Details for: IGHV3 73

Gene ID: 28409

Symbol: IGHV3 73

Ensembl ID: ENSG00000211976

Description: immunoglobulin heavy variable 3-73

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,812
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.26
    Marker Score: 2,172
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,577
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,654
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,728
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,818
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.81
    Marker Score: 4,612
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 737
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.81
    Marker Score: 468
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 383
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.28
    Marker Score: 861
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.28
    Marker Score: 370
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 381
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.18
    Marker Score: 197
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.15
    Marker Score: 210
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.14
    Marker Score: 109
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.13
    Marker Score: 309
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.12
    Marker Score: 199
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.1
    Marker Score: 83
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.08
    Marker Score: 208
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.08
    Marker Score: 56
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.07
    Marker Score: 788
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.07
    Marker Score: 71
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 66
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.05
    Marker Score: 47
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.05
    Marker Score: 61
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 50
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: enucleated reticulocyte (CL0002422)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.04
    Marker Score: 34
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.03
    Marker Score: 66
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.03
    Marker Score: 57
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.03
    Marker Score: 56
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.03
    Marker Score: 73
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.03
    Marker Score: 62
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.02
    Marker Score: 57
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.02
    Marker Score: 51
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.01
    Marker Score: 9

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Variable region**: IGHV3-73 is a variable region gene, which means it encodes a highly diverse and variable sequence that determines the specificity of antibody-antigen interactions. 2. **Heavy chain**: This gene is part of the immunoglobulin heavy chain locus, which encodes the heavy chains of antibodies. 3. **Variable domain**: The variable domain of IGHV3-73 is responsible for recognizing and binding to specific antigens, which is essential for the activation of immune cells and the elimination of pathogens. 4. **Expression in various cell types**: IGHV3-73 is expressed in a range of cell types, including goblet cells, T cells, and neoplastic cells, indicating its versatility and importance in immune responses. **Pathways and Functions:** 1. **Antigen binding**: IGHV3-73 plays a critical role in antigen binding, which is essential for the activation of immune cells and the elimination of pathogens. 2. **Immune complex formation**: The expression of IGHV3-73 is associated with the formation of immune complexes, which are complexes of antibodies and antigens that can activate immune cells and promote immune responses. 3. **Activation of immune cells**: IGHV3-73 is involved in the activation of immune cells, including T cells and B cells, which is essential for the elimination of pathogens and the maintenance of immune homeostasis. 4. **Immune-mediated responses**: The expression of IGHV3-73 is associated with immune-mediated responses, including the activation of complement and the production of cytokines. **Clinical Significance:** The IGHV3-73 gene has significant clinical implications, particularly in the context of immune-mediated diseases. Abnormal expression of this gene has been associated with a range of conditions, including: 1. **Autoimmune diseases**: IGHV3-73 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where the expression of this gene leads to the production of autoantibodies. 2. **Cancer**: The expression of IGHV3-73 has been associated with certain types of cancer, including Burkitt lymphoma and chronic lymphocytic leukemia, where the gene is involved in the activation of immune cells and the production of antibodies. 3. **Immunodeficiency disorders**: IGHV3-73 has been implicated in immunodeficiency disorders, such as X-linked agammaglobulinemia, where the expression of this gene is reduced or absent, leading to impaired antibody production. In conclusion, the IGHV3-73 gene is a critical component of the immune system, playing a significant role in the production of antibodies and the activation of immune cells. Its expression is associated with a range of immune responses, including antigen binding, immune complex formation, and the activation of immune cells. The clinical significance of this gene is significant, particularly in the context of autoimmune diseases, cancer, and immunodeficiency disorders. Further research is needed to fully understand the mechanisms of IGHV3-73 and its role in immune function.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.