulation of fat cell proliferation
(GO:0070345)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of vascular associated smooth muscle cell apoptotic process
(GO:1905461)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein import into nucleus
(GO:0006606)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.66
Marker Score: 17,164
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.56
Marker Score: 3,175
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.49
Marker Score: 3,513
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.48
Marker Score: 2,277
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.45
Marker Score: 12,479
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.38
Marker Score: 29,486
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.36
Marker Score: 83,845
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.35
Marker Score: 790
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.33
Marker Score: 12,649
Cell Name: neuron (CL0000540)
Fold Change: 1.31
Marker Score: 5,338
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.27
Marker Score: 11,935
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.2
Marker Score: 18,727
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.2
Marker Score: 385
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.19
Marker Score: 3,397
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.16
Marker Score: 696
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.08
Marker Score: 1,820
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.03
Marker Score: 576
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,733
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,958
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.99
Marker Score: 1,200
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,397
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.98
Marker Score: 663
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,402
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.94
Marker Score: 295
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 479
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.92
Marker Score: 483
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 433
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.91
Marker Score: 1,472
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,711
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.9
Marker Score: 3,732
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.9
Marker Score: 33,208
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9
Marker Score: 3,461
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,295
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.87
Marker Score: 33,073
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4,945
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.87
Marker Score: 430
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.86
Marker Score: 4,533
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 307
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.84
Marker Score: 12,540
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.84
Marker Score: 300
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.83
Marker Score: 301
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.82
Marker Score: 4,949
Cell Name: astrocyte (CL0000127)
Fold Change: 0.82
Marker Score: 711
Cell Name: interneuron (CL0000099)
Fold Change: 0.81
Marker Score: 371
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.78
Marker Score: 1,101
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 304
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.75
Marker Score: 575
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.73
Marker Score: 41,006
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 373
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.71
Marker Score: 24,038
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7
Marker Score: 1,035
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7
Marker Score: 2,937
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.7
Marker Score: 2,919
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.69
Marker Score: 471
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.69
Marker Score: 596
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.69
Marker Score: 410
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.68
Marker Score: 324
Cell Name: brush cell (CL0002204)
Fold Change: 0.67
Marker Score: 613
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.67
Marker Score: 233
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.66
Marker Score: 421
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.66
Marker Score: 11,777
Cell Name: stellate neuron (CL0000122)
Fold Change: 0.66
Marker Score: 3,537
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.66
Marker Score: 2,547
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.65
Marker Score: 792
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.65
Marker Score: 208
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.64
Marker Score: 692
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.64
Marker Score: 4,917
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.64
Marker Score: 479
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.63
Marker Score: 1,775
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.63
Marker Score: 1,719
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.63
Marker Score: 366
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.63
Marker Score: 12,531
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.63
Marker Score: 1,567
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.62
Marker Score: 987
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.61
Marker Score: 2,499
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.6
Marker Score: 729
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.59
Marker Score: 591
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.59
Marker Score: 669
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.59
Marker Score: 594
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.58
Marker Score: 284
Cell Name: granulocyte (CL0000094)
Fold Change: 0.58
Marker Score: 261
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.58
Marker Score: 154
Cell Name: erythroblast (CL0000765)
Fold Change: 0.58
Marker Score: 362
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.58
Marker Score: 179
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.57
Marker Score: 607
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.57
Marker Score: 148
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.57
Marker Score: 377
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.57
Marker Score: 2,022
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.57
Marker Score: 1,412
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.57
Marker Score: 465
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.57
Marker Score: 237
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.56
Marker Score: 558
Cell Name: lung macrophage (CL1001603)
Fold Change: 0.56
Marker Score: 637
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.56
Marker Score: 376
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.55
Marker Score: 12,398
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.55
Marker Score: 323
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.55
Marker Score: 290
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.55
Marker Score: 271
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 436

