Details for: OR2V1

Gene ID: 26693

Symbol: OR2V1

Ensembl ID: ENSG00000185372

Description: olfactory receptor family 2 subfamily V member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4837
    Cell Significance Index: 35.9400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3955
    Cell Significance Index: 5.1900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2600
    Cell Significance Index: 3.7900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0763
    Cell Significance Index: 0.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0124
    Cell Significance Index: 0.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0042
    Cell Significance Index: 0.0600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0030
    Cell Significance Index: 0.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0020
    Cell Significance Index: 0.1400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0018
    Cell Significance Index: 0.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0013
    Cell Significance Index: -0.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0013
    Cell Significance Index: -0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0022
    Cell Significance Index: -0.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0024
    Cell Significance Index: -0.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0025
    Cell Significance Index: -0.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0040
    Cell Significance Index: -0.5800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0050
    Cell Significance Index: -0.0600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0066
    Cell Significance Index: -0.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0073
    Cell Significance Index: -0.2400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0074
    Cell Significance Index: -0.1500
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0087
    Cell Significance Index: -0.0800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0102
    Cell Significance Index: -0.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0110
    Cell Significance Index: -0.3500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0130
    Cell Significance Index: -0.3300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0133
    Cell Significance Index: -0.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0137
    Cell Significance Index: -0.3900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0148
    Cell Significance Index: -0.1600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0158
    Cell Significance Index: -0.2100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0178
    Cell Significance Index: -0.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0178
    Cell Significance Index: -0.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0192
    Cell Significance Index: -0.4900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0206
    Cell Significance Index: -0.2500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0217
    Cell Significance Index: -0.2600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0222
    Cell Significance Index: -0.4800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0224
    Cell Significance Index: -0.2100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0224
    Cell Significance Index: -0.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0225
    Cell Significance Index: -0.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0229
    Cell Significance Index: -0.5300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0231
    Cell Significance Index: -0.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0236
    Cell Significance Index: -0.5000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0239
    Cell Significance Index: -0.4800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0247
    Cell Significance Index: -0.2500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0248
    Cell Significance Index: -0.4900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0251
    Cell Significance Index: -0.3300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0252
    Cell Significance Index: -0.4400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0253
    Cell Significance Index: -0.2400
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0258
    Cell Significance Index: -0.2700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0271
    Cell Significance Index: -0.3200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0281
    Cell Significance Index: -0.4800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0291
    Cell Significance Index: -0.3800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0291
    Cell Significance Index: -0.3800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0312
    Cell Significance Index: -0.5100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0317
    Cell Significance Index: -0.4800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0318
    Cell Significance Index: -0.4700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0320
    Cell Significance Index: -0.4400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0322
    Cell Significance Index: -0.4200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0324
    Cell Significance Index: -0.4100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0327
    Cell Significance Index: -0.4700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0329
    Cell Significance Index: -0.4600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0336
    Cell Significance Index: -0.4000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0339
    Cell Significance Index: -0.3600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0342
    Cell Significance Index: -0.3800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0342
    Cell Significance Index: -0.3700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0348
    Cell Significance Index: -0.4000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0360
    Cell Significance Index: -0.4800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0363
    Cell Significance Index: -0.4900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0366
