Details for: GOLGA1

Gene ID: 2800

Symbol: GOLGA1

Ensembl ID: ENSG00000136935

Description: golgin A1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.53
    Marker Score: 640
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.31
    Marker Score: 764
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.3
    Marker Score: 1752
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.3
    Marker Score: 759
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.29
    Marker Score: 5238.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.26
    Marker Score: 5264.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.26
    Marker Score: 26812
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.25
    Marker Score: 45992
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.24
    Marker Score: 1374
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.24
    Marker Score: 1503
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.24
    Marker Score: 76266
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.24
    Marker Score: 1913
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.23
    Marker Score: 12691
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.17
    Marker Score: 10027
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.17
    Marker Score: 2037
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.17
    Marker Score: 10961
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.16
    Marker Score: 17351
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.16
    Marker Score: 11017
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.15
    Marker Score: 314
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.15
    Marker Score: 4427
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 17012
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.05
    Marker Score: 40061
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.03
    Marker Score: 2101
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71747.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47972
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.99
    Marker Score: 19662
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.95
    Marker Score: 7295
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.94
    Marker Score: 276
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 441
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2717
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.9
    Marker Score: 1985.5
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.89
    Marker Score: 283
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.88
    Marker Score: 1091
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4958.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.86
    Marker Score: 3579
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.82
    Marker Score: 461
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.81
    Marker Score: 485
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.79
    Marker Score: 250
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.78
    Marker Score: 246
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.78
    Marker Score: 17327
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.77
    Marker Score: 664
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.75
    Marker Score: 4816
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.74
    Marker Score: 253
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.74
    Marker Score: 497
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.74
    Marker Score: 366
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.72
    Marker Score: 2576.5
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.72
    Marker Score: 3121
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.72
    Marker Score: 350
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2982
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7
    Marker Score: 209
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 623
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.68
    Marker Score: 4057
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.66
    Marker Score: 189
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.65
    Marker Score: 2242
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.65
    Marker Score: 1530
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.65
    Marker Score: 386
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.65
    Marker Score: 929
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.64
    Marker Score: 740
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.64
    Marker Score: 1222
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.63
    Marker Score: 934
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.62
    Marker Score: 1493
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.62
    Marker Score: 614
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.62
    Marker Score: 3321
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.61
    Marker Score: 196
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.6
    Marker Score: 463
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.6
    Marker Score: 298
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.58
    Marker Score: 275
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 379
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.56
    Marker Score: 606
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.56
    Marker Score: 1274
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.56
    Marker Score: 366
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.55
    Marker Score: 292
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.55
    Marker Score: 552
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.55
    Marker Score: 2141
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.55
    Marker Score: 678
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.55
    Marker Score: 575
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.54
    Marker Score: 498
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.53
    Marker Score: 199
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.53
    Marker Score: 140
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.52
    Marker Score: 741
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.52
    Marker Score: 210
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.51
    Marker Score: 348
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.5
    Marker Score: 186
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.5
    Marker Score: 529
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.49
    Marker Score: 153
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.49
    Marker Score: 255
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.49
    Marker Score: 477.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.49
    Marker Score: 627
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.49
    Marker Score: 463

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * Golgin A1 is a large protein (510 amino acids) that is expressed in the endoplasmic reticulum. * It is a member of the Golgin subfamily A, which are characterized by their ability to interact with the Golgi apparatus. * Golgin A1 is a multi-subunit protein that is composed of two immunoglobulin heavy chains and two immunoglobulin light chains. * It is involved in the sorting and trafficking of proteins between the endoplasmic reticulum and the Golgi apparatus. **Pathways and functions:** * Golgin A1 is involved in the formation of the acrosomal vesicle, which is a protein complex that is responsible for sorting and packaging proteins for transport to the cell membrane. * It is also involved in the retrograde transport of proteins from the cell membrane to the endoplasmic reticulum. * Golgin A1 is a key component of the Golgi apparatus, where it is involved in the sorting and packaging of proteins. * It is also involved in the formation of the trans-Golgi network, a network of vesicles that connects the Golgi apparatus to the endoplasmic reticulum. **Clinical significance:** Mutations in the GOLGA1 gene have been linked to a number of human diseases, including Usher syndrome and retinitis pigmentosa. In Usher syndrome, mutations in GOLGA1 lead to the accumulation of a mutant protein in the retina, which results in the development of progressive blindness. In retinitis pigmentosa, mutations in GOLGA1 lead to the accumulation of a mutant protein in the cornea, which results in the development of night blindness.

Genular Protein ID: 4245510724

Symbol: GOGA1_HUMAN

Name: Golgin subfamily A member 1

UniProtKB Accession Codes:

Q92805 Q5T164 Q8IYZ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9324025

Title: Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjoegren's syndrome.

PubMed ID: 9324025

DOI: 10.1002/art.1780400920

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10209123

Title: A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins.

PubMed ID: 10209123

DOI: 10.1016/s0960-9822(99)80167-5

PubMed ID: 10209125

Title: A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins.

PubMed ID: 10209125

DOI: 10.1016/s0960-9822(99)80168-7

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29084197

Title: TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi.

PubMed ID: 29084197

DOI: 10.1038/ncb3627

Sequence Information:

  • Length: 767
  • Mass: 88184
  • Checksum: 8E235EAA92D6C61F
  • Sequence:
    • MFAKLKKKIA EETAVAQRPG GATRIPRSVS KESVASMGAD SGDDFASDGS SSREDLSSQL 
LRRNEQIRKL EARLSDYAEQ VRNLQKIKEK LEIALEKHQD SSMRKFQEQN ETFQANRAKM 
AEGLALALAR KDQEWSEKMD QLEKEKNILT AQLQEMKNQS MNLFQRRDEM DELEGFQQQE 
LSKIKHMLLK KEESLGKMEQ ELEARTRELS RTQEELMNSN QMSSDLSQKL EELQRHYSTL 
EEQRDHVIAS KTGAESKITA LEQKEQELQA LIQQLSIDLQ KVTAETQEKE DVITHLQEKV 
ASLEKRLEQN LSGEEHLQEL LKEKTLAEQN LEDTRQQLLA ARSSQAKAIN TLETRVRELE 
QTLQASEEQL QQSKGIVAAQ ETQIQELAAA NQESSHVQQQ ALALEQQFLE RTQALEAQIV 
ALERTRAADQ TTAEQGMRQL EQENAALKEC RNEYERSLQN HQFELKKLKE EWSQREIVSV 
AMAQALEEVR KQREEFQQQA ANLTAIIDEK EQNLREKTEV LLQKEQEILQ LERGHNSALL 
QIHQLQAELE ALRTLKAEEA AVVAEQEDLL RLRGPLQAEA LSVNESHVTS RAMQDPVFQL 
PTAGRTPNGE VGAMDLTQLQ KEKQDLEQQL LEKNKTIKQM QQRMLELRKT LQKELKIRPD 
NELFEVREKP GPEMANMAPS VTNNTDLTDA REINFEYLKH VVLKFMSCRE SEAFHLIKAV 
SVLLNFSQEE ENMLKETLEY KMSWFGSKPA PKGSIRPSIS NPRIPWS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.