Details for: IGHV3 73

Gene ID: 28409

Symbol: IGHV3 73

Ensembl ID: ENSG00000211976

Description: immunoglobulin heavy variable 3-73

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4114
    Cell Significance Index: 9.9700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1928
    Cell Significance Index: 2.8100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1564
    Cell Significance Index: 2.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1177
    Cell Significance Index: -3.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1412
    Cell Significance Index: -4.1600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1678
    Cell Significance Index: -3.2800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1850
    Cell Significance Index: -4.6200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1865
    Cell Significance Index: -3.0200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2017
    Cell Significance Index: -5.1400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2115
    Cell Significance Index: -3.9100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2276
    Cell Significance Index: -3.8900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2318
    Cell Significance Index: -2.7400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2412
    Cell Significance Index: -3.1600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2496
    Cell Significance Index: -2.5500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2523
    Cell Significance Index: -3.4600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.2598
    Cell Significance Index: -1.7300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2756
    Cell Significance Index: -3.1200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2761
    Cell Significance Index: -3.3300
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.2766
    Cell Significance Index: -2.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2814
    Cell Significance Index: -13.1200
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2839
    Cell Significance Index: -2.4200
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2938
    Cell Significance Index: -2.8200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2945
    Cell Significance Index: -4.0900
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.2961
    Cell Significance Index: -2.3800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2984
    Cell Significance Index: -3.1700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3102
    Cell Significance Index: -3.6500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.3205
    Cell Significance Index: -3.4600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3206
    Cell Significance Index: -3.9000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3325
    Cell Significance Index: -3.6500
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.3363
    Cell Significance Index: -3.4600
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.3392
    Cell Significance Index: -2.8000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3401
    Cell Significance Index: -3.7700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3420
    Cell Significance Index: -4.4300
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.3425
    Cell Significance Index: -3.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3458
    Cell Significance Index: -3.9300
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.3508
    Cell Significance Index: -3.4600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3514
    Cell Significance Index: -3.8500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3528
    Cell Significance Index: -4.0600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.3534
    Cell Significance Index: -3.9500
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3574
    Cell Significance Index: -4.1500
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.3627
    Cell Significance Index: -4.1600
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.3644
    Cell Significance Index: -3.3100
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.3698
    Cell Significance Index: -3.9500
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.3702
    Cell Significance Index: -2.8300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3714
    Cell Significance Index: -3.6200
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.3722
    Cell Significance Index: -3.8000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3738
    Cell Significance Index: -4.9100
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.3767
    Cell Significance Index: -3.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.3777
    Cell Significance Index: -3.6300
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.3802
    Cell Significance Index: -4.1000
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.3805
    Cell Significance Index: -3.1700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.3828
    Cell Significance Index: -3.4200
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.3830
    Cell Significance Index: -3.3700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.3842
    Cell Significance Index: -3.3600
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.3868
    Cell Significance Index: -3.4500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3880
    Cell Significance Index: -4.0900
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.3890
    Cell Significance Index: -4.1000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3897
    Cell Significance Index: -4.5200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3938
    Cell Significance Index: -4.3800
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.3950
    Cell Significance Index: -4.1500
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.3990
    Cell Significance Index: -3.6800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3992
    Cell Significance Index: -4.4600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4001
    Cell Significance Index: -5.1400
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.4027
    Cell Significance Index: -3.8100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4029
    Cell Significance Index: -3.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4030
    Cell Significance Index: -11.6100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.4138
    Cell Significance Index: -4.1300
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.4154
    Cell Significance Index: -3.8700
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.4162
    Cell Significance Index: -4.5000
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.4170
    Cell Significance Index: -4.3600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.4218
    Cell Significance Index: -4.0100
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.4229
    Cell Significance Index: -3.4700
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.4232
    Cell Significance Index: -4.1800
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.4309
    Cell Significance Index: -4.1500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4350
    Cell Significance Index: -5.7800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.4385
    Cell Significance Index: -4.0700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.4405
    Cell Significance Index: -4.4700
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.4405
    Cell Significance Index: -3.1000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.4423
    Cell Significance Index: -4.7100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.4433
    Cell Significance Index: -5.1500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4437
    Cell Significance Index: -5.0000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.4446
    Cell Significance Index: -4.4800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.4466
    Cell Significance Index: -5.1400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.4569
    Cell Significance Index: -3.7000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.4627
    Cell Significance Index: -4.1700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4659
    Cell Significance Index: -5.8200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.4671
    Cell Significance Index: -5.5200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.4724
    Cell Significance Index: -5.0800
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: -0.4781
    Cell Significance Index: -3.3700
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.4793
    Cell Significance Index: -3.6800
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.4795
    Cell Significance Index: -4.5100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.4819
    Cell Significance Index: -5.1100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.4833
    Cell Significance Index: -4.5000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.4850
    Cell Significance Index: -4.1900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.4854
    Cell Significance Index: -4.4900
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.4863
    Cell Significance Index: -3.3700
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.4931
    Cell Significance Index: -5.1100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.4938
    Cell Significance Index: -5.6100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.4946
    Cell Significance Index: -5.0200
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.5008
    Cell Significance Index: -4.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Variable region**: IGHV3-73 is a variable region gene, which means it encodes a highly diverse and variable sequence that determines the specificity of antibody-antigen interactions. 2. **Heavy chain**: This gene is part of the immunoglobulin heavy chain locus, which encodes the heavy chains of antibodies. 3. **Variable domain**: The variable domain of IGHV3-73 is responsible for recognizing and binding to specific antigens, which is essential for the activation of immune cells and the elimination of pathogens. 4. **Expression in various cell types**: IGHV3-73 is expressed in a range of cell types, including goblet cells, T cells, and neoplastic cells, indicating its versatility and importance in immune responses. **Pathways and Functions:** 1. **Antigen binding**: IGHV3-73 plays a critical role in antigen binding, which is essential for the activation of immune cells and the elimination of pathogens. 2. **Immune complex formation**: The expression of IGHV3-73 is associated with the formation of immune complexes, which are complexes of antibodies and antigens that can activate immune cells and promote immune responses. 3. **Activation of immune cells**: IGHV3-73 is involved in the activation of immune cells, including T cells and B cells, which is essential for the elimination of pathogens and the maintenance of immune homeostasis. 4. **Immune-mediated responses**: The expression of IGHV3-73 is associated with immune-mediated responses, including the activation of complement and the production of cytokines. **Clinical Significance:** The IGHV3-73 gene has significant clinical implications, particularly in the context of immune-mediated diseases. Abnormal expression of this gene has been associated with a range of conditions, including: 1. **Autoimmune diseases**: IGHV3-73 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where the expression of this gene leads to the production of autoantibodies. 2. **Cancer**: The expression of IGHV3-73 has been associated with certain types of cancer, including Burkitt lymphoma and chronic lymphocytic leukemia, where the gene is involved in the activation of immune cells and the production of antibodies. 3. **Immunodeficiency disorders**: IGHV3-73 has been implicated in immunodeficiency disorders, such as X-linked agammaglobulinemia, where the expression of this gene is reduced or absent, leading to impaired antibody production. In conclusion, the IGHV3-73 gene is a critical component of the immune system, playing a significant role in the production of antibodies and the activation of immune cells. Its expression is associated with a range of immune responses, including antigen binding, immune complex formation, and the activation of immune cells. The clinical significance of this gene is significant, particularly in the context of autoimmune diseases, cancer, and immunodeficiency disorders. Further research is needed to fully understand the mechanisms of IGHV3-73 and its role in immune function.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.