Details for: RNU5A 1

Gene ID: 26831

Symbol: RNU5A 1

Ensembl ID: ENSG00000199568

Description: RNA, U5A small nuclear 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 11.2736
    Cell Significance Index: -4.5800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 1.5579
    Cell Significance Index: 18.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8698
    Cell Significance Index: 25.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7437
    Cell Significance Index: 33.7100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.4231
    Cell Significance Index: 4.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3998
    Cell Significance Index: 5.9900
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.2745
    Cell Significance Index: 2.4000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.2443
    Cell Significance Index: 2.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2074
    Cell Significance Index: 9.6700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.1649
    Cell Significance Index: 1.7100
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.1287
    Cell Significance Index: 1.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0416
    Cell Significance Index: 2.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0401
    Cell Significance Index: 1.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0140
    Cell Significance Index: 0.3800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0074
    Cell Significance Index: 0.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0051
    Cell Significance Index: 0.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0014
    Cell Significance Index: 0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0019
    Cell Significance Index: -0.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0037
    Cell Significance Index: -6.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0042
    Cell Significance Index: -2.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0044
    Cell Significance Index: -6.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0056
    Cell Significance Index: -7.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0113
    Cell Significance Index: -5.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0119
    Cell Significance Index: -3.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0320
    Cell Significance Index: -6.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0360
    Cell Significance Index: -4.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0400
    Cell Significance Index: -1.3100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0418
    Cell Significance Index: -0.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0438
    Cell Significance Index: -2.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0582
    Cell Significance Index: -6.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0604
    Cell Significance Index: -3.1400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0666
    Cell Significance Index: -1.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0709
    Cell Significance Index: -2.2700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0776
    Cell Significance Index: -0.8100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0787
    Cell Significance Index: -1.3600
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0788
    Cell Significance Index: -0.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0804
    Cell Significance Index: -4.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0894
    Cell Significance Index: -2.4000
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1024
    Cell Significance Index: -1.2900
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1562
    Cell Significance Index: -1.1400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1596
    Cell Significance Index: -2.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1620
    Cell Significance Index: -2.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1863
    Cell Significance Index: -6.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1894
    Cell Significance Index: -5.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1900
    Cell Significance Index: -6.0500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1967
    Cell Significance Index: -2.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1970
    Cell Significance Index: -6.9000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2118
    Cell Significance Index: -2.5600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2151
    Cell Significance Index: -5.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2246
    Cell Significance Index: -5.6000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2254
    Cell Significance Index: -4.8700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2296
    Cell Significance Index: -3.9000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2349
    Cell Significance Index: -5.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2362
    Cell Significance Index: -4.9000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2399
    Cell Significance Index: -4.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2416
    Cell Significance Index: -5.2900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2427
    Cell Significance Index: -3.8500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2438
    Cell Significance Index: -7.7100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2470
    Cell Significance Index: -3.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2490
    Cell Significance Index: -5.0000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2604
    Cell Significance Index: -2.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2683
    Cell Significance Index: -5.7000
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.2729
    Cell Significance Index: -2.9500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2735
    Cell Significance Index: -6.8300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2760
    Cell Significance Index: -2.6900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2773
    Cell Significance Index: -2.3400
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.2801
    Cell Significance Index: -2.8600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2880
    Cell Significance Index: -5.7000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2889
    Cell Significance Index: -3.6600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2907
    Cell Significance Index: -2.9500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.3034
    Cell Significance Index: -3.1000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3068
    Cell Significance Index: -5.1600
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.3090
    Cell Significance Index: -3.0600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3129
    Cell Significance Index: -5.2700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.3157
    Cell Significance Index: -2.8500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3157
    Cell Significance Index: -3.8400
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.3197
    Cell Significance Index: -3.9700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.3235
    Cell Significance Index: -4.1800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3243
    Cell Significance Index: -3.0800
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.3311
    Cell Significance Index: -2.9100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3349
    Cell Significance Index: -4.3800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3410
    Cell Significance Index: -3.8100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.3413
    Cell Significance Index: -3.6300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3424
    Cell Significance Index: -4.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3493
    Cell Significance Index: -7.4400
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.3534
    Cell Significance Index: -3.7000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3586
    Cell Significance Index: -4.2800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3592
    Cell Significance Index: -3.3600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3622
    Cell Significance Index: -4.3100
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.3721
    Cell Significance Index: -4.0400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.3835
    Cell Significance Index: -3.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3861
    Cell Significance Index: -5.7000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3885
    Cell Significance Index: -4.8800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.3933
    Cell Significance Index: -4.6900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.3945
    Cell Significance Index: -4.5400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.4007
    Cell Significance Index: -5.5400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4023
    Cell Significance Index: -5.0300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4065
    Cell Significance Index: -4.7800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.4092
    Cell Significance Index: -3.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RNU5A1 is a small RNA molecule that is part of the U5 snRNP complex. It has a unique structure and function, which allows it to interact with other snRNP components to facilitate the assembly of the U4/U6/U5 tri-snRNP complex. This complex is a multifunctional entity that is required for the accurate splicing of pre-mRNA, which involves the removal of introns and the joining of exons. RNU5A1 has a high degree of sequence homology with other U5 snRNP components, suggesting that it plays a conserved role in snRNP biogenesis and function. **Pathways and Functions** RNU5A1 is involved in the following pathways and functions: 1. **Formation of the U4/U6/U5 tri-snRNP complex**: RNU5A1 interacts with other snRNP components to form the U4/U6/U5 tri-snRNP complex, which is a critical step in the assembly of the spliceosomal machinery. 2. **Gene expression (transcription)**: RNU5A1 is required for the accurate splicing of pre-mRNA, which is a critical process in gene expression. The U4/U6/U5 tri-snRNP complex is involved in the recognition and processing of pre-mRNA, allowing for the accurate removal of introns and the joining of exons. 3. **RNA polymerase II transcription**: RNU5A1 is also involved in the transcription of snRNA genes by RNA polymerase II, which is a key enzyme in the transcription of protein-coding genes. 4. **Spliceosomal tri-snrnp complex assembly**: RNU5A1 is required for the assembly of the spliceosomal tri-snrnp complex, which is a multifunctional entity that is involved in the recognition and processing of pre-mRNA. **Clinical Significance** Dysregulation of the RNU5A1 gene has been implicated in various diseases, including: 1. **Immune disorders**: RNU5A1 is expressed in immature innate lymphoid cells, which are involved in the regulation of the immune response. Dysregulation of RNU5A1 may contribute to immune disorders, such as autoimmune diseases. 2. **Cardiac diseases**: RNU5A1 is also expressed in cardiac cells, where it may play a role in the regulation of cardiac function. Dysregulation of RNU5A1 may contribute to cardiac diseases, such as heart failure. 3. **Cancer**: RNU5A1 has been implicated in the regulation of gene expression in cancer cells. Dysregulation of RNU5A1 may contribute to the development and progression of cancer. In conclusion, the RNU5A1 gene plays a critical role in the regulation of gene expression and the assembly of the spliceosomal machinery. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.