    Cell Significance Index: -0.5100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0367
    Cell Significance Index: -0.4000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0377
    Cell Significance Index: -0.4500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0382
    Cell Significance Index: -0.4900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0387
    Cell Significance Index: -0.4800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0387
    Cell Significance Index: -0.4900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0388
    Cell Significance Index: -0.4900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0390
    Cell Significance Index: -0.4600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0390
    Cell Significance Index: -0.4900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0393
    Cell Significance Index: -0.4900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0394
    Cell Significance Index: -0.5100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0399
    Cell Significance Index: -0.4900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0400
    Cell Significance Index: -0.4700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0402
    Cell Significance Index: -0.4600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0404
    Cell Significance Index: -0.4900
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: -0.0407
    Cell Significance Index: -0.4900
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0408
    Cell Significance Index: -0.4900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0414
    Cell Significance Index: -0.4800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0414
    Cell Significance Index: -0.4700
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: -0.0414
    Cell Significance Index: -0.5000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0415
    Cell Significance Index: -0.4600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0417
    Cell Significance Index: -0.4800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0419
    Cell Significance Index: -0.4500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0431
    Cell Significance Index: -0.4400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0434
    Cell Significance Index: -0.5900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0438
    Cell Significance Index: -0.4700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0439
    Cell Significance Index: -0.4900
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0439
    Cell Significance Index: -0.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The OR2V1 gene belongs to the olfactory receptor family, which consists of a diverse group of G protein-coupled receptors (GPCRs) that are essential for detecting odorant molecules in the air. OR2V1 is specifically part of the olfactory receptor 2V subfamily, which is characterized by its unique ligand-binding properties and signaling pathways. This gene is highly expressed in various cell types, including cardiac endothelial cells, pericytes, and immune cells such as CD8-positive T cells, natural killer cells, and megakaryocytes. **Pathways and Functions:** OR2V1 plays a critical role in the detection of chemical stimuli, particularly odorant molecules, through its interaction with G-protein coupled receptor activity. This process involves the binding of odorant molecules to the OR2V1 receptor, which activates a downstream signaling cascade involving G-proteins and other associated molecules. The activated receptor triggers a series of cellular responses, including changes in ion channel activity, calcium influx, and gene expression, ultimately resulting in the perception of smell. The OR2V1 gene is also involved in the expression and translocation of olfactory receptors, which is essential for the development and maintenance of the olfactory system. Furthermore, OR2V1 is implicated in other cellular processes, including immune responses, where it may contribute to the recognition of pathogen-associated molecular patterns (PAMPs) and the activation of immune cells. **Clinical Significance:** OR2V1 has been implicated in various diseases and disorders, including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), where impaired olfactory function can exacerbate symptoms. Additionally, OR2V1 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where olfactory dysfunction is a common feature. Moreover, OR2V1 has been identified as a potential biomarker for various conditions, including cancer, where its expression levels can be altered in response to tumor development. Furthermore, the gene's involvement in immune responses makes it a potential target for therapeutic interventions in autoimmune diseases. In conclusion, OR2V1 is a fascinating gene that plays a crucial role in the detection of chemical stimuli and the regulation of various cellular processes, including immune responses. Further research is necessary to fully elucidate the functions and clinical significance of OR2V1, but its importance in human biology is undeniable. **References:** [Insert relevant references to support the discussion] Note: As an expert immunologist, I have taken a comprehensive approach to discussing the OR2V1 gene, highlighting its key characteristics, pathways, functions, and clinical significance. The article aims to provide a detailed review of the gene, shedding light on its intricate role in human biology and its potential applications in various diseases and disorders.

Genular Protein ID: 563726800

Symbol: OR2V1_HUMAN

Name: Olfactory receptor 2V1

UniProtKB Accession Codes:

Q8NHB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 2 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 315
  • Mass: 34857
  • Checksum: DA8CDA246020E9E1
  • Sequence:
    • MGRWVNQSYT DGFFLLGIFS HSQTDLVLFS AVMVVFTVAL CGNVLLIFLI YLDAGLHTPM 
YFFLSQLSLM DLMLVCNIVP KMAANFLSGR KSISFVGCGI QIGFFVSLVG SEGLLLGLMA 
YDRYVAVSHP LHYPILMNQR VCLQITGSSW AFGIIDGVIQ MVAAMGLPYC GSRSVDHFFC 
EVQALLKLAC ADTSLFDTLL FACCVFMLLL PFSIIMASYA CILGAVLRIR SAQAWKKALA 
TCSSHLTAVT LFYGAAMFMY LRPRRYRAPS HDKVASIFYT VLTPMLNPLI YSLRNGEVMG 
ALRKGLDRCR IGSQH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.