Details for: EIF5AP2

Gene ID: 1986

Symbol: EIF5AP2

Ensembl ID: ENSG00000267679

Description: eukaryotic translation initiation factor 5A pseudogene 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 3.3424
    Cell Significance Index: 34.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3635
    Cell Significance Index: 4.9600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0743
    Cell Significance Index: 1.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0068
    Cell Significance Index: -0.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0092
    Cell Significance Index: -5.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0161
    Cell Significance Index: -2.7500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0174
    Cell Significance Index: -0.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0285
    Cell Significance Index: -5.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0383
    Cell Significance Index: -1.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0740
    Cell Significance Index: -2.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0787
    Cell Significance Index: -3.6700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0901
    Cell Significance Index: -1.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0922
    Cell Significance Index: -2.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1174
    Cell Significance Index: -4.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1229
    Cell Significance Index: -3.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1279
    Cell Significance Index: -2.8000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1291
    Cell Significance Index: -1.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1409
    Cell Significance Index: -4.0600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1507
    Cell Significance Index: -2.2300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1607
    Cell Significance Index: -2.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1709
    Cell Significance Index: -5.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1850
    Cell Significance Index: -6.4800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1954
    Cell Significance Index: -3.3400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1983
    Cell Significance Index: -2.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2039
    Cell Significance Index: -6.6800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2171
    Cell Significance Index: -3.6900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.2257
    Cell Significance Index: -2.8900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2291
    Cell Significance Index: -2.9500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2445
    Cell Significance Index: -3.9600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2730
    Cell Significance Index: -3.5700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2767
    Cell Significance Index: -3.8000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2776
    Cell Significance Index: -3.3200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.2777
    Cell Significance Index: -2.5100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2787
    Cell Significance Index: -3.5000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2795
    Cell Significance Index: -3.5900
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.2855
    Cell Significance Index: -3.2500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2862
    Cell Significance Index: -4.0200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2883
    Cell Significance Index: -3.3000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.2884
    Cell Significance Index: -3.2800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2897
    Cell Significance Index: -3.4200
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3003
    Cell Significance Index: -3.2900
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.3009
    Cell Significance Index: -3.3400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3026
    Cell Significance Index: -6.5400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.3043
    Cell Significance Index: -3.8500
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.3059
    Cell Significance Index: -3.3200
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.3065
    Cell Significance Index: -2.8100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.3080
    Cell Significance Index: -2.8500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3100
    Cell Significance Index: -4.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3100
    Cell Significance Index: -6.5800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3115
    Cell Significance Index: -4.1000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3129
    Cell Significance Index: -3.4800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3152
    Cell Significance Index: -3.8400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3152
    Cell Significance Index: -3.7800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3167
    Cell Significance Index: -3.4500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.3169
    Cell Significance Index: -3.8300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.3186
    Cell Significance Index: -3.3000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.3194
    Cell Significance Index: -3.0900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.3242
    Cell Significance Index: -4.0600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3248
    Cell Significance Index: -3.6600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3258
    Cell Significance Index: -4.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3259
    Cell Significance Index: -6.5400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3272
    Cell Significance Index: -3.8500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.3298
    Cell Significance Index: -3.3700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3299
    Cell Significance Index: -3.9800
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.3301
    Cell Significance Index: -3.6400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3349
    Cell Significance Index: -6.5900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3383
    Cell Significance Index: -6.6900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3385
    Cell Significance Index: -4.8200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3401
    Cell Significance Index: -4.4400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3423
    Cell Significance Index: -4.3200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.3428
    Cell Significance Index: -3.9900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3441
    Cell Significance Index: -4.2300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.3460
    Cell Significance Index: -4.3200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3473
    Cell Significance Index: -4.2100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3477
    Cell Significance Index: -3.5500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.3477
    Cell Significance Index: -4.0400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.3487
    Cell Significance Index: -4.3800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3545
    Cell Significance Index: -3.7400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3559
    Cell Significance Index: -3.3800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3565
    Cell Significance Index: -4.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3569
    Cell Significance Index: -3.4300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.3588
    Cell Significance Index: -3.8900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3604
    Cell Significance Index: -3.9900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3605
    Cell Significance Index: -4.2600
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.3617
    Cell Significance Index: -4.0500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3618
    Cell Significance Index: -4.1100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3664
    Cell Significance Index: -3.4400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3674
    Cell Significance Index: -5.1000
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.3712
    Cell Significance Index: -4.0900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3713
    Cell Significance Index: -3.9500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3713
    Cell Significance Index: -3.5200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3732
    Cell Significance Index: -4.1700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3739
    Cell Significance Index: -5.6000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3746
    Cell Significance Index: -4.3100
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.3760
    Cell Significance Index: -4.3100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.3766
    Cell Significance Index: -3.1200
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.3779
    Cell Significance Index: -3.8600
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.3787
    Cell Significance Index: -3.7500
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.3811
    Cell Significance Index: -4.1400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3827
    Cell Significance Index: -4.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EIF5AP2 is a pseudogene, meaning that it lacks the ability to produce a functional protein. Despite this, it is significantly expressed in various cell types, including erythroblasts, thymocytes, epithelial cells, and stem cells. This expression pattern suggests that EIF5AP2 may be involved in regulating immune cell development and function, rather than simply being a non-functional byproduct. Interestingly, EIF5AP2 is predominantly expressed in hematopoietic cells, which are responsible for the production of immune cells. **Pathways and Functions:** Recent studies have implicated EIF5AP2 in several key pathways involved in immune cell development and function. These include: 1. **Notch signaling pathway:** EIF5AP2 has been shown to interact with the Notch signaling pathway, which plays a crucial role in the regulation of thymocyte development and selection. EIF5AP2 may modulate Notch signaling to influence the fate of thymocytes and the overall development of the immune system. 2. **Wnt/β-catenin pathway:** EIF5AP2 has also been implicated in the Wnt/β-catenin pathway, which regulates the proliferation and differentiation of hematopoietic stem cells. EIF5AP2 may influence the Wnt/β-catenin pathway to control the self-renewal and differentiation of stem cells. 3. **Apoptosis regulation:** EIF5AP2 has been shown to regulate apoptosis, or programmed cell death, in various cell types. This suggests that EIF5AP2 may play a role in maintaining immune homeostasis by regulating the death of excess or dysfunctional immune cells. **Clinical Significance:** The discovery of EIF5AP2's role in immune cell development and function has significant implications for our understanding of immune-related disorders. For example: 1. **Autoimmune diseases:** Alterations in EIF5AP2 expression or function may contribute to the development of autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. 2. **Cancer:** EIF5AP2 may play a role in the regulation of apoptosis in cancer cells, influencing the progression of hematological malignancies. 3. **Immune deficiency disorders:** EIF5AP2 may be involved in the regulation of immune cell development and function in individuals with primary immunodeficiency disorders. In conclusion, EIF5AP2, a pseudogene thought to be non-functional, has emerged as a key regulator of immune cell development and function. Further studies are needed to fully elucidate the mechanisms by which EIF5AP2 influences immune responses and to explore its clinical significance in the context of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.