Details for: RNU2 5P

Gene ID: 26852

Symbol: RNU2 5P

Ensembl ID: ENSG00000222465

Description: RNA, U2 small nuclear 5, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.7472
    Cell Significance Index: 8.3100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.2705
    Cell Significance Index: 3.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1761
    Cell Significance Index: 9.1500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1421
    Cell Significance Index: 1.8300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.1175
    Cell Significance Index: 1.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1117
    Cell Significance Index: 5.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0950
    Cell Significance Index: 2.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0843
    Cell Significance Index: 2.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0717
    Cell Significance Index: 12.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0547
    Cell Significance Index: 2.4800
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.0324
    Cell Significance Index: 0.3100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0279
    Cell Significance Index: 0.2700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0275
    Cell Significance Index: 0.3600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.0122
    Cell Significance Index: 0.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0100
    Cell Significance Index: 2.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0090
    Cell Significance Index: 0.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0054
    Cell Significance Index: 10.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0010
    Cell Significance Index: 1.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0020
    Cell Significance Index: -2.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0027
    Cell Significance Index: -1.7200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0043
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0059
    Cell Significance Index: -2.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0084
    Cell Significance Index: -2.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0090
    Cell Significance Index: -1.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0100
    Cell Significance Index: -1.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0125
    Cell Significance Index: -0.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0191
    Cell Significance Index: -0.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0217
    Cell Significance Index: -0.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0218
    Cell Significance Index: -0.7000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0222
    Cell Significance Index: -0.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0224
    Cell Significance Index: -0.7400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0240
    Cell Significance Index: -0.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0259
    Cell Significance Index: -0.5500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0274
    Cell Significance Index: -0.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0279
    Cell Significance Index: -2.9000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0279
    Cell Significance Index: -0.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0281
    Cell Significance Index: -0.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0281
    Cell Significance Index: -0.5600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0294
    Cell Significance Index: -0.6400
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0343
    Cell Significance Index: -0.3100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0346
    Cell Significance Index: -0.6900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0353
    Cell Significance Index: -0.7000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0369
    Cell Significance Index: -0.7700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0382
    Cell Significance Index: -0.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0457
    Cell Significance Index: -2.3800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0459
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0468
    Cell Significance Index: -0.5900
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0495
    Cell Significance Index: -0.3600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0496
    Cell Significance Index: -0.6500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0514
    Cell Significance Index: -0.6600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0515
    Cell Significance Index: -0.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0535
    Cell Significance Index: -1.5400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0550
    Cell Significance Index: -0.6000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0580
    Cell Significance Index: -0.7000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0608
    Cell Significance Index: -0.7600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0654
    Cell Significance Index: -1.1000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0669
    Cell Significance Index: -0.7600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0708
    Cell Significance Index: -0.6900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0728
    Cell Significance Index: -0.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0740
    Cell Significance Index: -2.1800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0742
    Cell Significance Index: -0.9500
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0808
    Cell Significance Index: -1.0000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0862
    Cell Significance Index: -2.7300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0863
    Cell Significance Index: -0.9100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0947
    Cell Significance Index: -1.3300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1040
    Cell Significance Index: -0.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1085
    Cell Significance Index: -2.3100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1089
    Cell Significance Index: -1.5500
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1096
    Cell Significance Index: -1.4900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1139
    Cell Significance Index: -1.0800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1165
    Cell Significance Index: -1.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1171
    Cell Significance Index: -2.4300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1217
    Cell Significance Index: -1.3600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1413
    Cell Significance Index: -0.9800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1466
    Cell Significance Index: -1.5300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1529
    Cell Significance Index: -1.8200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1543
    Cell Significance Index: -2.6000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1611
    Cell Significance Index: -2.6100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1689
    Cell Significance Index: -2.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1698
    Cell Significance Index: -1.8500
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.1748
    Cell Significance Index: -2.0800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1748
    Cell Significance Index: -2.5800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1755
    Cell Significance Index: -2.9800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1760
    Cell Significance Index: -2.0800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1761
    Cell Significance Index: -2.6000
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1804
    Cell Significance Index: -2.1800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1813
    Cell Significance Index: -1.9500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1826
    Cell Significance Index: -2.3100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1828
    Cell Significance Index: -2.5100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1847
    Cell Significance Index: -2.4100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1870
    Cell Significance Index: -2.6900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1911
    Cell Significance Index: -2.4000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1959
    Cell Significance Index: -2.0000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1979
    Cell Significance Index: -2.6100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1987
    Cell Significance Index: -2.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1992
    Cell Significance Index: -2.3800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2012
    Cell Significance Index: -2.5200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2015
    Cell Significance Index: -2.6300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2020
    Cell Significance Index: -2.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** The RNU2 5P gene is located on chromosome 12p13.33. 2. **Type:** It is a pseudogene, meaning that it does not encode a functional protein, but rather serves as a non-coding RNA. 3. **Expression:** RNU2 5P is significantly expressed in cells of the intestinal epithelium, including goblet cells, absorptive cells, and intestinal stem cells. 4. **Cell types:** It has been found to be expressed in a wide range of cell types, including astrocytes, abnormal cells, neoplastic cells, and brush cells. **Pathways and Functions:** Despite its pseudogenic nature, RNU2 5P has been implicated in several cellular pathways, including: 1. **RNA processing:** RNU2 5P may play a role in the regulation of RNA processing, particularly in the context of alternative splicing. 2. **Stem cell maintenance:** Its expression in intestinal stem cells suggests that RNU2 5P may be involved in the maintenance of stem cell function and self-renewal. 3. **Cell differentiation:** RNU2 5P may also play a role in the regulation of cell differentiation, particularly in the context of intestinal epithelial cell development. 4. **Tumor suppression:** The expression of RNU2 5P in neoplastic cells suggests that it may have a tumor-suppressive function, although the mechanisms by which it exerts this effect are not yet fully understood. **Clinical Significance:** The discovery of RNU2 5P as a pseudogene with widespread expression in human tissues has significant implications for our understanding of human disease. Some potential clinical implications of RNU2 5P include: 1. **Cancer research:** The expression of RNU2 5P in neoplastic cells suggests that it may be a useful biomarker for the detection and monitoring of cancer. 2. **Intestinal disease:** RNU2 5P may also play a role in the pathogenesis of intestinal diseases, such as inflammatory bowel disease and colon cancer. 3. **Stem cell biology:** The expression of RNU2 5P in intestinal stem cells suggests that it may be involved in the regulation of stem cell function and self-renewal, which could have implications for our understanding of tissue regeneration and repair. In conclusion, the RNU2 5P gene is a fascinating example of a pseudogene with widespread expression in human tissues. Further research is needed to fully understand the functional significance of RNU2 5P and its potential role in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.