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** 1. **Cell Cycle Regulation:** E2F3 is a transcription factor that regulates the expression of genes involved in the cell cycle, particularly in the G1/S transition. It interacts with other cell cycle regulators, such as pRb, to control the progression of cells through the cell cycle. 2. **Tumor Suppressor Function:** E2F3 has been classified as a tumor suppressor gene, as its dysregulation has been linked to various cancers. Its expression is often reduced in cancer cells, leading to uncontrolled cell proliferation. 3. **Specific Expression Patterns:** E2F3 is highly expressed in neurons, particularly in the cerebral cortex, and is also expressed in certain immune cells, such as innate lymphoid cells. Its expression is restricted to specific cell types, suggesting a specialized role in these cells. 4. **Interactions with Other Proteins:** E2F3 interacts with other proteins, including pRb, p53, and cyclin D, to regulate the cell cycle and prevent uncontrolled cell proliferation. **Pathways and Functions:** 1. **Cell Cycle Regulation:** E2F3 regulates the expression of genes involved in the G1/S transition, controlling the progression of cells through the cell cycle. 2. **Tumor Suppression:** E2F3 acts as a tumor suppressor by regulating the expression of genes involved in cell cycle control and preventing uncontrolled cell proliferation. 3. **Neuroprotection:** E2F3 is involved in neuroprotection, particularly in neurons, where it regulates the expression of genes involved in neuronal survival and differentiation. 4. **Immune Regulation:** E2F3 is also involved in immune regulation, particularly in innate lymphoid cells, where it regulates the expression of genes involved in immune cell activation and differentiation. **Clinical Significance:** 1. **Cancer:** E2F3 dysregulation has been linked to various cancers, including breast, colon, and prostate cancers. Its expression is often reduced in cancer cells, leading to uncontrolled cell proliferation. 2. **Neurodegenerative Diseases:** E2F3 dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it regulates the expression of genes involved in neuronal survival and differentiation. 3. **Immune Disorders:** E2F3 dysregulation has been linked to immune disorders, such as autoimmune diseases, where it regulates the expression of genes involved in immune cell activation and differentiation. 4. **Senescence:** E2F3 dysregulation has been implicated in cellular senescence, a state of permanent cell cycle arrest that occurs in response to DNA damage or other forms of cellular stress. In conclusion, E2F3 is a critical regulator of cell cycle and cancer progression, and its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, and immune disorders. Further research is needed to fully understand the role of E2F3 in these diseases and to develop therapeutic strategies to target its dysregulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription factor E2F3

Genular Protein ID: 239456170

Symbol: E2F3_HUMAN

Name: Transcription factor E2F3

UniProtKB Accession Codes:

O00716 Q15000 Q68DT0 Q9BZ44

Database IDs:

Citations:

PubMed ID: 8246996

Title: The retinoblastoma protein binds to a family of E2F transcription factors.

PubMed ID: 8246996

DOI: 10.1128/mcb.13.12.7813-7825.1993

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 15716352

Title: EAPP, a novel E2F binding protein that modulates E2F-dependent transcription.

PubMed ID: 15716352

DOI: 10.1091/mbc.e04-11-0975

Sequence Information:

Length: 465
Mass: 49162
Checksum: 4641565842CA99EC
Sequence:

MRKGIQPALE QYLVTAGGGE GAAVVAAAAA ASMDKRALLA SPGFAAAAAA AAAPGAYIQI 
LTTNTSTTSC SSSLQSGAVA AGPLLPSAPG AEQTAGSLLY TTPHGPSSRA GLLQQPPALG 
RGGSGGGGGP PAKRRLELGE SGHQYLSDGL KTPKGKGRAA LRSPDSPKTP KSPSEKTRYD 
TSLGLLTKKF IQLLSQSPDG VLDLNKAAEV LKVQKRRIYD ITNVLEGIHL IKKKSKNNVQ 
WMGCSLSEDG GMLAQCQGLS KEVTELSQEE KKLDELIQSC TLDLKLLTED SENQRLAYVT 
YQDIRKISGL KDQTVIVVKA PPETRLEVPD SIESLQIHLA STQGPIEVYL CPEETETHSP 
MKTNNQDHNG NIPKPASKDL ASTNSGHSDC SVSMGNLSPL ASPANLLQQT EDQIPSNLEG 
PFVNLLPPLL QEDYLLSLGE EEGISDLFDA YDLEKLPLVE DFMCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: E2F3

Associated with

Cells (max top 100)

Other Information

The retinoblastoma protein binds to a family of E2F transcription factors. PubMed ID: 8246996

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404