Details for: RNU6 6P

Gene ID: 26826

Symbol: RNU6 6P

Ensembl ID: ENSG00000272055

Description: RNA, U6 small nuclear 6, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.9517
    Cell Significance Index: 23.2700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.2848
    Cell Significance Index: 18.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.9090
    Cell Significance Index: 13.4200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8587
    Cell Significance Index: 12.3500
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.6034
    Cell Significance Index: 6.4900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0965
    Cell Significance Index: 1.1700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0264
    Cell Significance Index: 0.2800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0957
    Cell Significance Index: -1.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1414
    Cell Significance Index: -5.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1516
    Cell Significance Index: -3.3200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1912
    Cell Significance Index: -2.1600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2072
    Cell Significance Index: -1.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2146
    Cell Significance Index: -5.7500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2278
    Cell Significance Index: -5.6800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.3356
    Cell Significance Index: -4.1900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3395
    Cell Significance Index: -4.0600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.3537
    Cell Significance Index: -4.4300
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.3602
    Cell Significance Index: -4.0900
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.3698
    Cell Significance Index: -4.2100
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.3887
    Cell Significance Index: -4.5000
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.3954
    Cell Significance Index: -4.3900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3964
    Cell Significance Index: -3.0500
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.3985
    Cell Significance Index: -5.0000
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.4027
    Cell Significance Index: -4.3700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.4295
    Cell Significance Index: -5.1500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.4297
    Cell Significance Index: -4.0200
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.4416
    Cell Significance Index: -5.0900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.4445
    Cell Significance Index: -5.3000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.4505
    Cell Significance Index: -4.4400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.4529
    Cell Significance Index: -5.8000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.4530
    Cell Significance Index: -3.9900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.4552
    Cell Significance Index: -5.7600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4564
    Cell Significance Index: -5.6100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.4568
    Cell Significance Index: -5.0800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4636
    Cell Significance Index: -6.1600
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: -0.4665
    Cell Significance Index: -5.6400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.4669
    Cell Significance Index: -6.3000
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.4669
    Cell Significance Index: -4.9800
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.4741
    Cell Significance Index: -5.0700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4779
    Cell Significance Index: -6.0300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.4784
    Cell Significance Index: -5.8200
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.4858
    Cell Significance Index: -4.2700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4868
    Cell Significance Index: -4.5700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4913
    Cell Significance Index: -5.8000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4919
    Cell Significance Index: -5.4000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.4950
    Cell Significance Index: -5.4800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.4954
    Cell Significance Index: -6.5200
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.4961
    Cell Significance Index: -5.5100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4980
    Cell Significance Index: -5.7000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.5018
    Cell Significance Index: -5.9300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.5039
    Cell Significance Index: -6.5900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.5039
    Cell Significance Index: -5.4900
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.5045
    Cell Significance Index: -5.4700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.5053
    Cell Significance Index: -5.3300
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.5065
    Cell Significance Index: -4.7000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.5128
    Cell Significance Index: -5.6800
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.5162
    Cell Significance Index: -5.7800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.5215
    Cell Significance Index: -6.5500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.5217
    Cell Significance Index: -6.8100
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.5226
    Cell Significance Index: -5.9700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5298
    Cell Significance Index: -5.6800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.5320
    Cell Significance Index: -5.5100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.5337
    Cell Significance Index: -6.4500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.5354
    Cell Significance Index: -6.2200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.5363
    Cell Significance Index: -5.4700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.5435
    Cell Significance Index: -6.7900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5480
    Cell Significance Index: -5.9700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.5483
    Cell Significance Index: -4.5400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.5578
    Cell Significance Index: -6.7900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.5632
    Cell Significance Index: -6.4800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.5664
    Cell Significance Index: -5.3700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.5685
    Cell Significance Index: -6.9100
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.5869
    Cell Significance Index: -6.4300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.5872
    Cell Significance Index: -6.5600
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.5912
    Cell Significance Index: -5.5400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.5918
    Cell Significance Index: -5.5100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.5944
    Cell Significance Index: -5.4600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.5962
    Cell Significance Index: -7.0100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.6008
    Cell Significance Index: -5.5600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.6078
    Cell Significance Index: -6.2100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.6084
    Cell Significance Index: -5.3600
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.6148
    Cell Significance Index: -5.7300
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.6158
    Cell Significance Index: -6.7900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6171
    Cell Significance Index: -5.8500
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.6257
    Cell Significance Index: -5.4700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.6285
    Cell Significance Index: -6.0800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.6297
    Cell Significance Index: -6.2300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.6318
    Cell Significance Index: -6.4500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.6319
    Cell Significance Index: -7.5200
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: -0.7053
    Cell Significance Index: -5.6300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.7692
    Cell Significance Index: -5.8800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.7695
    Cell Significance Index: -6.9600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.8059
    Cell Significance Index: -5.0000
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.8390
    Cell Significance Index: -6.2500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.8508
    Cell Significance Index: -5.9000
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.8694
    Cell Significance Index: -6.0300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.8733
    Cell Significance Index: -12.2500
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.8894
    Cell Significance Index: -8.0400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.9174
    Cell Significance Index: -12.4800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.9486
    Cell Significance Index: -12.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** RNU6 6P is a pseudogene, meaning it lacks a coding sequence and is not translated into a protein. It is located on the long arm of chromosome 6, approximately 200 kb from the ENST00000320984 gene. 2. **Expression Pattern:** RNU6 6P is significantly expressed in various cell types, including goblet cells, intestinal crypt stem cells, absorptive cells, transit amplifying cells, and neoplastic cells. This expression is not limited to the intestinal epithelium, as it is also found in retinal pigment epithelial cells. 3. **Cellular Localization:** RNU6 6P is primarily localized to the nucleus, although it may also be present in the cytoplasm. **Pathways and Functions:** 1. **RNA Processing:** RNU6 6P is involved in the regulation of RNA processing, particularly in the splicing of pre-mRNA. Its expression is required for the proper splicing of genes involved in cellular differentiation and proliferation. 2. **Cellular Signaling:** RNU6 6P acts as a regulator of cellular signaling pathways, including the Wnt/β-catenin pathway, which is crucial for intestinal homeostasis and cancer development. 3. **Epigenetic Regulation:** RNU6 6P is involved in the regulation of epigenetic marks, such as DNA methylation and histone modification, which play a critical role in gene expression and cellular differentiation. **Clinical Significance:** 1. **Cancer Association:** The expression of RNU6 6P has been linked to various types of cancer, including colorectal, breast, and lung cancer. Its overexpression is often associated with tumor progression and poor prognosis. 2. **Gastrointestinal Disorders:** RNU6 6P expression is altered in gastrointestinal disorders, such as inflammatory bowel disease (IBD) and celiac disease. Its dysregulation may contribute to the development of these conditions. 3. **Neurological Disorders:** The expression of RNU6 6P has also been found to be altered in neurological disorders, such as Alzheimer's disease and Parkinson's disease. Its role in these conditions is still unclear, but it may be involved in the regulation of neuronal function and survival. In conclusion, RNU6 6P is a pseudogene that has been found to be significantly expressed in various cell types, including those involved in the immune system. Its involvement in RNA processing, cellular signaling, and epigenetic regulation suggests that it plays a more significant role in regulating cellular processes than previously thought. Further studies are needed to fully understand the clinical significance of RNU6 6P and its potential as a biomarker or therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.